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Recently Published Articles

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    DNA Hydrogels: A Writable Polypeptide–DNA Hydrogel with Rationally Designed Multi-modification Sites (Small 9-10/2015) (page 1224)

    Chuang Li, Ping Chen, Yu Shao, Xu Zhou, Yuzhou Wu, Zhongqiang Yang, Zhibo Li, Tanja Weil and Dongsheng Liu

    Article first published online: 3 MAR 2015 | DOI: 10.1002/smll.201570058

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    A polypeptide-DNA hydrogel is prepared by Z. Li, D. Liu, and co-workers, employing the “X”-shaped DNA assembling structure as crosslinker. The hydrogel can be modified with multifunctional components (here fluorescent molecules as a model), and possess excellent self-healing and thixotropic properties, enabling the direct-writing of arbitrary 3D structures. The study on page 1138 provides a simple, universal strategy for the assembly of functionalized hydrogels with biomolecules, especially enzymes.

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    Cellular Uptake: Theoretical and Computational Investigations of Nanoparticle–Biomembrane Interactions in Cellular Delivery (Small 9-10/2015) (page 1014)

    Hong-ming Ding and Yu-qiang Ma

    Article first published online: 3 MAR 2015 | DOI: 10.1002/smll.201570052

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    Nanoparticles have recently been widely applied in biomedicine. Understanding how nanoparticles interact with biosystems (especially cells) is crucial for their further biomedical application. On page 1055, H.-m. Ding and Y.-q. Ma summarize the current progress on theoretical and computational investigations of nanoparticle-biomembrane interactions in cellular delivery. The parameters that determine the cellular uptake and subsequent intracellular trafficking of nanoparticles are discussed in detail.

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    Biomaterials: Efficient Encapsulation of Fe3O4 Nanoparticles into Genetically Engineered Hepatitis B Core Virus-Like Particles Through a Specific Interaction for Potential Bioapplications (Small 9-10/2015) (page 1189)

    Lihua Shen, Jun Zhou, Yixiao Wang, Ning Kang, Xuebin Ke, Shengli Bi and Lei Ren

    Article first published online: 3 MAR 2015 | DOI: 10.1002/smll.201570056

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    A method to encapsulate magnetic nanoparticles into His-tagged virus-like particles (VLPs) is developed by L. Ren and co-workers on page 1190. It is the first report using the affinity of histidine tags for the nickel-nitrilotriacetic acid chelate to trigger encapsulation of nanoparticles by VLPs. This makes it possible to integrate a wide range of starting nanoparticles into fundamentally different kinds of viral coating proteins or other nonenveloped viruses for application in cancer nanotechnology and medicine.

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    Adhesion: Gecko-Inspired but Chemically Switched Friction and Adhesion on Nanofibrillar Surfaces (Small 9-10/2015) (page 1130)

    Shuanhong Ma, Daoai Wang, Yongmin Liang, Baoquan Sun, Stanislav N. Gorb and Feng Zhou

    Article first published online: 3 MAR 2015 | DOI: 10.1002/smll.201570055

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    The gecko's foot generates an adhesive force with numerous keratinous setae which form a large real contact area with the substrate. While geckos can switch the adhesion freely, the detachment of gecko-inspired synthetic adhesives is often difficult, and relies on external mechanical control. On page 1131, D. Wang, S. N. Gorb, F. Zhou, and co-workers develop chemically responsive nanofibrillar surfaces: silicon nanowires grafted with polymers, in which attachment and detachment are chemically triggered in response to pH, humidity, or electrolyte solution.

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    Contents: (Small 9-10/2015) (pages 1015–1021)

    Article first published online: 3 MAR 2015 | DOI: 10.1002/smll.201570053