Advanced Functional Materials

Cover image for Vol. 26 Issue 17

19_21b/2009Protein Immobilization: Capturing Complex Protein Gradients on Biomimetic Hydrogels for Cell-Based Assays (Adv. Funct. Mater. 21/2009)

A versatile microfluidic strategy to rapidly and selectively immobilize gradients of virtually any desired protein on soft poly(ethylene glycol) (PEG) hydrogel surfaces is developed by S. Cosson et al. on page 3411. The selectivity and orthogonality of the chosen protein immobilization schemes allows for forming parallel and orthogonal overlapping gradients of multiple proteins. This platform can be exploited to perform a wealth of cell-based assays on biomimetic surfaces.

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