Advanced Functional Materials
Copyright © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Sensors: DNA Sensing Using Nanocrystalline Surface-Enhanced Al2O3 Nanopore Sensors (Adv. Funct. Mater. 8/2010)
R. Bashir and co-workers report on page 1266 the development of solid-state Al2O3 nanopore sensors with enhanced surface properties for the real-time detection and analysis of individual DNA molecules. The cover illustrates the extension of coiled double-stranded DNA in the high-field region surrounding a nanocrystalline Al2O3 nanopore, followed by DNA transport. Nanocrystallite nucleation during pore formation helps enhance the single-molecule sensitivity and surface-charge characteristics of these devices and enables the potential fabrication of nanometer-scale metallic contacts in the pore. This technology finds broad application in drug screening, medicine, and bio-nanotechnology.