Cover image for Vol. 17 Issue 1-2

Editor-in-Chief: Lorna Stimson, Deputy Editor: Lucie Kalvodova

Impact Factor: 4.079

ISI Journal Citation Reports © Ranking: 2015: 13/77 (BIOCHEMICAL RESEARCH METHODS); 75/289 (Biochemistry & Molecular Biology)

Online ISSN: 1615-9861

Associated Title(s): PROTEOMICS - Clinical Applications

Comments to the Viewpoint article

Is a gene-centric human proteome project the best way for proteomics to serve biology?
Thierry Rabilloud, Denis Hochstrasser, Richard J. Simpson

Published Online: Jul 20 2010
DOI: 10.1002/pmic.201000220

Comment from:Dr. Juan Ignacio Castrillo
Short affiliation:Dept. of Biochemistry. University of Cambridge, UK    Date: 20 September 2010

With more than 90% of human RNA transcripts undergoing alternative splicing in human tissues and the fact of different expression of specific proteins in male and/or female during dfferent stages of life, development - pregnancy, as a child, during puberty and in adult stages (even here with different programs of expression of proteins in males and females, controlled by complex metabolite-RNA-protein regulated mechanisms (hormonal cycles, etc; e.g. menstrual cycle; new pregnancy...), I think the field will probably have to go progressively towards a more 'protein-centric' or discovery-oriented approach, together with comprehensive (epi)-genome, transcriptome and metabolome discoveries (integrative Systems Biology). Looking ahead, I think we'll need to go progressively (long-term...) to get good information on:

1) The 'male proteome' at: a) the development (pregnancy) stage; b) child; c) puberty; d) adult stage.

and (very important, -towards proper studies on main mechanims underlying pregnancy viability, prenatal studies and women-related health- ):

2) The 'woman proteome' at the: a) development (pregnancy) stage; child; puberty; adult stage (hormonal cycles, menstrual, etc...).