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Recently Published Articles
- Peptide-Directed Self-Assembly of Functionalized Polymeric Nanoparticles Part I: Design and Self-Assembly of Peptide–Copolymer Conjugates into Nanoparticle Fibers and 3D Scaffoldsa
Xiaochu Ding, Jagadeesh Janjanam, Ashutosh Tiwari, Martin Thompson and Patricia A. Heiden
Article first published online: 7 MAR 2014 | DOI: 10.1002/mabi.201300569
A fundamentally new approach to fabricate an ionic complementary peptide-directed self-assembly of polymeric nanoparticles into continuous nanoparticle fibers and 3D scaffolds is presented. This scaffolding system possesses the advantages of individually controlling the release of each drug-loaded nanoparticle with the potential to serve as a scaffolding.
- Enzymatic Mineralization of Silk Scaffolds
Sangram K. Samal, Mamoni Dash, Heidi A. Declercq, Tom Gheysens, Jolien Dendooven, Pascal Van Der Voort, Ria Cornelissen, Peter Dubruel and David L. Kaplan
Article first published online: 7 MAR 2014 | DOI: 10.1002/mabi.201300513
Alkaline phosphatase-mediated formation of apatitic minerals on porous silk protein (SFP) scaffolds. The mineral structures differ as a function of ALP concentration. The mineralized SFP scaffolds are effective in improving cellular adhesion, proliferation, and colonization by osteogenic cells.
- You have full text access to this OnlineOpen articleSilk-Pectin Hydrogel with Superior Mechanical Properties, Biodegradability, and Biocompatibility
Keiji Numata, Shoya Yamazaki, Takuya Katashima, Jo-Ann Chuah, Naofumi Naga and Takamasa Sakai
Article first published online: 7 MAR 2014 | DOI: 10.1002/mabi.201300482
The silk-pectin hydrogel reported here is composed of a heterogeneous network, which is different from fiber-reinforced, interpenetrated networks and double-network hydrogels. The silk-pectin hydrogel is also high-strength hydrogel (elastic modulus of 4.7 ± 0.9 MPa, elastic stress limit of 3.9 ± 0.1 MPa, and elastic strain limit of 48.4 ± 0.5%) with regard to biocompatibility and biodegradability.
- Cell Behavior on Surface Modified Polydimethylsiloxane (PDMS)
Morgan M. Stanton, Johanna M. Rankenberg, Byung-Wook Park, W. Grant McGimpsey, Christopher Malcuit and Christopher R. Lambert
Article first published online: 6 MAR 2014 | DOI: 10.1002/mabi.201300504
A biochemical micro-pattern is successfully combined with a micro-rough polymer surface as a scaffold to mimic in vivo environments for tissue engineering. Cells cultured on the modified polymer exhibit alignment and significantly altered gene expression. This novel substrate has useful applications for complex tissue design and biomimetic scaffolds.
- Poly(hydroxybutyrate-co-hydroxyvalerate) Bilayer Skin Tissue Engineering Constructs with Improved Epidermal Rearrangement
Alessandra Zonari, Mariana T. Cerqueira, Silviene Novikoff, Alfredo M. Goes, Alexandra P. Marques, Vitor M. Correlo and Rui L. Reis
Article first published online: 4 MAR 2014 | DOI: 10.1002/mabi.201400005
Taking in consideration skin two main strata, epidermis and dermis, a bilayer structure based on poly(hydroxybutyrate-co-hydroxyvalerate) is developed, combining a 2D thin nanoporous upper layer and a 3D scaffold. The bilayer system favors human fibroblasts and keratinocytes performance under defined co-culture conditions and leads to the particular rearrangement of human keratinocytes in a multilayer structure.