Advanced Functional Materials
Copyright © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Editor-in-Chief: Joern Ritterbusch, Deputy Editors: Mary Farrell, Yan Li
Online ISSN: 1616-3028
Associated Title(s): Advanced Energy Materials, Advanced Engineering Materials, Advanced Healthcare Materials, Advanced Materials, Advanced Materials Interfaces, Advanced Optical Materials, Particle & Particle Systems Characterization, Small
Biomedical Applications: Controlling The Mobility Of Oligonucleotides In The Nanochannels Of Mesoporous Silica (Adv. Funct. Mater. 1/2012)
Mesoporous silica particles represent a novel, highly versatile class of drug-delivery systems. On page 106, Thomas Bein, Christoph Bräuchle, and co-workers utilize these materials as a host for the incorporation of short oligonucleotides as model gene therapeutics. The diffusion of a labelled oligo-nucleotide through a nanometer-sized silica pore is shown. Organic functionalization of the silica pore system offers a means to control oligonucleotide mobility and stability.