Advanced Functional Materials

Cover image for Vol. 27 Issue 20

19_06b/2009Biological Sensor Platforms: Photoluminescence Detection of Biomolecules by Antibody-Functionalized Diatom Biosilica (Adv. Funct. Mater. 6/2009)

Microscopic shells of single-celled algae called diatoms possess intricate nanoscale features composed of photoluminescent biosilica. On page 926, the functionalization of the 10 µm centric diatom Cyclotella (center image) with the antibody Immunoglobulin G, and its use as a biosensor for immunocomplex formation are reported by D. K. Gale et al. Such formation is visible across the entire biosilica surface using FITC-labeled antigen (green image) and antigen labeled with 10 nm gold nanoparticles (top image).

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