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Editor-in-Chief: José Oliveira; Deputy Editors: Yan Li, Guangchen Xu
Online ISSN: 1613-6829
Associated Title(s): Advanced Electronic Materials, Advanced Energy Materials, Advanced Engineering Materials, Advanced Functional Materials, Advanced Healthcare Materials, Advanced Materials, Advanced Materials Interfaces, Advanced Materials Technologies, Advanced Optical Materials, Advanced Science, Particle & Particle Systems Characterization
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- Templated Solid-State Dewetting of Thin Silicon Films
Meher Naffouti, Thomas David, Abdelmalek Benkouider, Luc Favre, Anne Delobbe, Antoine Ronda, Isabelle Berbezier and Marco Abbarchi
Version of Record online: 22 SEP 2016 | DOI: 10.1002/smll.201601744
Templated solid-state dewetting of thin silicon films allows for the deterministic nucleation and positioning of Si- and SiGe-based nanocrystals in complex assemblies. The dewetting dynamics is guided by pattern size and shape controlling the number, size, shape, and position of the particles. Islands dimensions and relative distances are in the hundreds nm range and fluctuate ≈11% and ≈5%, respectively.
- Continuous Production of Discrete Plasmid DNA-Polycation Nanoparticles Using Flash Nanocomplexation
Jose Luis Santos, Yong Ren, John Vandermark, Maani M. Archang, John-Michael Williford, Heng-Wen Liu, Jason Lee, Tza-Huei Wang and Hai-Quan Mao
Version of Record online: 22 SEP 2016 | DOI: 10.1002/smll.201601425
A flash nanocomplexation method is developed to prepare linear polyethyleneimine/plasmid DNA nanoparticles with narrow size distribution and tunable size and shape under continuous flow operation. The method offers high versatility for preparing various polyelectrolyte coacervate nanoparticles in a scalable process with high efficiency and reproducibility.
- Corrosion-Activated Chemotherapeutic Function of Nanoparticulate Platinum as a Cisplatin Resistance-Overcoming Prodrug with Limited Autophagy Induction
Hsien-Jen Cheng, Te-Haw Wu, Chih-Te Chien, Hai-Wei Tu, Ting-Shan Cha and Shu-Yi Lin
Version of Record online: 22 SEP 2016 | DOI: 10.1002/smll.201602374
The corrosion susceptibility of nanoparticulate platinum (nano-Pt) can be triggered by inducing the oxidization of superficial Pt atoms, which can kill both cisplatin-sensitive and cisplatin-resistant cancer cells. Again, the limiting autophagy induction by nano-Pt might prevent cancer cells from acquiring autophagy-related drug resistance. With such advantages, nano-Pt could potentially develop as a cisplatin resistant-overcoming prodrug for anticancer therapy.
- Controllable Large-Scale Transfection of Primary Mammalian Cardiomyocytes on a Nanochannel Array Platform
Lingqian Chang, Daniel Gallego-Perez, Chi-Ling Chiang, Paul Bertani, Tairong Kuang, Yan Sheng, Feng Chen, Zhou Chen, Junfeng Shi, Hao Yang, Xiaomeng Huang, Veysi Malkoc, Wu Lu and Ly James Lee
Version of Record online: 20 SEP 2016 | DOI: 10.1002/smll.201601465
A nanochannel array platform trap and precisely transfect primary adult mammalian cardiomyocytes with high efficiency/cell viability. A simple “dipping-trap” approach precisely positions single cell on chip. Nanochannel-based electroporation can determine the dose of delivery, offering quality control of microRNA-based gene therapy in cardiovascular cells as demonstrated by delivering miR-29 into primary cardiomyocytes for determining dose effect for apoptosis.