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Materials Science Weekly Newsletter
Recently Published Articles
- Polymer Brushes Interfacing Blood as a Route Toward High Performance Blood Contacting Devices
František Surman, Tomáš Riedel, Michael Bruns, Nina Yu. Kostina, Zdeňka Sedláková and Cesar Rodriguez-Emmenegger
Article first published online: 21 JAN 2015 | DOI: 10.1002/mabi.201400470
Hydrophilic polymer brushes based on HPMA prepared by surface initiated ATRP provide an excellent surface modification to prevent the adhesion of blood components as well as the fouling from whole blood. This surface modification opens new opportunities to improve the performance of blood contacting devices.
- Reduction-Sensitive Amphiphilic Triblock Copolymers Self-Assemble Into Stimuli-Responsive Micelles for Drug Delivery
Smahan Toughraï, Violeta Malinova, Raffaello Masciadri, Sindhu Menon, Pascal Tanner, Cornelia Palivan, Nico Bruns and Wolfgang Meier
Article first published online: 13 JAN 2015 | DOI: 10.1002/mabi.201400400
Polymeric micelles obtained from the self-assembly of redox-sensitive amphiphilic triblock copolymers with a cleavable disulfide bond in the center of the hydrophobic block were investigated as potential drug delivery systems. The degradation products of the micelles are amphiphilic diblock copolymers and should therefore allow for facile clearing from biological systems.
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- Cell—Cell Crosslinking by Bio-Molecular Recognition of Heparin-Based Layer-by-Layer Nanofilmsa
Akihiro Nishiguchi, Michiya Matsusaki and Mitsuru Akashi
Article first published online: 9 JAN 2015 | DOI: 10.1002/mabi.201400415
Bio-molecular recognition between living cells and polymer nanofilms allows for the rapid cellular assembly to form cell aggregates. The aggregates display viscous properties and network structures crosslinked with polymer nanofilms. Specific inter-domain interactions between proteins and glycosaminoglycan cause cell—cell crosslinking. The assembly method supports in vitro 3D-tissue formation.
- Stable Emulsions Prepared by Self-assembly of Hyaluronic Acid and Chitosan for Papain Loading
Donghua Zhao, Wei Wei, Ye Zhu, Jianhua Sun, Qiong Hu and Xiaoya Liu
Article first published online: 9 JAN 2015 | DOI: 10.1002/mabi.201400486
Papain/hyaluronic acid/chitosan complex colloidal particles are obtained through electrostatic interactions. The complexes can be used as biocompatible emulsifiers and novel potential carriers for papain loading. Formation of the complexes in a compact form can protect the enzyme and even cause an increase in enzymatic activity, increasing the applications in the cosmetic, food, and pharmaceuticals industries.