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Recently Published Articles

  1. Single-Cell Detection of mRNA Expression Using Nanofountain-Probe Electroporated Molecular Beacons

    Juan P. Giraldo-Vela, Wonmo Kang, Rebecca L. McNaughton, Xuemei Zhang, Brian M. Wile, Andrew Tsourkas, Gang Bao and Horacio D. Espinosa

    Article first published online: 1 FEB 2015 | DOI: 10.1002/smll.201401137

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    Individual cells within a population are probed for mRNA expression by localized electroporation using a nanofountain probe electroporation system. DNA-based and RNA-based molecular beacons are delivered to bind to the mRNA of interest. A unique feature demonstrated is that the nanofountain probe electroporation method allows for the same cell to be probed over time.

  2. Precise Manipulation and Patterning of Protein Crystals for Macromolecular Crystallography Using Surface Acoustic Waves

    Feng Guo, Weijie Zhou, Peng Li, Zhangming Mao, Neela H. Yennawar, Jarrod B. French and Tony Jun Huang

    Article first published online: 1 FEB 2015 | DOI: 10.1002/smll.201403262

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    The increasing flux and decreasing beam size at X-ray sources has made data collection using crystals commonplace, necessitating automation of crystal manipulation and harvesting. An acoustic-based device for manipulating and patterning micrometer sized crystals is developed here. This robust, biocompatible and easy-to-implement technology will increase throughput, lower sample requirements and make data collection possible for previously intractable samples.

  3. Microfluidic Single-Cell Analysis with Affinity Beads

    Michael Werner, Raghavendra Palankar, Loïc Arm, Ruud Hovius and Horst Vogel

    Article first published online: 29 JAN 2015 | DOI: 10.1002/smll.201402650

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    A micrometer-sized affinity bead (red) is (i) taken up into a cell by phagocytosis, (ii) photochemically released from phagosomes, (iii) optically trapped by the cell, and (iv) isolated by cell lysis for subsequent analysis of captured intracellular analyte (green).

  4. Tailored Crumpling and Unfolding of Spray-Dried Pristine Graphene and Graphene Oxide Sheets

    Dorsa Parviz, Shane D. Metzler, Sriya Das, Fahmida Irin and Micah J. Green

    Article first published online: 29 JAN 2015 | DOI: 10.1002/smll.201403466

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    The morphological transition of 2D graphene nanosheets to 3D crumpled particles is achieved via a scalable spray-drying technique. In-situ microscopy shows that factors such as nanosheet elasticity and surface chemistry affect the crumpling process, such that the crumpling mechanism differs between pristine graphene and graphene oxide. Unfolding of crumpled graphene upon rewetting depends on nanosheet–solvent interactions.

  5. Facet-Dependent Stripping Behavior of Cu2O Microcrystals Toward Lead Ions: A Rational Design for the Determination of Lead Ions

    Zhong-Gang Liu, Yu-Feng Sun, Wen-Kai Chen, Yuan Kong, Zhen Jin, Xing Chen, Xiao Zheng, Jin-Huai Liu, Xing-Jiu Huang and Shu-Hong Yu

    Article first published online: 29 JAN 2015 | DOI: 10.1002/smll.201402146

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    Facet-dependent stripping behavior in the determination of Pb(II): Well-defined Cu2O microcrystals with different structures show facet-dependent electrochemical behaviors toward heavy metal ions. This provides an important insight into the understanding the efficiency of facet-dependent properties of microcrystals on electroanalytical performance for the rational design of electrochemical analytical techniques for efficient detection of heavy metal ions.