Copyright © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Materials Science Weekly Newsletter
Recently Published Articles
- Poly(anhydride-ester) and Poly(N-vinyl-2-pyrrolidone) Blends: Salicylic Acid-Releasing Blends with Hydrogel-Like Properties that Reduce Inflammation
Michelle A. Ouimet, Renata Fogaça, Sabrina S. Snyder, Sameer Sathaye, Luiz H. Catalani, Darrin J. Pochan and Kathryn E. Uhrich
Article first published online: 21 OCT 2014 | DOI: 10.1002/mabi.201400238
Hydrogels-like polymer blends that combine the biocompatibility and hydrophilicity of PVP with controlled release of salicylic acid to reduce inflammation are presented. These copolymer blends substantially reduce the inflammatory cytokine, TNF-α, in vitro and indicate no cytotoxic or anti-proliferative effects. Based upon the unique combination, these blended polymer films show great potential for wound healing.
- Multi-Technique Characterization of Poly-L-lysine Dendrigrafts–Cu(II) Complexes for Biocatalysis
Jean-Christophe Rossi, Barbara Maret, Kevin Vidot, Jean-Patrick Francoia, Michela Cangiotti, Susanna Lucchi, Concetta Coppola and Maria Francesca Ottaviani
Article first published online: 20 OCT 2014 | DOI: 10.1002/mabi.201400341
Significant structural features of poly-L-lysine dendrigrafts (DGLs) – Cu(II) complexes are characterized to implement the use of these complexes as biocatalysts. The agreement and complementarity among EPR, potentiometric titration, UV-Vis and CD measurements provide an exhaustive view of the Cu(II)-DGL complexation behavior as a function of DGL generation, relative concentrations, and pH.
- Thermoresponsive Nanodevices in Biomedical Applications
Julián Bergueiro and Marcelo Calderón
Article first published online: 16 OCT 2014 | DOI: 10.1002/mabi.201400362
Thermoresponsive nanodevices are one of the most promising systems in nanomedicine. Due to new building blocks, a number of promising smart systems have been rapidly developed in response to the needs of nanomedicine. This article reviews the innovations in this field from the last four years.
- Blending of Diblock and Triblock Copolypeptide Amphiphiles Yields Cell Penetrating Vesicles with Low Toxicity
April R. Rodriguez, Uh-Joo Choe, Daniel T. Kamei and Timothy J. Deming
Article first published online: 16 OCT 2014 | DOI: 10.1002/mabi.201400348
Diblock and triblock copolypeptides were blended to form vesicle populations with uniform compositions. Mixing of cationic and non-ionic amphiphiles in these vesicles gave optimized properties of good cellular uptake while maintaining minimal cytotoxicity. Copolypeptide mixing is a promising strategy to provide useful functionality without requiring the use of complicated synthesis procedures.
- Glycosylated Star Polypeptides from NCA Polymerization: Selective Binding as a Function of Degree of Branching and Glycosylation
Mark Byrne, Robert Mildner, Henning Menzel and Andreas Heise
Article first published online: 15 OCT 2014 | DOI: 10.1002/mabi.201400371
Poly(glutamic acid) star polymers with up to 64 arms were synthesized via N-carboxy-anhydride (NCA) polymerization from dendritic initiators. Glycosylation afforded star-shaped glyco- peptides with varying degrees of sugar conjugation. The secondary structure and the ability to selectively bind to lectin ConA was found to be dependent on sugar content and polymer structure, respectively.