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Recently Published Articles
- Protein-Containing Multilayer Capsules by Templating on Mesoporous CaCO3 Particles: POST- and PRE-Loading Approaches
Nadezhda G. Balabushevich, Anna V. Lopez de Guerenu, Natalia A. Feoktistova, Andre G. Skirtach and Dmitry Volodkin
Article first published online: 26 AUG 2015 | DOI: 10.1002/mabi.201500243
Protein encapsulation into polymer-based multilayer capsules is performed by templating on sacrificial porous CaCO3 microparticles. We focus on protein encapsulation by considering two approaches: POST-loading into performed capsules and PRE-loading into the carbonate microparticles by adsorption or co-synthesis. Protein content and its activity strongly depend on the encapsulation approach to be chosen for successful encapsulation.
- Highly Fluorescent Gene Carrier Based on Ag–Au Alloy Nanoclusters
Ping Wang, Lin Lin, Zhaopei Guo, Jie Chen, Huayu Tian, Xuesi Chen and Hua Yang
Article first published online: 19 AUG 2015 | DOI: 10.1002/mabi.201500235
This research has successfully prepared a highly fluorescent gene carrier Ag–Au–PEI, which shows much higher quantum yield than most of the reported gold nanocluster-based quantum dots. The high fluorescent Ag–Au–PEI conjugates not only exhibit remarkable high gene transfection efficiencies and relatively low cytotoxicity in vitro but also possess bioimaging capacity in vivo.
- Enhanced Cytoplasmic Delivery of RAGE siRNA Using Bioreducible Polyethylenimine-based Nanocarriers for Myocardial Gene Therapy
Min Jung Yang, Sook Hee Ku, Dongkyu Kim, Won Jong Kim, Hyejung Mok, Sun Hwa Kim and Ick Chan Kwon
Article first published online: 19 AUG 2015 | DOI: 10.1002/mabi.201500213
Bioreducible polyethylenimine (rPEI) is synthesized from low molecular weight PEI via cleavable disulfide linkages to achieve high stability, high transfection efficiency, high cytoplasmic siRNA release, and low cytotoxicity. rPEI/siRAGE polyplex can reduce RAGE expression in ischemic/reperfused myocardium, thereby leading to attenuation of myocardial infarction.
- Self-Assembly of a Multifunctional Lipid With Core–Shell Dendrimer DNA Nanoparticles Enhanced Efficient Gene Delivery at Low Charge Ratios into RPE Cells
Da Sun, Hiroshi Maeno, Maneesh Gujrati, Rebecca Schur, Akiko Maeda, Tadao Maeda, Krzysztof Palczewski and Zheng-Rong Lu
Article first published online: 13 AUG 2015 | DOI: 10.1002/mabi.201500192
A hybrid gene delivery system comprised of a multifunctional lipid ECO and a core–shell dendrimer mediates high gene transfection efficiency at a low charge ratio in RPE cells. The non-viral delivery system is effective for in vivo gene transfection in the RPE cells after subretinal injection and promising in treating genetic disorders of the eye.
- Asymmetric AB3 Miktoarm Star Polymers: Synthesis, Self-Assembly, and Study of Micelle Stability Using AF4 for Efficient Drug Delivery
Alexandre Moquin, Anjali Sharma, Yiming Cui, Anthony Lau, Dusica Maysinger and Ashok Kakkar
Article first published online: 11 AUG 2015 | DOI: 10.1002/mabi.201500186
AB3 (PCL–PEG3) miktoarm polymers form micelles and incorporate large amount of hydrophobic drug (curcumin). Size distribution of the micelles is narrow as determined by AF4 fractionation. Curcumin-loaded AB3 micelles exert significant cell loss in glioblastoma (GBM) spheroids.