Macromolecular Bioscience

Cover image for Vol. 15 Issue 9

Editor-in-Chief: Kirsten Severing, Editor: Anne Pfisterer

Online ISSN: 1616-5195

Associated Title(s): Advanced Healthcare Materials, Macromolecular Chemistry and Physics, Macromolecular Materials and Engineering, Macromolecular Rapid Communications

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Recently Published Articles

  1. Phenolic Acid-based Poly(anhydride-esters) as Antioxidant Biomaterials

    Almudena Prudencio, Jonathan J. Faig, MinJung Song and Kathryn E. Uhrich

    Article first published online: 1 OCT 2015 | DOI: 10.1002/mabi.201500244

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    Naturally occurring, antioxidant-based poly(anhydride-esters) are synthesized in high yields via solution polymerization methods. Structures of precursor and polymer are determined and verified by NMR and Fourier transform IR spectroscopies. The polymers exhibit sustained hydrolytic release of phenolic acids over the 30 day study, maintaining antioxidant potency when compared to free bioactives.

  2. Layer-by-Layers of Polymeric Micelles as a Biomimetic Drug-Releasing Network

    Sundar P. Authimoolam, Andrew L. Lakes, David A. Puleo and Thomas D. Dziubla

    Article first published online: 29 SEP 2015 | DOI: 10.1002/mabi.201500310

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    Filomicelle networks possess high biomimetic relevance to natural mucin. In this work, these synthetic networks are evaluated for its ability to function as drug-releasing network. In developing a tunable release, dense barrier is deposited atop networks, and critically evaluated for its drug release and chemical stability. These tunable networks can potentially serve as a functional coat rendering localized delivery.

  3. Synthesis and Enzymatic Degradation of Soft Aliphatic Polyesters

    Viola Buchholz, Seema Agarwal and Andreas Greiner

    Article first published online: 24 SEP 2015 | DOI: 10.1002/mabi.201500279

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    Synthesis of novel aliphatic enzymatically degradable polyesters with short side chains leads to variable features. The influence of the reduced crystallinity on thermal and mechanical properties, melting behavior and Young's modulus, is reported. The controllable degradation behavior in combination with the reduced brittleness offers new possible applications for aliphatic polyesters.

  4. A Novel Small-Caliber Bacterial Cellulose Vascular Prosthesis: Production, Characterization, and Preliminary In Vivo Testing

    Alexandre F. Leitão, Miguel A. Faria, Augusto M. R. Faustino, Ricardo Moreira, Petra Mela, Luís Loureiro, Ivone Silva and Miguel Gama

    Article first published online: 21 SEP 2015 | DOI: 10.1002/mabi.201500251

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    Bacterial cellulose (BC) is among the polymers being studied for use as an off-the-shelf vascular graft. The authors present a novel, facile, and cost-effective method for small caliber BC grafts production. The morphology of the graft wall, tensile strength, and luminal topography all show promising results. The in vivo behavior of these BC grafts further demonstrate their viability achieving, one month patency with neo-vessels, and endothelial cells presenting on the luminal surface of the graft.

  5. Chemoenzymatic Synthesis of Oligo(l-cysteine) for Use as a Thermostable Bio-Based Material

    Yinan Ma, Ryota Sato, Zhibo Li and Keiji Numata

    Article first published online: 21 SEP 2015 | DOI: 10.1002/mabi.201500255

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    Oligomerization of thiol-unprotected l-cysteine ethyl ester catalyzed by proteinase K in aqueous solution has been used to synthesize oligo(l-cysteine) with high free thiol content and relative large degree of polymerization. The products exhibit stable thermal properties and have great potential for use as a thermostable bio-based material with resistance to oxidation.