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Recently Published Articles
- Design of a Novel Composite H2S-Releasing Hydrogel for Cardiac Tissue Repair
Arianna Mauretti, Annalisa Neri, Olga Kossover, Dror Seliktar, Paolo Di Nardo and Sonia Melino
Article first published online: 9 FEB 2016 | DOI: 10.1002/mabi.201500430
New composite 3D-hydrogel scaffolds with embedded protein-microbubbles are manufactured and assessed for their potential scaffolding properties for the growth of both fibroblasts and Sca1+ cardiac progenitor cells. Furthermore, enzymatic H2S-releasing microbubbles are produced and embedded in 3D scaffolds for tissue repair. The effects of this important gasotransmitter on the cell proliferation of human progenitor cells are studied using a novel 3D H2S-releasing scaffold.
- Polydopamine Inter-Fiber Networks: New Strategy for Producing Rigid, Sticky, 3D Fluffy Electrospun Fibrous Polycaprolactone Sponges
Wuyong Choi, Slgirim Lee, Seung-Hyun Kim and Jae-Hyung Jang
Article first published online: 8 FEB 2016 | DOI: 10.1002/mabi.201500375
Inter-molecular crosslinking polydopamine networks with polycaprolactone fibers are employed to spatially expand and mechanically strengthen fibrous matrices. Iron ions play a role as a catalyst for rapid formation of irreversible dopamine polymerization. The adhesive catecholamine reinforces the mechanical properties of 3D electrospun fibers and triggers the robust immobilization of biomolecules, ultimately demonstrating their potential as drug or cell delivery vehicles.
- The Effect of Sterilization Methods on the Structural and Chemical Properties of Fibrin Microthread Scaffolds
Jonathan M. Grasman, Megan P. O'Brien, Kevin Ackerman, Keith A. Gagnon, Gregory M. Wong and George D. Pins
Article first published online: 4 FEB 2016 | DOI: 10.1002/mabi.201500410
The structural and chemical properties of fibrin-based scaffolds are affected by crosslinking and sterilization protocols. Ethanol and ethylene oxide gas sterilization procedures are performed on uncrosslinked, 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC), or ultraviolet light crosslinked fibrin microthreads to evaluate the mechanical, structural, and chemical properties of these materials. The data presented here inform the strategic design of fibrin-based scaffolds.
- Crosslinked Redox-Responsive Micelles Based on Lipoic Acid-Derived Amphiphiles for Enhanced siRNA Delivery
Ariane Tschiche, Bala N. S. Thota, Falko Neumann, Andreas Schäfer, Nan Ma and Rainer Haag
Article first published online: 4 FEB 2016 | DOI: 10.1002/mabi.201500363
Disulfide-based reversibly stabilized micelles based on crosslinkable lipoic acid amphiphiles are developed in the present study, which show degradation upon reductive conditions, and thus lead to efficient cargo release. In particular, one candidate out of this series is able to efficiently release siRNA due to its redox-responsive biodegradable profile, thereby leading to potent gene silencing.
- pH-Triggered Charge-Reversal Polyurethane Micelles for Controlled Release of Doxorubicin
Wanying He, Xu Zheng, Qi Zhao, Lijie Duan, Qiang Lv, Guang Hui Gao and Shuangjiang Yu
Article first published online: 3 FEB 2016 | DOI: 10.1002/mabi.201500358
A pH-triggered charge-reversal nanocarrier is fabricated for efficient anticancer-drug delivery. The charge-reversal behavior is tunable by changing the molar ratio of piperazine/carboxyl. With reducing the pH, the surface charge of nanocarriers can be changed from negative to positive which enhance the cellular uptake and intracellular drug release.