Chinese Journal of Chemistry

Cover image for Vol. 32 Issue 8

Editors: Guozhen Ji, Shengming Ma

Online ISSN: 1614-7065

Associated Title(s): Chemistry - A European Journal, Chemistry – An Asian Journal, Israel Journal of Chemistry, The Chemical Record

32_08/2014Cover Picture: Nucleophilic Difluoro(phenylsulfonimidoyl)methylation of Unactivated Alkyl Bromides with PhSO(NTBS)CF2H: Facile Entry into gem-Difluoroalkenes (Chin. J. Chem. 8/2014)

The cover picture shows an efficient nucleophilic difluoro(phenylsulfonimidoyl)methylation of unactivated primary alkyl bromides with PhSO(NTBS)CF2H. It is particularly remarkable that, when 1.5 equiv. of alkyl bromides are used, the substitution products are obtained in moderate to excellent yields. The prepared difluoro(phenylsulfonimidoyl)-methylated alkanes can be readily transformed to gem-difluoroalkenes via base-mediated β-elimination reaction. More details are discussed in the article by Hu et al. on page 703–708.

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