Macromolecular Bioscience

Cover image for Vol. 17 Issue 9

Editor-in-Chief: Kirsten Severing, Editor: Anne Pfisterer

Online ISSN: 1616-5195

Associated Title(s): Advanced Healthcare Materials, Macromolecular Chemistry and Physics, Macromolecular Materials and Engineering, Macromolecular Rapid Communications

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Best of Macros 2017 is now online. Click here to read about the selected articles and their authors.

Recently Published Articles

  1. Hemocompatibility of Ca2+-Crosslinked Nanocellulose Hydrogels: Toward Efficient Management of Hemostasis

    Alex Basu, Jaan Hong and Natalia Ferraz

    Version of Record online: 21 SEP 2017 | DOI: 10.1002/mabi.201700236

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    Ca2+-crosslinked nanofibrillated cellulose hydrogels are presented as potential hemostatic wound dressings. Negatively charged functionalized nanocellulose-based hydrogels efficiently trigger blood coagulation and have a minimal effect on the complement system. The incorporation of the bioactive agents kaolin and collagen into the nanocellulose hydrogels gives a solid base for the development of advanced dressings with tuned wound healing properties.

  2. Polymer Cancerostatics Targeted with an Antibody Fragment Bound via a Coiled Coil Motif: In Vivo Therapeutic Efficacy against Murine BCL1 Leukemia

    Michal Pechar, Robert Pola, Olga Janoušková, Irena Sieglová, Vlastimil Král, Milan Fábry, Barbora Tomalová and Marek Kovář

    Version of Record online: 15 SEP 2017 | DOI: 10.1002/mabi.201700173

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    Synthesis of actively targeted N-(2-hydroxypropyl)methacrylamide copolymer with an anticancer drug pirarubicin is described. Recombinant targeting fragment derived from B1 monoclonal antibody is attached to the polymer drug conjugate via a coiled coil peptide linker. The targeted polymer conjugate exhibits significantly better therapeutic efficacy against murine BCL1 leukemia in vivo than both the free drug and the nontargeted polymer conjugate.

  3. Solid Tumor Immunotherapy with T Cell Engager-Armed Oncolytic Viruses

    Eleanor M. Scott, Margaret R. Duffy, Joshua D. Freedman, Kerry D. Fisher and Leonard W. Seymour

    Version of Record online: 13 SEP 2017 | DOI: 10.1002/mabi.201700187

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    Oncolytic viruses are multimodal anticancer agents which can be engineered to express and secrete biologics locally within the tumor microenvironment. Here, arming oncolytic viruses with bispecific T cell engagers (BiTEs), capable of activating endogenous T cells to kill target cells, is explored. This strategy should improve the safety of BiTEs, while simultaneously affording the opportunity for synergy with viral oncolysis.

  4. Design of a Novel Two-Component Hybrid Dermal Scaffold for the Treatment of Pressure Sores

    Vaibhav Sharma, Nupur Kohli, Dale Moulding, Halimat Afolabi, Lilian Hook, Chris Mason and Elena García-Gareta

    Version of Record online: 12 SEP 2017 | DOI: 10.1002/mabi.201700185

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    A novel two-component hybrid scaffold combining a porous fibrin/alginate matrix with a plasma polymerized polydimethylsiloxane (Sil) membrane for pressure sores is designed. The matrix is intact after addition of the Sil membrane that significantly increases the shear modulus G′. Dermal fibroblasts proliferate and infiltrate the scaffolds.

  5. EGFR Targeting and Shielding of pDNA Lipopolyplexes via Bivalent Attachment of a Sequence-Defined PEG Agent

    Stephan Morys, Sarah Urnauer, Christine Spitzweg and Ernst Wagner

    Version of Record online: 6 SEP 2017 | DOI: 10.1002/mabi.201700203

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    For improved epidermal growth factor receptor-targeted gene delivery, a bidentate postmodification strategy for sequence-defined oligomers is established. Core lipopolyplexes formed by T-shaped bis-oleoyl-oligoethanamino amide structures containing cysteines are postmodified via disulfide exchange with a bivalent polyethylene glycol–GE11 peptide agent. This results in enhanced transfection efficacy compared to coating with analogous monovalent agents.