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Recently Published Articles

  1. Ultrahigh Capacity Due to Multi-Electron Conversion Reaction in Reduced Graphene Oxide-Wrapped MoO2 Porous Nanobelts

    Wei Tang, Cheng Xin Peng, Chang Tai Nai, Jie Su, Yan Peng Liu, M. V. Venkatashamy Reddy, Ming Lin and Kian Ping Loh

    Article first published online: 23 JAN 2015 | DOI: 10.1002/smll.201403018

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    Reduced graphene-oxide sheet-wrapped MoO2 porous nanobelts are fabricated and applied as the anode material in a lithium ion battery. The composite affords an unprecedented, full-scale, multi-electron conversion reaction, giving a high capacity, ultrafast rate capability, and cycle stability.

  2. Correlation between Membrane Partitioning and Functional Activity in a Single Lipid Vesicle Assay Establishes Design Guidelines for Antiviral Peptides

    Joshua A. Jackman, Rathi Saravanan, Yibang Zhang, Seyed R. Tabaei and Nam-Joon Cho

    Article first published online: 23 JAN 2015 | DOI: 10.1002/smll.201403638

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    The nanometer-scale discrimination of virus-rupturing peptides is tested using lipid membrane platforms. In combination with single-vesicle analysis of peptide-induced vesicle rupture, a correlation between membrane partitioning and biologically relevant activities is established. Taken together, the findings support that the degree of rupture activity should be balanced by membrane curvature-selectivity for optimal therapeutic properties of antiviral peptides.

  3. Real-Time Analysis of Magnetic Hyperthermia Experiments on Living Cells under a Confocal Microscope

    Vincent Connord, Pascal Clerc, Nicolas Hallali, Darine El Hajj Diab, Daniel Fourmy, Véronique Gigoux and Julian Carrey

    Article first published online: 23 JAN 2015 | DOI: 10.1002/smll.201402669

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    A miniaturized electromagnet makes possible the generation of a high-frequency magnetic field under a confocal microscope. Several physical and biological events occurring in cells containing magnetic nanoparticles and submitted to such a field are observed and quantified in real-time: cell damages, reactive oxygen species production, lysosome permeabilization, and nanoparticles self-assembling.

  4. Multifunctional Assembly of Micrometer-Sized Colloids for Cell Sorting

    Chenyao Nie, Bing Wang, Jiangyan Zhang, Yongqiang Cheng, Fengting Lv, Libing Liu and Shu Wang

    Article first published online: 22 JAN 2015 | DOI: 10.1002/smll.201402970

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    A bottom-up approach for constructing self-assembled micrometer-sized magnetic colloids is developed. The colloids possess multifunctionality, including magnetic, optical, and biological activities. Biotinylated oligo (p-phenylene vinylene) derivatives are designed to mediate the self-assembly of streptavidin-modified magnetic beads. The colloidal assembly reveals better performance in cell isolation by amplified magnetic response in comparison to monodisperse colloids.

  5. Supramolecular Nanosubstrate-Mediated Delivery for Reprogramming and Transdifferentiation of Mammalian Cells

    Shuang Hou, Jin-sil Choi, Kuan-Ju Chen, Yang Zhang, Jinliang Peng, Mitch A. Garcia, Jue-Hua Yu, Kaushali Thakore-Shah, Tracy Ro, Jie-Fu Chen, Parham Peyda, Guoping Fan, April D. Pyle, Hao Wang and Hsian-Rong Tseng

    Article first published online: 22 JAN 2015 | DOI: 10.1002/smll.201402602

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    Supramolecular nanosubstrate-mediated delivery (SNSMD) leverages the power of molecular self-assembly and a nanostructured substrate platform for the low toxicity, highly efficient co-delivery of biological factors encapsulated in a nanovector. Human fibroblasts are successfully reprogrammed into induced pluripotent stems and transdifferentiated into induced neuronal-like cells.