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Recently Published Articles

  1. Microenvironment-Responsive Three-Pronged Approach Breaking Traditional Chemotherapy to Target Cancer Stem Cells for Synergistic Inoperable Large Tumor Therapy

    Yan Li, Ruilong Zhang, Zhiguo Lu, Guanghui Ma, Lei Chen, Qunwei Tang and Xin Zhang

    Version of Record online: 24 AUG 2016 | DOI: 10.1002/smll.201601932

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    Three-pronged nanoparticles (NPs) that can efficiently prohibit the proliferation of large tumor are developed for inoperable large tumor therapy. The NPs achieve spatially and temporally controlled release of drugs in target sites. The NPs induce the apoptosis of differentiated cancer cells, cancer stem cells, and vascular niches simultaneously. Importantly, the three-pronged NPs inhibit the growth of large tumor without recurrence.

  2. Scalable Fabrication of Multiplexed Plasmonic Nanoparticle Structures Based on AFM Lithography

    Jianmei Chen, Yinghui Sun, Liubiao Zhong, Weijing Shao, Jing Huang, Feng Liang, Zequn Cui, Zhiqiang Liang, Lin Jiang and Lifeng Chi

    Version of Record online: 24 AUG 2016 | DOI: 10.1002/smll.201602250

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    A controllable and scalable strategy is developed to fabricate multiplexed plasmonic nanoparticle structures by mechanical scratching with AFM lithography, which exhibit multiplex plasmonic properties and surface-enhanced Raman scattering responses. It offers an intuitive way to explore the plasmonic effects on performance of organic light-emitting diodes device integrating with multiplexed plasmonic nanostructures.

  3. Highly Efficient Water Oxidation Photoanode Made of Surface Modified LaTiO2N Particles

    Seiji Akiyama, Mamiko Nakabayashi, Naoya Shibata, Tsutomu Minegishi, Yusuke Asakura, Md. Abdulla-Al-Mamun, Takashi Hisatomi, Hiroshi Nishiyama, Masao Katayama, Taro Yamada and Kazunari Domen

    Version of Record online: 24 AUG 2016 | DOI: 10.1002/smll.201601929

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    An improved variation of highly active/durable O2- evolving LaTiO2N powder-based photoelectrode has been fabricated by pre-cleaning the powder with mild polysulfonic acid and by homogeneous deposition of CoOx co-catalyst aided by microwave annealing. Fabricated into particle-transferred electrodes on Ti, the modified LaTiO2N serves as a highly active photoanode, achieving 8.9 mA cm−2 of the photocurrent density at 1.23 V versus RHE and longer active periods than those by previous methods.

  4. Microstructured Multilevel Bacterial Cellulose Allows the Guided Growth of Neural Stem Cells

    Natalie Geisel, Jasmin Clasohm, Xudian Shi, Lallepak Lamboni, Junchuan Yang, Kamil Mattern, Guang Yang, Karl-Herbert Schäfer and Monika Saumer

    Version of Record online: 24 AUG 2016 | DOI: 10.1002/smll.201601679

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    Repeated photolithographic and etching processes allow the production of multileveled polymer microstructures that can be used as templates to produce bacterial cellulose with defined surfaces on demand. By applying this approach, the bacterial cellulose surface obtains new properties and its use for culturing neural stem cells cellulose substrate topography influences the cell growth in a defined manner.

  5. Aggregation Induced Emission Fluorogens Based Nanotheranostics for Targeted and Imaging-Guided Chemo-Photothermal Combination Therapy

    Ke Wang, Xingliang Fan, Lingyun Zhao, Xiaoyong Zhang, Xiqi Zhang, Zhen Li, Qian Yuan, Qingsong Zhang, Zengfang Huang, Wensheng Xie, Yuanyuan Zhang and Yen Wei

    Version of Record online: 24 AUG 2016 | DOI: 10.1002/smll.201601473

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    Aggregation induced emission (AIE) fluorogens based targeted nanotheranostics are facilely fabricated through paclitaxel induced assembly of proteins for the first time, which demonstrates outstanding in vitro and in vivo targeted fluorescence imaging and imaging guided chemo-photothermal combination therapy efficacy. These results indicate that AIE fluorogens based nanotheranostics will find a promising prospect in further improved multimodal imaging and cancer treatment.