Advanced Synthesis & Catalysis

Cover image for Vol. 358 Issue 10

Early View (Online Version of Record published before inclusion in an issue)

Editor: Joe P. Richmond, Chairman of the Editorial Board: Eric N. Jacobsen

Impact Factor: 5.663

ISI Journal Citation Reports © Ranking: 2014: 2/72 (Chemistry Applied); 6/58 (Chemistry Organic)

Online ISSN: 1615-4169

Associated Title(s): Angewandte Chemie International Edition, Asian Journal of Organic Chemistry, Chemistry - A European Journal, Chemistry – An Asian Journal, ChemCatChem, European Journal of Organic Chemistry

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  1. 1 - 48
  1. Full Papers

    1. Very Important Publication

      Palladium-Catalyzed One-Pot Synthesis of 5-(1-Arylvinyl)-1H-benzimidazoles: Overcoming the Limitation of Acetamide Partners

      Timothée Naret, Pascal Retailleau, Jérôme Bignon, Jean-Daniel Brion, Mouad Alami and Abdallah Hamze

      Version of Record online: 25 MAY 2016 | DOI: 10.1002/adsc.201600173

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  2. Cover Pictures

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      N-Tosylhydrazones in Action

      Timothée Naret, Pascal Retailleau, Jérôme Bignon, Jean-Daniel Brion, Mouad Alami and Abdallah Hamze

      Version of Record online: 25 MAY 2016 | DOI: 10.1002/adsc.201600491

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      The cover picture, provided by Abdallah Hamze and co-workers, reports an efficient one-pot metal-catalyzed process between N-tosylhydrazones, N-(dihalophenyl)-imidates, and amines. During this transformation, one C[BOND]C bond and two C[BOND]N bonds were created by a single palladium-catalyzed reaction leading to a library of 5-(1-arylvinyl)-1H-benzimidazoles. Imidates were found to be an ideal partner for the cross-coupling with hydrazones in comparison with acetamides. Among several derivatives evaluated, one compound exhibits excellent antiproliferative activity in the nanomolar concentration range. Details can be found in the full paper on pages xxxx–xxxx (T. Naret, P. Retailleau, J. Bignon, J.-D. Brion, M. Alami, A. Hamze, Adv. Synth. Catal.­ 2016, 358, xxxx–xxxx; DOI: 10.1002/adsc.201600173).

  3. Communications

    1. Very Important Publication

    2. Very Important Publication

  4. Cover Pictures

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      Going under the Bridge

      Huan Sun, Yi Zhang, Ping Chen, Yun-Dong Wu, Xinhao Zhang and Yong Huang

      Version of Record online: 24 MAY 2016 | DOI: 10.1002/adsc.201600460

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      The front cover image, provided by Wu, Zhang, Huang and co-workers, illustrates a synergistic effort of experimental and computational studies of a palladium-catalyzed direct fluorination reaction. There is strong evidence that the oxidation of palladium from II to IV is energetically demanding for substrates bearing a chelating directing group, such as 8-aminoquinoline. We find that this problematic step can be resolved using a simple quinoxazline ligand that significantly lowers the energy of the transition state of palladium oxidation. This discovery led to a practical synthesis of β-fluoro amides. Details can be found in the full paper on pages xxxx–xxxx (H. Sun, Y. Zhang, P. Chen, Y.-D. Wu, X. Zhang, Y. Huang, Adv. Synth. Catal.­ 2016, 358, xxxx–xxxx; DOI: 10.1002/adsc.201600015).

  5. Full Papers

    1. Peptiligase, an Enzyme for Efficient Chemoenzymatic Peptide Synthesis and Cyclization in Water

      Ana Toplak, Timo Nuijens, Peter J. L. M. Quaedflieg, Bian Wu and Dick B. Janssen

      Version of Record online: 24 MAY 2016 | DOI: 10.1002/adsc.201600017

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    2. C[BOND]H Bond Arylation of Diamondoids Catalyzed by Palladium(II) Acetate

      Marta Larrosa, Sven Heiles, Jonathan Becker, Bernhard Spengler and Radim Hrdina

      Version of Record online: 24 MAY 2016 | DOI: 10.1002/adsc.201600156

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    3. Very Important Publication

  6. Updates

    1. Efficient Synthesis of Unsymmetrical Sulfamides via a Lossen-Like Rearrangement

      Loïc Pantaine, François Richard, Jérôme Marrot, Xavier Moreau, Vincent Coeffard and Christine Greck

      Version of Record online: 24 MAY 2016 | DOI: 10.1002/adsc.201501139

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    2. Oxidative Cycloaddition of Aldoximes with Maleimides using Catalytic Hydroxy(aryl)iodonium Species

      Akira Yoshimura, Khiem C. Nguyen, Gregory T. Rohde, Akio Saito, Mekhman S. Yusubov and Viktor V. Zhdankin

      Version of Record online: 24 MAY 2016 | DOI: 10.1002/adsc.201600331

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    3. Palladium Nanoparticles in Water: A Reusable Catalytic System for the Cycloetherification or Benzannulation of α-Allenols

      Benito Alcaide, Pedro Almendros, Ana M. González, Amparo Luna and Sagrario Martínez-Ramírez

      Version of Record online: 24 MAY 2016 | DOI: 10.1002/adsc.201501132

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  7. Full Papers

  8. Communications

    1. Umpolung Synthesis of Diarylmethylamines via Palladium- Catalyzed Arylation of N-Benzyl Aldimines

      Minyan Li, Baris Yucel, Jacqueline Jiménez, Madeline Rotella, Yue Fu and Patrick J. Walsh

      Version of Record online: 12 MAY 2016 | DOI: 10.1002/adsc.201600075

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    2. Very Important Publication

    3. Silver-Catalyzed Direct Cequation image[BOND]H Phosphorylation of Indoles Leading to Phosphoindoles

      Wang-Bin Sun, Jian-Fei Xue, Guo-Yu Zhang, Run-Sheng Zeng, Li-Tao An, Pei-Zhi Zhang and Jian-Ping Zou

      Version of Record online: 3 MAY 2016 | DOI: 10.1002/adsc.201600001

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    4. Simple N-Heterocyclic Carbenes as Ligands in Ullmann-Type Ether and Thioether Formations

      Jiang-Ping Wu, Anjan K. Saha, Nizar Haddad, Carl A. Busacca, Jon C. Lorenz, Heewon Lee and Chris H. Senanayake

      Version of Record online: 3 MAY 2016 | DOI: 10.1002/adsc.201600316

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  10. Updates

  11. Communications

    1. Cobalt-Catalyzed Cequation image[BOND]Cequation image Homocoupling

      Yingxiao Cai, Xin Qian and Corinne Gosmini

      Version of Record online: 3 MAY 2016 | DOI: 10.1002/adsc.201600213

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  12. Cover Pictures

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      Expedient Synthesis of Substituted Benzoheterocycles using 2-Butoxy-2,3-dihydrofurans as [4+2] Benzannulation Reagents

      Changhui Liu, Wenbo Huang, Man Wang, Bin Pan and Yanlong Gu

      Version of Record online: 3 MAY 2016 | DOI: 10.1002/adsc.201600411

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      The front cover picture, provided by Yanlong Gu and co-workers, describes a class of versatile benzannulation reagents, 2-alkoxy-2,3-dihydrofurans that can be obtained from readily available substrates through a simple synthetic operation. Indoles, carbazoles, naphthalenes, benzofurans, and benzothiophenes can be synthesized via the [4+2] annulation of 2-butoxy-2,3-dihydrofuran with various electron-rich heterocycles or arenes in the presence of Lewis acid or Brønsted acid catalysts. Details can be found in the communication on pages xxxx–xxxx (C. Liu, W. Huang, M. Wang, B. Pan, Y. Gu, Adv. Synth. Catal.­ 2016, 358, xxxx–xxxx; DOI: 10.1002/adsc.201600185).

  13. Communications

    1. Copper-Catalyzed C[BOND]N Bond Formation via Oxidative Cross-Coupling of Amines with α-Aminocarbonyl Compounds

      Xing-Xing Liu, Zhao-Yang Wu, Yong-Qin He, Xiao-Qiang Zhou, Ting Hu, Chao-Wei Ma and Guo-Sheng Huang

      Version of Record online: 27 APR 2016 | DOI: 10.1002/adsc.201600132

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  15. Communications

    1. One for Many: A Universal Reagent for Acylation Processes

      Hyun Kyung Moon, Gi Hyeon Sung, Bo Ram Kim, Jong Keun Park, Yong-Jin Yoon and Hyo Jae Yoon

      Version of Record online: 27 APR 2016 | DOI: 10.1002/adsc.201501177

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  16. Full Papers

    1. Self-Assembled Multilayer-Stabilized Nickel Nanoparticle Catalyst for Ligand-Free Cross-Coupling Reactions: in situ Metal Nanoparticle and Nanospace Simultaneous Organization

      Naoyuki Hoshiya, Katsumasa Fujiki, Takahisa Taniguchi, Tetsuo Honma, Yusuke Tamenori, Mincen Xiao, Nozomi Saito, Mami Yokoyama, Akira Ishii, Hiromichi Fujioka, Satoshi Shuto, Yoshihiro Sato and Mitsuhiro Arisawa

      Version of Record online: 27 APR 2016 | DOI: 10.1002/adsc.201600024

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  17. Updates

    1. Rhodium-Catalyzed [2+2+2] Cycloadditions of Diynes with Morita–Baylis–Hillman Adducts: A Stereoselective Entry to Densely Functionalized Cyclohexadiene Scaffolds

      Martí Fernández, Magda Parera, Teodor Parella, Agustí Lledó, Jean Le Bras, Jacques Muzart, Anna Pla-Quintana and Anna Roglans

      Version of Record online: 27 APR 2016 | DOI: 10.1002/adsc.201600039

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  18. Full Papers

    1. Construction of 2,3,4,7-Tetrahydro-1,2,4,5-oxatriazepines via [4+3] Cycloadditions of α-Halogeno Hydrazones with Nitrones

      Hong-Wu Zhao, Hai-Liang Pang, Ting Tian, Bo Li, Xiao-Qin Chen, Xiu-Qing Song, Wei Meng, Zhao Yang, Yue-Yang Liu and Yu-Di Zhao

      Version of Record online: 26 APR 2016 | DOI: 10.1002/adsc.201600093

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  19. Communications

  20. Updates

    1. Zinc Iodide-Mediated Direct Synthesis of 2,3-Dihydroisoxazoles from Alkynes and Nitrones

      Zu-Feng Xiao, Ting-Hui Ding, Sheng-Wei Mao, Xiao-Shan Ning and Yan-Biao Kang

      Version of Record online: 25 APR 2016 | DOI: 10.1002/adsc.201600044

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  21. Communications

  22. Full Papers

  23. Updates

  24. Cover Pictures

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      A Chiral Disulfoxide Ligand for the Efficient Rhodium-Catalyzed 1,2-Addition of Arylboroxines to N-Tosylarylimines

      Guang-Zhen Zhao, Gellért Sipos, Alvaro Salvador, Arnold Ou, Pengchao Gao, Brian W. Skelton and Reto Dorta

      Version of Record online: 21 APR 2016 | DOI: 10.1002/adsc.201600322

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      The front cover image, provided by Dorta and co-workers, illustrates how to access diarylmethylamines in high yields and enantioselectivities through the use of a chiral disulfoxide/rhodium precatalyst that effects the 1,2-addition of arylboroxines to aromatic imines. The system is very simple and combines ease of synthesis of the chiral ligand with low catalyst loadings, mild reaction conditions without requiring any external bases or other additives. Details can be found in the full paper on pages xxxx–xxxx (G.-Z. Zhao, G. Sipos, A. Salvador, A. Ou, P. Gao, B. W. Skelton, R. Dorta, Adv. Synth. Catal.­ 2016, 358, xxxx–xxxx; DOI: 10.1002/adsc.201500975).

  25. Full Papers

    1. Very Important Publication

      Ligand-Assisted Palladium(II)/(IV) Oxidation for sp3 C[BOND]H Fluorination

      Huan Sun, Yi Zhang, Ping Chen, Yun-Dong Wu, Xinhao Zhang and Yong Huang

      Version of Record online: 13 APR 2016 | DOI: 10.1002/adsc.201600015

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    2. An Improved Catalyst for Iodine(I/III)-Catalysed Intermolecular C[BOND]H Amination

      Nicola Lucchetti, Michelangelo Scalone, Serena Fantasia and Kilian Muñiz

      Version of Record online: 31 MAR 2016 | DOI: 10.1002/adsc.201600191

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    3. A Chiral Disulfoxide Ligand for the Efficient Rhodium-Catalyzed 1,2-Addition of Arylboroxines to N-Tosylarylimines

      Guang-Zhen Zhao, Gellért Sipos, Alvaro Salvador, Arnold Ou, Pengchao Gao, Brian W. Skelton and Reto Dorta

      Version of Record online: 26 JAN 2016 | DOI: 10.1002/adsc.201500975

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