Macromolecular Bioscience

Cover image for Vol. 17 Issue 7

Editor-in-Chief: Kirsten Severing, Editor: Anne Pfisterer

Online ISSN: 1616-5195

Associated Title(s): Advanced Healthcare Materials, Macromolecular Chemistry and Physics, Macromolecular Materials and Engineering, Macromolecular Rapid Communications

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Best of Macros 2017 is now online. Click here to read about the selected articles and their authors.

Recently Published Articles

  1. Autoinducer Sensing Microarrays by Reporter Bacteria Encapsulated in Hybrid Supramolecular-Polysaccharide Hydrogels

    Ping Li, Xiaoqiu Dou, Mareike Müller, Chuanliang Feng, Matthew Wook Chang, Martin Frettlöh and Holger Schönherr

    Version of Record online: 25 JUL 2017 | DOI: 10.1002/mabi.201700176

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    Mechanically robust supramolecular polysaccharide hybrid hydrogels are adapted for the incorporation and containment of functional reporter bacteria. The bacteria loaded hybrid hydrogels are micropatterned to afford microarray and microparticle-based whole cell biosensor arrays for detection and signaling of N-acyl homoserine lactone autoinducers at relevant concentrations as secreted by Pseudomonas aeruginosa.

  2. Self-Assembled Polyprodrug Amphiphile for Subcutaneous Xenograft Tumor Inhibition with Prolonged Acting Time In Vivo

    Dong Chen, Yu Huang, Shuting Xu, Huangyong Jiang, Jieli Wu, Xin Jin and Xinyuan Zhu

    Version of Record online: 24 JUL 2017 | DOI: 10.1002/mabi.201700174

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    A diblock amphipathic polymer comprised of nonfouling segment poly(2-methylacryloyloxyethyl phosphorylcholine) (pMPC) and polyprodrug segment poly(10-hydroxy-camptothecin methacrylate) (pHCPT) is synthesized via two-step reversible addition-fragmentation chain transfer polymerization, which can self-assemble into micelles under physiological condition. This nanosystem exhibits prolonged retention time in vivo, alleviated by-effect, and high prohibitive efficacy to tumor, thus can be considered as promising candidate for cancer therapy.

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    Chemoenzymatic Synthesis of Polypeptides for Use as Functional and Structural Materials

    Kousuke Tsuchiya and Keiji Numata

    Version of Record online: 19 JUL 2017 | DOI: 10.1002/mabi.201700177

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    Chemoenzymatic polymerization using proteases is a facile, environmentally benign, readily scalable, and atom-economical synthetic method for the development of functional polypeptide materials. In this review, recent progress in chemoenzymatic polypeptide synthesis with conventional procedures is summarized to explore the feasibility of its application to the production of functional and structural materials inspired by natural proteins.

  4. In Vitro and In Vivo Characterization of Biodegradable Reactive Isocyanate-Terminated Three-Armed- and Hyperbranched Block Copolymeric Tissue Adhesives

    Agnieszka I. Bochyńska, Gerjon Hannink, Jan J. Rongen, Dirk W. Grijpma and Pieter Buma

    Version of Record online: 17 JUL 2017 | DOI: 10.1002/mabi.201700125

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    This study evaluates physicochemical and adhesive properties, degradation in vitro and in vivo, and the tissue reaction after subcutaneous injection in rats of the novel biodegradable three-armed- and hyperbranched block copolymeric adhesives. The results show sufficient adhesive strength to meniscus tissue (66–88 kPa), promising mechanical tensile properties and degradation profiles, and only mild inflammatory reaction.

  5. Simple Radical Polymerization of Poly(Alginate-Graft-N-Isopropylacrylamide) Injectable Thermoresponsive Hydrogel with the Potential for Localized and Sustained Delivery of Stem Cells and Bioactive Molecules

    Sreekanth Pentlavalli, Philip Chambers, Binulal N. Sathy, Michelle O'Doherty, Marine Chalanqui, Daniel J. Kelly, Tammy Haut-Donahue, Helen O. McCarthy and Nicholas J. Dunne

    Version of Record online: 17 JUL 2017 | DOI: 10.1002/mabi.201700118

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    Free radical synthesis of injectable, biocompatible, and biodegradable thermoresponsive hydrogel that offers tailored viscoelastic properties is investigated. Hydrogel provided enables cell encapsulation without affecting differentiation capability. Technology offers a versatile and improved platform for drug delivery and bone tissue engineering applications.