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Materials Science Weekly Newsletter
Recently Published Articles
- Boronic Acid Shell-Crosslinked Dextran-b-PLA Micelles for Acid-Responsive Drug Delivery
Ziwei Zhao, Xuemei Yao, Zhe Zhang, Li Chen, Chaoliang He and Xuesi Chen
Article first published online: 21 AUG 2014 | DOI: 10.1002/mabi.201400251
3-carboxy-5-nitrophenylboronic acid (CNPBA) shell-crosslinked micelles based on amphiphilic dextran-block-polylactide (Dex-b-PLA) are prepared and used for efficient intracellular drug delivery. The pH-responsive biodegradable CNPBA-Dex-b-PLA can efficiently load and deliver DOX into tumor cells and enhance the inhibition of cellular proliferation in vitro, providing a favorable platform as a drug delivery system for cancer therapy.
- Functional Brush-Decorated Poly(globalide) Films by ARGET-ATRP for Bioconjugation
Zeliha Ates, Fabrice Audouin, Amy Harrington, Brendan O'Connor and Andreas Heise
Article first published online: 21 AUG 2014 | DOI: 10.1002/mabi.201400282
Poly(acrylic) acid brushes were grafted from polyester films obtained from the unsaturated macrolactone globalide by ARGET ATRP of tert.-butyl acrylate. After mild in situ deprotection high-density acrylic acid functional films were obtained while avoiding polyester hydrolysis. The conjugation with green fluorescent protein (GFP) and an enzyme was successfully carried out retaining the enzymatic activity.
- Monodisperse Carboxyl-Functionalized Poly(Ethylene Glycol)-Coated Magnetic Poly(Glycidyl Methacrylate) Microspheres: Application to the Immunocapture of β-Amyloid Peptides
Daniel Horák, Helena Hlídková, Mohamed Hiraoui, Myriam Taverna, Vladimír Proks, Eliška Mázl Chánová, Claire Smadja and Zdenka Kučerová
Article first published online: 21 AUG 2014 | DOI: 10.1002/mabi.201400249
Monodisperse magnetic poly(glycidyl methacrylate) microspheres coated with α-amino-ω-methoxy-PEG5000/α-amino-ω-Boc-NH-PEG5000substantially reduced non-specific protein adsorption. Anti-Aβ 6E10-immobilized microspheres specifically captured β-amyloid peptide (Aβ) from model solutions. Identification and evaluation of small changes in Aβ levels in cerebrospinal fluid is of crucial importance for early detection of Alzheimer's disease.
- Micropatterning Electrospun Scaffolds to Create Intrinsic Vascular Networks
Eric M. Jeffries, Shintaro Nakamura, Kee-Won Lee, Jimmy Clampffer, Hiroyuki Ijima and Yadong Wang
Article first published online: 20 AUG 2014 | DOI: 10.1002/mabi.201400306
Engineered microvasculature that effectively perfuses the parenchyme and directly integrates with host circulation remains the challenge of organ engineering. Described is a method for patterning microvascular structures in electrospun scaffolds using water-soluble templates produced by fused deposition modeling. The fibrous nature mimicks extracellular matrix and permits nutrient diffusion. Additionally, scaffolds are biodegradable and suturable. In vitro endothelialization demonstrates feasible vascularization.
- Electrospun Honeycomb as Nests for Controlled Osteoblast Spatial Organization
Salima Nedjari, Sandy Eap, Anne Hébraud, Corinne R. Wittmer, Nadia Benkirane-Jessel and Guy Schlatter
Article first published online: 19 AUG 2014 | DOI: 10.1002/mabi.201400226
PCL and PLA nanofibrous scaffolds with honeycomb micro-patterns are prepared by electrospinning. It is shown that the relief of the scaffolds depends on the distribution of fiber diameters. Mimicking hemi-osteons, cell gathering is observed inside the PCL honeycomb fibrous nests with a characteristic size greater than 80 μm.