Macromolecular Bioscience

Cover image for Vol. 16 Issue 7

Editor-in-Chief: Kirsten Severing, Editor: Anne Pfisterer

Online ISSN: 1616-5195

Associated Title(s): Advanced Healthcare Materials, Macromolecular Chemistry and Physics, Macromolecular Materials and Engineering, Macromolecular Rapid Communications

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Recently Published Articles

  1. RGDS- and SIKVAVS-Modified Superporous Poly(2-hydroxyethyl methacrylate) Scaffolds for Tissue Engineering Applications

    Hana Macková, Zdeněk Plichta, Vladimír Proks, Ilya Kotelnikov, Jan Kučka, Helena Hlídková, Daniel Horák, Šárka Kubinová and Klára Jiráková

    Version of Record online: 27 JUL 2016 | DOI: 10.1002/mabi.201600159

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    Superporous RGDS-poly(2-hydroxyethyl methacrylate) scaffold supports mesenchymal and neural stem cell attachment, proliferation, and growth. This makes the scaffold attractive for accommodation of cells in tissue engineering applications such as spinal cord repair.

  2. Influence of Structural Features on the Cellular Uptake Behavior of Non-Targeted Polyester-Based Nanocarriers

    Carlos E. de Castro, Jean-Jacques Bonvent, Maria C. C. da Silva, Fabiane L. F. Castro and Fernando C. Giacomelli

    Version of Record online: 27 JUL 2016 | DOI: 10.1002/mabi.201600138

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    The cellular uptake behavior of a library of polymeric nanoparticles is evaluated. The experimental results evidence that cell internalization is inversely related to the length of the hydrophilic corona. Additionally, higher degree of core hydrophobicity and high negative surface charge respectively enhances and restricts cellular uptake.

  3. Polypyrrole/Alginate Hybrid Hydrogels: Electrically Conductive and Soft Biomaterials for Human Mesenchymal Stem Cell Culture and Potential Neural Tissue Engineering Applications

    Sumi Yang, LindyK. Jang, Semin Kim, Jongcheol Yang, Kisuk Yang, Seung-Woo Cho and Jae Young Lee

    Version of Record online: 26 JUL 2016 | DOI: 10.1002/mabi.201600148

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    Conductive and soft polypyrrole/alginate hydrogels are synthesized by chemically polymerizing polypyrrole within alginate hydrogel networks for human mesenchymal stem culture. The conductive hydrogels can display more than ten times high electrical conductivities and softness (<200 kPa Young's modulus). These conductive hydrogels promoted human mesenchymal stem cell adhesion and growth, and also greatly up-regulated neural differentiation markers.

  4. Cell-Free HA-MA/PLGA Scaffolds with Radially Oriented Pores for In Situ Inductive Regeneration of Full Thickness Cartilage Defects

    Yuankun Dai, Zhenzhen Gao, Lie Ma, Dongan Wang and Changyou Gao

    Version of Record online: 26 JUL 2016 | DOI: 10.1002/mabi.201600218

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    Methacrylated hyaluronic acid/PLGA scaffolds with radially oriented pores are fabricated, which are able to realize in situ inductive regeneration of cartilage in a full thickness articular cartilage defect model in rabbit without employment of any extraneous cells or chondrogenetic growth factors.

  5. Biocompatibility of a Self-Assembled Crosslinkable Hyaluronic Acid Nanogel

    Sílvia Santos Pedrosa, Paula Pereira, Alexandra Correia, Susana Moreira, Hugo Rocha and Francisco Miguel Gama

    Version of Record online: 26 JUL 2016 | DOI: 10.1002/mabi.201600221

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    Crosslinkable Hyaluronic acid nanogels immunocompatibility and hemocompatability and general biocompatibility is assessed in this work. Cytotoxicity on three different cell lines is confirmed through various approaches. Further, BMDM nanogels uptake suggests low recognition by immune system and in vivo results confirms its long circulation time.