Advanced Functional Materials
© WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Editor-in-Chief: Joern Ritterbusch, Deputy Editors: Mary De Vita, Yan Li
Online ISSN: 1616-3028
Associated Title(s): Advanced Electronic Materials, Advanced Energy Materials, Advanced Engineering Materials, Advanced Healthcare Materials, Advanced Materials, Advanced Materials Interfaces, Advanced Materials Technologies, Advanced Optical Materials, Advanced Science, Particle & Particle Systems Characterization, Small
Cover Picture: Self-assembled Cationic Peptide Nanoparticles Capable of Inducing Efficient Gene Expression In Vitro (Adv. Funct. Mater. 6/2008)
On p. 943, Yi-Yan Yang and co-workers report on cationic and amphiphilic oligopeptides as nonviral vectors for gene delivery. The oligopeptides were able to self-assemble into core/shell nanoparticles at concentrations above the CMC value. The formation of the nanoparticles yielded a greater local concentration of positive charges, providing a stronger DNA binding ability, thus efficiently preventing DNA from enzymatic degradation. The peptide nanoparticles had little cytotoxicity against cell lines but did induce high gene expression levels in vitro.