Macromolecular Bioscience

Cover image for Vol. 18 Issue 3

Editor-in-Chief: Kirsten Severing, Editor: Anne Pfisterer

Online ISSN: 1616-5195

Associated Title(s): Advanced Healthcare Materials, Macromolecular Chemistry and Physics, Macromolecular Materials and Engineering, Macromolecular Rapid Communications

Recently Published Issues

See all

Best of Macromolecular Journals

Best of Macros

Best of Macros 2018 is now online. Click here to read the articles selected this year.

Recently Published Articles

  1. Reduction-Triggered Self-Cross-Linked Hyperbranched Polyglycerol Nanogels for Intracellular Delivery of Drugs and Proteins

    Haeree Park, Yeongkyu Choi, M. T. Jeena, Eungjin Ahn, Yuri Choi, Myeong-Gyun Kang, Chae Gyu Lee, Tae-Hyuk Kwon, Hyun-Woo Rhee, Ja-Hyoung Ryu and Byeong-Su Kim

    Version of Record online: 15 MAR 2018 | DOI: 10.1002/mabi.201700356

    Thumbnail image of graphical abstract

    A self-cross-linked hyperbranched polyglycerol nanogel is synthesized by using the thiol–disulfide exchange reaction. A series of structural analyses confirm the tunable size and cross-linking density depending on the amount of reducing agent, used in the preparation of the nanogels. The nanogels can encapsulate not only small molecular therapeutics but also large enzymes such as β-galactosidase.

  2. Self-Folded Hydrogel Tubes for Implantable Muscular Tissue Scaffolds

    Lorenzo Vannozzi, Immihan Ceren Yasa, Hakan Ceylan, Arianna Menciassi, Leonardo Ricotti and Metin Sitti

    Version of Record online: 14 MAR 2018 | DOI: 10.1002/mabi.201700377

    Thumbnail image of graphical abstract

    Morphing hydrogels from 2D stacked layers to 3D tubes at the micron size scale are accomplished. It is shown that these tubes can encapsulate skeletal and cardiac muscle cells. Thorough characterizations and physical modeling to understand the self-folding process and cell behavior inside folded tubes are provided.

  3. Telechelic, Antimicrobial Hydrophilic Polycations with Two Modes of Action

    Lena Richter, Montasser Hijazi, Fatima Arfeen, Christian Krumm and Joerg C. Tiller

    Version of Record online: 7 MAR 2018 | DOI: 10.1002/mabi.201700389

    Thumbnail image of graphical abstract

    Telechelic polycations with dual antimicrobial modes of action are synthesized by hydrolyzing the backbone of poly(2-methyl-2-oxazoline) with two hydrophobic quaternary ammonium end groups to poly(ethylene imine). The resulting polymers are active against Staphylococcus aureus and Escherichia coli. The activity in the presence of calcium ions reveals the individual contributions of the end groups and the backbone to the overall antimicrobial action.

  4. Spherical and Worm-Like Micelles from Fructose-Functionalized Polyether Block Copolymers

    Tobias C. Majdanski, David Pretzel, Justyna A. Czaplewska, Jürgen Vitz, Pelin Sungur, Stephanie Höppener, Stephanie Schubert, Felix H. Schacher, Ulrich S. Schubert and Michael Gottschaldt

    Version of Record online: 28 FEB 2018 | DOI: 10.1002/mabi.201700396

    Thumbnail image of graphical abstract

    A fructose derivative is used as initiator for the anionic ring-opening polymerization of ethylene oxide and, subsequently, ethyl hexyl glycidyl ether. The resulting block copolymers form different micellar structures depending on the length of the hydrophobic or hydrophilic block. Fructosylated worm-like micelles reveal an enhanced uptake into breast cancer cells in comparison to spherical or non-fructosylated micelles.

  5. Polyplex Particles Based on Comb-Like Polyethylenimine/Poly(2-ethyl-2-oxazoline) Copolymers: Relating Biological Performance with Morphology and Structure

    Emi Haladjova, Silviya Halacheva, Denitsa Momekova, Veselina Moskova-Doumanova, Tanya Topouzova-Hristova, Kirilka Mladenova, Jordan Doumanov, Maria Petrova and Stanislav Rangelov

    Version of Record online: 28 FEB 2018 | DOI: 10.1002/mabi.201700349

    Thumbnail image of graphical abstract

    Experiments with lysosomal fluorescence staining reveal that the internalization pathways and transfection efficiency of polyplex particles depend on their morphology and structure, which, in turn, are governed by the copolymer chain topology and composition. The systems are based on comb-like polyethylenimine/poly(2-ethyl-2-oxazoline) copolymers and can be considered as promising for gene transfection in eukaryotic cells.