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Recently Published Articles

  1. Physical Deposition Improved SERS Stability of Morphology Controlled Periodic Micro/Nanostructured Arrays Based on Colloidal Templates

    Honghua Zhang, Mao Liu, Fei Zhou, Dilong Liu, Guangqiang Liu, Guotao Duan, Weiping Cai and Yue Li

    Article first published online: 30 OCT 2014 | DOI: 10.1002/smll.201402630

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    Via a colloidal template-induced precursor solution dipping strategy, a semi-hollow sphere array is formed, and its morphology changed to a novel ordered honeycomb-shaped micro/nanostructured array after magnetron sputtering deposition. After coating a gold thin layer, the periodic array is used as SERS active substrate and demonstrates very stable SERS performance.

  2. Sperm Dynamics in Tubular Confinement

    Veronika Magdanz, Britta Koch, Samuel Sanchez and Oliver G. Schmidt

    Article first published online: 30 OCT 2014 | DOI: 10.1002/smll.201401881

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    An on-chip system that mimics tubular microenvironments is presented for the study of spermatozoa motion in confinement. Using rolled up transparent silicon oxide/dioxide microtubes, the influence of tube diameter on the velocity, directionality, and linearity of spermatozoa is investigated. Tubular microenvironments of diameters 20–45 μm facilitate sperm migration through channels.

  3. Seed-Induced Growth of Flower-Like Au–Ni–ZnO Metal–Semiconductor Hybrid Nanocrystals for Photocatalytic Applications

    Yuanzhi Chen, Deqian Zeng, Michael B. Cortie, Annette Dowd, Huizhang Guo, Junbao Wang and Dong-Liang Peng

    Article first published online: 30 OCT 2014 | DOI: 10.1002/smll.201401853

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    Au–Ni–ZnO ternary metal–semiconductor hybrid nanocrystals are synthesized using a method that utilizes Au@Ni seeds formed in situ to induce the epitaxial growth of ZnO {0001} facets on Ni {111} facets. Excellent photocatalytic properties along with magnetic recycling ability are achieved. The prepared nanocrystals possess plasmonic, semiconducting, and magnetic functionalities and are expected to find wide application in multiple technological fields.

  4. Dynamic Biointerfaces: From Recognition to Function

    Baisong Chang, Mingxi Zhang, Guangyan Qing and Taolei Sun

    Article first published online: 29 OCT 2014 | DOI: 10.1002/smll.201402038

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    A dynamic biointerface based on synergetic chiral H-bonding interactions can transform weak signals of molecular or chiral recognitions into changes of the macroscopic behaviors of cells and biomolecules, which can break the limitation of conventional polymers and has the ability to solve the big challenges in life sciences.

  5. In vivo Gold Nanoparticle Delivery of Peptide Vaccine Induces Anti-Tumor Immune Response in Prophylactic and Therapeutic Tumor Models

    Joao Paulo Mattos Almeida, Adam Yuh Lin, Elizabeth Raquel Figueroa, Aaron Edward Foster and Rebekah Anna Drezek

    Article first published online: 29 OCT 2014 | DOI: 10.1002/smll.201402179

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    Gold nanoparticles (AuNPs) have a demonstrated efficacy in the delivery of cancer immunotherapies. This study demonstrates that AuNP-mediated delivery of the ovalbumin antigen and the CpG adjuvant induces strong antigen-specific immune responses. These responses subsequently result in anti-tumor activity and increased survival in prophylactic and established in vivo tumor models.