Macromolecular Bioscience

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Recently Published Articles

  1. Bioactive Microsphere-Based Scaffolds Containing Decellularized Cartilage

    Amanda Sutherland and Michael Detamore

    Article first published online: 27 MAR 2015 | DOI: 10.1002/mabi.201400472

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    Scaffolds were fabricated using sintered PLGA microspheres containing decellularized articular cartilage either encapsulated within the microspheres or coated on the surface of the microspheres. The encapsulated decellularized cartilage constructs showed the ability to induce bioactivity in rat bone marrow-derived mesenchymal stem cells, although there is opportunity for improved chondrogenesis.

  2. An Oligonucleotide Transfection Vector Based on HSA and PDMAEMA Conjugation: Effect of Polymer Molecular Weight on Cell Proliferation and on Multicellular Tumor Spheroids

    Yanyan Jiang, Chin Ken Wong and Martina H. Stenzel

    Article first published online: 25 MAR 2015 | DOI: 10.1002/mabi.201500006

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    A drug delivery system for nucleic acid drugs based on a polymer-protein conjugate is synthesized. The protein itself is based on human serum albumin. It is shown that a number-averaged molecular weight inline image of around 20 000 g mol−1 has the highest efficiency in delivering the oligonucleotide ISIS 5132, resulting in the highest toxicity and the most efficient destruction of multicellular breast cancer spheroids.

  3. The Human Embryoid Body Cystic Core Exhibits Architectural Complexity Revealed by use of High Throughput Polymer Microarrays

    Martin L. Tomov, Zachary T. Olmsted and Janet L. Paluh

    Article first published online: 25 MAR 2015 | DOI: 10.1002/mabi.201500051

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    The embryoid body is a classic and important stem cell intermediate used to mimic the three dimensional architecture in early embryos for differentiation. Formation methods for EBs are evolving, necessitating an improved understanding of critical EB parameters for differentiation. Here, we apply a uniform platform of custom polymer microarrays to comprehensively analyze EB formation methods, rate of formation, morphology, size, and differentiation protocols. Our analysis reveals a size-dependent resilient multicystic core architecture in larger EBs that contributes to non-uniformity during early differentiation.

  4. Supramolecular Polyelectrolyte Complexes of Bone Morphogenetic Protein-2 with Sulfonated Polyrotaxanes to Induce Enhanced Osteogenic Differentiation

    Masahiko Terauchi, Go Ikeda, Kei Nishida, Atsushi Tamura, Satoshi Yamaguchi, Kiyoshi Harada and Nobuhiko Yui

    Article first published online: 23 MAR 2015 | DOI: 10.1002/mabi.201500032

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    The sulfonated polyrotaxanes (S-PRX) composed of sulfonated α-cyclodextrin threaded onto a linear polymer were developed to protect bone morphogenetic protein-2 (BMP-2) from degradation and deactivation through the formation of polyelectrolyte complexes. The S-PRXs are promising candidates to induce enhanced osteoinduction ability of BMP-2 without toxicity and anticoagulant activity.

  5. Chitosan Grafted with Phosphorylcholine and Macrocyclic Polyamine as an Effective Gene Delivery Vector: Preparation, Characterization and In Vitro Transfection

    Ling Li, Fangfang Zhao, Baojing Zhao, Jin Zhang, Chao Li and Renzhong Qiao

    Article first published online: 20 MAR 2015 | DOI: 10.1002/mabi.201400518

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    Chitosan grafted with phosphorylcholine and macrocyclic polyamine is synthesized to deliver gene. It can efficiently wrap DNA into uniform nanoparticles in the appropriate size and protect DNA from nuclease. It also shows satisfactory water-solubility, low cytotoxicity, high cell uptake and superior in vitro transfection activity. All these results show that it could be used as a promising gene vector.