Macromolecular Bioscience

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Recently Published Articles

  1. Boronic Acid Shell-Crosslinked Dextran-b-PLA Micelles for Acid-Responsive Drug Delivery

    Ziwei Zhao, Xuemei Yao, Zhe Zhang, Li Chen, Chaoliang He and Xuesi Chen

    Article first published online: 21 AUG 2014 | DOI: 10.1002/mabi.201400251

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    3-carboxy-5-nitrophenylboronic acid (CNPBA) shell-crosslinked micelles based on amphiphilic dextran-block-polylactide (Dex-b-PLA) are prepared and used for efficient intracellular drug delivery. The pH-responsive biodegradable CNPBA-Dex-b-PLA can efficiently load and deliver DOX into tumor cells and enhance the inhibition of cellular proliferation in vitro, providing a favorable platform as a drug delivery system for cancer therapy.

  2. Functional Brush-Decorated Poly(globalide) Films by ARGET-ATRP for Bioconjugation

    Zeliha Ates, Fabrice Audouin, Amy Harrington, Brendan O'Connor and Andreas Heise

    Article first published online: 21 AUG 2014 | DOI: 10.1002/mabi.201400282

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    Poly(acrylic) acid brushes were grafted from polyester films obtained from the unsaturated macrolactone globalide by ARGET ATRP of tert.-butyl acrylate. After mild in situ deprotection high-density acrylic acid functional films were obtained while avoiding polyester hydrolysis. The conjugation with green fluorescent protein (GFP) and an enzyme was successfully carried out retaining the enzymatic activity.

  3. Monodisperse Carboxyl-Functionalized Poly(Ethylene Glycol)-Coated Magnetic Poly(Glycidyl Methacrylate) Microspheres: Application to the Immunocapture of β-Amyloid Peptides

    Daniel Horák, Helena Hlídková, Mohamed Hiraoui, Myriam Taverna, Vladimír Proks, Eliška Mázl Chánová, Claire Smadja and Zdenka Kučerová

    Article first published online: 21 AUG 2014 | DOI: 10.1002/mabi.201400249

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    Monodisperse magnetic poly(glycidyl methacrylate) microspheres coated with α-amino-ω-methoxy-PEG5000/α-amino-ω-Boc-NH-PEG5000substantially reduced non-specific protein adsorption. Anti-Aβ 6E10-immobilized microspheres specifically captured β-amyloid peptide (Aβ) from model solutions. Identification and evaluation of small changes in Aβ levels in cerebrospinal fluid is of crucial importance for early detection of Alzheimer's disease.

  4. Micropatterning Electrospun Scaffolds to Create Intrinsic Vascular Networks

    Eric M. Jeffries, Shintaro Nakamura, Kee-Won Lee, Jimmy Clampffer, Hiroyuki Ijima and Yadong Wang

    Article first published online: 20 AUG 2014 | DOI: 10.1002/mabi.201400306

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    Engineered microvasculature that effectively perfuses the parenchyme and directly integrates with host circulation remains the challenge of organ engineering. Described is a method for patterning microvascular structures in electrospun scaffolds using water-soluble templates produced by fused deposition modeling. The fibrous nature mimicks extracellular matrix and permits nutrient diffusion. Additionally, scaffolds are biodegradable and suturable. In vitro endothelialization demonstrates feasible vascularization.

  5. Electrospun Honeycomb as Nests for Controlled Osteoblast Spatial Organization

    Salima Nedjari, Sandy Eap, Anne Hébraud, Corinne R. Wittmer, Nadia Benkirane-Jessel and Guy Schlatter

    Article first published online: 19 AUG 2014 | DOI: 10.1002/mabi.201400226

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    PCL and PLA nanofibrous scaffolds with honeycomb micro-patterns are prepared by electrospinning. It is shown that the relief of the scaffolds depends on the distribution of fiber diameters. Mimicking hemi-osteons, cell gathering is observed inside the PCL honeycomb fibrous nests with a characteristic size greater than 80 μm.