New Lignans from the Leaves and Stems of Schisandra chinensis and Their Anti-HIV-1 Activities
Yiming Shi, Weimao Zhong, Huan Chen, Ruirui Wang, Shanzhai Shang, Chengqin Liang, Zhonghua Gao, Yongtang Zheng, Weilie Xiao and Handong Sun
Article first published online: 13 MAR 2014 | DOI: 10.1002/cjoc.201400001
Six new lignans were isolated from the leaves and stems of Schisandra chinensis. The structures of the new compounds were established on the basis of spectroscopic methods including 1D- and 2D-NMR techniques and CD experiments. All the new compounds showed anti-HIV-1 activities with EC50 values in the range 17.89–138.23 µg/mL.