Advanced Functional Materials

Cover image for Vol. 26 Issue 28

22_16b/20123D Photografting: Selective Functionalization of 3D Matrices Via Multiphoton Grafting and Subsequent Click Chemistry (Adv. Funct. Mater. 16/2012)

This 180 μm wide, 3D pattern is produced by laser-induced immobilization of fluorescent molecules onto a polymeric matrix. On page 3429 Aleksandr Ovsianikov, Robert Liska, and co-workers report a versatile and straightforward photografting method based on photolysis of an aromatic azide via multiphoton absorption. Because multiphoton-induced reactions occur in a confined area within the laser focal spot, accurate functionalization with high spatial resolution in 3D is possible. The presented results indicate the great potential of the 3D, site-specific, function-alization method for applications in microarray-based proteome analysis, studies of cell–surface interactions, sensing applications, and drug screening.

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