Macromolecular Bioscience

Cover image for Vol. 17 Issue 2

Editor-in-Chief: Kirsten Severing, Editor: Anne Pfisterer

Online ISSN: 1616-5195

Associated Title(s): Advanced Healthcare Materials, Macromolecular Chemistry and Physics, Macromolecular Materials and Engineering, Macromolecular Rapid Communications

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Recently Published Articles

  1. Enhanced Antimetastatic Activity of the Ruthenium Anticancer Drug RAPTA-C Delivered in Fructose-Coated Micelles

    Mingxia Lu, Fan Chen, Janina-Miriam Noy, Hongxu Lu and Martina H. Stenzel

    Version of Record online: 24 FEB 2017 | DOI: 10.1002/mabi.201600513

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    Coating micelles with fructose can enhance the antimetastatic effect of ruthenium drugs. The sugar-based nanocarrier, compared to a micelle based on a nonfunctional nanocarrier, shows higher uptake by breast cancer cells and better penetration in MCF-7 tumor spheroids.

  2. Regulation of Scaffold Cell Adhesion Using Artificial Membrane Binding Proteins

    Madeline Burke, James P. K. Armstrong, Andrew Goodwin, Robert C. Deller, Benjamin M. Carter, Robert L. Harniman, Aasiya Ginwalla, Valeska P. Ting, Sean A. Davis and Adam W. Perriman

    Version of Record online: 24 FEB 2017 | DOI: 10.1002/mabi.201600523

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    A novel strategy is developed where chemical, biochemical, and morphological properties of biomaterials scaffolds are varied by the covalent coupling of cationized and surfactant-conjugated proteins. These artificial membrane binding proteins not only increase cellular adhesion via electrostatic and hydrophobic mechanisms, but can also be used as oxygen reservoirs to prevent slowdown of proliferation in hypoxic conditions.

  3. Washless Method Enables Multilayer Coating of an Aggregation-Prone Nanoparticulate Drug Delivery System with Enhanced Yields, Colloidal Stability, and Scalability

    Lamees Nayef, Rafael Castiello and Maryam Tabrizian

    Version of Record online: 22 FEB 2017 | DOI: 10.1002/mabi.201600535

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    Washless method titrations allow coating aggregation-prone liposome core nanoparticle with eight layers of polyelectrolyte with higher yields and reproducibility promising greater success in investigating a broader range of multilayer-coated nanoparticles for applications like drug delivery.

  4. Imaging Cell–Matrix Interactions in 3D Collagen Hydrogel Culture Systems

    Aaron R. Short, Catherine Czeisler, Benjamin Stocker, Sara Cole, José Javier Otero and Jessica O. Winter

    Version of Record online: 21 FEB 2017 | DOI: 10.1002/mabi.201600478

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    Hydrogels provide more accurate representations of cell behaviors in vivo; however, imaging in hydrogels can be challenging. This work develops new methods that enable imaging of cellular interactions with their hydrogel microenvironments in a collagen model.

  5. A Robust Method to Generate Mechanically Anisotropic Vascular Smooth Muscle Cell Sheets for Vascular Tissue Engineering

    Daniel E. Backman, Bauer L. LeSavage, Shivem B. Shah and Joyce Y. Wong

    Version of Record online: 16 FEB 2017 | DOI: 10.1002/mabi.201600434

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    Vascular smooth muscle cell sheets are cultured using a novel, micropatterned, thermoresponsive cell culture platform. The method is optimized to produce vascular smooth muscle cell sheets with cellular and extracellular alignment. Aligned cell sheets exhibit nonlinear, anisotropic mechanical properties that make them an attractive material for building a vascular graft that mimics the structural and mechanical properties of native vascular tissue.