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Materials Science Weekly Newsletter
Recently Published Articles
- Hybrid Polyglycerols with Long Blood Circulation: Synthesis, Biocompatibility, and Biodistribution
Muhammad Imran ul-haq, Benjamin F. L. Lai and Jayachandran N. Kizhakkedathu
Article first published online: 11 JUL 2014 | DOI: 10.1002/mabi.201400152
Hybrid polyglycerols ( ≈ 100 kDa) with different compositions (15–80 mol% linear polyglycerol) with excellent blood and cell compatibility are synthesized. The polymers show long blood circulation with minimal organ accumulation in mice and are attractive for the development of multifunctional drug delivery systems.
- Cell–Microsphere Constructs Formed with Human Adipose-Derived Stem Cells and Gelatin Microspheres Promotes Stemness, Differentiation, and Controlled Pro-Angiogenic Potential
Anjaneyulu Kodali, Thiam Chye Lim, David Tai Leong and Yen Wah Tong
Article first published online: 1 JUL 2014 | DOI: 10.1002/mabi.201400094
Three-dimensional cell–microsphere constructs formed with gelatin microspheres are found to be suitable platforms for the growth and differentiation of adipose-derived stem cells (ADSCs). These constructs also tend to preserve the stemness properties of the ADSCs along with enhancing their pro-angiogenic properties.
- Toward Anticancer Immunotherapeutics: Well-Defined Polymer–Antibody Conjugates for Selective Dendritic Cell Targeting
Kristof Tappertzhofen, Monika Bednarczyk, Kaloian Koynov, Matthias Bros, Stephan Grabbe and Rudolf Zentel
Article first published online: 30 JUN 2014 | DOI: 10.1002/mabi.201400190
The synthesis of multifunctionalizable semitelechelic maleimide-modifided HPMA based polymers of narrow dispersity that can be conjugated to anti-DEC-205 antibodies affording “star-like” topologies is described. Primary in vitro studies show their high potential to target dendritic cells (DCs). This opens the opportunity to present tumor antigens to DCs and thus to induce antitumor immune responses.
- Enzymatic Synthesis of Dendritic Amphoteric α-Glucans by Thermostable Phosphorylase Catalysis
Yusei Takata, Riko Shimohigoshi, Kazuya Yamamoto and Jun-Ichi Kadokawa
Article first published online: 30 JUN 2014 | DOI: 10.1002/mabi.201400204
Enzymatic synthesis of dendritic amphoteric α-glucans having both glucuronic acid and glucosamine residues at the non-reducing ends is performed by phosphorylase catalysis, which shows inherent isoelectric points and assembling/disassembling behaviors in water in accordance of the pH values.
- Synthesis of Functionalized Poly(ester carbonate) with Laminin-Derived Peptide for Promoting Neurite Outgrowth of PC12 cells
Dongming Xing, Lie Ma and Changyou Gao
Article first published online: 25 JUN 2014 | DOI: 10.1002/mabi.201400186
Laminin-derived peptide functionalized poly(ester carbonate) (PEC) is synthesized to promote neurite outgrowth of PC12 cells. The maleimide-functionalized PECs are clicked with various thiol-containing molecules. The CQAASIKVAV-grafted PEC could support cell proliferation and neurite outgrowth. Therefore, the maleimide-functionalized PECs can serve as a versatile platform for diverse functionalization and have comprehensive potential in biomedical applications.