Journal of Separation Science
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Online ISSN: 1615-9314
July 31, 2007
Electrochromatographic separation on a poly(dimethylsiloxane)/glass chipMiniaturization of analytical instruments has attracted a wide interest in analytical chemistry over the past decade because of the advantages of reduced reagent consumption, better analytical performance, and shorter analysis time. Jean-Louis Rocca, Maximilien Blas and Nathalie Delauney present an approach to perform electrochromatographic separations on poly(dimethylsiloxane) chips: A fused-silica capillary containing a stationary phase was introduced directly into the chip. This approach was supposed to offer great flexibility since capillary modification methods are well known, and thus, with this kind of chip, different microfluidic devices having various functionalizations could be prepared. Electrophoretic separations were first achieved by integrating into the chip an empty capillary to evaluate the analytical performances of this system. They were compared to those obtained with a classical chip. Also, an electrochromatographic separation was performed, involving a capillary containing a hexyl acrylate-based monolith. The first results show that this approach is promising. Better adjustment of the dimension and the shape of the section between the chip channels and the capillary will further reduce band broadening.
J.-L. Rocca, M. Blas, N. Delauney, J. Sep. Sci. 2007, 30 (17).
Full article online, DOI: 10.1002/jssc.200700132