Copyright © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Editor-in-Chief: José Oliveira; Deputy Editor: Mary Farrell
Online ISSN: 1613-6829
Associated Title(s): Advanced Energy Materials, Advanced Engineering Materials, Advanced Functional Materials, Advanced Healthcare Materials, Advanced Materials, Advanced Materials Interfaces, Advanced Optical Materials, Particle & Particle Systems Characterization
Recently Published Articles
- Nanoneedle-Assisted Delivery of Site-Selective Peptide-Functionalized DNA Nanocages for Targeting Mitochondria and Nuclei
Miu Shan Chan and Pik Kwan Lo
Article first published online: 10 DEC 2013 | DOI: 10.1002/smll.201302993
Peptide-functionalized DNA nano-objects selectively target mitochondria and the nucleus by means of nanoneedle-assisted delivery. This technology preserves the cell viability and structural integrity of nanostructures and assists the nano-objects in escaping degradation by endocytosis. This method opens up a new avenue for further in vitro studies of intracellular behaviors of DNA assemblies and their interactions in specific organelles.
- Polyarginine Induces an Antitumor Immune Response through Binding to Toll-Like Receptor 4
Yong Yang, Joy Wolfram, Xiaohong Fang, Haifa Shen and Mauro Ferrari
Article first published online: 10 DEC 2013 | DOI: 10.1002/smll.201302887
A novel function of polyarginine as an activator of the immune system is reported. Single-molecule fluorescence imaging and single-molecule force measurements demonstrate that polyarginine binds specifically to the toll-like receptor 4 (TLR4), inducing receptor dimerization and activation. Moreover, polyarginine induced immune activation inhibits tumor growth. These results suggest the potential use of polyarginine for cancer immunotherapy.
- Powder, Paper and Foam of Few-Layer Graphene Prepared in High Yield by Electrochemical Intercalation Exfoliation of Expanded Graphite
Liqiong Wu, Weiwei Li, Peng Li, Shutian Liao, Shengqiang Qiu, Mingliang Chen, Yufen Guo, Qi Li, Chao Zhu and Liwei Liu
Article first published online: 9 DEC 2013 | DOI: 10.1002/smll.201302730
High-yield preparation of graphene is important for its wide applications; however, it is still a challenging task. A facile and high-yield approach is demonstrated to prepare few layer graphene by electrochemical intercalation exfoliation of expanded graphite using stage-1 H2SO4-graphite intercalation compound as a key intermediate. Freestanding graphene papers with excellent conductivity and light-weight graphene foams are fabricated from the electrochemical exfoliated graphene sheets.
- Tuning Cellular Response to Nanoparticles via Surface Chemistry and Aggregation
Jie An Yang, Samuel E. Lohse and Catherine J. Murphy
Article first published online: 9 DEC 2013 | DOI: 10.1002/smll.201302835
By first mixing gold nanoparticles (Au NPs) with serum proteins then buffer, Au NP aggregation, commonly observed through direct addition to cell media, is prevented. Cells in cell media with non-aggregated Au NPs exhibit better cell viability and lower uptake of Au NPs. F-actin disruption appears to be related to Au NP uptake and surface chemistry.
- All-Oxide Raman-Active Traps for Light and Matter: Probing Redox Homeostasis Model Reactions in Aqueous Environment
Ivano Alessandri and L. E. Depero
Article first published online: 9 DEC 2013 | DOI: 10.1002/smll.201303166
Core–shell colloidal crystals can act as very efficient traps for light and analytes. Here it is shown that Raman-active probes can be achieved using SiO2–TiO2 core–shell beads. These systems are successfully tested in monitoring of glutathione redox cycle at physiological concentration in aqueous environment, without need of any interfering enhancers. These materials represent a promising alternative to conventional, metal-based SERS probes for investigating chemical and biochemical reactions under real working conditions.