7_23i/2011DNA Sensors: Combining a Nanowire SERRS Sensor and a Target Recycling Reaction for Ultrasensitive and Multiplex Identification of Pathogenic Fungi (Small 23/2011)

The cover picture shows a detection of pathogenic fungal DNAs by combining a surface-enhanced resonance Raman scattering sensor comprising patterned Au nanowires on a film and an exonuclease-III-assisted target recycling reaction. The patterned Au nanowires allow the identification of multiple pathogen DNAs in a single step, and the enzymatic reaction provides highly improved sensitivity. By using this sensor, multiple label-free DNAs from clinical samples are successfully identified with a detection limit of 100 fm. We anticipate that this sensor can apply to high-throughput diagnostic sensors for various infectious diseases. For more information, please read the Full Paper “Combining a Nanowire SERRS Sensor and a Target Recycling Reaction for Ultrasensitive and Multiplex Identification of Pathogenic Fungi” by S. Y. Lee, B. Kim, and co-workers, beginning on page 3371.

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