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Recently Published Articles

  1. Plasmofluidics: Merging Light and Fluids at the Micro-/Nanoscale

    Mingsong Wang, Chenglong Zhao, Xiaoyu Miao, Yanhui Zhao, Joseph Rufo, Yan Jun Liu, Tony Jun Huang and Yuebing Zheng

    Article first published online: 3 JUL 2015 | DOI: 10.1002/smll.201500970

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    The most recent advances in the emerging field of plasmofluidics, which seeks the synergistic integration of plasmonics and micro/nanofluidics in devices and applications in order to enhance performance, are discussed in this review.

  2. Passively Targeted Curcumin-Loaded PEGylated PLGA Nanocapsules for Colon Cancer Therapy In Vivo

    Rebecca Klippstein, Julie Tzu-Wen Wang, Riham I. El-Gogary, Jie Bai, Falisa Mustafa, Noelia Rubio, Sukhvinder Bansal, Wafa T. Al-Jamal and Khuloud T. Al-Jamal

    Article first published online: 3 JUL 2015 | DOI: 10.1002/smll.201403799

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    An oil-cored nanocapsule (NC) containing a high dose of curcumin is prepared. The NC delivers curcumin to colon cancer (CT26) in vitro, and reaches solid tumor after intravenous injection in mouse models, as shown by optical imaging and single photon emission computed tomography/computed tomography (SPECT/CT). The presence of the drug in the tumor is confirmed by high-performance liquid chromatography. Apoptosis of proliferating cells is confirmed by TUNEL staining.

  3. Quantum Optical Signature of Plasmonically Coupled Nanocrystal Quantum Dots

    Feng Wang, Niladri S. Karan, Hue Minh Nguyen, Benjamin D. Mangum, Yagnaseni Ghosh, Chris J. Sheehan, Jennifer A. Hollingsworth and Han Htoon

    Article first published online: 3 JUL 2015 | DOI: 10.1002/smll.201500823

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    Small clusters of two to three silica-coated nanocrystals coupled to plasmonic gap-bar antennas can exhibit photon antibunching, a characteristic of single quantum emitters. Through a detailed analysis of their photoluminescence emissions characteristics, it is shown that the observed photon antibunching is the evidence of coupled quantum dot formation resulting from the plasmonic enhancement of dipole–dipole interaction.

  4. Fabrication of Supported AuPt Alloy Nanocrystals with Enhanced Electrocatalytic Activity for Formic Acid Oxidation through Conversion Chemistry of Layer-Deposited Pt2+ on Au Nanocrystals

    Seong Hyeon Kim, Hwakyeung Jeong, Jongwon Kim and In Su Lee

    Article first published online: 1 JUL 2015 | DOI: 10.1002/smll.201500947

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    A novel synthetic strategy for electrocatalytic AuPt alloy nanocrystals is devised through the finding that a Pt2+-monolayer is spontaneously deposited on in-situ generated Au nanocrystals and can be thermally converted into AuPt alloy nano­crystals during nanosilica-confined transformation. This method is extended into a surfactant-free protocol for AuPt/Fe3O4/reduced graphene oxide triple-junction nanocomposites with improved activity and durability in electrocatalysis of formic acid oxidation.

  5. Pulmonary Codelivery of Doxorubicin and siRNA by pH-Sensitive Nanoparticles for Therapy of Metastatic Lung Cancer

    Caina Xu, Ping Wang, Jingpeng Zhang, Huayu Tian, Kinam Park and Xuesi Chen

    Article first published online: 1 JUL 2015 | DOI: 10.1002/smll.201501034

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    A codelivery system (PEI-CA-DOX/Bcl2 siRNA) is successfully constructed for pulmonary delivery. The pulmonary codelivery system has high cytotoxicity in vitro, significantly inhibits the tumor growth in vivo, prolongs residence time in lungs, and results in increased accumulation in the tumor tissues in lungs. Pulmonary codelivery of DOX and Bcl2 siRNA is a promising strategy for treating the metastatic lung cancer.