Advanced Functional Materials
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Cover Picture: Self-assembled Cationic Peptide Nanoparticles Capable of Inducing Efficient Gene Expression In Vitro (Adv. Funct. Mater. 6/2008)
On p. 943, Yi-Yan Yang and co-workers report on cationic and amphiphilic oligopeptides as nonviral vectors for gene delivery. The oligopeptides were able to self-assemble into core/shell nanoparticles at concentrations above the CMC value. The formation of the nanoparticles yielded a greater local concentration of positive charges, providing a stronger DNA binding ability, thus efficiently preventing DNA from enzymatic degradation. The peptide nanoparticles had little cytotoxicity against cell lines but did induce high gene expression levels in vitro.