Macromolecular Bioscience

Cover image for Vol. 17 Issue 7

Editor-in-Chief: Kirsten Severing, Editor: Anne Pfisterer

Online ISSN: 1616-5195

Associated Title(s): Advanced Healthcare Materials, Macromolecular Chemistry and Physics, Macromolecular Materials and Engineering, Macromolecular Rapid Communications

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Best of Macros 2017 is now online. Click here to read about the selected articles and their authors.

Recently Published Articles

  1. You have full text access to this OnlineOpen article
    Chemoenzymatic Synthesis of Polypeptides for Use as Functional and Structural Materials

    Kousuke Tsuchiya and Keiji Numata

    Version of Record online: 19 JUL 2017 | DOI: 10.1002/mabi.201700177

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    Chemoenzymatic polymerization using proteases is a facile, environmentally benign, readily scalable, and atom-economical synthetic method for the development of functional polypeptide materials. In this review, recent progress in chemoenzymatic polypeptide synthesis with conventional procedures is summarized to explore the feasibility of its application to the production of functional and structural materials inspired by natural proteins.

  2. In Vitro and In Vivo Characterization of Biodegradable Reactive Isocyanate-Terminated Three-Armed- and Hyperbranched Block Copolymeric Tissue Adhesives

    Agnieszka I. Bochyńska, Gerjon Hannink, Jan J. Rongen, Dirk W. Grijpma and Pieter Buma

    Version of Record online: 17 JUL 2017 | DOI: 10.1002/mabi.201700125

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    This study evaluates physicochemical and adhesive properties, degradation in vitro and in vivo, and the tissue reaction after subcutaneous injection in rats of the novel biodegradable three-armed- and hyperbranched block copolymeric adhesives. The results show sufficient adhesive strength to meniscus tissue (66–88 kPa), promising mechanical tensile properties and degradation profiles, and only mild inflammatory reaction.

  3. Simple Radical Polymerization of Poly(Alginate-Graft-N-Isopropylacrylamide) Injectable Thermoresponsive Hydrogel with the Potential for Localized and Sustained Delivery of Stem Cells and Bioactive Molecules

    Sreekanth Pentlavalli, Philip Chambers, Binulal N. Sathy, Michelle O'Doherty, Marine Chalanqui, Daniel J. Kelly, Tammy Haut-Donahue, Helen O. McCarthy and Nicholas J. Dunne

    Version of Record online: 17 JUL 2017 | DOI: 10.1002/mabi.201700118

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    Free radical synthesis of injectable, biocompatible, and biodegradable thermoresponsive hydrogel that offers tailored viscoelastic properties is investigated. Hydrogel provided enables cell encapsulation without affecting differentiation capability. Technology offers a versatile and improved platform for drug delivery and bone tissue engineering applications.

  4. Codelivery for Paclitaxel and Bcl-2 Conversion Gene by PHB-PDMAEMA Amphiphilic Cationic Copolymer for Effective Drug Resistant Cancer Therapy

    Xiaoyuan Wang, Sing Shy Liow, Qiaoqiong Wu, Chuang Li, Cally Owh, Zibiao Li, Xian Jun Loh and Yun-Long Wu

    Version of Record online: 17 JUL 2017 | DOI: 10.1002/mabi.201700186

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    A series of amphiphilic cationic poly[(R)-3-hydroxybutyrate]-b-poly(2-(dimethylamino)ethyl methacrylate) copolymers are designed as nonviral gene carrier with cationic micelle formation ability for hydrophobic drug encapsulation and enhanced stability. Furthermore, they are selected to codeliver chemotherapeutic paclitaxel and Bcl-2 conversion Nur77 gene in drug resistant HepG2/Bcl-2 cancer cells, which lead to increased Nur77 protein expression in intracellular mitochondria and drug resistant cancer cell death.

  5. Comprehensive Examination of Mechanical and Diffusional Effects on Cell Behavior Using a Decoupled 3D Hydrogel System

    Suntae Kim, Sung Bo Sim, Kangseok Lee and Chaenyung Cha

    Version of Record online: 10 JUL 2017 | DOI: 10.1002/mabi.201700162

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    3D hydrogel-based cell culture system with decoupled mechanical and diffusional properties is developed by using a hydrophilic polymeric crosslinker with tunable number of reactive functional groups. This polymeric crosslinker allows for the control of mechanical properties without affecting diffusional properties of the hydrogel.