Macromolecular Bioscience

Cover image for Vol. 17 Issue 11

Editor-in-Chief: Kirsten Severing, Editor: Anne Pfisterer

Online ISSN: 1616-5195

Associated Title(s): Advanced Healthcare Materials, Macromolecular Chemistry and Physics, Macromolecular Materials and Engineering, Macromolecular Rapid Communications

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Best of Macros 2017 is now online. Click here to read about the selected articles and their authors.

Recently Published Articles

  1. In Vitro Evaluation of Anti-Aggregation and Degradation Behavior of PEGylated Polymeric Nanogels under In Vivo Like Conditions

    Yinan Chen, George R. Dakwar, Kevin Braeckmans, Twan Lammers, Wim E. Hennink and Josbert M. Metselaar

    Version of Record online: 20 NOV 2017 | DOI: 10.1002/mabi.201700127

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    Fluorescence single particle tracking, tangential flow filtration, and fluorescence fluctuation spectroscopy are developed and optimized to study the stability and degradation of polymeric nanogels with various degrees of PEGylation and crosslinking densities. They are valuable in vitro strategies to predict the in vivo behavior of nanocarriers prior to animal studies.

  2. Microfibers as Physiologically Relevant Platforms for Creation of 3D Cell Cultures

    Marilyn C. McNamara, Farrokh Sharifi, Alex H. Wrede, Daniel F. Kimlinger, Deepak-George Thomas, Jonathan B. Vander Wiel, Yuanfen Chen, Reza Montazami and Nicole N. Hashemi

    Version of Record online: 17 NOV 2017 | DOI: 10.1002/mabi.201700279

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    Microfibers have received much attention due to their promise for creating flexible and highly relevant platforms for biomedical applications. This paper not only provides a unique and detailed overview of creating and designing fibers with tunable mechanical properties and surface topographies, but also covers fibers' uses in biomedical fields, including tissue modeling, subcutaneous injection for therapeutic purposes, and drug delivery.

  3. Tailor-Made Molecularly Imprinted Polymer for Selective Recognition of the Urinary Tumor Marker Pseudouridine

    Aleksandra Krstulja, Stefania Lettieri, Andrew J. Hall, Vincent Roy, Patrick Favetta and Luigi A. Agrofoglio

    Version of Record online: 16 NOV 2017 | DOI: 10.1002/mabi.201700250

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    The development of technologies able to recognize selectively tumor biomarker is vital to help its prognosis and diagnosis. That is why, for the first time, a selective tailor-made imprinted polymer material to the marker pseudouridine is synthetized. Here, the molecularly imprinted polymer selectivity and efficiency in human urine are demonstrated, and doors are opened to its use in disposable sensors.

  4. Hyaluronic Acid-Based Micelles as Ocular Platform to Modulate the Loading, Release, and Corneal Permeation of Corticosteroids

    Flavia Bongiovì, Giulia Di Prima, Fabio S. Palumbo, Mariano Licciardi, Giovanna Pitarresi and Gaetano Giammona

    Version of Record online: 16 NOV 2017 | DOI: 10.1002/mabi.201700261

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    The amphiphilic derivative HAC16b is used to prepare polymeric micelles. They are able to efficiently entrap corticosteroid drugs and to establish stable contact with mucin. Their ocular potential use is confirmed by the ex vivo permeation study that allows to establish the role of these micelles as permeation and penetration enhancers across bovine cornea specimens.

  5. 3D Printed Anchoring Sutures for Permanent Shaping of Tissues

    Wei Wei, Yuxiao Li, Huazhe Yang, Reza Nassab, Fatemeh Shahriyari, Ali Akpek, Xiaofei Guan, Yanhui Liu, Shahrouz Taranejoo, Ali Tamayol, Yu Shrike Zhang, Ali Khademhosseini and Hae Lin Jang

    Version of Record online: 16 NOV 2017 | DOI: 10.1002/mabi.201700304

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    Suture anchors that can permanently reshape tissues are designed using orthogonal arrays and 3D printed in a way that can smoothly propagate along the suturing direction, while have maximized resistive force against external force once it is fixed in tissues. Tissue reshaping function of anchoring sutures is demonstrated by using swine skin, ear, and nose, and bovine tendon.

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