Macromolecular Bioscience

Cover image for Vol. 17 Issue 3

Editor-in-Chief: Kirsten Severing, Editor: Anne Pfisterer

Online ISSN: 1616-5195

Associated Title(s): Advanced Healthcare Materials, Macromolecular Chemistry and Physics, Macromolecular Materials and Engineering, Macromolecular Rapid Communications

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Best of Macros 2017 is now online. Click here to read about the selected articles and their authors.

Recently Published Articles

  1. Rational Design of a Conductive Collagen Heart Patch

    Peter C. Sherrell, Artur Cieślar-Pobuda, Malin Silverå Ejneby, Laura Sammalisto, Amy Gelmi, Ebo de Muinck, Johan Brask, Marek J. Łos and Mehrdad Rafat

    Version of Record online: 21 MAR 2017 | DOI: 10.1002/mabi.201600446

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    Conductivity and mechanical strength are two core requirements for a tissue-engineered patch targeting myocardial infarction. Combining carbon nanotubes with collagen hydrogels create electrically conductive, mechanically strong, and biocompatible materials for the support of both stem and myocardial cells. Patch clamping shows a demonstrable effect of the carbon nanotube concentration and type on the cellular response.

  2. Functionalizing Nanoemulsions with Carboxylates: Impact on the Biodistribution and Pharmacokinetics in Mice

    Mohamed F. Attia, Sidy M. Dieng, Mayeul Collot, Andrey S. Klymchenko, Caroline Bouillot, Christophe A. Serra, Marc Schmutz, Meriem Er-Rafik, Thierry F. Vandamme and Nicolas Anton

    Version of Record online: 17 MAR 2017 | DOI: 10.1002/mabi.201600471

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    A new method for functionalizing nanoemulsion droplets is based on the interfacial hydrolysis of lipophilic polymer after formulation, study of impact of the surface charge on the interactions between droplets and cells in vitro, and on the in vivo behavior after i.v. administration.

  3. Photoreversibility and Biocompatibility of Polydimethylsiloxane-Coumarin as Adjustable Intraocular Lens Material

    Rachid Jellali, Virginie Bertrand, Michaël Alexandre, Nancy Rosière, Magda Grauwels, Marie-Claire De Pauw-Gillet and Christine Jérôme

    Version of Record online: 15 MAR 2017 | DOI: 10.1002/mabi.201600495

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    Photoresponsive polydimethylsiloxane for use as in situ adjustable intraocular lense (IOL) are synthesized. Polymers are able to photoreversibly cured by cycloaddition/retro-cycloaddition of coumarin. The controlled shape modification by diffusion in a partially uncrosslinked network is demonstrated. Prepared IOL disks are biocompatible, with low level of cell adhesion, which could be an advantage to reduce the posterior capsule opacification in vivo.

  4. Polyvalent 2D Entry Inhibitors for Pseudorabies and African Swine Fever Virus

    Benjamin Ziem, Jessica Rahn, Ievgen Donskyi, Kim Silberreis, Luis Cuellar, Jens Dernedde, Günther Keil, Thomas C. Mettenleiter and Rainer Haag

    Version of Record online: 15 MAR 2017 | DOI: 10.1002/mabi.201600499

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    Efficient inhibition of African swine fever virus and pseudorabies virus by novel polyvalent 2D nanoarchitectures is functionalized with polyglycerol sulfates. The developed entry inhibitors bind virus particles by electrostatic interaction and thereby prevent viral adhesion to the host cell, resulting in strong and efficient inhibitory effects. Overall, the concept of 2D nanoarchitecture has a high potential to develop new virus inhibitors.

  5. Aligned Poly(ε-caprolactone) Nanofibers Guide the Orientation and Migration of Human Pluripotent Stem Cell-Derived Neurons, Astrocytes, and Oligodendrocyte Precursor Cells In Vitro

    Anu Hyysalo, Mervi Ristola, Tiina Joki, Mari Honkanen, Minnamari Vippola and Susanna Narkilahti

    Version of Record online: 15 MAR 2017 | DOI: 10.1002/mabi.201600517

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    Human pluripotent stem cell-derived neurons, astrocytes, and oligodendrocyte precursor cells are oriented using poly(ε-caprolactone)-nanofiber platform. Nanofiber-mediated orientation of neurons is also demonstrated in 3D hydrogel scaffold. Aligned cell orientation mimics the in vivo structure of the spinal cord, and the results of this study can be applied for development of regenerative medicine applications for spinal cord injury repair.

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