Novel Linear Polymers Able to Inhibit Bacterial Quorum Sensing
Eliana Cavaleiro PhD, Ana Sofia Duarte PhD, Ana Cristina Esteves PhD, António Correia PhD, Michael J. WhitcombePhD, Elena V. Piletska PhD, Sergey A. Piletsky PhD and Iva Chianella PhD
Article first published online: 28 JAN 2015 | DOI: 10.1002/mabi.201400447
The conventional treatment of bacterial infections is based on the administration of antibiotics, which promotes bacterial resistance. We present the development of linear polymers able to disrupt quorum sensing as shown by the reduction of bacterial bioluminescence and biofilm formation. The polymers could be used to control bacterial virulence without promoting resistance, thus constituting a safe alternative to the use of antibiotics.