Advanced Functional Materials

Cover image for Vol. 27 Issue 12

21_22/2011Drug Delivery: Paclitaxel-Loaded Polymer Nanoparticles for the Reversal of Multidrug Resistance in Breast Cancer Cells (Adv. Funct. Mater. 22/2011)

Water-soluble paclitaxel-loaded polymer nanoparticles, synthesized by Kurt E. Geckeler and coworkers on page 4211, show a significant reversal of the chemoresistance in drug-resistant human breast cancer cell lines. The front cover illustrates different cellular interaction patterns between the paclitaxel (red) and the polymer nanoparticles (blue spheres containing red particle) on the drug-resistant P-glycoprotein (purple) expressing human breast cancer cells. Paclitaxel is continuously transported by the P-glycoprotein, however, the paclitaxel-loaded nanoparticles taken up by endocytosis are able to reverse the multidrug resistance by bypassing the P-glycoprotein.

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