Macromolecular Bioscience

Cover image for Vol. 17 Issue 2

Editor-in-Chief: Kirsten Severing, Editor: Anne Pfisterer

Online ISSN: 1616-5195

Associated Title(s): Advanced Healthcare Materials, Macromolecular Chemistry and Physics, Macromolecular Materials and Engineering, Macromolecular Rapid Communications

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Recently Published Articles

  1. A Robust Method to Generate Mechanically Anisotropic Vascular Smooth Muscle Cell Sheets for Vascular Tissue Engineering

    Daniel E. Backman, Bauer L. LeSavage, Shivem B. Shah and Joyce Y. Wong

    Version of Record online: 16 FEB 2017 | DOI: 10.1002/mabi.201600434

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    Vascular smooth muscle cell sheets are cultured using a novel, micropatterned, thermoresponsive cell culture platform. The method is optimized to produce vascular smooth muscle cell sheets with cellular and extracellular alignment. Aligned cell sheets exhibit nonlinear, anisotropic mechanical properties that make them an attractive material for building a vascular graft that mimics the structural and mechanical properties of native vascular tissue.

  2. Synthesis and Characterization of Stimuli-Responsive Star-Like Polypept(o)ides: Introducing Biodegradable PeptoStars

    Regina Holm, Benjamin Weber, Philipp Heller, Kristina Klinker, Dana Westmeier, Dominic Docter, Roland H. Stauber and Matthias Barz

    Version of Record online: 15 FEB 2017 | DOI: 10.1002/mabi.201600514

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    The synthesis of three-arm polypeptoid and polypept(o)ide star polymers is reported. Incorporation of disulfide bonds between the core and the individual side chains enables degradation of star polymers in the presence of glutathione. The size of star polymers can be adjusted between 4 and 10 nm, yielding core–shell structures well tolerated by HeLa, HEK 293, and DC 2.4 cells.

  3. Bioprinting Using Mechanically Robust Core–Shell Cell-Laden Hydrogel Strands

    Pritesh Mistry, Ahmed Aied, Morgan Alexander, Kevin Shakesheff, Andrew Bennett and Jing Yang

    Version of Record online: 3 FEB 2017 | DOI: 10.1002/mabi.201600472

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    Combining good biological and mechanical properties in bioprinted constructs is desirable for them to be employed in many tissue engineering and regenerative medicine applications. Bioprinted cell-laden constructs with core–shell strands have been developed. The cell-supporting materials in the core support high cell viability and tissue-like functions while the shell material offers mechanical robustness to the bioprinted constructs.

  4. Polymeric Delivery of siRNA against Integrin-β1 (CD29) to Reduce Attachment and Migration of Breast Cancer Cells

    Daniel Nisakar Meenakshi Sundaram, Cezary Kucharski, Manoj B. Parmar, Remant Bahadur KC and Hasan Uludağ

    Version of Record online: 3 FEB 2017 | DOI: 10.1002/mabi.201600430

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    Cancer cell migration is inhibited by targeting cell-surface integrins with lipopolymer/siRNA complexes.

  5. Reverse Thermal Gel for In Utero Coverage of Spina Bifida Defects: An Innovative Bioengineering Alternative to Open Fetal Repair

    Ahmed I. Marwan, Sarah M. Williams, James R. Bardill, Jane Gralla, Noraishah M. Abdul-Aziz and Daewon Park

    Version of Record online: 30 JAN 2017 | DOI: 10.1002/mabi.201600473

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    Neural tube defects (NTDs) cause progressive damage to the central nervous system during development. Covering NTDs in fetuses has demonstrated improved outcomes but the associated invasiveness causes significant risks to mother and fetus. Our solution is to cover NTDs with an injectable biomaterial at earlier stages of pregnancy without invasive surgical intervention, potentially providing fewer risks to mother and fetus.