3_03/2007Cover Picture: A Single-Step Photolithographic Interface for Cell-Free Gene Expression and Active Biochips (Small 3/2007)

The cover picture shows an image of fluorescent-labeled double-stranded DNA molecules encoded for entire genes some 2000 base-pairs long. The molecules were immobilized on a silicon dioxide chip at one of their ends. The brightest regions of the image correspond to a high density of genes on the surface with 30 nm between molecules. Such gene chips can now be prepared using a new single-step biocompatible photolithographic interface. This interface provides an adequate and simple-to-use platform for biosynthetic reactions localized to submicrometer resolution. The ability to fabricate gene layouts on a chip opens many new possibilities to explore artificial biological systems based on cell-free gene expression at the scale of a living cell. For more information, please read the Full Paper, “A Single-Step Photolithographic Interface for Cell-Free Gene Expression and Active Biochips” by R. Bar-Ziv and co-workers on page 500 ff.

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