Macromolecular Bioscience

Cover image for Vol. 15 Issue 6

Editor-in-Chief: Kirsten Severing, Editor: Anne Pfisterer

Online ISSN: 1616-5195

Associated Title(s): Advanced Healthcare Materials, Macromolecular Chemistry and Physics, Macromolecular Materials and Engineering, Macromolecular Rapid Communications

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Recently Published Articles

  1. Visualizing the Inner Architecture of Poly(ϵ-caprolactone)-Based Biomaterials and Its Impact on Performance Optimization

    Adam J. P. Bauer, Yitian Wu, Jianzhao Liu and Bingbing Li

    Article first published online: 7 JUL 2015 | DOI: 10.1002/mabi.201500175

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    This study demonstrates the superior degradation selectivity of Candida antarctica lipase B (CALB) enzyme; when used at low concentrations, it preferentially breaks down the amorphous chains of poly(ϵ-caprolactone) (PCL) prior to its crystalline chains. Top-down dissection using this enzyme is performed on several PCL-based model systems. The spatial distribution of the amorphous compartments are precisely mapped out, which otherwise cannot be achieved.

  2. A New Hyaluronic Acid Derivative Obtained from Atom Transfer Radical Polymerization as a siRNA Vector for CD44 Receptor Tumor Targeting

    Fabio Salvatore Palumbo, Antonella Bavuso Volpe, Flavia Bongiovì, Giovanna Pitarresi and Gaetano Giammona

    Article first published online: 1 JUL 2015 | DOI: 10.1002/mabi.201500129

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    New cationic HA derivatives (HA-EDA-pDEAEMA), synthesized by atom transfer radical polymerization (ATRP) are able to complex siRNA and to form self-assembled nanosystems. In vitro studies performed on HCT 116 cell line, which over express CD44 receptor, demonstrate a receptor-mediated uptake of complexes.

  3. Multi-Layered Scaffolds for Osteochondral Tissue Engineering: In Vitro Response of Co-Cultured Human Mesenchymal Stem Cells

    Sofia Amadori, Paola Torricelli, Silvia Panzavolta, Annapaola Parrilli, Milena Fini and Adriana Bigi

    Article first published online: 30 JUN 2015 | DOI: 10.1002/mabi.201500165

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    Multi-layered, easily synthesized scaffolds made of gelatin and hydroxyapatite are able to promote chondrogenic and osteogenic differentiation of human mesenchymal stem cells.

  4. Advanced Evaluation Strategies for Protein-Imprinted Polymer Nanobeads

    Bettina Pluhar and Boris Mizaikoff

    Article first published online: 26 JUN 2015 | DOI: 10.1002/mabi.201500106

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    An analytical strategy for providing exhaustive information on the selective binding and inhibition properties of nano-MIPs. Inhibited and active pepsin, respectively, along with two other proteins were incubated to equilibrium with pepsin-imprinted nanobeads, separated from the nanobeads by centrifugation, and the remaining supernatant was analyzed via SDS-PAGE.

  5. EGFP-Based Protein Nanoparticles with Cell-Penetrating Peptide for Efficient siRNA Delivery

    Xingang Guan, Xiuli Hu, Fengchao Cui, Yunqi Li, Xiabing Jing and Zhigang Xie

    Article first published online: 24 JUN 2015 | DOI: 10.1002/mabi.201500163

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    Fluorescent protein (EGFP) nanoparticles are developed and used for siRNA delivery. Protein nanoparticle can condense siRNA into stable nanoparticle/siRNA complexes, and transfect cy3-labelled siRNA into tumor cells.