Macromolecular Bioscience

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Early View (Online Version of Record published before inclusion in an issue)

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  1. 1 - 42
  1. Full Papers

    1. Improved Gene Transfection Efficacy and Cytocompatibility of Multifunctional Polyamidoamine-Cross-Linked Hyaluronan Particles

      Akshay Srivastava, Claire Cunningham, Abhay Pandit and J. Gerard Wall

      Article first published online: 29 JAN 2015 | DOI: 10.1002/mabi.201400401

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      Multi-functional, cationic HA-based particles are developed by cross-linking HA chains with polyamidoamine (PAMAM). The well segregated, cationized particles complex plasmid DNA efficiently and can be functionalized with recombinant antibody fragments for cell targeting. They exhibit improved transfection efficiency and negligible cytotoxicity toward bovine intervertebral disk cells compared with Superfect® or non-cationized particles

    2. Facile Synthesis and Structural Characterization of Amylose–Fatty Acid Inclusion Complexes

      Zheng Cao, Albert J. J. Woortman, Petra Rudolf and Katja Loos

      Article first published online: 29 JAN 2015 | DOI: 10.1002/mabi.201400464

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      Amylose–fatty acid complexes can be prepared by mixing various fatty acids with amylose in hot aqueous solutions. Each fatty acid is selective for a specific fraction of amylose leading to a fractionation effect.

    3. Injectable Hybrid Hydrogels of Hyaluronic Acid Crosslinked by Well-Defined Synthetic Polycations: Preparation and Characterization In Vitro and In Vivo

      Daisy Cross, Xiaoze Jiang, Weihang Ji, Wenqing Han and Chun Wang

      Article first published online: 28 JAN 2015 | DOI: 10.1002/mabi.201400491

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      Hyaluronic acid and well-defined synthetic cationic copolymers form hybrid hydrogels through electrostatic interactions. These materials may have potential medical applications such as injectable carriers for cells.

    4. New Ionic bis-MPA and PAMAM Dendrimers: A Study of Their Biocompatibility and DNA-Complexation

      Julie Movellan, Rebeca González-Pastor, Pilar Martín-Duque, Teresa Sierra, Jesús M. de la Fuente and José Luis Serrano

      Article first published online: 28 JAN 2015 | DOI: 10.1002/mabi.201400422

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      Ionic dendrimers are described that consist on quaternary salts of amino-terminated PAMAM and bis-MPA derivatives and biocompatible chains derived from 2-[2-(2-methoxyethoxy) ethoxy]acetic acid. Whereas the PAMAM compounds remain cytotoxic, the I-bis-MPA compound exhibits high loading capacity for pDNA and very low toxicity.

    5. Novel Linear Polymers Able to Inhibit Bacterial Quorum Sensing

      Eliana Cavaleiro PhD, Ana Sofia Duarte PhD, Ana Cristina Esteves PhD, António Correia PhD, Michael J. WhitcombePhD, Elena V. Piletska PhD, Sergey A. Piletsky PhD and Iva Chianella PhD

      Article first published online: 28 JAN 2015 | DOI: 10.1002/mabi.201400447

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      The conventional treatment of bacterial infections is based on the administration of antibiotics, which promotes bacterial resistance. We present the development of linear polymers able to disrupt quorum sensing as shown by the reduction of bacterial bioluminescence and biofilm formation. The polymers could be used to control bacterial virulence without promoting resistance, thus constituting a safe alternative to the use of antibiotics.

    6. Polymer Brushes Interfacing Blood as a Route Toward High Performance Blood Contacting Devices

      František Surman, Tomáš Riedel, Michael Bruns, Nina Yu. Kostina, Zdeňka Sedláková and Cesar Rodriguez-Emmenegger

      Article first published online: 21 JAN 2015 | DOI: 10.1002/mabi.201400470

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      Hydrophilic polymer brushes based on HPMA prepared by surface initiated ATRP provide an excellent surface modification to prevent the adhesion of blood components as well as the fouling from whole blood. This surface modification opens new opportunities to improve the performance of blood contacting devices.

    7. Reduction-Sensitive Amphiphilic Triblock Copolymers Self-Assemble Into Stimuli-Responsive Micelles for Drug Delivery

      Smahan Toughraï, Violeta Malinova, Raffaello Masciadri, Sindhu Menon, Pascal Tanner, Cornelia Palivan, Nico Bruns and Wolfgang Meier

      Article first published online: 13 JAN 2015 | DOI: 10.1002/mabi.201400400

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      Polymeric micelles obtained from the self-assembly of redox-sensitive amphiphilic triblock copolymers with a cleavable disulfide bond in the center of the hydrophobic block were investigated as potential drug delivery systems. The degradation products of the micelles are amphiphilic diblock copolymers and should therefore allow for facile clearing from biological systems.

  2. Communications

    1. Cell—Cell Crosslinking by Bio-Molecular Recognition of Heparin-Based Layer-by-Layer Nanofilmsa

      Akihiro Nishiguchi, Michiya Matsusaki and Mitsuru Akashi

      Article first published online: 9 JAN 2015 | DOI: 10.1002/mabi.201400415

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      Bio-molecular recognition between living cells and polymer nanofilms allows for the rapid cellular assembly to form cell aggregates. The aggregates display viscous properties and network structures crosslinked with polymer nanofilms. Specific inter-domain interactions between proteins and glycosaminoglycan cause cell—cell crosslinking. The assembly method supports in vitro 3D-tissue formation.

  3. Full Papers

    1. Stable Emulsions Prepared by Self-assembly of Hyaluronic Acid and Chitosan for Papain Loading

      Donghua Zhao, Wei Wei, Ye Zhu, Jianhua Sun, Qiong Hu and Xiaoya Liu

      Article first published online: 9 JAN 2015 | DOI: 10.1002/mabi.201400486

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      Papain/hyaluronic acid/chitosan complex colloidal particles are obtained through electrostatic interactions. The complexes can be used as biocompatible emulsifiers and novel potential carriers for papain loading. Formation of the complexes in a compact form can protect the enzyme and even cause an increase in enzymatic activity, increasing the applications in the cosmetic, food, and pharmaceuticals industries.

  4. Full Paper

    1. Tuning the Buffering Capacity of Polyethylenimine with Glycerol Molecules for Efficient Gene Delivery: Staying In or Out of the Endosomes

      Bijay Singh, Sushila Maharjan, Tae-Eun Park, Tao Jiang, Sang-Kee Kang, Yun-Jaie Choi and Chong-Su Cho

      Article first published online: 8 JAN 2015 | DOI: 10.1002/mabi.201400463

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      Non-viral gene delivery vehicles are developed by tuning the buffering capacity of PEI with glycerol molecules. Mechanistic studies reveal that the glycerol-crosslinked PEI appears to trigger macropinocytosis for higher cellular uptake, in addition to clathrin- and caveolae-mediated endocytosis. Independent of endocytic pathway, the endosomal escape of polyplexes depends on the buffering capacity of the polymers, elucidating the intracellular fate of polyplexes.

  5. Full Papers

    1. The Application of LbL-Microcarriers for the Treatment of Chronic Inflammation: Monitoring the Impact of LbL-Microcarriers on Cell Viability

      Mandy Fichtner, Claudia Claus, Jacqueline Lessig-Owlanj, Jürgen Arnhold and Uta Reibetanz

      Article first published online: 7 JAN 2015 | DOI: 10.1002/mabi.201400405

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      Layer-by-Layer (LbL) coated microparticles and microcapsules represent a unique drug delivery system due to their modular, as well as multifunctional characteristic. A promising application is the treatment of chronic inflammation. LbL-microcarriers transporting anti-inflammatory substances into the affected tissue provide to overcome several drawbacks of conventional therapy. However, microcarrier-induced loss of cell viability has to be strongly avoided.

  6. Communications

    1. Tough, In-Situ Thermogelling, Injectable Hydrogels for Biomedical Applications

      Ghulam Jalani, Derek H. Rosenzweig, Georges Makhoul, Sherif Abdalla, Renzo Cecere, Fiorenzo Vetrone, Lisbet Haglund and Marta Cerruti

      Article first published online: 3 JAN 2015 | DOI: 10.1002/mabi.201400406

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      Homogenous, in-situ thermogelling, highly tough, non-toxic injectable hydrogels from chitosan and hyaluronic acid co-crosslinked with β-glycerophophate and genipin are produced. The co-crosslinked gels form faster than genipin only crosslinked gels and are 2.5 times stronger than ionically crosslinked gels. Homogenously dispersed cells express enhanced amount of collagen II, showing great potential of these gels for cartilage tissue engineering.

  7. Full Papers

    1. Agarose-Assisted Micro-Contact Printing for High-Quality Biomolecular Micro-Patterns

      Min Jee Jang and Yoonkey Nam

      Article first published online: 3 JAN 2015 | DOI: 10.1002/mabi.201400407

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      We present a novel surface modification method for a PDMS stamp with agarose hydrogel in order to enhance the micro-contact printing of biomolecules. A thin film of agarose was formed on the stamp by a simple dip-coating procedure, which dramatically enhanced the transferability of ink molecules to the substrate and the uniformity of printed patterns.

    2. Effects of Permeability and Living Space on Cell Fate and Neo-Tissue Development in Hydrogel-Based Scaffolds: A Study With Cartilaginous Model

      Changjiang Fan and Dong-An Wang

      Article first published online: 2 JAN 2015 | DOI: 10.1002/mabi.201400453

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      The effects of permeability and living space of hydrogel scaffolds on cell fate and neo-tissue development are studied, respectively. The better permeability of hydrogel facilitates cell survival and rapid proliferation. The presence of macro-porous living spaces favors the formation of larger cell clusters, which significantly enhance ECM deposition and eventually induce formation of neo-tissue.

    3. Phosphorylcholine-Modified Chitosan Films as Effective Promoters of Cell Aggregation: Correlation Between the Films Properties and Cellular Response

      Baowen Qi, Piotr Kujawa, Sayaka Toita, Grégory Beaune and Françoise M. Winnik

      Article first published online: 2 JAN 2015 | DOI: 10.1002/mabi.201400439

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      Polymer substrates composed of an adhesive part, Chitosan, and of an antifouling part, phosphorylcholine, are prepared and characterized. Surface topography, zeta potential, and protein adsorption are investigated as a function of phosphorylcholine content. These results are related to the capacity of the substrates containing most of phosphorylcholine to promote the aggregation of cells.

  8. Communications

    1. PEG-Poly(l-alanine) Thermogel As a 3D Scaffold of Bone-Marrow-Derived Mesenchymal Stem Cells

      Min Hee Park, Hyo Jung Moon, Jin Hye Park, Usha Pramod Shinde, Du Young Ko and Byeongmoon Jeong

      Article first published online: 16 DEC 2014 | DOI: 10.1002/mabi.201400426

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      Polypeptide thermogel prepared by increasing the temperature of cell suspended polymer aqueous solution to 37 °C provides an excellent 3D culture matrix of bone-marrow-derived mesenchymal stem cells. Both in vitro and in vivo studies on three-dimensional culture of the stem cells prove the preferential chondrogenic differentiation of the stem cells in the in situ formed hydrogel.

  9. Full Papers

    1. Enhanced Efficacy of Pluronic Copolymer Micelle Encapsulated SCR7 against Cancer Cell Proliferation

      Franklin John, Jinu George, Supriya V. Vartak, Mrinal Srivastava, P. A. Hassan, V. K. Aswal, Subhas. S. Karki and Sathees C. Raghavan

      Article first published online: 16 DEC 2014 | DOI: 10.1002/mabi.201400480

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      Encapsulation of 5,6-bis-(benzylideneamino)-2-mercaptopyrimidin-4-ol (SCR7) in Pluronic P123 copolymer resulted in accumulation of DNA breaks within the cells, leading to cell cycle arrest at G1 phase and activation of apoptosis. Micellar encapsulation rendered the molecule about 5 times more effective than the parenteral form.

  10. Reviews

    1. Self-assembled Monolayers and Nanocomposite Hydrogels of Functional Nanomaterials for Tissue Engineering Applications

      Nermin Seda Kehr, Seda Atay and Bahar Ergün

      Article first published online: 16 DEC 2014 | DOI: 10.1002/mabi.201400363

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      Self-assembled monolayers (SAMs) and nanocomposite (NC) hydrogels of functional nanomaterials (NMs) have gained high interest as biomaterials to mimic natural extracellular matrix and to control cell/material interactions. This paper highlights some of the recent reports on the use of SAMs and NC hydrogels of functional NMs as biomaterials particularly in cell culturing applications.

  11. Full Papers

    1. Semiconductor Polymer Dots Induce Proliferation in Human Gastric Mucosal and Adenocarcinoma Cells

      Shouying Li, Jia Chen, Geng Chen, Qiong Li, Kai Sun, Zhen Yuan, Weiping Qin, Hong Xu and Changfeng Wu

      Article first published online: 12 DEC 2014 | DOI: 10.1002/mabi.201400428

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      Highly fluorescent polymer dots induce apparent proliferation in human gastric mucosal and adenocarcinoma cells, as validated by MTT viability studies, cell cycle analysis, ROS generation, and MMP changes. The Pdot-induced cell proliferation represents a distinctive finding as most of other nanoparticles interacted with cells typically cause cell damage and inhibit cell growth.

    2. Synthesis and Functions of Well-defined Polymer-drug Conjugates as Efficient Nanocarriers for Intravesical Chemotherapy of Bladder Cancer

      Qingsong Yu, Jiajing Zhang, Guan Zhang and Zhihua Gan

      Article first published online: 12 DEC 2014 | DOI: 10.1002/mabi.201400416

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      Water-soluble polymer-doxorubicin conjugates based on poly(ethylene glycol)-b-poly(N-2-(hydroxypropyl methacrylamide)) for controlled release of anti-cancer drugs under mild acidic conditions are synthesized by RAFT polymerization and post-polymerization technique. With further indroducing targeting moiety folate, the conjugates show enhanced cytotoxicity against T24 cells.

    3. Peptide-Directed Self-Assembly of Functionalized Polymeric Nanoparticles. Part II: Effects of Nanoparticle Composition on Assembly Behavior and Multiple Drug Loading Ability

      Xu Xiang, Xiaochu Ding, Trevor Moser, Qi Gao, Tolou Shokuhfar and Patricia A. Heiden

      Article first published online: 4 DEC 2014 | DOI: 10.1002/mabi.201400438

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      A novel nanoparticle scaffolding system is demonstrated using controlled-release, drug-loaded nanoparticles that yield ordered fibers and scaffolds using ionic complementary peptide-directed self-assembly. The scaffolding system possesses the advantages of individually controlling the release of each loaded drug and the ability to control their assembly sequence.

  12. Feature Articles

    1. Recent Advances in Nanoscale Bioinspired Materials

      Melik C. Demirel, Murat Cetinkaya, Abdon Pena-Francesch and Huihun Jung

      Article first published online: 4 DEC 2014 | DOI: 10.1002/mabi.201400324

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      This feature article highlights structural and functional characteristics of bio-derived materials, which will expedite the design, fabrication, and synthesis of eco-friendly, recyclable, advanced nano-materials and devices. Recent Advances in Nanoscale Bioinspired Materials.

  13. Full Papers

    1. Engineering a Freestanding Biomimetic Cardiac Patch Using Biodegradable Poly(lactic-co-glycolic acid) (PLGA) and Human Embryonic Stem Cell-derived Ventricular Cardiomyocytes (hESC-VCMs)

      Yin Chen, Junping Wang, Bo Shen, Camie W. Y. Chan, Chaoyi Wang, Yihua Zhao, Ho N. Chan, Qian Tian, Yangfan Chen, Chunlei Yao, I-Ming Hsing, Ronald A. Li and Hongkai Wu

      Article first published online: 25 NOV 2014 | DOI: 10.1002/mabi.201400448

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      A facile method for engineering a freestanding biomimetic cardiac patch using biodegradable poly(lactic-co-glycolic acid) (PLGA) and stem cell-derived cardiomyocytes is presented. The biomimetic cardiac patch fabricated with microgrooved PLGA film recapitulates the anisotropic electrophysiological feature of native cardiac tissue and is believed to be applicable in the treatment of myocardial infarction.

    2. Multiphase Protein Microgels

      Ulyana Shimanovich, Yang Song, Jasna Brujic, Ho Cheung Shum and Tuomas P. J. Knowles

      Article first published online: 19 NOV 2014 | DOI: 10.1002/mabi.201400366

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      We show that the characteristics of aqueous two-phase systems can be exploited in combination with protein self-assembly for controlling aggregation and structuring of fibrillar proteins into 3D core–shell microgels.

    3. A Cationic Poly(2-oxazoline) with High In Vitro Transfection Efficiency Identified by a Library Approach

      Alexandra C. Rinkenauer, Lutz Tauhardt, Felix Wendler, Kristian Kempe, Michael Gottschaldt, Anja Traeger and Ulrich S. Schubert

      Article first published online: 18 NOV 2014 | DOI: 10.1002/mabi.201400334

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      An 18-membered library of cationic poly(2-oxazoline)-based copolymers has been prepared. The influence of different polymer parameters, namely the polymer side chain hydrophobicity and the type and content of amino groups, on the pDNA condensation, the transfection efficiency, the cytotoxicity, and cellular membrane interaction as well as the size, charge, and stability of the polyplexes was studied and first structure–property relationships elucidated.

    4. Protein Compatibility of Selected Cross-linking Reactions for Hydrogels

      Nadine Hammer, Ferdinand P. Brandl, Susanne Kirchhof, Viktoria Messmann and Achim M. Goepferich

      Article first published online: 14 NOV 2014 | DOI: 10.1002/mabi.201400379

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      Despite years of research, finding cross-linking reactions for hydrogels that are compatible with incorporated proteins is still challenging. The authors, therefore, investigate side reactions between a model protein and methoxypolyethylene glycol functionalized with maleimide, vinyl sulfone, acrylamide, thiol, and furyl moieties. The extent of protein modification was found to depend on the cross-linking agent and the pH during incubation.

    5. Novel Cationic Triblock Copolymer of Poly[2-(dimethylamino)ethyl methacrylate]-block-poly(β-amino ester)-block-poly[2-(dimethylamino)ethyl methacrylate]: A Promising Non-Viral Gene Delivery System

      Rosemeyre A. Cordeiro, Dina Farinha, Nuno Rocha, Arménio C. Serra, Henrique Faneca and Jorge F. J. Coelho

      Article first published online: 14 NOV 2014 | DOI: 10.1002/mabi.201400424

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      An efficient block copolymer non-viral vector composed by poly[2-(dimethylamino)ethyl methacrylate] and poly(β-amino ester) for plasmid DNA delivery. The new cationic block copolymers of poly[2-(dimethylamino)ethyl methacrylate]-b-poly(β-amino ester)-b-poly[2-(dimethylamino)ethyl methacrylate] efficiently bind pDNA and show high transfection activity in HeLa and COS-7 cell lines compared to bPEI and TurboFect™ polymeric non-viral vector standards.

    6. Targeted Delivery of Vaccine to Dendritic Cells by Chitosan Nanoparticles Conjugated with a Targeting Peptide Ligand Selected by Phage Display Technique

      Su-Na Jung, Sang-Kee Kang, Guen-Hye Yeo, Hai-Ying Li, Tao Jiang, Jae-Woon Nah, Jin-Duck Bok, Chong-Su Cho and Yun-Jaie Choi

      Article first published online: 13 NOV 2014 | DOI: 10.1002/mabi.201400352

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      Delivering antigen to dendritic cells (DCs) is a promising strategy for enhancing vaccine efficacy. A novel DC-targeting peptide ligand is isolated by phage display technique. DC-targeting peptide conjugated chitosan nanoparticles (TPC-NPs) are designed and evaluated for their targeting efficiency to DCs. Furthermore, immunization of mice with antigen-carrying TPC-NPs induces strong and balanced immune responses, demonstrating that TPC-NPs can further improve the immunogenicity of vaccine.

    7. Micellization of Antineoplastic Agent to Significantly Upregulate Efficacy and Security

      Chen Li, Weiguo Xu, Jianxun Ding, Ying Zhang, Jincheng Wang, Xiuli Zhuang and Xuesi Chen

      Article first published online: 7 NOV 2014 | DOI: 10.1002/mabi.201400356

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      Doxorubicin-incorporated micelle is prepared by noncovalent interaction-assissed nanoprecipitation of drug and methoxy poly(ethylene glycol)-block-oligo(D,L-leucine). The loading micelle exhibits enhanced cellular interalization and antiproliferative activity in vitro, improved intratumoral distribution, and upregulated antitumor efficacy and security in vivo, which all indicate its great potential for smart delivery of antineoplastic agents.

    8. Diblock Copolymers of Polyethylene Glycol and a Polymethacrylamide with Side-Chains Containing Twin Ortho Ester Rings: Synthesis, Characterization, and Evaluation as Potential pH-Responsive Micelles

      Xiaojing Zhou, Shi Luo, Rupei Tang, Rui Wang and Jun Wang

      Article first published online: 5 NOV 2014 | DOI: 10.1002/mabi.201400395

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      Block copolymers, PEG-b-PMEA, bearing twin five-membered ortho ester pendants, formed micelles with pH-responsive solubility as a result of accelerated release of payload. The micelles were compatible with cells, and paclitaxel-loaded micelles killed cancer cells with potency equivalent to free drug, suggesting potential use as effective nano-carriers for anticancer drugs without toxic side-effects.

    9. Effect of Amphiphilic PCL–PEG Nano-Micelles on HepG2 Cell Migration

      Yang Shen, Mengtian Leng, Hongchi Yu, Qin Zhang, Xianglin Luo, Hans Gregersen, Guixue Wang and Xiaoheng Liu

      Article first published online: 4 NOV 2014 | DOI: 10.1002/mabi.201400376

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      Nano-sized polymer micelles attract attentions to their biocompatibility and biodegradability in antitumor therapy. However, few investigations focus on exploring the effect of internalized nano-micelles on the cancer cells migration. We demonstrated that amphiphilic PCL–PEG NPs-induced cell migration depended on integrin-FAK-Rho GTPases pathway, which expected to evoke more attentions in the design of drug delivery systems based on polymer micelles.

    10. Degradable Glycine-Based Photo-Polymerizable Polyphosphazenes for Use as Scaffolds for Tissue Regeneration

      Sandra Rothemund, Tamara B. Aigner, Aitziber Iturmendi, Maria Rigau, Branislav Husár, Florian Hildner, Eleni Oberbauer, Martina Prambauer, Gbenga Olawale, Reinhard Forstner, Robert Liska, Klaus R. Schröder, Oliver Brüggemann and Ian Teasdale

      Article first published online: 30 OCT 2014 | DOI: 10.1002/mabi.201400390

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      Hydrolytically degradable, porous matrices are prepared via a mild and simple photopolymerization of functionalized poly(organo)phosphazenes. The modular system allows for facile surface functionalization and property tuning. The novel materials are biocompatible and have tunable degradation rates to non-toxic small molecules and thus are promising for use as synthetic scaffolds for tissue regeneration.

    11. Substrate-induced PC12 Cell Differentiation Without Filopodial, Lamellipodial Activity or NGF Stimulation

      Guillaume Lamour, Sylvie Souès and Ahmed Hamraoui

      Article first published online: 28 OCT 2014 | DOI: 10.1002/mabi.201400323

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      PC12 cells are driven to extend neurites through cell-substrate interactions only, that is, without nerve growth factor (NGF) stimulation. Actin polymerization is destabilized by treating the cells with cytochalasin. As a result the cells are deprived of both filopodia and lamellipodia. However, they extend neurites continuously. This shows that neither filopodia nor lamellipodia are required to trigger substrate-induced neuronal differentiation of PC12 cells.

    12. Poly(anhydride-ester) and Poly(N-vinyl-2-pyrrolidone) Blends: Salicylic Acid-Releasing Blends with Hydrogel-Like Properties that Reduce Inflammation

      Michelle A. Ouimet, Renata Fogaça, Sabrina S. Snyder, Sameer Sathaye, Luiz H. Catalani, Darrin J. Pochan and Kathryn E. Uhrich

      Article first published online: 21 OCT 2014 | DOI: 10.1002/mabi.201400238

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      Hydrogels-like polymer blends that combine the biocompatibility and hydrophilicity of PVP with controlled release of salicylic acid to reduce inflammation are presented. These copolymer blends substantially reduce the inflammatory cytokine, TNF-α, in vitro and indicate no cytotoxic or anti-proliferative effects. Based upon the unique combination, these blended polymer films show great potential for wound healing.

    13. Multi-Technique Characterization of Poly-L-lysine Dendrigrafts–Cu(II) Complexes for Biocatalysis

      Jean-Christophe Rossi, Barbara Maret, Kevin Vidot, Jean-Patrick Francoia, Michela Cangiotti, Susanna Lucchi, Concetta Coppola and Maria Francesca Ottaviani

      Article first published online: 20 OCT 2014 | DOI: 10.1002/mabi.201400341

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      Significant structural features of poly-L-lysine dendrigrafts (DGLs) – Cu(II) complexes are characterized to implement the use of these complexes as biocatalysts. The agreement and complementarity among EPR, potentiometric titration, UV-Vis and CD measurements provide an exhaustive view of the Cu(II)-DGL complexation behavior as a function of DGL generation, relative concentrations, and pH.

  14. Feature Articles

    1. Thermoresponsive Nanodevices in Biomedical Applications

      Julián Bergueiro and Marcelo Calderón

      Article first published online: 16 OCT 2014 | DOI: 10.1002/mabi.201400362

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      Thermoresponsive nanodevices are one of the most promising systems in nanomedicine. Due to new building blocks, a number of promising smart systems have been rapidly developed in response to the needs of nanomedicine. This article reviews the innovations in this field from the last four years.

  15. Full Papers

    1. Porous Polylactic Acid–Silica Hybrids: Preparation, Characterization, and Study of Mesenchymal Stem Cell Osteogenic Differentiation

      Christos Pandis, Sara Trujillo, Joana Matos, Sara Madeira, Joaquín Ródenas-Rochina, Sotiria Kripotou, Apostolos Kyritsis, João F. Mano and José Luis Gómez Ribelles

      Article first published online: 10 OCT 2014 | DOI: 10.1002/mabi.201400339

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      Polymer/silica porous hybrids are prepared by a novel strategy using sol–gel reactions inside the pores of polylactic acid (PLA) membranes. The link between organic and inorganic phase is achieved by functionalizing PLA and using glycidoxypropyltrimethoxysilane (GPTMS) as coupling agent. The adjustment of silica precursors ratio allows modifying the thermomechanical properties. The proliferation and osteoblastic differentiation potential is studied.

    2. Biocompatible, Biodegradable and Porous Liquid Crystal Elastomer Scaffolds for Spatial Cell Cultures

      Anshul Sharma, Abdollah Neshat, Cory J. Mahnen, Alek d. Nielsen, Jacob Snyder, Tory L. Stankovich, Benjamin G. Daum, Emily M. LaSpina, Gabrielle Beltrano, Yunxiang Gao, Shuo Li, Byung-Woo Park, Robert J. Clements, Ernest J. Freeman, Christopher Malcuit, Jennifer A. McDonough, LaShanda T. J. Korley, Torsten Hegmann and Elda Hegmann

      Article first published online: 10 OCT 2014 | DOI: 10.1002/mabi.201400325

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      A new trick for LC elastomers: Biocompatible, biodegradable and porous liquid crystal (LC) elastomers were used for the first time as viable, soft scaffolds for cell growth and proliferation in a spatial (3D) fashion.

    3. Microcellular Open Porous Monoliths for Cell Growth by Thiol-Ene Polymerization of Low-Toxicity Monomers in High Internal Phase Emulsions

      Maja Sušec, Robert Liska, Günter Russmüller, Jiři Kotek and Peter Krajnc

      Article first published online: 8 OCT 2014 | DOI: 10.1002/mabi.201400219

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      Combination of high internal phase emulsion templating and thiol-ene polymerization of vinyl esters and thiols produced highly porous polymers with an interconnected morphology and tunable pore size. Usefulness of novel material is demonstrated by application as a scaffold for in vitro osteoblasts growth.

  16. Reviews

    1. Tissue-Engineered Cartilage: The Crossroads of Biomaterials, Cells and Stimulating Factors

      Nandana Bhardwaj, Dipali Devi and Biman B. Mandal

      Article first published online: 3 OCT 2014 | DOI: 10.1002/mabi.201400335

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      Over the years, cartilage tissue engineering is growing by leaps and bounds. Not only are various biomaterials being opted for repair, but newer methodologies being invented. With an aim to present an overview of current progress, we have summed up the advances and problems in cartilage regeneration with strong emphasis on material types, cells, stimulating factors and culture conditions.

  17. Full Papers

    1. Adsorption of Fibronectin on Salt-Etched Polyelectrolyte Multilayers and its Roles in Mediating the Adhesion and Migration of Vascular Smooth Muscle Cells

      Jun Deng, Mingcong Sun, Shasha Wang, Lulu Han, Zhengwei Mao, Dan Li, Hong Chen and Changyou Gao

      Article first published online: 3 OCT 2014 | DOI: 10.1002/mabi.201400344

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      The adsorption of fibronectin (Fn) and the adhesion and migration of vascular smooth muscle cells (VSMCs) are characterized and correlated on salt-treated PEI(PSS/PDDA)7 multilayers. The swelling properties and surface charge of the salt-treated multilayers jointly govern the adsorption manner, conformation, and activity of Fn, which in turn contribute heavily to the adhesion, spreading, and migration of VSMCs.

    2. New Semi-Biodegradable Materials from Semi-Interpenetrated Networks of Poly(ϵ-caprolactone) and Poly(ethyl acrylate)

      P. Lozano Picazo, M. Pérez Garnes, C. Martínez Ramos, A. Vallés-Lluch and M. Monleón Pradas

      Article first published online: 30 SEP 2014 | DOI: 10.1002/mabi.201400331

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      Semi-degradable materials may have find applications. Poly-(ethyl acrylate) and poly(ϵ-caprolactone) are here combined as semi-IPNs. Materials are obatined which combine their outstanding biological properties and possess mechanical properties tunable in a wide range of moduli. The behavior of fibroblasts and adipose-tissue-derived stem cells on these new materials is studied.

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