Macromolecular Bioscience

Cover image for Vol. 17 Issue 3

Editor-in-Chief: Kirsten Severing, Editor: Anne Pfisterer

Online ISSN: 1616-5195

Associated Title(s): Advanced Healthcare Materials, Macromolecular Chemistry and Physics, Macromolecular Materials and Engineering, Macromolecular Rapid Communications

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Best of Macros 2017 is now online. Click here to read about the selected articles and their authors.

Recently Published Articles

  1. Controllable Synthesis of Multiarm Star-Shaped Copolymers Composed of Phosphoester Chains and Their Application on Drug Delivery

    Li Zhang, Dongjian Shi, Chunling Shi, Liangliang Dong, Xiaojie Li and Mingqing Chen

    Version of Record online: 29 MAR 2017 | DOI: 10.1002/mabi.201600522

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    Amphiphilic multiarm star-shaped copolymers consisting of dendritic poly(amido amine) and biodegradable poly(phosphoester)s are controllably synthesized and co-assemble with doxorubicin into supramolecular micelles. Size and loading capacity of micelles can be tuned by simply altering the chain length of polymers. The biodegradability of polymer chains endows slow and sustained release of drugs. Therefore, these copolymers have great potential in drug delivery.

  2. Exploring Tyrosine-Triazolinedione (TAD) Reactions for the Selective Conjugation and Cross-Linking of N-Carboxyanhydride (NCA) Derived Synthetic Copolypeptides

    Saltuk B. Hanay, Bas Ritzen, Dermot Brougham, Aylvin A. Dias and Andreas Heise

    Version of Record online: 29 MAR 2017 | DOI: 10.1002/mabi.201700016

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    The tyrosine-triazolinedione reaction is used to selectively cross-link a copolymer of lysine and tyrosine. Reaction occurs only on the tyrosine offering the advantage of a selective click-like reaction on a natural amino acid in the synthetic polypeptides. This overcomes issues with functional non-natural amino acids commonly used for click reactions in polypeptides.

  3. Well-Defined Poly(Ortho Ester Amides) for Potential Drug Carriers: Probing the Effect of Extra- and Intracellular Drug Release on Chemotherapeutic Efficacy

    Guoqing Yan, Jun Wang, Jiejie Qin, Liefeng Hu, Panpan Zhang, Xin Wang and Rupei Tang

    Version of Record online: 29 MAR 2017 | DOI: 10.1002/mabi.201600503

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    To compare chemotherapeutic efficacy determined by tumoral extracellular and intracellular drug release strategies, poly(ortho ester amides)-based drug carriers with different pH-sensitivities are successfully constructed. In vitro and in vivo results demonstrate that the intracellular drug release strategy has the stronger overall therapeutic efficacy, which may provide a guidance to design an efficient drug carrier in chemotherapy.

  4. Physicochemical Characterization of the Shell Composition of PBCA-Based Polymeric Microbubbles

    Lia Appold, Yang Shi, Stephan Rütten, Alexander Kühne, Andrij Pich, Fabian Kiessling and Twan Lammers

    Version of Record online: 29 MAR 2017 | DOI: 10.1002/mabi.201700002

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    Polymeric microbubbles (MB) are useful for drug delivery purposes. The authors analyzed the influence of synthesis parameters on the molecular weight distribution of the polymer chains constituting the shell of poly(butyl cyanoacrylate) (PBCA) MB using gel permeation chromatography. More than 99% of the polymer chains composing the PBCA MB-shell were found to be below the kidney clearance threshold of 40 kDa.

  5. d-Fructose Modification Enhanced Internalization of Mixed Micelles in Breast Cancer Cells via GLUT5 Transporters

    Xu Zhou, Xianyan Qin, Tao Gong, Zhi-Rong Zhang and Yao Fu

    Version of Record online: 27 MAR 2017 | DOI: 10.1002/mabi.201600529

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    d-Fructose modified poly(ε-caprolactone)-polyethylene glycol (PCL-PEG-Fru) is self-assembled with D-α-tocopheryl polyethylene glycol 1000 succinate into mixed micelles (PPF MM), which shows enhanced internalization efficiency in MCF-7 cells with overexpressed GLUT5 transporters as compared to fructose-free mixed micelles (PPN MM). The results may contribute to the development of GLUT5-mediated cell specific targeting strategy.