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Recently Published Articles
- RGDS- and SIKVAVS-Modified Superporous Poly(2-hydroxyethyl methacrylate) Scaffolds for Tissue Engineering Applications
Hana Macková, Zdeněk Plichta, Vladimír Proks, Ilya Kotelnikov, Jan Kučka, Helena Hlídková, Daniel Horák, Šárka Kubinová and Klára Jiráková
Version of Record online: 27 JUL 2016 | DOI: 10.1002/mabi.201600159
Superporous RGDS-poly(2-hydroxyethyl methacrylate) scaffold supports mesenchymal and neural stem cell attachment, proliferation, and growth. This makes the scaffold attractive for accommodation of cells in tissue engineering applications such as spinal cord repair.
- Influence of Structural Features on the Cellular Uptake Behavior of Non-Targeted Polyester-Based Nanocarriers
Carlos E. de Castro, Jean-Jacques Bonvent, Maria C. C. da Silva, Fabiane L. F. Castro and Fernando C. Giacomelli
Version of Record online: 27 JUL 2016 | DOI: 10.1002/mabi.201600138
The cellular uptake behavior of a library of polymeric nanoparticles is evaluated. The experimental results evidence that cell internalization is inversely related to the length of the hydrophilic corona. Additionally, higher degree of core hydrophobicity and high negative surface charge respectively enhances and restricts cellular uptake.
- Polypyrrole/Alginate Hybrid Hydrogels: Electrically Conductive and Soft Biomaterials for Human Mesenchymal Stem Cell Culture and Potential Neural Tissue Engineering Applications
Sumi Yang, LindyK. Jang, Semin Kim, Jongcheol Yang, Kisuk Yang, Seung-Woo Cho and Jae Young Lee
Version of Record online: 26 JUL 2016 | DOI: 10.1002/mabi.201600148
Conductive and soft polypyrrole/alginate hydrogels are synthesized by chemically polymerizing polypyrrole within alginate hydrogel networks for human mesenchymal stem culture. The conductive hydrogels can display more than ten times high electrical conductivities and softness (<200 kPa Young's modulus). These conductive hydrogels promoted human mesenchymal stem cell adhesion and growth, and also greatly up-regulated neural differentiation markers.
- Cell-Free HA-MA/PLGA Scaffolds with Radially Oriented Pores for In Situ Inductive Regeneration of Full Thickness Cartilage Defects
Yuankun Dai, Zhenzhen Gao, Lie Ma, Dongan Wang and Changyou Gao
Version of Record online: 26 JUL 2016 | DOI: 10.1002/mabi.201600218
Methacrylated hyaluronic acid/PLGA scaffolds with radially oriented pores are fabricated, which are able to realize in situ inductive regeneration of cartilage in a full thickness articular cartilage defect model in rabbit without employment of any extraneous cells or chondrogenetic growth factors.
- Biocompatibility of a Self-Assembled Crosslinkable Hyaluronic Acid Nanogel
Sílvia Santos Pedrosa, Paula Pereira, Alexandra Correia, Susana Moreira, Hugo Rocha and Francisco Miguel Gama
Version of Record online: 26 JUL 2016 | DOI: 10.1002/mabi.201600221
Crosslinkable Hyaluronic acid nanogels immunocompatibility and hemocompatability and general biocompatibility is assessed in this work. Cytotoxicity on three different cell lines is confirmed through various approaches. Further, BMDM nanogels uptake suggests low recognition by immune system and in vivo results confirms its long circulation time.