Advanced Synthesis & Catalysis

Cover image for Vol. 358 Issue 9

Editor: Joe P. Richmond, Chairman of the Editorial Board: Eric N. Jacobsen

Impact Factor: 5.663

ISI Journal Citation Reports © Ranking: 2014: 2/72 (Chemistry Applied); 6/58 (Chemistry Organic)

Online ISSN: 1615-4169

Associated Title(s): Angewandte Chemie International Edition, Asian Journal of Organic Chemistry, Chemistry - A European Journal, Chemistry – An Asian Journal, ChemCatChem, European Journal of Organic Chemistry

Notice to Authors 2016

1. General Information

Advanced Synthesis & Catalysis is an international journal dedicated to the advancement of efficient and practical synthesis, which is a joint effort by academic and industrial chemists to meet the global and societal challenges with which chemistry is faced in the 21st Century. The journal brings together chemists from various areas of research including synthetic organic chemistry, organometallics, metal-complex catalysis, organic catalysis, biocatalysis, biotechnology, and process chemistry. Advanced Synthesis & Catalysis succeeds the time-honored German "Journal für Praktische Chemie" (founded 1828).

From 2016, the journal is published online only and color can be used at no charge to the authors.

Manuscripts should be submitted in English to the editor, Joe P. Richmond, via ScholarOneTM Manuscripts. Online submission is mandatory.

Prepare your manuscript in keeping with the guidelines given below (§3 and §4). Please use the manuscript templates, which are available on the Advanced Synthesis & Catalysis homepage.

  • For the submission of new manuscripts, a single PDF file needs to be uploaded as "Main Document" on the File Upload screen. Tables and all graphics should be embedded in the PDF file in the text where they belong (not collected at the end). The graphic abstract for the table of contents should be embedded at the end of the PDF file. Supporting Information should be uploaded as a single, separate PDF file with all graphics embedded by choosing the file designation "Supplementary Material for Review".
  • For the submission of revised manuscripts and final manuscript files for production, the manuscript needs to be uploaded as a single Word DOC or DOCX file with all tables and graphics embedded in the text where they belong (not collected at the end). Upload this file as "Main Document". All graphics, including the graphic abstract, need to be uploaded as separate graphic files in ChemDraw format (*.cdx) or, if not prepared in ChemDraw, as TIFF, JPEG or PDF files with high resolution. For all graphic files choose the designation "Image" on the File Upload screen. If you have more than 5 graphic files, they should be uploaded in a single ZIP file. Figure and Scheme captions should not be embedded into the graphic files, but rather included as text in the manuscript. Supporting information is uploaded as a single, separate PDF file with all graphics embedded by choosing the file designation "Supplementary Material for Review".

Steps for using the Advanced Synthesis & Catalysis online submission system:

  • Go to and log in.
  • If you use the system for the first time, you need to click on the "Create Account" link. If you have been an author or referee for Advanced Synthesis & Catalysis recently, your email address will already be in the database. In that case, enter your email address under "Password Help" on the Log In screen. You will receive an automatically generated e-mail, providing you with the details to access your personal homepage (user ID and password). Avoid creating multiple accounts.
  • Once logged in, please click on "Author Center" and let the system guide you through the submission process. Online help is available at all times. It will be possible to exit and re-enter the system without losing any information at any stage of the submission process. All submissions are kept strictly confidential. It is necessary to register all correspondence authors, but not all coauthors; all authors are required on the title page of the manuscript.
  • If applicable, please choose a Special Issue to which you have been invited to contribute.
  • Authors can follow the progress of their manuscripts on their personal homepage. This homepage should also be used to upload the revised and final versions of all manuscripts submitted to Advanced Synthesis & Catalysis.
  • For the submission of revised manuscripts and final manuscript files for production: When multiple files are uploaded as "Main Document" or "Image", the system generates a single PDF file. IMPORTANT: only Word DOC(X), TIFF and JPG files are included in the PDF file generated. File formats not included in the PDF generated are Excel XLS, PowerPoint PPT, ChemDraw CDX, ISIS Draw SKC, GIF, PCT, PSD, BMP, 123, RAR, SIT and ZIP.

With the exception of Commentaries and Book Reviews, all manuscripts are peer-reviewed, and if accepted, edited with a view to clarity, brevity and consistency. Manuscripts judged not to be appropriate for the journal by the editors can be rejected without consultation of referees. Authors are required to inform the editor of any related manuscripts that have been submitted or are soon to be submitted to any journal. Copies of these manuscripts are to be supplied to the editor and their relationship to the submitted manuscript explained. Authors are required to inform the editor in the cover letter if the manuscript, or a previous version, has been submitted to and rejected by any other journal. Authors are also requried to ensure that the data provided, including the spectra in the supporting information, are original and were not manipulated or taken from previous work. Failure to do so is an ethical violation and can result in rejection of the submitted manuscript.

All queries regarding manuscripts should be addressed to the editor at

The main correspondence author is entitled to a PDF for 25 hardcopies of the publication. Reprints and high-resolution PDFs can be ordered for a reasonable price when the corrected proofs are returned.

The Ethical Guidelines of the European Association of Chemical and Molecular Sciences are followed by Advanced Synthesis & Catalysis (, which are binding for editors, authors and referees. In particular, authors should reveal all sources of funding for the work presented in the manuscript and should declare any conflict of interest.

On behalf of our authors who are US National Institutes of Health (NIH) grantees, we will deposit in PubMed Central (PMC) the accepted, peer-reviewed version of the author's primary research manuscript, which will be made public after 12 months. By assuming this responsibility, we will ensure our authors are in compliance with the NIH request, as well as make certain the appropriate version of the manuscript is deposited. We reserve the right to change or rescind this policy. For more information, please go to To guarantee that your publication is uploaded correctly in PMC, please make sure that 1) the NIH grant numbers are free from misspellings: clearly distinguish between letters (i, o, l) and digits (1, 0), no spaces or hyphens and 2) the e-mail address that is known at NIH/PubMed is identical to the one given in the publication.

If authors have to or want to make their publications freely available at the moment they are published (open access), Advanced Synthesis & Catalysis offers such a service. Under the keyword OnlineOpen you can find all the information about this subject on our homepage: In general we recommend that authors link on their homepage to their publication in Advanced Synthesis & Catalysis through the "Digital Object Identifier" (DOI). Only in this way can CrossRef function correctly and full-text downloads be tallied.

2. Aims and Scope

Although total synthesis reached extraordinary levels of sophistication in the last century, the development of practical and efficient synthetic methodologies is still in its infancy. Achieving chemical reactions that are highly selective, economical, safe, resource- and energy-efficient, and environmentally benign is a primary challenge to chemistry in this century. Realizing this goal will demand the highest level of scientific creativity, insight and understanding in a combined effort by academic, government and industrial chemists and engineers.

Advanced Synthesis & Catalysis promotes that process by publishing high-impact research results reporting the development and application of efficient synthetic methodologies and strategies for organic targets that range from pharmaceuticals to organic materials. Homogeneous catalysis, biocatalysis, organocatalysis and heterogeneous catalysis directed towards organic synthesis are playing an ever increasing role in achieving synthetic efficiency. Asymmetric catalysis remains a topic of central importance. In addition, Advanced Synthesis & Catalysis includes other areas that are making a contribution to green synthesis, such as synthesis design, reaction techniques, flow chemistry and continuous processing, multiphase catalysis, green solvents, catalyst immobilization and recycling, separation science and process development.

Practical processes involve development of effective integrated strategies, from an elegant synthetic route based on mechanistic and structural insights at the molecular level through to process optimization at larger scales. These endeavors often entail a multidisciplinary approach that spans the broad fields of chemistry, biology, and engineering and involve contributions from academic, government, and industrial laboratories.

The unique focus of Advanced Synthesis & Catalysis has rapidly made it the leading organic chemistry and catalysis journal. The goal of Advanced Synthesis & Catalysis is to help inspire a new era of chemical science, based on the efforts of synthetic chemists and on interdisciplinary collaboration, so that chemistry will make an even greater contribution to the quality of life than it does now.

3. Categories of Contributions

Commentaries are editorial statements by the editors or by other responsible leaders from academia, industry and politics on issues of relevance to the goals of the journal and of importance to the chemical community. The subjects discussed can range widely, from questions directly concerned with synthetic science to those at the interface of chemistry with social and global problems associated with the health, materials, food, energy, environment, and many others. Commentaries are generally written upon invitation. Unsolicited manuscripts are welcome, as long as they fit into the concept of the journal.

Reviews are concise overviews of developments in a given area of high interest to the readership. As with other sections of the journal, the areas covered are not restricted to synthesis, but can include theoretical or mechanistic studies, separation science, reaction techniques and other subjects that are of interest to the practical synthetic chemist. The value added, above and beyond what one gets from compiling the results of a literature search, is that the authors apply their expertise and experience to critically analyze all of the literature available and provide the reader with a conceptual, comparative survey, using selected examples to illustrate the principles involved. The author places the subject into the broader scientific context for the benefit of non-specialist readers. In the coverage of a given methodology, not only the scope but also the limitations should be discussed. The practical utility and the future potential of the area should be central themes of the coverage. To the extent possible, the authors are encouraged to provide optimized experimental procedures, which have not been published previously. The material should be presented simply and understandably so that the broad readership of the journal can rapidly grasp the essential aspects of the area. A biographical sketch (maximum length 800 characters) and a portrait-quality photograph of the author(s) should be submitted. Reviews are generally written upon invitation. Unsolicited manuscripts are welcome, as long as they fit into the concept of the journal.

Communications report results of scientific studies that have not previously been published and whose immediate significance to the readership justifies their urgent publication. The authors are requested to address the question of usefulness and practical potential of the work presented, which will be taken into consideration during the peer-reviewing process. Essential experimental details for new methodology are required, including, for example, information on catalyst preparation and characterization, catalyst loading and reaction times. This should be summarized in a section with the heading Experimental Section at the end of the manuscript before the acknowledgments and references. Full experimental details, spectroscopic data, spectra and chromatograms used to determine er or dr are required and should be submitted as supporting information (see "Supporting Information" below). The rest of the text should not have headings. Since full experimental details are required, these are not preliminary publications, but are the definitive publication of the results reported.

Full Papers give a detailed report of significant results not published previously. The role of a full paper has changed since supporting information with full experimental details is now routinely published with communications. For a full paper to qualify for publication in Advanced Synthesis & Catalysis, it has to contain new results that are important in their own right and represent a significant advance. Results that have been previously published, for example in a communication, need to be clearly identified as such. The usefulness and future potential of the work should be discussed. Complete experimental details should be included in the experimental section. The supporting information should contain non-essential experimental information (e.g., routine use of a known method), characterization data, spectra of compounds made, and chromatograms used to determine er or dr. The length of the manuscript depends on the amount of scientific content being presented.

Updates allow authors to report new advances and insights obtained for projects that are being actively pursued; e.g., improvements in catalyst synthesis, reaction conditions, etc. These advances are expected to have significant practical impact, but need not have the urgency of communications or the scope of full papers.

Book Reviews give critical evaluations of recently published books or multimedia products of interest to the readership. Publishers should send books directly to the editor. Unsolicited books will not be returned.

4. Preparation of Manuscripts

See the instructions above for online submission.

Unless stated otherwise, the following instructions apply to all sections of the journal, except for Commentaries and Book Reviews.

Title page information includes title (see below); authors names and alphabetical references as superscripts ([a], [b], [c], etc.) referring to addresses, and an asterisk to denote the correspondence author; affiliations of all the authors including the full postal address; for the correspondence author(s), fax number, e-mail address, and home page (if available). A dedication is allowed.

Title should accurately describe the work reported. To facilitate electronic searching, the title should contain keywords such as the type of reaction, starting materials, products, and catalyst. It should reflect the scope and not be more general than the results reported; e.g., do not say "alkyl halides" if the scope was limited to benzylic or allylic halides. Do not use subjective descriptors such as novel, new, innovative, original, first, highly, or facile, which do not have quantifiable scientific meaning. The title should not contain chemical symbols (e.g., Pd-Catalyzed should be Palladium-Catalyzed) or chemical formulas (e.g., FeCl3 should be Iron(III) Chloride).

Abstract should be brief (600–2000 characters) and not too technical. The purpose of the research, the principal results, and the conclusions should be summarized concisely and objectively. The scope and limitations of the work need to be clearly stated.

Table of Contents (reviews only) should contain Arabic numbers for the sections and subsections (e.g. 1, 1.1, 1.2, etc.).

Keywords should be given in alphabetical order. At least four keywords from the keyword catalogue should be included to aid online searching.

Introduction (the heading is only for reviews and full papers, optional for updates) should state the nature of the work and why it was undertaken. Put the work into the context of other work in the field, both by the authors and other groups, including pertinent references. Work of others should be described objectively and fairly. Directly relevant work should be discussed and not hidden in a list of references.

Results and Discussion (the heading is only required for full papers, optional for updates) may be combined or kept separate and may be further divided by subheadings. This section should not be cluttered with technical details. The discussion should not only summarize the scope and limitations of the work, but also make a comparative evaluation of its practical significance and the potential for further development. To what extent do the results satisfy the initial expectations? What further improvements are necessary? For synthetic methodology, the discussion of scope and limitations should include consideration of isolated yield, selectivity, scale, catalyst stability, catalyst loading, reaction times, temperature restrictions, functional group compatibility, restrictions in solvent or conditions, wastes produced, and also an indication if further work is necessary to determine the general applicability. Mechanistic proposals should not be made without any supporting data or solely on the basis of computational data; solid experimental evidence should be provided. The structures of organometallic catalysts and reagents should not be overly speculative, for example, empirically made merely according to the stoichiometry of the precursory ingredients. This is often an oversimplification: the characterization of organometallic catalysts and reagents is difficult, because of the instability, sensitivity and equilibration with other species.

Conclusion (the heading is only for full papers, optional for updates) objectively summarizes the results obtained and addresses questions such as: To what extent do the results satisfy the initial expectations? What further improvements are necessary? Subjective exaggerations of the importance of the work reported do not belong in the conclusion section or anywhere else in the manuscript.

Experimental Section (full papers, updates and communications) should be given in full detail so that others can repeat your work.

  • Equipment and conditions used for the measurement of physical data, as well as any enzymes or nucleic acids used, should be described at the beginning of the experimental section.
  • The source and purity of reagents and catalysts obtained commercially should be given.
  • For catalytic methodologies, the catalyst preparation and characterization should be described in detail (unless it is commercially available).
  • In so far as practical, authors should use a systematic name for each title compound in the experimental section.
  • Common abbreviations and acronyms can be used (e.g., mmol, h, THF, binap). Chemical formulas can be used in the experimental section for common solvents, reagents, elements and catalysts (e.g., MeOH, CsOAc, Pd, CuBr2).
  • In the individual experimental procedures, quantities of reactants, solvents, etc. should be included, and placed in parentheses rather than in the running text, e.g., Ph3SnCl (0.964 g, 2.5 mmol) in toluene (20 mL). Information on catalyst loading (or S/C ratio or TON) and on reaction times (or TOF or rate) must be included. Physical data (using SI units whenever possible) should be quoted with decimal points and negative exponents (e.g., 25.8 J K−1mol−1).
  • All yields should refer to isolated and purified products; color, physical appearance, weight and percentage yield of product should be reported. Product yields determined by HPLC or GC are not acceptable, since they are not accurate without co-injection of authentic samples; in such cases, only conversion of starting materials can be reported. Isolated yields are needed for synthetic methodologies and a representative example on a preparative scale is generally required.
  • Enantiomeric purity can be expressed as enantiomeric excess (ee) or enantiomeric ratio (er); er is preferred and should be expressed either as a ratio, xx:1, or as a percentage, yy:zz. For diastereomers, only the diastereomeric ratio (dr) is acceptable and should be expressed as a percentage, yy:zz. The use of % selectivity should be abandoned.
  • Optimized experimental procedures reported in Reviews should be incorporated into the text where appropriate following the instructions above regarding content and style.

For all known compounds, a reference to characterization data in the literature should be provided, whether they are made by a procedure that is published or new. The structure and purity of all known compounds made by new procedures and all new compounds should be verified by characterization data; in a supporting information file (see below), original spectra (1H NMR, 13C NMR, MS, chromatograms for, e.g., er/dr determination) need to be provided. The identity and purity of all new compounds should be additionally verified by elemental analysis, to an accuracy of within ±0.4%, or by HR-MS, within ±0.003 of the calculated value.

Acknowledgements should be as brief as possible and placed before the references. It should acknowledge the sources of funding for the research and the help of others, such as by useful discussions, technical assistance or the gift of chemicals.

References should be included for work related to the study being reported. The number of self-citations needs to be limited to those that are directly related to the work reported. In the text the numbers should be typed in square brackets as superscripts (e.g., Noyori[3]) and, if applicable, after punctuation. The references need to be converted to text before submission; they must not be linked to the reference numbers. The initials of the authors in the references need to be placed before the last names. Journal titles should be abbreviated according to the Chemical Abstracts Service Source Index (CASSI); unpublished results and lectures should only be cited for exceptional reasons. Please follow the examples below (page range is optional but should be consistent throughout).

Journals: [1] a) H. Miyamura, A. Suzuki, T. Yasukawa, S. Kobayashi, Adv. Synth. Catal. 2015, 357, 3815–3819; b) Y.-Q. Fang, P. M. Tadross, E. N. Jacobsen, J. Am. Chem. Soc 2014, 136, 17966–17968.

[2] J. H. Schrittwieser, S. Velikogne, W. Kroutil, Adv. Synth. Catal. 2015, 357, 1655ndash;1685, and references cited therein.

Books without editor: [3] E. M. Carreira, L. Kvaerno, Classics in Stereoselective Synthesis, Wiley-VCH, Weinheim, 2008.

Books with editor: [4] F. Rascón, C. Copéret, in: Catalysis. From Principles to Applications (Eds.: M. Beller, A. Renken, R. A. van Santen), Wiley-VCH, Weinheim, 2012, pp 401–419.

Miscellaneous: [5] a) T. Aratani, H. Yoshihara, G. Susukamo (Sumitomo Chemical Company), US Patent 4,552,972, 4,603,218, 1985; Chem. Abstr. 1985, 103, 71551m; b) A. Student, PhD thesis, University of Cambridge (U.K.), 1998; c) P. Knochel, Science of Synthesis 2004, Vol. 3, pp. 5–90; d) M. T. Reetz, X. Li, Synthesis 2005, 3183–3185; e) D. E. Bergbreiter, J. Li, Top. Curr. Chem. 2004, 242, 113–176.

Captions: Each figure and scheme should have a caption, which is placed under the graphic in the text. Figure and scheme captions should not be embedded into the graphic files, but rather included as text in the manuscript. Don't label graphics as "Charts"; designate such graphics as "Figures" instead.

Tables should be constructed using the table function in Word; do not make tables using the tabulator. Footnotes in tables are denoted [a], [b], [c], etc. All graphics in tables need to be embedded in the table where they belong, and for revised and final manuscript files, also supplied as separate graphics. When a table consists mainly of graphic elements, the entire body of the table should be prepared in ChemDraw using the alignment function (do not use the ChemDraw table tool) and uploaded as a single ChemDraw file. In this case, the title and the footnotes of the table remain as text in the manuscript and not as part of the graphic.

Illustrations (structural formulas, figures, schemes) must be readable after reduction to a one-column (8.5 cm wide) or two-column format (17.7 cm wide). We recommend use of the "Adv. Synth. Catal. Document" style sheet, which is supplied with ChemDraw and can also be downloaded from the Advanced Synthesis & Catalysis website at The settings are: One-Column Drawing Width 13 cm, Two-Column Drawing Width 26.7 cm; Caption and Label Font: Helvetica or Arial [Symbol Font for minus (− not -) or multiplication (× not x) signs], Font Style Standard, Font Size 10 pt; Chain Angle 120°, Bond Spacing 18% of length, Fixed Length 17 pt, Bold Width 2 pt, Line Width 1 pt, Margin Width 1.6 pt, Hash Spacing 2.5 pt. Illustrations not prepared with ChemDraw need to be supplied as TIFF, JPG or PDF files with high resolution.

Computer-aided image enhancement is often unavoidable. However, such manipulation cannot result in data that are less relevant or unrepresentative being shown and/or genuine and significant signals being lost. A clear relationship must remain between the original data and the images that result from those data. If an image has been electronically modified, the form of the modification shall be given in the Figure caption. If computer-aided processing or modification of an image is a fundamental part of the experimental work, then the form that this processing takes must be clearly described in the experimental section.

Color can be used in Schemes and Figures at no cost to the authors.

Cover Picture: It is possible to propose a color graphic picture for the front, back or inside cover, representing work reported in an accepted manuscript. The editor decides which cover proposals will be accepted. The graphic should be 180 mm wide and 140 mm high with a transparent background; it will have the background of the standard cover. A descriptive text up to 500 characters will be required if accepted. The author is required to pay part of the production costs, the amount of which depends on placement.

Symbols: In Microsoft Word, do not use the field or object commands on the insert menu to create symbols graphically. Use the symbol command on the insert menu; it opens a dialog box that contains a font box. Your options for this font box are "Normal Text Font" and "Symbol Font"; do not use MS Linedraw. Use these "Symbol" and "Normal" text fonts to insert Greek letters and characters with umlauts, accents, tildes, etc.: α, Å, ã, ä, à. Italicize symbols of physical quantities, but not their units (e.g., T for temperature; J, but Hz; a, but nm), stereochemical information (cis, Z, R, etc.), locants (N-methyl, α-amino) and symmetry designations (C2v). Chemical formulas should be numbered with boldface Arabic numerals (e.g., 1). In labels of axes the units should be placed in square brackets (e.g., T [K]). Abbreviations such as Me, Et, n-Bu, i-Pr, s-Bu, t-Bu and Ph (not Φ) may be used in formulas. General substituents should be indicated by R1, R2 (not R2, which means 2R) or R, R'. The spatial arrangement of the substituents should be indicated by hatched lines and a wedge. The symbol font should be used for minus signs. Some symbols available in the Macintosh environment, such as °C, are not reproduced properly in Windows; reproducibility in Windows should be checked before submission.

Abbreviations and acronyms should be limited to those that are used commonly. Where they first appear in the text, they should – apart from the most common ones such as NMR, HPLC, and THF – be defined. In exceptional cases, such as for some review articles, the abbreviations and acronyms used can be listed after the written abstract. Enzyme names should be accompanied by the respective Enzyme Commission (EC) numbers.

Graphical Abstract appears in the table of contents of the issue. It should be a visual representation of the work presented and be stand-alone. An accompanying text should not be included. Color can be used in the graphic abstract at no cost. The size of the graphic should be ca. 60 cm × 130 mm, which will be reduced to 65%; the fonts used must be large enough to be readable at this size.

Nomenclature: Follow the recommendations of the International Union of Pure and Applied Chemistry (IUPAC:, the International Union of Biochemistry and Molecular Biology (IUBMB:, or Chemical Abstracts Service (CAS: IUPAC recommendations are on the WWW at or Please do not use computer programs to generate elaborate systematic names, nor use long multi-line compound names; for the sake of clarity general descriptors such as compound 2, dendrimer 3, or alcohol 4 should be used in the experimental procedures and in the general text.

English spelling may be British or American, but consistency should be maintained throughout a manuscript.

Supporting Information is required as a single PDF. It must contain full experimental details and characterization data, if not already present in the manuscript, as well as spectra and chromatographic traces (see Experimental Section above). The supporting information may also contain other data that are related to the paper, e.g., supplemental experimental data, additional or color illustrations and tables; include information that is more convenient in electronic form, such as coordinates, spectral data, etc., or that cannot be printed: animations, audio recordings, and videos. Color can be used in the supporting information at no cost. Experimental procedures for crystallographic studies can be included, but do not include the cif data or the complete crystallographic data; the latter need to be deposited in an appropriate database prior to submission of the manuscript (see Crystal Structural Analysis below).

Crystal Structural Analysis: Prior to manuscript submission, the author(s) must deposit their data or update data already available, so that referees can retrieve the information electronically directly from the database. Guidelines for depositing data can be found on the Advanced Synthesis & Catalysis website at

Contact Information

Editorial Office:

Joe P. Richmond, Editor

Thomas Kast, Associate Editor

Karen du Plooy, Associate Editor

Li Grundl, Associate Editor

Advanced Synthesis & Catalysis

Dantestrasse 22

69115 Heidelberg, Germany

Tel.: +49 (0)6221-6737427; Fax: +49 (0)6221-6737428



Copy-Editing and Proofs:

Richard E. Dunmur, Senior Associate Editor

Advanced Synthesis & Catalysis

Schillerstrasse 6

71254 Ditzingen, Germany