Advanced Synthesis & Catalysis

Cover image for Vol. 356 Issue 11‐12

Editor: Joe P. Richmond, Chairman of the Editorial Board: Ryoji Noyori

Impact Factor: 5.542

ISI Journal Citation Reports © Ranking: 2013: 2/71 (Chemistry Applied); 5/58 (Chemistry Organic)

Online ISSN: 1615-4169

Associated Title(s): Angewandte Chemie International Edition, Asian Journal of Organic Chemistry, Chemistry - A European Journal, Chemistry – An Asian Journal, ChemCatChem, European Journal of Organic Chemistry

356_11-12/2014Cover Picture: (Adv. Synth. Catal. 11-12/2014)

The front cover picture, designed by Yannis Boultadakis-Arapinis illustrates the concerted and step-wise reaction mechanisms that might be encountered during the insertion of metallo-carbenes into inert C-H bonds. In their article, Lecourt, Gandon and co-workers describe the influence of short-distance and long-range electronic effects on the mechanism and stereoselectivity of the insertion of Rh(II)-carbene. A fine-tuning of the reactivity of the C-H bond can thus induce a switch from a concerted and fully diastereoselective mechanism with a Curtin-Hammet-like kinetic profile, to two fully disconnected step-wise and stereoselective processes. Details can be found in the full paper on pages 2493–2505 (M. Boultadakis-Arapinis, V. Gandon, E. Prost, L. Micouin, T. Lecourt, Adv. Synth. Catal. 2014, 356, 2493–2505; DOI: 10.1002/adsc.201300984).

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