Chinese Journal of Chemistry
Copyright © 2014 SIOC, CAS, Shanghai & WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Cover Picture: Nucleophilic Difluoro(phenylsulfonimidoyl)methylation of Unactivated Alkyl Bromides with PhSO(NTBS)CF2H: Facile Entry into gem-Difluoroalkenes (Chin. J. Chem. 8/2014)
The cover picture shows an efficient nucleophilic difluoro(phenylsulfonimidoyl)methylation of unactivated primary alkyl bromides with PhSO(NTBS)CF2H. It is particularly remarkable that, when 1.5 equiv. of alkyl bromides are used, the substitution products are obtained in moderate to excellent yields. The prepared difluoro(phenylsulfonimidoyl)-methylated alkanes can be readily transformed to gem-difluoroalkenes via base-mediated β-elimination reaction. More details are discussed in the article by Hu et al. on page 703–708.