Macromolecular Bioscience

Cover image for Vol. 18 Issue 2

Editor-in-Chief: Kirsten Severing, Editor: Anne Pfisterer

Online ISSN: 1616-5195

Associated Title(s): Advanced Healthcare Materials, Macromolecular Chemistry and Physics, Macromolecular Materials and Engineering, Macromolecular Rapid Communications

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Recently Published Articles

  1. You have free access to this content
    Happy Times for the Macromolecular Journals

    Kirsten Severing and Anne Pfisterer

    Version of Record online: 13 FEB 2018 | DOI: 10.1002/mabi.201800003

  2. Silk Fibroin-Based Fibrous Anal Fistula Plug with Drug Delivery Function

    Xusheng Xie, Lei Liu, Zhaozhu Zheng, Zhifen Han, Min Zhi, David L. Kaplan, Gang Li and Xiaoqin Wang

    Version of Record online: 7 FEB 2018 | DOI: 10.1002/mabi.201700384

    Thumbnail image of graphical abstract

    Crohn's disease is a serious bowel disease. Hence, it is important to treat and control this disease. This paper describes a drug-loaded silk fibroin membrane that can be attached to the surface of an anal fistula plug. The membrane with core–shell structure and functional encapsulation of drugs shall be useful for further studies toward the treatment of Crohn's disease.

  3. Water Soluble Antioxidant Dextran–Quercetin Conjugate with Potential Anticancer Properties

    Susan Oliver, Eugene Yee, Maria Kavallaris, Orazio Vittorio and Cyrille Boyer

    Version of Record online: 7 FEB 2018 | DOI: 10.1002/mabi.201700239

    Thumbnail image of graphical abstract

    Quercetin is limited in therapeutic use owing to its poor water solubility and stability. Quercetin is conjugated to dextran to yield a water-soluble quercetin-functionalized polymer. The conjugate has improved stability compared with native quercetin while maintaining substantial free-radical scavenging activity. Furthermore, it is shown to be cytotoxic to neuroblastoma cells but shows no activity against nonmalignant cells.

  4. Hemostatic Ability of Chitosan-Phosphate Inspired by Coagulation Mechanisms of Platelet Polyphosphates

    Younseon Wang, Keumyeon Kim, Moon Sue Lee and Haeshin Lee

    Version of Record online: 2 FEB 2018 | DOI: 10.1002/mabi.201700378

    Thumbnail image of graphical abstract

    Phosphorylation of chitosan (Chi-P) improves hemostatic properties by mimicking polyphosphates (polyPs) secreted from platelets. Chi-Ps are synthesized as soluble and insoluble forms which are dependent on the tethering positions of backbone hydroxyl groups. Independent of the Chi-P solubility, dense conjugations of phosphate groups exhibit enhanced hemostasis.

  5. Poly(N-methylvinylamine)-Based Copolymers for Improved Gene Transfection

    Mathilde Dréan, Antoine Debuigne, Christine Jérôme, Cristine Goncalves, Patrick Midoux, Jutta Rieger and Philippe Guégan

    Version of Record online: 2 FEB 2018 | DOI: 10.1002/mabi.201700353

    Thumbnail image of graphical abstract

    Chemical modifications of poly(N-methylvinylamines) backbones are performed to further improve transfection efficiency while maintaining low degree of cytotoxicity. Two polymethylvinylamine-based copolymers, one containing 20% of imidazole moieties and another one composed of 12% of guanidinyl units allow remarkable transfection efficiency of HeLa, pulmonary (16HBE), skeletal muscle (C2C12), and dendritic (DC2.4) cells.