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Recently Published Articles
- A Novel 3D Integrated Platform for the High-Resolution Study of Cell Migration Plasticity
Julian Schneider, Tobias Bachmann, Davide Franco, Patrizia Richner, Patrick Galliker, Manish K. Tiwari, Aldo Ferrari and Dimos Poulikakos
Article first published online: 19 JUN 2013 | DOI: 10.1002/mabi.201200416
A novel approach to fabricate optically accessible, 3D integrated platforms – simulating the cell microenvironment during interstitial migration – is presented. The platforms consist of free-form, 3D micropores printed on demand on basal scaffolds with microgratings. The platforms are employed to monitor cancer cell migration using high-resolution optical microscopy.
- Protein Encapsulation in Biodegradable Polymeric Nanoparticles: Morphology, Fluorescence Behaviour and Stem Cell Uptake
Nicoletta Rescignano, Luigi Tarpani, Roberto Tiribuzi, Simona Montesano, Sabata Martino, Loredana Latterini, Josè Maria Kenny and Ilaria Armentano
Article first published online: 17 JUN 2013 | DOI: 10.1002/mabi.201300140
Biodegradable polymeric nanoparticles (NPs) loaded with bovine serum albumin marked with fluorescein isothiocynate (FITC-BSA) are developed, showing a spherical shape and a narrow size distribution. Fluorescence measurements allow the protein macromolecular structure to be analyzed. NPs are rapidly taken up in the stem cells, and, due to the green fluorescence of the FITC, they can be readily monitored.
- The Influence of Matrix Degradation and Functionality on Cell Survival and Morphogenesis in PEG-Based Hydrogels
Asad Raza and Chien-Chi Lin
Article first published online: 17 JUN 2013 | DOI: 10.1002/mabi.201300044
Hydrogels with different hydrolytic degradabilities are prepared from norbornene-functionalized PEG macromers and dithiol-containing linkers such as dithiothreitol or biscysteine-containing peptides. The influence of thiol-ene gel degradability on cell survival and morphogenesis in 3D is studied.