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Recently Published Articles
- A Robust Method to Generate Mechanically Anisotropic Vascular Smooth Muscle Cell Sheets for Vascular Tissue Engineering
Daniel E. Backman, Bauer L. LeSavage, Shivem B. Shah and Joyce Y. Wong
Version of Record online: 16 FEB 2017 | DOI: 10.1002/mabi.201600434
Vascular smooth muscle cell sheets are cultured using a novel, micropatterned, thermoresponsive cell culture platform. The method is optimized to produce vascular smooth muscle cell sheets with cellular and extracellular alignment. Aligned cell sheets exhibit nonlinear, anisotropic mechanical properties that make them an attractive material for building a vascular graft that mimics the structural and mechanical properties of native vascular tissue.
- Synthesis and Characterization of Stimuli-Responsive Star-Like Polypept(o)ides: Introducing Biodegradable PeptoStars
Regina Holm, Benjamin Weber, Philipp Heller, Kristina Klinker, Dana Westmeier, Dominic Docter, Roland H. Stauber and Matthias Barz
Version of Record online: 15 FEB 2017 | DOI: 10.1002/mabi.201600514
The synthesis of three-arm polypeptoid and polypept(o)ide star polymers is reported. Incorporation of disulfide bonds between the core and the individual side chains enables degradation of star polymers in the presence of glutathione. The size of star polymers can be adjusted between 4 and 10 nm, yielding core–shell structures well tolerated by HeLa, HEK 293, and DC 2.4 cells.
- Bioprinting Using Mechanically Robust Core–Shell Cell-Laden Hydrogel Strands
Pritesh Mistry, Ahmed Aied, Morgan Alexander, Kevin Shakesheff, Andrew Bennett and Jing Yang
Version of Record online: 3 FEB 2017 | DOI: 10.1002/mabi.201600472
Combining good biological and mechanical properties in bioprinted constructs is desirable for them to be employed in many tissue engineering and regenerative medicine applications. Bioprinted cell-laden constructs with core–shell strands have been developed. The cell-supporting materials in the core support high cell viability and tissue-like functions while the shell material offers mechanical robustness to the bioprinted constructs.
- Polymeric Delivery of siRNA against Integrin-β1 (CD29) to Reduce Attachment and Migration of Breast Cancer Cells
Daniel Nisakar Meenakshi Sundaram, Cezary Kucharski, Manoj B. Parmar, Remant Bahadur KC and Hasan Uludağ
Version of Record online: 3 FEB 2017 | DOI: 10.1002/mabi.201600430
Cancer cell migration is inhibited by targeting cell-surface integrins with lipopolymer/siRNA complexes.
- Reverse Thermal Gel for In Utero Coverage of Spina Bifida Defects: An Innovative Bioengineering Alternative to Open Fetal Repair
Ahmed I. Marwan, Sarah M. Williams, James R. Bardill, Jane Gralla, Noraishah M. Abdul-Aziz and Daewon Park
Version of Record online: 30 JAN 2017 | DOI: 10.1002/mabi.201600473
Neural tube defects (NTDs) cause progressive damage to the central nervous system during development. Covering NTDs in fetuses has demonstrated improved outcomes but the associated invasiveness causes significant risks to mother and fetus. Our solution is to cover NTDs with an injectable biomaterial at earlier stages of pregnancy without invasive surgical intervention, potentially providing fewer risks to mother and fetus.