Macromolecular Bioscience

Cover image for Vol. 18 Issue 1

Editor-in-Chief: Kirsten Severing, Editor: Anne Pfisterer

Online ISSN: 1616-5195

Associated Title(s): Advanced Healthcare Materials, Macromolecular Chemistry and Physics, Macromolecular Materials and Engineering, Macromolecular Rapid Communications

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Recently Published Articles

  1. You have free access to this content
    Happy Birthday Karel!

    Tomáš Etrych, Petr Chytil and Michal Pechar

    Version of Record online: 15 JAN 2018 | DOI: 10.1002/mabi.201700400

  2. Design of Enzyme Micelles with Controllable Concavo-Convex Micromorphologies for Highly Enhanced Stability and Catalytical Activity

    Tao Chen, Yuanhong Xu, Wenrong Yang, Aihua Li, Yao Wang, Jing Sun and Jingquan Liu

    Version of Record online: 15 JAN 2018 | DOI: 10.1002/mabi.201700312

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    Poly (methyl methacrylate)-block-poly (sodium p-styrene sulfonate) is synthesized via reversible addition–fragmentation chain transfer polymerization to modify shellac enzyme and immobilize Cu2+. Both the well-defined and concavo-convex micelles are prepared via self-assembling polymer-enzyme conjugates with the same and different polymer chains. The concavo-convex micelles exhibit the higher enzyme stability (300%) and bioactivity (760%) comparing with the well-defined ones.

  3. Antibacterial and Antifungal Activity of Poly(Lactic Acid)–Bovine Lactoferrin Nanofiber Membranes

    Raul Machado, André da Costa, Dina M. Silva, Andreia C. Gomes, Margarida Casal and Vitor Sencadas

    Version of Record online: 15 JAN 2018 | DOI: 10.1002/mabi.201700324

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    Bovine lactoferrin (bLF), an iron-binding glycoprotein, displays a wide set of physiological roles including a strong antimicrobial activity. The development of antimicrobial membranes by incorporating bLF in a poly(lactic acid) matrix is reported. The membranes show a strong sporicidal activity and mycelium growth inhibition against the filamentous fungi Aspergillus nidulans. These results strongly support their application for fungal infection management.

  4. Gelatin Methacryloyl Hydrogels in the Absence of a Crosslinker as 3D Glioblastoma Multiforme (GBM)-Mimetic Microenvironment

    Pelin Erkoc, Fidan Seker, Tugba Bagci-Onder and Seda Kizilel

    Version of Record online: 15 JAN 2018 | DOI: 10.1002/mabi.201700369

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    Visible-light-induced crosslinking of gelatin is reported in the absence of an additional crosslinker. Visible-light-induced crosslinking promotes cancer microenvironment mimetic system without compromising cell viability. Suspension and spheroid-based models of GBM are used to investigate cellular behavior, expression profiles of malignancy and apoptosis-related genes, and sensitivity to an anticancer drug, Digitoxigenin, in detail.

  5. A New Colorimetric Platform for Protein Detection Based on Recognition-Induced Cascade of Polymeric Nanoparticles Disassembly

    Fang Fang, Jin Liu, Yushu Li, Junjiao Yang and Jing Yang

    Version of Record online: 11 JAN 2018 | DOI: 10.1002/mabi.201700392

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    The polymeric nanoparticles as a sensing scaffold formed via self-assembly of amphiphilic block polymer poly(ethylene glycol)-block-poly(3-​acryl aminophenylboronic acid) complexing with alizarin red S is successfully developed to visual and homogeneous assay based on recognition-induced disassembly of nanoparticles and the competitive binding of α-cyclodextrin with boronic acid. This colorimetric platform will open one convenient and time-saving new way for protein detection.