Macromolecular Bioscience

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Recently Published Articles

  1. Sulfated Hyaluronan Influences the Formation of Artificial Extracellular Matrices and the Adhesion of Osteogenic Cells

    Alina Miron, Sandra Rother, Linda Huebner, Ute Hempel, Iris Käppler, Stephanie Moeller, Matthias Schnabelrauch, Dieter Scharnweber and Vera Hintze

    Article first published online: 12 SEP 2014 | DOI: 10.1002/mabi.201400292

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    The presence of sulfated glycosaminoglycans (GAG), like sulfated hyaluronan derivatives and chondroitin sulfate, during in vitro-fibrillogenesis of collagen type I alters the structure of the resulting artificial extracellular matrices. Besides, the GAG amount associated to collagen increases in a sulfation-dependent manner. Moreover, GAG sulfation influences the cytoskeletal arrangement of SaOS-2 cells which implies that adhesion-related intracellular signaling is affected.

  2. pH-Responsive Single Walled Carbon Nanotube Dispersion for Target Specific Release of Doxorubicin to Cancer Cells

    Moumita Ghosh, Sayanti Brahmachari and Prasanta Kumar Das

    Article first published online: 11 SEP 2014 | DOI: 10.1002/mabi.201400290

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    pH Responsive cholesterol based dipeptide carboxylates were synthesized as efficient dispersing agents for SWNTs in water. These highly dispersed nanotubes were used for the uploading of anticancer drug doxorubicin. The nanohybrid showed excellent pH responsive drug release at the extracellular tumorogenic environmental pH (6.0–6.5) and selectively kills cancer cells.

  3. Liposomal Drug Deposits in Poly(Dopamine) Coatings: Effect of Their Composition, Cell Type, Uptake Pathway Considerations, and Shear Stress

    Martin E. Lynge, Marina Fernandez-Medina, Almar Postma and Brigitte Städler

    Article first published online: 11 SEP 2014 | DOI: 10.1002/mabi.201400350

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    Different types of liposome-containing poly(dopamine)-based films were assembled and their interaction with adhering cells was assessed. The internalization of cargo was not affected by the presence of lipophilic dopamine conjugates in the lipid membrane but by the charge of the liposomes. Clathrin-mediated endocytosis was identified as uptake pathway. Shear stress had an impact on the interaction of adhering endothelial cells with the composite films.

  4. Sprayed Cells and Polyelectrolyte Films for Biomaterial Functionalization: The Influence of Physical PLL–PGA Film Treatments on Dental Pulp Cell Behavior

    Ivan V. Panayotov, Pierre-Yves Collart-Dutilleul, Hamideh Salehi, Marta Martin, Attila Végh, Jacques Yachouh, Boyan Vladimirov, Péter Sipos, Balázs Szalontai, Csilla Gergely and Frédéric J. G. Cuisinier

    Article first published online: 11 SEP 2014 | DOI: 10.1002/mabi.201400256

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    A good manufacturing practice (GMP)-compliant spraying method is described for the buildup of polyelectro-lyte multilayer (PEM) films constructed by poly-L-lysine (PLL) and poly-glutamic acid (PGA), onto which dental pulp cells are also deposited by spraying. The prepared PEM films were exposed to UV irradiation and drying/re-hydrating cycle. This procedure renders the films thicker, rougher and stiffer, enhancing dental pulp cell adhesion and proliferation.

  5. Bamboo Leaf-Like Micro-Nano Sheets Self-Assembled by Block Copolymers as Wafers for Cells

    Wen Zhu, Bo Peng, Jing Wang, Ke Zhang, Lixin Liu and Yongming Chen

    Article first published online: 10 SEP 2014 | DOI: 10.1002/mabi.201400283

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    Bamboo leaf-like micro-nano sheets are prepared via crystallization-driven self-assembly of poly(ethylene oxide)-b-poly(ϵ-caprolactone). The preparation is quite convenient within 1 h. These polymer sheets look like wafers for cells, and they do display a selective internalization to different cells. The macrophages show great interest in the wafers.