Advanced Functional Materials

Cover image for Vol. 24 Issue 48

21_14/2011Biomimetic Structures: Biomimetic Structures: Biological Implications of Dipeptide-Substituted Polyphosphazene–Polyester Blend Nanofiber Matrices for Load-Bearing Bone Regeneration (Adv. Funct. Mater. 14/2011)

Successful bone regeneration benefits from 3D bioresorbable scaffolds that mimic the hierarchical architecture and mechanical characteristics of the native tissue extracellular matrix. On page 2641, Cato T. Laurencin and co-workers present a new biomimetic scaffold design composed of electrospun polymeric nanofibers that combines unique material chemistry, hierarchical architecture, and mechanics suitable for load-bearing bone regeneration. This study, for the first time, demonstrates the feasibility of developing a mechanically competent nanofiber matrix via a biomimetic strategy.

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