2_03/2006Cover Picture: Selective Loading of Kinesin-Powered Molecular Shuttles with Protein Cargo and its Application to Biosensing (Small 3/2006)

The cover picture illustrates a functionalized microtubule transported by surface-adhered kinesin motor proteins. Through a streptavidin bridge, biotinylated antibodies are attached to the microtubule (outer diameter of 24 nm) and are able to capture antigens, such as the heart attack marker myoglobin. Successful capture is reported via the binding of fluorescently-labeled antibodies, which complete the double-antibody sandwich assay on the microtubule. The motor-driven, active transport of this nanoscale bioassay will enable further separation and concentration, as well as sensitive detection. For more information please read the Communication "Selective Loading of Kinesin-Powered Molecular Shuttles with Protein Cargo and its Application to Biosensing" by H. Hess and co-workers on page 330 ff.

Read Full Text  | Table of Contents

Cover Gallery

SEARCH

SEARCH BY CITATION