Investigation of Functionalized Poly(N,N-dimethylacrylamide)-block-polystyrene Nanoparticles As Novel Drug Delivery System to Overcome the Blood–Brain Barrier In Vitro
Maria Gregori, Daniela Bertani, Emanuela Cazzaniga, Antonina Orlando, Michele Mauri, Alberto Bianchi, Francesca Re, Silvia Sesana, Stefania Minniti, Maura Francolini, Alfredo Cagnotto, Mario Salmona, Luca Nardo, Domenico Salerno, Francesco Mantegazza, Massimo Masserini and Roberto Simonutti
Article first published online: 21 JUL 2015 | DOI: 10.1002/mabi.201500172
In the search of novel drug carriers for brain drug delivery, poly(N,N-dimethylacrylamide)-b-polystyrene nanoparticles (NP) have been functionalized with a modified fragment of Apolipoprotein E (mApoE). These NP show to be uptaken and to overcome a BBB in vitro cellular model. The cytotoxicity of NP is also investigated on different cell lines, showing high biocompatibility.