Macromolecular Bioscience

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Recently Published Articles

  1. Polymer Brushes Interfacing Blood as a Route Toward High Performance Blood Contacting Devices

    František Surman, Tomáš Riedel, Michael Bruns, Nina Yu. Kostina, Zdeňka Sedláková and Cesar Rodriguez-Emmenegger

    Article first published online: 21 JAN 2015 | DOI: 10.1002/mabi.201400470

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    Hydrophilic polymer brushes based on HPMA prepared by surface initiated ATRP provide an excellent surface modification to prevent the adhesion of blood components as well as the fouling from whole blood. This surface modification opens new opportunities to improve the performance of blood contacting devices.

  2. Reduction-Sensitive Amphiphilic Triblock Copolymers Self-Assemble Into Stimuli-Responsive Micelles for Drug Delivery

    Smahan Toughraï, Violeta Malinova, Raffaello Masciadri, Sindhu Menon, Pascal Tanner, Cornelia Palivan, Nico Bruns and Wolfgang Meier

    Article first published online: 13 JAN 2015 | DOI: 10.1002/mabi.201400400

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    Polymeric micelles obtained from the self-assembly of redox-sensitive amphiphilic triblock copolymers with a cleavable disulfide bond in the center of the hydrophobic block were investigated as potential drug delivery systems. The degradation products of the micelles are amphiphilic diblock copolymers and should therefore allow for facile clearing from biological systems.

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    Peptide-based Materials for Nanomedicine (pages 7–8)

    Neil Cameron and Tim Deming

    Article first published online: 13 JAN 2015 | DOI: 10.1002/mabi.201400499

  4. Cell—Cell Crosslinking by Bio-Molecular Recognition of Heparin-Based Layer-by-Layer Nanofilmsa

    Akihiro Nishiguchi, Michiya Matsusaki and Mitsuru Akashi

    Article first published online: 9 JAN 2015 | DOI: 10.1002/mabi.201400415

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    Bio-molecular recognition between living cells and polymer nanofilms allows for the rapid cellular assembly to form cell aggregates. The aggregates display viscous properties and network structures crosslinked with polymer nanofilms. Specific inter-domain interactions between proteins and glycosaminoglycan cause cell—cell crosslinking. The assembly method supports in vitro 3D-tissue formation.

  5. Stable Emulsions Prepared by Self-assembly of Hyaluronic Acid and Chitosan for Papain Loading

    Donghua Zhao, Wei Wei, Ye Zhu, Jianhua Sun, Qiong Hu and Xiaoya Liu

    Article first published online: 9 JAN 2015 | DOI: 10.1002/mabi.201400486

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    Papain/hyaluronic acid/chitosan complex colloidal particles are obtained through electrostatic interactions. The complexes can be used as biocompatible emulsifiers and novel potential carriers for papain loading. Formation of the complexes in a compact form can protect the enzyme and even cause an increase in enzymatic activity, increasing the applications in the cosmetic, food, and pharmaceuticals industries.