Macromolecular Bioscience

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Recently Published Articles

  1. Poly(anhydride-ester) and Poly(N-vinyl-2-pyrrolidone) Blends: Salicylic Acid-Releasing Blends with Hydrogel-Like Properties that Reduce Inflammation

    Michelle A. Ouimet, Renata Fogaça, Sabrina S. Snyder, Sameer Sathaye, Luiz H. Catalani, Darrin J. Pochan and Kathryn E. Uhrich

    Article first published online: 21 OCT 2014 | DOI: 10.1002/mabi.201400238

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    Hydrogels-like polymer blends that combine the biocompatibility and hydrophilicity of PVP with controlled release of salicylic acid to reduce inflammation are presented. These copolymer blends substantially reduce the inflammatory cytokine, TNF-α, in vitro and indicate no cytotoxic or anti-proliferative effects. Based upon the unique combination, these blended polymer films show great potential for wound healing.

  2. Multi-Technique Characterization of Poly-L-lysine Dendrigrafts–Cu(II) Complexes for Biocatalysis

    Jean-Christophe Rossi, Barbara Maret, Kevin Vidot, Jean-Patrick Francoia, Michela Cangiotti, Susanna Lucchi, Concetta Coppola and Maria Francesca Ottaviani

    Article first published online: 20 OCT 2014 | DOI: 10.1002/mabi.201400341

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    Significant structural features of poly-L-lysine dendrigrafts (DGLs) – Cu(II) complexes are characterized to implement the use of these complexes as biocatalysts. The agreement and complementarity among EPR, potentiometric titration, UV-Vis and CD measurements provide an exhaustive view of the Cu(II)-DGL complexation behavior as a function of DGL generation, relative concentrations, and pH.

  3. Thermoresponsive Nanodevices in Biomedical Applications

    Julián Bergueiro and Marcelo Calderón

    Article first published online: 16 OCT 2014 | DOI: 10.1002/mabi.201400362

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    Thermoresponsive nanodevices are one of the most promising systems in nanomedicine. Due to new building blocks, a number of promising smart systems have been rapidly developed in response to the needs of nanomedicine. This article reviews the innovations in this field from the last four years.

  4. Blending of Diblock and Triblock Copolypeptide Amphiphiles Yields Cell Penetrating Vesicles with Low Toxicity

    April R. Rodriguez, Uh-Joo Choe, Daniel T. Kamei and Timothy J. Deming

    Article first published online: 16 OCT 2014 | DOI: 10.1002/mabi.201400348

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    Diblock and triblock copolypeptides were blended to form vesicle populations with uniform compositions. Mixing of cationic and non-ionic amphiphiles in these vesicles gave optimized properties of good cellular uptake while maintaining minimal cytotoxicity. Copolypeptide mixing is a promising strategy to provide useful functionality without requiring the use of complicated synthesis procedures.

  5. Glycosylated Star Polypeptides from NCA Polymerization: Selective Binding as a Function of Degree of Branching and Glycosylation

    Mark Byrne, Robert Mildner, Henning Menzel and Andreas Heise

    Article first published online: 15 OCT 2014 | DOI: 10.1002/mabi.201400371

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    Poly(glutamic acid) star polymers with up to 64 arms were synthesized via N-carboxy-anhydride (NCA) polymerization from dendritic initiators. Glycosylation afforded star-shaped glyco- peptides with varying degrees of sugar conjugation. The secondary structure and the ability to selectively bind to lectin ConA was found to be dependent on sugar content and polymer structure, respectively.