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Recently Published Articles
- Enhanced Antimetastatic Activity of the Ruthenium Anticancer Drug RAPTA-C Delivered in Fructose-Coated Micelles
Mingxia Lu, Fan Chen, Janina-Miriam Noy, Hongxu Lu and Martina H. Stenzel
Version of Record online: 24 FEB 2017 | DOI: 10.1002/mabi.201600513
Coating micelles with fructose can enhance the antimetastatic effect of ruthenium drugs. The sugar-based nanocarrier, compared to a micelle based on a nonfunctional nanocarrier, shows higher uptake by breast cancer cells and better penetration in MCF-7 tumor spheroids.
- Regulation of Scaffold Cell Adhesion Using Artificial Membrane Binding Proteins
Madeline Burke, James P. K. Armstrong, Andrew Goodwin, Robert C. Deller, Benjamin M. Carter, Robert L. Harniman, Aasiya Ginwalla, Valeska P. Ting, Sean A. Davis and Adam W. Perriman
Version of Record online: 24 FEB 2017 | DOI: 10.1002/mabi.201600523
A novel strategy is developed where chemical, biochemical, and morphological properties of biomaterials scaffolds are varied by the covalent coupling of cationized and surfactant-conjugated proteins. These artificial membrane binding proteins not only increase cellular adhesion via electrostatic and hydrophobic mechanisms, but can also be used as oxygen reservoirs to prevent slowdown of proliferation in hypoxic conditions.
- Washless Method Enables Multilayer Coating of an Aggregation-Prone Nanoparticulate Drug Delivery System with Enhanced Yields, Colloidal Stability, and Scalability
Lamees Nayef, Rafael Castiello and Maryam Tabrizian
Version of Record online: 22 FEB 2017 | DOI: 10.1002/mabi.201600535
Washless method titrations allow coating aggregation-prone liposome core nanoparticle with eight layers of polyelectrolyte with higher yields and reproducibility promising greater success in investigating a broader range of multilayer-coated nanoparticles for applications like drug delivery.
- Imaging Cell–Matrix Interactions in 3D Collagen Hydrogel Culture Systems
Aaron R. Short, Catherine Czeisler, Benjamin Stocker, Sara Cole, José Javier Otero and Jessica O. Winter
Version of Record online: 21 FEB 2017 | DOI: 10.1002/mabi.201600478
Hydrogels provide more accurate representations of cell behaviors in vivo; however, imaging in hydrogels can be challenging. This work develops new methods that enable imaging of cellular interactions with their hydrogel microenvironments in a collagen model.
- A Robust Method to Generate Mechanically Anisotropic Vascular Smooth Muscle Cell Sheets for Vascular Tissue Engineering
Daniel E. Backman, Bauer L. LeSavage, Shivem B. Shah and Joyce Y. Wong
Version of Record online: 16 FEB 2017 | DOI: 10.1002/mabi.201600434
Vascular smooth muscle cell sheets are cultured using a novel, micropatterned, thermoresponsive cell culture platform. The method is optimized to produce vascular smooth muscle cell sheets with cellular and extracellular alignment. Aligned cell sheets exhibit nonlinear, anisotropic mechanical properties that make them an attractive material for building a vascular graft that mimics the structural and mechanical properties of native vascular tissue.