Advanced Functional Materials
© WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Editor-in-Chief: Joern Ritterbusch, Deputy Editors: Mary De Vita, Yan Li, Hakim Meskine
Online ISSN: 1616-3028
Associated Title(s): Advanced Electronic Materials, Advanced Energy Materials, Advanced Engineering Materials, Advanced Healthcare Materials, Advanced Materials, Advanced Materials Interfaces, Advanced Materials Technologies, Advanced Optical Materials, Advanced Science, Particle & Particle Systems Characterization, Small
Drug Delivery: Paclitaxel-Loaded Polymer Nanoparticles for the Reversal of Multidrug Resistance in Breast Cancer Cells (Adv. Funct. Mater. 22/2011)
Water-soluble paclitaxel-loaded polymer nanoparticles, synthesized by Kurt E. Geckeler and coworkers on page 4211, show a significant reversal of the chemoresistance in drug-resistant human breast cancer cell lines. The front cover illustrates different cellular interaction patterns between the paclitaxel (red) and the polymer nanoparticles (blue spheres containing red particle) on the drug-resistant P-glycoprotein (purple) expressing human breast cancer cells. Paclitaxel is continuously transported by the P-glycoprotein, however, the paclitaxel-loaded nanoparticles taken up by endocytosis are able to reverse the multidrug resistance by bypassing the P-glycoprotein.