Macromolecular Bioscience

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Recently Published Articles

  1. Poly(ornithine-co-arginine-co-glycine-co-aspartic Acid): Preparation via NCA Polymerization and its Potential as a Polymeric Tumor-Penetrating Agent

    Haiyang Yu, Zhaohui Tang, Dawei Zhang, Wantong Song, Taicheng Duan, Jingkai Gu and Xuesi Chen

    Article first published online: 4 MAR 2015 | DOI: 10.1002/mabi.201500040

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    A novel random copolypeptide Poly(O,R,G,D) is prepared through the ring-opening polymerization of N-δ-carbobenzoxy-l-ornithine N-carboxyanhydride, l-glycine N-carboxyanhydride and β-benzyl l-aspartate N-carboxyanhydride, following by subsequent deprotection and guanidization. The Poly(O,R,G,D) can be proteolytically cleaved in a treated tumor to expose the cryptic CendR elements that mediates binding to neuropilin-1, inducing vascular and tissue permeabilization.

  2. Synthesis and Properties of Star HPMA Copolymer Nanocarriers Synthesised by RAFT Polymerisation Designed for Selective Anticancer Drug Delivery and Imaging

    Petr Chytil, Eva Koziolová, Olga Janoušková, Libor Kostka, Karel Ulbrich and Tomáš Etrych

    Article first published online: 2 MAR 2015 | DOI: 10.1002/mabi.201400510

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    Well-defined water-soluble high-molecular-weight star polymer drug nanocarriers, based on HPMA copolymers, enabling the pH-sensitive drug release in the tumour tissue were synthesised and their properties were studied. The nanocarriers showed a low dispersity and contained different functionalities, which enabled the attachment of drugs along the polymer chains and also the one-point attachment for the targeting ligands and/or a labelling moiety.

  3. Inclusion Complexes Between Polytetrahydrofuran-b-Amylose Block Copolymers and Polytetrahydrofuran Chains

    Rachmawati Rachmawati, Albert J. J. Woortman, Kamlesh Kumar and Katja Loos

    Article first published online: 23 FEB 2015 | DOI: 10.1002/mabi.201400515

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    Polytetrahydrofuran-block-amylose is able to act as a host molecule which can include guest polytetrahydrofuran chains to result in complexes. The amylose helices in the resulting complexesare in the form of a V amylose with six glucose residues per helical turn. This complexation between the host block copolymer and the guest homopolymer offers a facile route to building supramolecular structures.

  4. Optimization of Aqueous SI-ATRP Grafting of Poly(Oligo(Ethylene Glycol) Methacrylate) Brushes from Benzyl Chloride Macroinitiator Surfaces

    Andrew E. Rodda, Francesca Ercole, David R. Nisbet, John S. Forsythe and Laurence Meagher

    Article first published online: 17 FEB 2015 | DOI: 10.1002/mabi.201400512

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    Surface Initiated ATRP of poly(OEGMA) was performed from macroinitiators bearing the stable benzyl chloride moiety. Despite the structural mismatch between the initiator and monomer and expected poor kinetics, dense polymer brush coatings were grafted from the surface under a set of optimised conditions in aqueous solution. These coatings were highly effective at reducing protein fouling and cell adhesion.

  5. Organic Radical Contrast Agents Based on Polyacetylenes Containing 2,2,6,6-Tetramethylpiperidine 1-Oxyl (TEMPO): Targeted Magnetic Resonance (MR)/Optical Bimodal Imaging of Folate Receptor Expressing HeLa Tumors in Vitro and in Vivo

    Lixia Huang, Chenggong Yan, Danting Cui, Yichen Yan, Xiang Liu, Xinwei Lu, Xiangliang Tan, Xiaodan Lu, Jun Xu, Yikai Xu and Ruiyuan Liu

    Article first published online: 13 FEB 2015 | DOI: 10.1002/mabi.201400403

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    Folic acid modified paramagnetic fluorescent bimodal organic radical contrast agents (ORCAs) are prepared using polyacetylenes containing 2,2,6,6-tetramethylpiperidine 1-oxyl (TEMPO). The ORCAs exhibit satisfactory magnetic resonance imaging (MRI) contrast efficacy with low cytotoxicity. In vitro and in vivo MRI/optical imaging demonstrate the active targetability of the targeted ORCAs to folate receptor-positive HeLa tumors.

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