Macromolecular Bioscience

Cover image for Vol. 17 Issue 4

Editor-in-Chief: Kirsten Severing, Editor: Anne Pfisterer

Online ISSN: 1616-5195

Associated Title(s): Advanced Healthcare Materials, Macromolecular Chemistry and Physics, Macromolecular Materials and Engineering, Macromolecular Rapid Communications

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Best of Macros 2017 is now online. Click here to read about the selected articles and their authors.

Recently Published Articles

  1. Controlling and Monitoring Intracellular Delivery of Anticancer Polymer Nanomedicines

    Claudia Battistella and Harm-Anton Klok

    Version of Record online: 26 APR 2017 | DOI: 10.1002/mabi.201700022

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    Control over the intracellular delivery of drugs is crucial for their therapeutic efficiency. This article presents the approaches that have been developed to control delivery of polymer nanomedicines to specific subcellular compartments (the cytoplasm, the mitochondria, the Golgi apparatus, the endoplasmic reticulum, the nucleus) as well as the methods that have been used to monitor these processes.

  2. A Dendritic Amphiphile for Efficient Control of Biomimetic Calcium Phosphate Mineralization

    Doreen Hentrich, Soraya Taabache, Gerald Brezesinski, Nele Lange, Wolfgang Unger, Christian Kübel, Annabelle Bertin and Andreas Taubert

    Version of Record online: 18 APR 2017 | DOI: 10.1002/mabi.201600524

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    A cholesterol-based dendritic amphiphile forms highly charged and stable monolayers at the air–liquid interface offering exquisite control over calcium phosphate mineralization.

  3. Enhanced Self-Renewal and Accelerated Differentiation of Human Fetal Neural Stem Cells Using Graphene Oxide Nanoparticles

    Jin Kim, Kisuk Yang, Jong Seung Lee, Yong Hwa Hwang, Hyun-Ji Park, Kook In Park, Dong Yun Lee and Seung-Woo Cho

    Version of Record online: 10 APR 2017 | DOI: 10.1002/mabi.201600540

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    The application of graphene oxide (GO) nanoparticles (GO-NPs) to engineer self-renewal and differentiation of human fetal neural stem cells (hfNSCs) is reported. Incorporation of GO-NPs into hfNSC neurospheres significantly promotes cell-to-cell and cell-to-matrix interactions, leading to enhanced self-renewal ability and accelerated differentiation of hfNSCs. Thus, GO-NPs can be proposed as a promising nanobiomaterial to engineer stem cell therapeutics for neuronal tissue regeneration.

  4. Synthesis and Validation of Functional Nanogels as pH-Sensors in the Hair Follicle

    Mathias Dimde, Fitsum Feleke Sahle, Virginia Wycisk, Dirk Steinhilber, Luis Cuellar Camacho, Kai Licha, Jürgen Lademann and Rainer Haag

    Version of Record online: 10 APR 2017 | DOI: 10.1002/mabi.201600505

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    Nanosensors for the pH measurement inside the hair follicle (HF) are described. Dye-labeled dendritic polyglycerol based nanogels (dPG-NG) are used to penetrate inside the HF and measure the pH values using an ex vivo porcine ear model. The dPG-NGs are synthesized with a mild and surfactant-free Thiol–Michael reaction using an inverse nanoprecipitation method and can be fine-tuned to particle sizes of 100 nm to 1 µm.

  5. Immobilization of Enzymes on PLGA Sub-Micrometer Particles by Crosslinked Layer-by-Layer Deposition

    Sandro Sieber, Stefan Siegrist, Stéphanie Schwarz, Fabiola Porta, Susanne H. Schenk and Jörg Huwyler

    Version of Record online: 7 APR 2017 | DOI: 10.1002/mabi.201700015

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    Enzyme immobilization on poly(lactide-co-glycolide) (PLGA) particles via crosslinked layer-by-layer deposition. Model enzymes (brown) are immobilized on sub-micrometer PLGA particles (green) by a combined approach based on electrostatic adsorption and covalent crosslinking according to the layer-by-layer principle. Two opposite charged polyelectrolytes, poly(allylamine hydrochloride) (red) and poly(styrene sulfonate) (blue), are combined with the crosslinking agent glutaraldehyde.