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Recently Published Articles
- Hybrid POSS-Containing Brush on Gold Surfaces for Protein Resistance
Xiaolu Ye, Junbo Gong, Zhongping Wang, Zengming Zhang, Sheng Han and Xuesong Jiang
Article first published online: 22 MAY 2013 | DOI: 10.1002/mabi.201200461
A hybrid polymer brush containing poly(ethylene glycol) (PEG) chains and polyhedral oligomeric silsesquioxane (POSS) units is immobilized on a gold surface and exhibits an excellent protein resistance with long-term stability.
- Self-Assembly of Near-Monodisperse Redox-Sensitive Micelles from Cholesterol-Conjugated Biomimetic Copolymers
Yin Wang, Haibo Wang, Gongyan Liu, Xiangsheng Liu, Qiao Jin and Jian Ji
Article first published online: 22 MAY 2013 | DOI: 10.1002/mabi.201300052
Near-monodisperse redox-sensitive micelles can be obtained from cholesterol-conjugated biomimetic copolymers, which are prepared by sequential ROP and ATRP using a novel kind of double-dead initiator. The resultant micelles can be used as a carrier to encapsulate hydrophobic guest molecules, and the release manner can be regulated by a redox reagent, DTT.
- Incorporation of Poly[(R)-3-hydroxybutyrate] into Cationic Copolymers Based on Poly(2-(dimethylamino)ethyl methacrylate) to Improve Gene Delivery
Xian Jun Loh, Shi Jie Ong, Yin Ting Tung and Hoi Teng Choo
Article first published online: 22 MAY 2013 | DOI: 10.1002/mabi.201300050
A series of novel triblock copolymers with poly(2-(dimethylamino)ethyl methacrylate) (DMAEMA) blocks flanking a hydrophobic poly[(R)-3-hydroxybutyrate] (PHB) block is synthesized and the gene transfection efficiencies of these polymers are reported. Compared with PEI or PDMAEMA homopolymers, the incorporation of PHB significantly improves the gene transfection efficiency. This exciting finding heralds new developments in the area of polymeric gene delivery vectors.
- Nanobody-Functionalized Polymersomes for Tumor-Vessel Targeting
Marjoke F. Debets, William P. J. Leenders, Kiek Verrijp, Marleen Zonjee, Silvie A. Meeuwissen, Irene Otte-Höller and Jan C. M. van Hest
Article first published online: 21 MAY 2013 | DOI: 10.1002/mabi.201300039
The preparation of polymersomes with tumor-targeting potential is described. To this end, polymersomes are equipped with a strained cyclooctyne and a tumor targeting single-domain antibody (A12) is functionalized with an azide using expressed protein ligation (EPL). Conjugation of the two yields polymersomes with an A12-coated surface.
- Design and Engineering of Disulfide Crosslinked Nanocomplexes of Polyamide Polyelectrolytes: Stability under Biorelevant Conditions and Potent Cellular Internalization of Entrapped Model Peptide
Aashish Sharma, Somanath Kundu, Amarendar Reddy M, Avinash Bajaj and Aasheesh Srivastava
Article first published online: 21 MAY 2013 | DOI: 10.1002/mabi.201300018
Polyamide polyelectrolytes (PEs) with controlled thiolation are prepared from an L-aspartic acid-derived precursor, polysuccinimide. These counter PEs form complexes that undergo spontaneous, reagentless self-crosslinking via bioreducible disulfide bonds, significantly augmenting their stability under biorelevant conditions. These complexes efficiently transport an entrapped peptide cargo inside A549 cell lines with high cell viability.