Advanced Functional Materials

Cover image for Vol. 27 Issue 35

18_09/2008Cover Picture: An Engineered Mannoside Presenting Platform: Escherichia coli Adhesion under Static and Dynamic Conditions (Adv. Funct. Mater. 9/2008)

Molecular assembly of glycosylated polycationic copolymers can provide a well-defined surface platform for the presentation of engineered mono-and oligoglycosides at controlled densities and in specific patterns, as reported by Geraldine Coullerez and co-workers on p. 1459. These engineered surfaces are ideal for the study of adhesion of pathogens to surfaces and are believed to be promising tools to investigate early stages of surface colonization and infection. Escherichia coli adhesion (see cover) is highly specific to the type of mannosides and their density and linker chemistry, and depends strongly on flow rate.

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