Macromolecular Bioscience

Cover image for Vol. 17 Issue 5

Editor-in-Chief: Kirsten Severing, Editor: Anne Pfisterer

Online ISSN: 1616-5195

Associated Title(s): Advanced Healthcare Materials, Macromolecular Chemistry and Physics, Macromolecular Materials and Engineering, Macromolecular Rapid Communications

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Best of Macros 2017 is now online. Click here to read about the selected articles and their authors.

Recently Published Articles

  1. Local Release of VEGF Using Fiber Mats Enables Effective Transplantation of Layered Cardiomyocyte Sheets

    Kenichi Nagase, Yuhei Nagumo, Miri Kim, Hee-Jung Kim, Hei-Won Kyung, Hye-Jin Chung, Hidekazu Sekine, Tatsuya Shimizu, Hideko Kanazawa, Teruo Okano, Seung-Jin Lee and Masayuki Yamato

    Version of Record online: 26 MAY 2017 | DOI: 10.1002/mabi.201700073

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    Development of a vascular endothelial growth factor (VEGF)-releasing fiber mat that allows for the effective transplantation of multilayered cardiomyocyte sheets in a single procedure is shown. Local supply of VEGF to cardiomyocyte sheets enhances their vascularization in vivo, overcoming necrosis and leading to improved survival. These VEGF-releasing mats therefore expand the use of cell sheet transplantation for potential therapeutic applications.

  2. Comparative Study of Osteogenic Activity of Multilayers Made of Synthetic and Biogenic Polyelectrolytes

    Deepak Guduru, Marcus S. Niepel, Cristina Gonzalez-Garcia, Manuel Salmeron-Sanchez and Thomas Groth

    Version of Record online: 26 MAY 2017 | DOI: 10.1002/mabi.201700078

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    A comparative study of synthetic and biogenic polyelectrolyte multilayer systems on osteogenic activity showed that multilayers composed of fibrinogen and poly-l-lysine have superior effect on cell adhesion and growth, while multilayers made of biotinylated chondroitin sulfate and avidin promote osteogenic differentiation of cells, which is more effective than multilayers made of polystyrene sulfonate and poly(allylamine).

  3. Biomimetic Macroporous PCL Scaffolds for Ex Vivo Expansion of Cord Blood-Derived CD34+ Cells with Feeder Cells Support

    Xiuwei Pan, Qiong Sun, Yuanhao Zhang, Haibo Cai, Yun Gao, Yongjia Shen and Weian Zhang

    Version of Record online: 24 MAY 2017 | DOI: 10.1002/mabi.201700054

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    Biomimetic macroporous poly(ε-caprolactone) (PCL) scaffolds and feeder cells (human amniotic membrane-derived stromal cells) are utilized in hematopoietic cultures to mimic the physical and biological parameters of hematopoietic stem cell niche. Four culture conditions are designed to evaluate the influence of PCL scaffolds, feeder cells, and contact manner on ex vivo expansion of HSPCs.

  4. Development of Enzyme Loaded Polyion Complex Vesicle (PICsome): Thermal Stability of Enzyme in PICsome Compartment and Effect of Coencapsulation of Dextran on Enzyme Activity

    Hengmin Tang, Yuki Sakamura, Takeshi Mori, Yoshiki Katayama and Akihiro Kishimura

    Version of Record online: 19 MAY 2017 | DOI: 10.1002/mabi.201600542

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    Enzyme encapsulation without deactivation and long-term enzyme storage are still problematic. This study reports on the confinement effects on enzyme activity for the development of a high-performance enzymatic nanoreactor. This approach enhances the enzyme stability at 37 °C. Coloading of dextran helps to maintain the enzyme activity at −20 °C.

  5. Fluorinated PEG-Polypeptide Polyplex Micelles Have Good Serum-Resistance and Low Cytotoxicity for Gene Delivery

    Ting Wu, Longhai Wang, Shenggang Ding and Yezi You

    Version of Record online: 19 MAY 2017 | DOI: 10.1002/mabi.201700114

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    Nonviral gene vectors used in gene delivery must have a high stability to tolerate harsh conditions in physiological fluids. Here a novel PEGylation polypeptide conjugated with fluorocarbon chains is synthesized which has good serum-resistance and low cytotoxicity for gene delivery. The results suggest that the fluorinated polypeptides are promising for safe and efficient gene delivery.