Macromolecular Bioscience

Cover image for Vol. 15 Issue 11

Editor-in-Chief: Kirsten Severing, Editor: Anne Pfisterer

Online ISSN: 1616-5195

Associated Title(s): Advanced Healthcare Materials, Macromolecular Chemistry and Physics, Macromolecular Materials and Engineering, Macromolecular Rapid Communications

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Recently Published Articles

  1. A Supramolecular Gel Approach to Minimize the Neural Cell Damage during Cryopreservation Process

    Jie Zeng, Yixia Yin, Li Zhang, Wanghui Hu, Chaocan Zhang and Wanyu Chen

    Article first published online: 27 NOV 2015 | DOI: 10.1002/mabi.201500277

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    A thermoreversible supramolecular gel cryopreservation system increases the viabilities of cells during cryopreservation since it confines ice crystal growth in its porous network and it reduces the change rate of osmotic shock when the cryoprotective agent is loaded and unloaded. Moreover, this supramolecular gel can be removed easily so it does not hinder the adherence, growth, and proliferation of thawed cells.

  2. Development of Non-Cell Adhesive Vascular Grafts Using Supramolecular Building Blocks

    Geert C. van Almen, Hanna Talacua, Bastiaan D. Ippel, Björne B. Mollet, Mellany Ramaekers, Marc Simonet, Anthal I. P. M. Smits, Carlijn V. C. Bouten, Jolanda Kluin and Patricia Y. W. Dankers

    Article first published online: 27 NOV 2015 | DOI: 10.1002/mabi.201500278

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    This proof-of-concept study demonstrates that mixing of ureido-pyrimidinone (UPy) modified poly(ethylene glycol) (UPy-PEG) with a chain-extended UPy-functionalized polycaprolactone results in a mechanically stable material that can be electrospun into vascular tubular grafts. It is shown that only 10% of this UPy-PEG is sufficient to obtain reduced cell infiltration in vivo, after a relatively short implantation time.

  3. Two-Phase Electrospinning to Incorporate Polyelectrolyte Complexes and Growth Factors into Electrospun Chitosan Nanofibers

    Laura W. Place, Maria Sekyi, Julia Taussig and Matt J. Kipper

    Article first published online: 27 NOV 2015 | DOI: 10.1002/mabi.201500288

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    Three methods are described for electrospinning chitosan nanofibers containing heparin/growth factor nanoparticles in a separate phase. Electrospinning a water-in-organic emulsion does not achieve growth factor incorporation. Electrospinning nanofibers using a compound needle with a chitosan organic phase and a poly(vinyl alcohol) aqueous phase achieves the most successful growth factor incorporation and delivery, when the aqueous phase is in the core.

  4. Paclitaxel-Loaded β-Cyclodextrin-Modified Poly(Acrylic Acid) Nanoparticles through Multivalent Inclusion for Anticancer Therapy

    Shanmei Yuan, Jiao Chen, Jie Sheng, Yong Hu and Zhongying Jiang

    Article first published online: 27 NOV 2015 | DOI: 10.1002/mabi.201500302

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    Paclitaxel-loaded multivalent inclusion nanoparticles (NPs) are fabricated. These obtained NPs have a negative surface charge and show an enhanced paclitaxel (PTX) solubility. They can accumulate in the tumor tissue and have a superior antitumor activity compared to commercially available Taxol, which indicates that these NPs own potential application in the PTX delivery system.

  5. Synthesis of Novel Cellulose Carbamates Possessing Terminal Amino Groups and Their Bioactivity

    Kristin Ganske, Cornelia Wiegand, Uta-Christina Hipler and Thomas Heinze

    Article first published online: 27 NOV 2015 | DOI: 10.1002/mabi.201500324

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    Novel cellulose carbamates are synthesized by aminolysis of cellulose phenyl carbonates. The ω-aminoethyl-p-aminobenzylcellulose carbamate shows antimicrobial activity and a moderate biocompatibility not only in solution but also as films on cotton and polyester. Cotton coated with cellulose carbamate inhibits bacteria growth in case of Staphylococcus aureus and Klebsiella pneumoniae completely.