Advanced Synthesis & Catalysis

Cover image for Vol. 357 Issue 6

Editor: Joe P. Richmond, Chairman of the Editorial Board: Ryoji Noyori

Impact Factor: 5.542

ISI Journal Citation Reports © Ranking: 2013: 2/71 (Chemistry Applied); 5/58 (Chemistry Organic)

Online ISSN: 1615-4169

Associated Title(s): Angewandte Chemie International Edition, Asian Journal of Organic Chemistry, Chemistry - A European Journal, Chemistry – An Asian Journal, ChemCatChem, European Journal of Organic Chemistry

357_06/2015Cover Picture: Hypoiodite-Catalyzed Regioselective Oxidation of Alkenes: An Expeditious Access to Aldehydes in Aqueous Micellar Media (Adv. Synth. Catal. 6/2015)

The front cover picture, provided by Nama Narender and co-workers, illustrates a highly regioselective oxidation process for the synthesis of aldehydes from alkenes in aqueous micellar media. This novel metal-free catalytic system utilizes NH4I as a pre-catalyst and oxone as a terminal oxidant under mild conditions. The catalytic cycle starts with the in situ generation of hypoiodite species and involves the formation of co-iodo intermediate and deiodination-facilitated vicinal aryl group migration through a semipinacol rearrangement. Details can be found in the communication on pages 1125–1130 (P. Swamy, M. M. Reddy, M. Naresh, M. A. Kumar, K. Srujana, C. Durgaiah, N. Narender, Adv. Synth. Catal.­ 2015, 357, 1125–1130; DOI: 10.1002/adsc.201400986).

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357_06i/2015Inside Cover: Iridium-Catalyzed Intramolecular Enantioselective C-H Alkylation at the C-2 Position of N-Alkenylindoles (Adv. Synth. Catal. 6/2015)

The inside cover picture, provided by Takanori Shibata and co-workers, illustrates the development of an intramolecular and enantioselective C-2 alkylation of N-alkenylindoles. A p-anisoyl group at the C-3 position of the indole operates as an efficient directing group, and the combination of a cationic iridium(I) complex and chiral diphosphine ligands achieves excellent enantioselectivity in the intramolecular C-H alkylation. Synthetically important N-fused tricyclic compounds containing the indole skeleton were prepared in high to excellent ee (up to 98% ee). Details can be found in the communication on pages 1131–1135 (T. Shibata, N. Ryu, H. Takano, Adv. Synth. Catal.­ 2015, 357, 1131–1135; DOI: 10.1002/adsc.201401163).

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