Chinese Journal of Chemistry

Cover image for Vol. 32 Issue 12

Editors: Guozhen Ji, Shengming Ma

Online ISSN: 1614-7065

Associated Title(s): Chemistry - A European Journal, Chemistry – An Asian Journal, Israel Journal of Chemistry, The Chemical Record

32_11/2014Cover Picture: A Versatile Total Synthesis of 8-Oxyberberine and Oxohomoberberines (Chin. J. Chem. 11/2014)

The cover picture shows a new and expeditious approach for the synthesis of 8-oxyberberine and oxohomoberberines. Few general processes existed for the oxohomoberberine from the simple starting material. Reported methods generally required special reagents or complex procedures, and some are limited in scope. The total syntheses of 8-oxyberberine and oxohomoberberines were accomplished starting from commercially available 5-bromobenzo[d][1,3]dioxole, piperonal and sesamol. We have successfully presented a synthetic route for the synthesis of 8-oxyberberine 1a with high total yield of 43% from 5-bromobenzo[d][1,3]dioxole 2a in 7 steps. Meanwhile, we firstly described the synthesis of the oxohomoberberines 1b, 1c and 1d in a 46.2% overall yield (7 steps), a 22.9% overall yield (9 steps), and a 14% overall yield (6 steps), respectively. More details are discussed in the article by Wu et al. on page 1121–1127.

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