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Recently Published Articles
- Fabrication of Novel Reduction-Sensitive Gene Vectors Based on Three-Armed Peptides
Qi Lei, Yun-Xia Sun, Si Chen, Si-Yong Qin, Hui-Zhen Jia, Ren-Xi Zhuo and Xian-Zheng Zhang
Article first published online: 11 DEC 2013 | DOI: 10.1002/mabi.201300422
Two reduction-sensitive branched polypeptides (RBPs) are reported as non-viral gene vectors. The RBPs exhibit remarkably enhanced gene transfection with much reduced cytotoxicity. This highly branched reduction-sensitive polypeptide shows great potential for gene delivery.
- Gold Nanoparticle Loaded Hybrid Nanofibers for Cardiogenic Differentiation of Stem Cells for Infarcted Myocardium Regeneration
Rajeswari Ravichandran, Radhakrishnan Sridhar, Jayarama Reddy Venugopal, Subramanian Sundarrajan, Shayanti Mukherjee and Seeram Ramakrishna
Article first published online: 11 DEC 2013 | DOI: 10.1002/mabi.201300407
A novel therapeutic Au nanoparticles loaded PVA/BSA nanofibers is discussed in the present study for infarcted myocardium regeneration. These scaffolds can be used to improve the functional activity of differentiated MSCs by increasing the gap junction protein, connexin 43 (Cx43). This approach opens the frontiers for creating functional cardiac patch with desirable properties for enhanced cardiac regeneration.
- Recombinant Human Elastin-like Magnetic Microparticles for Drug Delivery and Targeting
Gianni Ciofani, Giada Graziana Genchi, Pablo Guardia, Barbara Mazzolai, Virgilio Mattoli and Antonella Bandiera
Article first published online: 9 DEC 2013 | DOI: 10.1002/mabi.201300361
Human elastin-like polypeptide microparticles are prepared through a water-in-oil emulsion followed by enzymatic crosslinking. Magnetic properties are given to this system by addition of superparamagnetic iron oxide nanoparticles. Obtained microparticles are characterized in terms of morphology, structure, magnetic properties, drug release, and magnetic drivability.
- Novel On-Demand Bioadhesion to Soft Tissue in Wet Environments
Vishal Mogal, Vladislav Papper, Alok Chaurasia, Gao Feng, Robert Marks and Terry Steele
Article first published online: 2 DEC 2013 | DOI: 10.1002/mabi.201300380
A novel diazirine-based bioadhesive that can be applied across various clinically important surfaces is developed. After plasma post-irradiation on PLGA films, on-demand and tuneable bioadhesion is demonstrated on ex vivo swine aorta soft tissues. The non-optimized bioadhesive strength is stronger than many hydrogel bioadhesives while having superior material properties. The poly-diazirine surface grafted thin films could allow expansion onto previously developed technologies for minimally invasive surgeries.
- Blocked Bacteria Escape by ATRP Grafting of a PMMA Shell on PVA Microparticles
Christian Knierim, Charles L. Greenblatt, Seema Agarwal and Andreas Greiner
Article first published online: 29 NOV 2013 | DOI: 10.1002/mabi.201300398
The escape of immobilized bacteria from hydrogel microparticles is prevented by water stable core–shell composites. Therefore, a surface initiated ATRP of MMA at room temperature is employed to obtain a hydrophobic PMMA shell. However, the viability of the immobilized bacteria is demonstrated afterwards. The core–shell architecture is examined by the copolymerization of FMA and MMA and by TEM.