Macromolecular Bioscience

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Recently Published Articles

  1. Elastin-Like Polypeptide Based Nanoparticles: Design Rationale Toward Nanomedicine

    Ferdinanda C. M. Smits, Bastiaan C. Buddingh, Mark B. van Eldijk and Jan C. M. van Hest

    Article first published online: 19 NOV 2014 | DOI: 10.1002/mabi.201400419

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    Elastin-like polypeptides (ELPs) are biocompatible, temperature responsive and can be made with high sequence control. This makes ELP-based materials very interesting for their use towards nanomedicine applications. Many ELP-based systems that show self-assembly into nanoparticles have been developed. This review will give an overview of the ELP-based block copolymers capable of nanoparticle formation and their design parameters.

  2. Multiphase Protein Microgels

    Ulyana Shimanovich, Yang Song, Jasna Brujic, Ho Cheung Shum and Tuomas P. J. Knowles

    Article first published online: 19 NOV 2014 | DOI: 10.1002/mabi.201400366

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    We show that the characteristics of aqueous two-phase systems can be exploited in combination with protein self-assembly for controlling aggregation and structuring of fibrillar proteins into 3D core–shell microgels.

  3. A Cationic Poly(2-oxazoline) with High In Vitro Transfection Efficiency Identified by a Library Approach

    Alexandra C. Rinkenauer, Lutz Tauhardt, Felix Wendler, Kristian Kempe, Michael Gottschaldt, Anja Traeger and Ulrich S. Schubert

    Article first published online: 18 NOV 2014 | DOI: 10.1002/mabi.201400334

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    An 18-membered library of cationic poly(2-oxazoline)-based copolymers has been prepared. The influence of different polymer parameters, namely the polymer side chain hydrophobicity and the type and content of amino groups, on the pDNA condensation, the transfection efficiency, the cytotoxicity, and cellular membrane interaction as well as the size, charge, and stability of the polyplexes was studied and first structure–property relationships elucidated.

  4. Protein Compatibility of Selected Cross-linking Reactions for Hydrogels

    Nadine Hammer, Ferdinand P. Brandl, Susanne Kirchhof, Viktoria Messmann and Achim M. Goepferich

    Article first published online: 14 NOV 2014 | DOI: 10.1002/mabi.201400379

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    Despite years of research, finding cross-linking reactions for hydrogels that are compatible with incorporated proteins is still challenging. The authors, therefore, investigate side reactions between a model protein and methoxypolyethylene glycol functionalized with maleimide, vinyl sulfone, acrylamide, thiol, and furyl moieties. The extent of protein modification was found to depend on the cross-linking agent and the pH during incubation.

  5. Novel Cationic Triblock Copolymer of Poly[2-(dimethylamino)ethyl methacrylate]-block-poly(β-amino ester)-block-poly[2-(dimethylamino)ethyl methacrylate]: A Promising Non-Viral Gene Delivery System

    Rosemeyre A. Cordeiro, Dina Farinha, Nuno Rocha, Arménio C. Serra, Henrique Faneca and Jorge F. J. Coelho

    Article first published online: 14 NOV 2014 | DOI: 10.1002/mabi.201400424

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    An efficient block copolymer non-viral vector composed by poly[2-(dimethylamino)ethyl methacrylate] and poly(β-amino ester) for plasmid DNA delivery. The new cationic block copolymers of poly[2-(dimethylamino)ethyl methacrylate]-b-poly(β-amino ester)-b-poly[2-(dimethylamino)ethyl methacrylate] efficiently bind pDNA and show high transfection activity in HeLa and COS-7 cell lines compared to bPEI and TurboFect™ polymeric non-viral vector standards.