Advanced Synthesis & Catalysis

Cover image for Vol. 357 Issue 2‐3

Editor: Joe P. Richmond, Chairman of the Editorial Board: Ryoji Noyori

Impact Factor: 5.542

ISI Journal Citation Reports © Ranking: 2013: 2/71 (Chemistry Applied); 5/58 (Chemistry Organic)

Online ISSN: 1615-4169

Associated Title(s): Angewandte Chemie International Edition, Asian Journal of Organic Chemistry, Chemistry - A European Journal, Chemistry – An Asian Journal, ChemCatChem, European Journal of Organic Chemistry

357_2-3/2015Cover Picture: Minutes Synthesis of 1,4,5-Trisubstituted 5-Dialkylamino-1,2,3-triazoles by 1-Copper(I)-Alkyne Controlled Tandem Process (Adv. Synth. Catal. 2-3/2015)

The front cover picture, provided by Bo Wang, Xinyan Wang, and Yuefei Hu, illustrates the characteristics of 1-copper(I)-2-phenylethyne in its preparation, properties and structure. By using its polymeric structure, the tandem reaction sequence of 1-Cu(I)-alkyne with an azide (cycloaddition) and then an electrophile E+ (electrophilic substitution) can be controlled efficiently. Thus, a general method for the synthesis of 1,4,5-trisubstituted 1,2,3-triazoles was developed by simply stirring the mixture of a 1-copper(I)-alkyne, an azide and an electroplile E+. Details can be found in the full paper on pages 401–407 (B. Wang, N. Liu, W. Chen, D. Huang, X. Wang, Y. Hu, Adv. Synth. Catal. 2015, 357, 401–407; DOI: 10.1002/adsc.201400471).

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357_2-3i/2015Inside Cover: Biotransformation of Linoleic Acid into Hydroxy Fatty Acids and Carboxylic Acids Using a Linoleate Double Bond Hydratase as Key Enzyme (Adv. Synth. Catal. 2-3/2015)

The inside cover picture, by D.-K. Oh, J.-B. Park and co-workers, illustrates the cloning and reaction of linoleate double bond hydratases of Lactobacillus acidophilus. The enzymes were highly specific for the hydration of the C-9 or the C-12 double bond of unsaturated fatty acids. Thereby, C-10 or C-13 hydroxy fatty acids could be selectively produced. In addition, the hydroxy fatty acids were further converted into industrially relevant carboxylic acids (e.g., 12-hydroxy-cis-9-dodecenoic acid, α,ω-tridec-9-enedioic acid) and lactones (i.e., δ-decalactone, γ-dodecelactone) via whole-cell biocatalysis. Details of this work can be found in the full paper on pages 408-416 (H.-J. Oh, S.-U. Kim, J.-W. Song, J.-H. Lee, W.-R. Kang, Y.-S. Jo, K.-R. Kim, U. T. Bornscheuer, D.-K. Oh, J.-B. Park, Adv. Synth. Catal. 2015, 357, 408–416; DOI: 10.1002/adsc.201400893).

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