Advanced Functional Materials

Cover image for Vol. 26 Issue 28

21_21b/2011Tissue Engineering: Stable Extracellular Matrix Protein Patterns Guide the Orientation of Osteoblast-like Cells (Adv. Funct. Mater. 21/2011)

On page 4079, Jian-Tao Zhang, Oliver Pullig, Klaus D. Jandt, and coworkers use a facile approach, microcontact printing, to fabricate stable extracellular matrix (ECM) protein microstructures on the surfaces of implant materials. These protein structures are highly stable due to an intermediate polymer layer between the ECM proteins and the materials. Interestingly, these structures can guide the adhesion, proliferation, and organization of osteoblast-like cells. The cell morphology and alignment are controllable by the protein patterns.

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