Advanced Functional Materials
© WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Editor-in-Chief: Joern Ritterbusch, Deputy Editors: Mary De Vita, Yan Li, Hakim Meskine
Online ISSN: 1616-3028
Associated Title(s): Advanced Electronic Materials, Advanced Energy Materials, Advanced Engineering Materials, Advanced Healthcare Materials, Advanced Materials, Advanced Materials Interfaces, Advanced Materials Technologies, Advanced Optical Materials, Advanced Science, Particle & Particle Systems Characterization, Small
Biomedical Applications: Imaging-Guided pH-Sensitive Photodynamic Therapy Using Charge Reversible Upconversion Nanoparticles under Near-Infrared Light (Adv. Funct. Mater. 24/2013)
Smart charge-reversible upconversion nanoparticles are reported on page 3077 by Zhuang Liu and co-workers for pH-responsive, in vivo, near-infrared light excited photodynamic therapy. While stable under normal physiological pH, highly sensitive acid-induced charge conversion of the nanoparticles is observed in a slightly acidic tumor microenvironment, resulting in significantly enhanced cellular internalization of nanoparticles and remarkably improved photodynamic cancer cell killing in vitro and in vivo.