Chinese Journal of Chemistry
© SIOC, CAS, Shanghai & WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Cover Picture: Inhibitors of HIV-1 Integrase-Human LEDGF/p75 Interaction Identified from Natural Products via Virtual Screening (Chin. J. Chem. 12/2012)
The cover picture shows the discovery of inhibitors targeting HIV-1 integrase-human LEDGF/p75 interaction via virtual screening. One of the most challenges for anti-HIV therapy is the rapid emergence of drug resistance. Protein-protein interaction inhibitors bring us hopes to overcome the viral resistance. We conducted a virtual screening combined with bioassays to search such inhibitors from natural product library. Several compounds were discovered to block integrase- LEDGF/p75 interaction with potent activities. These findings could be helpful for anti-HIV drug discovery. More details are discussed in the article by Tang et al. on page 2752–2758.