Macromolecular Bioscience

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Recently Published Articles

  1. Regulating Schwann Cells Growth by Chitosan Micropatterning for Peripheral Nerve Regeneration In Vitro

    Guicai Li, Xueying Zhao, Luzhong Zhang, Caiping Wang, Yunwei Shi and Yumin Yang

    Article first published online: 23 APR 2014 | DOI: 10.1002/mabi.201400098

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    Most Schwann Cells (SCs) grow along well with the chitosan micropatterning on 30/30 µm sample, while some cells grow across the micropatterning on the 20/20 µm sample. And the neurite of the SCs on the 30/30 µm sample present better ductility along the stripe structure than the 20/20 µm sample after culturing for 1 d.

  2. Polymeric Nanocarriers for siRNA Delivery to Murine Macrophages

    Diane C. Forbes and Nicholas A. Peppas

    Article first published online: 22 APR 2014 | DOI: 10.1002/mabi.201400027

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    This work investigates the interactions of a polycationic nanocarrier with siRNA and with RAW264.7 cells in order to better understand the capabilities and limitations of the carrier. The cross-linked, DEAEMA-based nanoparticles are synthesized using ARGET ATRP in a single-step reaction. The carriers efficiently bind siRNA and are internalized by cells for siRNA delivery.

  3. Magnetic Nanoclusters Engineered by Polymer-Controlled Self-Assembly for the Accurate Diagnosis of Atherosclerotic Plaques via Magnetic Resonance Imaging

    Myeong-Hoon Kim, Bongjune Kim, Eun-Kyung Lim, Yuna Choi, Jihye Choi, Eunjung Kim, Eunji Jang, Hyo Seon Park, Jin-Suck Suh, Yong-Min Huh and Seungjoo Haam

    Article first published online: 17 APR 2014 | DOI: 10.1002/mabi.201400029

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    Oleyl dextran (ODex) coated magnetic nanocluster (ODMC) is developed and engineered by polymer-controlled self-assembly to be used as efficient MR imaging nanoprobe of atherosclerosis. T2 relaxivity of ODMCs is highly enhanced by controlling the condition of ODex including the degree of substitution of the oleyl group and the concentration used for the synthesis of ODMCs.

  4. Electrospun Nanofiber Scaffolds and Plasma Polymerization: A Promising Combination Towards Complete, Stable Endothelial Lining for Vascular Grafts

    Houman Savoji, Afra Hadjizadeh, Marion Maire, Abdellah Ajji, Michael R. Wertheimer and Sophie Lerouge

    Article first published online: 17 APR 2014 | DOI: 10.1002/mabi.201300545

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    Electrospinning and plasma polymerization are combined to provide vascular graft scaffolds. These bear similarity to the extracellular matrix beneath the luminal endothelium, are mechanically compliant and biocompatible, and facilitate formation of a cofluent monolayer of endothelial cells on the lumen, one that is stable under static and shear-induced flow conditions.

  5. Sequential pH-Dependent Adsorption of Ionic Amphiphilic Diblock Copolymer Micelles and Choline Oxidase Onto Conductive Substrates: Toward the Design of Biosensors

    Larisa V. Sigolaeva, Ulrike Günther, Dmitry V. Pergushov, Snezhana Yu. Gladyr, Ilya N. Kurochkin and Felix H. Schacher

    Article first published online: 17 APR 2014 | DOI: 10.1002/mabi.201300580

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    Block copolymer/enzyme biosensors are prepared via electrostatically driven co-assembly. Amphiphilic diblock copolymer micelles of poly(n-butylmethacrylate)-block-poly(N,N-dimethylaminoethyl methacrylate) and choline oxidase are used as building blocks to fabricate bilayer films on conductive substrates (modified graphite or gold) at different pH-values. The resulting hybrid thin-films represent highly active and stable biosensors for choline.