Macromolecular Bioscience

Cover image for Vol. 14 Issue 8

Early View (Online Version of Record published before inclusion in an issue)

VIEW

  1. 1 - 40
  1. Full Papers

    1. Novel Poly(Ethylene Oxide)-b-Poly(Propylene Oxide) Copolymer-Glucose Conjugate by the Microwave-Assisted Ring Opening of a Sugar Lactone

      Romina J. Glisoni and Alejandro Sosnik

      Article first published online: 27 AUG 2014 | DOI: 10.1002/mabi.201400235

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      The surface modification of Pluronic® F127 polymeric micelles with glucose residues by means of a fast and efficient ring opening reaction of gluconolactone leads to their recognition by a soluble vegetal lectin, Concanavalin A, and their subsequent agglutination.

    2. Stabilization of Gelatin Nanoparticles Without Crosslinking

      Saeed Ahmad Khan and Marc Schneider

      Article first published online: 26 AUG 2014 | DOI: 10.1002/mabi.201400214

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      Crosslinking free preparation of gelatin nanoparticles is described, offering a flexible drug carrier system for hydrophilic materials. The structural integrity of gelatin nanoparticles is kept intact by coating them with Eudragit® E 100 forming hybrid nanospheres. For preparation, a hybrid technique of nanoprecipitation-emulsion solvent evaporation is employed.

    3. Synthesis of Homopolypeptides by Aminolysis Mediated by Proteases Encapsulated in Silica Nanospheres

      Peter J. Baker, Siddharth V. Patwardhan and Keiji Numata

      Article first published online: 25 AUG 2014 | DOI: 10.1002/mabi.201400295

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      The encapsulation of three different proteases (bromelain, papain, and trypsin) in bioinspired silica enhances their thermal stability for both hydrolysis and aminolysis reactions. The enhanced thermal activity resulted in increased production of poly-L-leucine, poly-L-alanine, and poly-L-valine by protease-mediated aminolysis at 50 °C.

    4. Boronic Acid Shell-Crosslinked Dextran-b-PLA Micelles for Acid-Responsive Drug Delivery

      Ziwei Zhao, Xuemei Yao, Zhe Zhang, Li Chen, Chaoliang He and Xuesi Chen

      Article first published online: 21 AUG 2014 | DOI: 10.1002/mabi.201400251

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      3-carboxy-5-nitrophenylboronic acid (CNPBA) shell-crosslinked micelles based on amphiphilic dextran-block-polylactide (Dex-b-PLA) are prepared and used for efficient intracellular drug delivery. The pH-responsive biodegradable CNPBA-Dex-b-PLA can efficiently load and deliver DOX into tumor cells and enhance the inhibition of cellular proliferation in vitro, providing a favorable platform as a drug delivery system for cancer therapy.

    5. Functional Brush-Decorated Poly(globalide) Films by ARGET-ATRP for Bioconjugation

      Zeliha Ates, Fabrice Audouin, Amy Harrington, Brendan O'Connor and Andreas Heise

      Article first published online: 21 AUG 2014 | DOI: 10.1002/mabi.201400282

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      Poly(acrylic) acid brushes were grafted from polyester films obtained from the unsaturated macrolactone globalide by ARGET ATRP of tert.-butyl acrylate. After mild in situ deprotection high-density acrylic acid functional films were obtained while avoiding polyester hydrolysis. The conjugation with green fluorescent protein (GFP) and an enzyme was successfully carried out retaining the enzymatic activity.

    6. Monodisperse Carboxyl-Functionalized Poly(Ethylene Glycol)-Coated Magnetic Poly(Glycidyl Methacrylate) Microspheres: Application to the Immunocapture of β-Amyloid Peptides

      Daniel Horák, Helena Hlídková, Mohamed Hiraoui, Myriam Taverna, Vladimír Proks, Eliška Mázl Chánová, Claire Smadja and Zdenka Kučerová

      Article first published online: 21 AUG 2014 | DOI: 10.1002/mabi.201400249

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      Monodisperse magnetic poly(glycidyl methacrylate) microspheres coated with α-amino-ω-methoxy-PEG5000/α-amino-ω-Boc-NH-PEG5000 substantially reduced non-specific protein adsorption. Anti-Aβ 6E10-immobilized microspheres specifically captured β-amyloid peptide (Aβ) from model solutions. Identification and evaluation of small changes in Aβ levels in cerebrospinal fluid is of crucial importance for early detection of Alzheimer's disease.

  2. Communication

    1. Micropatterning Electrospun Scaffolds to Create Intrinsic Vascular Networks

      Eric M. Jeffries, Shintaro Nakamura, Kee-Won Lee, Jimmy Clampffer, Hiroyuki Ijima and Yadong Wang

      Article first published online: 20 AUG 2014 | DOI: 10.1002/mabi.201400306

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      Engineered microvasculature that effectively perfuses the parenchyme and directly integrates with host circulation remains the challenge of organ engineering. Described is a method for patterning microvascular structures in electrospun scaffolds using water-soluble templates produced by fused deposition modeling. The fibrous nature mimicks extracellular matrix and permits nutrient diffusion. Additionally, scaffolds are biodegradable and suturable. In vitro endothelialization demonstrates feasible vascularization.

  3. Full Papers

    1. Electrospun Honeycomb as Nests for Controlled Osteoblast Spatial Organization

      Salima Nedjari, Sandy Eap, Anne Hébraud, Corinne R. Wittmer, Nadia Benkirane-Jessel and Guy Schlatter

      Article first published online: 19 AUG 2014 | DOI: 10.1002/mabi.201400226

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      PCL and PLA nanofibrous scaffolds with honeycomb micro-patterns are prepared by electrospinning. It is shown that the relief of the scaffolds depends on the distribution of fiber diameters. Mimicking hemi-osteons, cell gathering is observed inside the PCL honeycomb fibrous nests with a characteristic size greater than 80 μm.

    2. An Orthogonal Click-Chemistry Approach to Design Poly(glycerol monomethacrylate)-based Nanomaterials for Controlled Immunostimulation

      Lakshminarayanan Ragupathy, Douglas G. Millar, Nicola Tirelli and Francesco Cellesi

      Article first published online: 18 AUG 2014 | DOI: 10.1002/mabi.201400146

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      Immune active polymers based on poly(glycerol monomethacrylate) (PGMMA) are presented. Propargyl-terminated PGMMAs, modified with dangling acrylate groups, are conjugated with thiomannose through Michael-type addition. Orthogonal azide-alkyne cycloaddition can be used to prepare a final traceable nanomaterial. Depending on the mannose content, these polymers can activate dendritic cells, stimulating cytokine (TNFα) and surface activation marker (CD40) expression.

    3. Telechelic Poly(2-oxazoline)s with a Biocidal and a Polymerizable Terminal as Collagenase Inhibiting Additive for Long-Term Active Antimicrobial Dental Materials

      Christoph P. Fik, Stefan Konieczny, David H. Pashley, Christian J. Waschinski, Reinhild S. Ladisch, Ulrich Salz, Thorsten Bock and Joerg C. Tiller

      Article first published online: 8 AUG 2014 | DOI: 10.1002/mabi.201400220

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      A dental adhesive is rendered antimicrobially contact-active by an additive based on poly(2-methyloxazoline) equipped with a biocidal and a polymerizable end group. The polymeric additive also kills cariogenic bacteria in dentin tubuli and inhibits collagenases, such as human MMP that naturally adhere to dental tissue for preventing dentin degradation below a dental restoration.

    4. Stable Biochemically Micro-patterned Hydrogel Layers Control Specific Cell Adhesion and Allow Long Term Cyclic Tensile Strain Experiments

      Alexandra M. Greiner, Peter Hoffmann, Kristina Bruellhoff, Simon Jungbauer, Joachim P. Spatz, Martin Moeller, Ralf Kemkemer and Jürgen Groll

      Article first published online: 6 AUG 2014 | DOI: 10.1002/mabi.201400261

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      PDMS coated with sP(EO-stat-PO) is patterned with fibronectin by micro-contact printing and used for studies with human dermal fibroblasts exposed to uniaxial cyclic tensile strain (CTS). The coating has long term specific protein and cell anti- and pro-adhesive properties. The cells align along the fibronectin lines and orient accordingly their actin fibers independently of the direction of CTS application.

    5. A Novel Crosslinked Hyaluronic Acid Nanogel for Drug Delivery

      Sílvia Santos Pedrosa, Catarina Gonçalves, Laurent David and Miguel Gama

      Article first published online: 4 AUG 2014 | DOI: 10.1002/mabi.201400135

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      A simple two-step method is developed for the synthesis of a redox sensitive hyaluronic acid nanogel. Hyaluronic acid is chemically grafted with a thiolated alkyl chain that allows the reticulation of the self assembled nanogel by dissulfide bond. The nanogel presents high stability and drug loading efficiency.

    6. Rapid Flow Through Immunoassay for CRP Determination Based on Polyethylene Filters Modified with ω-Aminocellulose Carbamate

      Thomas Elschner, Friedrich Scholz, Peter Miethe and Thomas Heinze

      Article first published online: 4 AUG 2014 | DOI: 10.1002/mabi.201400179

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      A new covalent antibody immobilization method based on ω-aminocellulose carbamate coatings is investigated. The flow through immunoassay for CRP determination possesses a very low limit of detection (5 ng CRP mL−1) and a high precision (CV < 9.1%).

    7. 18F-Radiolabeling, Preliminary Evaluation of Folate-pHPMA Conjugates via PET

      Hanno Schieferstein, Annette Kelsch, Achim Reibel, Kaloian Koynov, Matthias Barz, Hans-Georg Buchholz, Nicole Bausbacher, Oliver Thews, Rudolf Zentel and Tobias L. Ross

      Article first published online: 4 AUG 2014 | DOI: 10.1002/mabi.201400200

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      For two new 18F-labeled pHPMA copolymers, which are functionalized with folate units, active targeting can be proved in vivo (Walker carcinoma) by blockade studies.

    8. Bioreducible Branched Polyethyleneimine Derivatives Physically Loaded with Hydrophobic Pheophorbide A: Preparation, Characterization, and Light-Induced Cytotoxicity

      Hana Cho, Li Li, You Han Bae, Kang Moo Huh and Han Chang Kang

      Article first published online: 1 AUG 2014 | DOI: 10.1002/mabi.201400145

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      Branched types of polyethyleneimine (bPEI) derivatives can load hydrophobic photosensitizers in neutral or basic pH-tuned hydrophobic cavities. However, drug release from bPEI derivatives is not activated by acidic pH but by cytosol-specific triggered biodegradation. This mechanism results in light-mediated cytotoxic effects when photosensitizer-loaded reducible bPEI derivatives are used that are not seen when non-reducible bPEI derivatives are used.

    9. Nanoparticle/Polymer Assembled Microcapsules with pH Sensing Property

      Pan Zhang, Xiaoxue Song, Weijun Tong and Changyou Gao

      Article first published online: 1 AUG 2014 | DOI: 10.1002/mabi.201400259

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      The dual-labeled microcapsules via nanoparticle/polymer assembly based on polyamine–salt aggregates are fabricated for the ratiometric intracellular pH sensing. The microcapsules are internalized by several kinds of cells naturally, and after being internalized they are all located in acidic organelles. Negatively charged drugs are easily encapsulated into capsules.

    10. Hybrid Polyglycerols with Long Blood Circulation: Synthesis, Biocompatibility, and Biodistribution

      Muhammad Imran ul-haq, Benjamin F. L. Lai and Jayachandran N. Kizhakkedathu

      Article first published online: 11 JUL 2014 | DOI: 10.1002/mabi.201400152

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      Hybrid polyglycerols (inline image ≈ 100 kDa) with different compositions (15–80 mol% linear polyglycerol) with excellent blood and cell compatibility are synthesized. The polymers show long blood circulation with minimal organ accumulation in mice and are attractive for the development of multifunctional drug delivery systems.

    11. Cell–Microsphere Constructs Formed with Human Adipose-Derived Stem Cells and Gelatin Microspheres Promotes Stemness, Differentiation, and Controlled Pro-Angiogenic Potential

      Anjaneyulu Kodali, Thiam Chye Lim, David Tai Leong and Yen Wah Tong

      Article first published online: 1 JUL 2014 | DOI: 10.1002/mabi.201400094

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      Three-dimensional cell–microsphere constructs formed with gelatin microspheres are found to be suitable platforms for the growth and differentiation of adipose-derived stem cells (ADSCs). These constructs also tend to preserve the stemness properties of the ADSCs along with enhancing their pro-angiogenic properties.

    12. Toward Anticancer Immunotherapeutics: Well-Defined Polymer–Antibody Conjugates for Selective Dendritic Cell Targeting

      Kristof Tappertzhofen, Monika Bednarczyk, Kaloian Koynov, Matthias Bros, Stephan Grabbe and Rudolf Zentel

      Article first published online: 30 JUN 2014 | DOI: 10.1002/mabi.201400190

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      The synthesis of multifunctionalizable semitelechelic maleimide-modifided HPMA based polymers of narrow dispersity that can be conjugated to anti-DEC-205 antibodies affording “star-like” topologies is described. Primary in vitro studies show their high potential to target dendritic cells (DCs). This opens the opportunity to present tumor antigens to DCs and thus to induce antitumor immune responses.

    13. Enzymatic Synthesis of Dendritic Amphoteric α-Glucans by Thermostable Phosphorylase Catalysis

      Yusei Takata, Riko Shimohigoshi, Kazuya Yamamoto and Jun-Ichi Kadokawa

      Article first published online: 30 JUN 2014 | DOI: 10.1002/mabi.201400204

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      Enzymatic synthesis of dendritic amphoteric α-glucans having both glucuronic acid and glucosamine residues at the non-reducing ends is performed by phosphorylase catalysis, which shows inherent isoelectric points and assembling/disassembling behaviors in water in accordance of the pH values.

    14. Synthesis of Functionalized Poly(ester carbonate) with Laminin-Derived Peptide for Promoting Neurite Outgrowth of PC12 cells

      Dongming Xing, Lie Ma and Changyou Gao

      Article first published online: 25 JUN 2014 | DOI: 10.1002/mabi.201400186

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      Laminin-derived peptide functionalized poly(ester carbonate) (PEC) is synthesized to promote neurite outgrowth of PC12 cells. The maleimide-functionalized PECs are clicked with various thiol-containing molecules. The CQAASIKVAV-grafted PEC could support cell proliferation and neurite outgrowth. Therefore, the maleimide-functionalized PECs can serve as a versatile platform for diverse functionalization and have comprehensive potential in biomedical applications.

    15. Thermoresponsive Double Network Micropillared Hydrogels for Controlled Cell Release

      Ruochong Fei, Huijie Hou, Dany Munoz-Pinto, Arum Han, Mariah S. Hahn and Melissa A. Grunlan

      Article first published online: 23 JUN 2014 | DOI: 10.1002/mabi.201400172

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      Thermoresponsive poly(N-isopropylacrylamide) (PNIPAAm) hydrogels may achieve “self-cleaning” via thermal cycling to cause cellular detachment. In this work, a double network (DN) design and micropatterning approaches are utilized for enhancing deswelling-driven cell release. DN hydrogels exhibit enhanced thermosensitivity and cell release efficiency versus the conventional single network (SN) hydrogel, particularly for the micropillar arrays.

    16. Hydrophobic Polyalanine Modified Hyperbranched Polyethylenimine as High Efficient pDNA and siRNA Carrier

      Zhaopei Guo, Huayu Tian, Lin Lin, Jie Chen, Chaoliang He, Zhaohui Tang and Xuesi Chen

      Article first published online: 20 JUN 2014 | DOI: 10.1002/mabi.201400044

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      Successful gene therapy for cancer and various human genetic diseases treatment relies on high efficient gene carriers. But for most carriers, either DNA or RNA can be effectively delivered. Here, amphiphilic copolymers polyethylenimine-polyalanine, with good biocompatibility, are prepared for high efficient transfection both in DNA and RNA.

    17. Star-Shape Redox-Responsive PEG-Sheddable Copolymer of Disulfide-Linked Polyethylene Glycol-Lysine-di-Tocopherol Succinate for Tumor-Triggering Intracellular Doxorubicin Rapid Release: Head-to-Head Comparison

      Xiaoyu Ai, Jin Sun, Lu Zhong, Chunnuan Wu, Handong Niu, Tao Xu, He Lian, Xiaopeng Han, Guolian Ren, Wenya Ding, Jia Wang, Xiaohui Pu and Zhonggui He

      Article first published online: 20 JUN 2014 | DOI: 10.1002/mabi.201400149

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      Self-assembled redox-responsive nanomicelles are endocytosed into tumor cells. Then, disulfide bonds in micelles are cleaved and poly(ethylene glycol) (PEG) hydration shell is shed, induced by the high glutathione concentration. The nanomicelles are disassembled and the loaded doxorubicin (DOX) is released into the plasma and translocates into the nucleus to exert its anticancer effect.

    18. Protease-Sensitive PEG Hydrogels Regulate Vascularization In Vitro and In Vivo

      Marina Vigen, Jacob Ceccarelli and Andrew J. Putnam

      Article first published online: 18 JUN 2014 | DOI: 10.1002/mabi.201400161

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      Co-encapsulation of endothelial cells and supportive fibroblasts within proteolyzable poly(ethylene glycol) (PEG)-based hydrogels led to vascular morphogenesis in vitro that was robust to changes in crosslinking peptide identity, but was significantly attenuated by gel crosslinking and MMP inhibition. In vivo, perfused vasculature formed from transplanted cells in all gel types, and vascularization was not attenuated in more crosslinked gels.

    19. Introducing PeptoPlexes: Polylysine-block-Polysarcosine Based Polyplexes for Transfection of HEK 293T Cells

      Philipp Heller, Alexander Birke, David Huesmann, Benjamin Weber, Karl Fischer, Angelika Reske-Kunz, Matthias Bros and Matthias Barz

      Article first published online: 18 JUN 2014 | DOI: 10.1002/mabi.201400167

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      The synthesis, characterization, and application of polypeptide-polypeptoid block copolymers and polyplexes thereof based on the body's own amino acids sarcosine and lysine are presented. The pathway to PLys-block-PSar and the use of the synthesized block ionomers for the formation of polyplexes (PeptoPlexes) and for first transfection studies in HEK 293T cells are described.

    20. Cisplatin Loaded Methoxy Poly (ethylene glycol)-block-Poly (L-glutamic acid-co-L-Phenylalanine) Nanoparticles against Human Breast Cancer Cell

      Zaheer Ahmad, Zhaohui Tang, Afzal Shah, Shixian Lv, Dawei Zhang, Ying Zhang and Xuesi Chen

      Article first published online: 16 JUN 2014 | DOI: 10.1002/mabi.201400109

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      Novel cisplatin loaded nanoparticles of poly (amino acids) block copolymers with two different formulations, CDDP/PGlu10 and CDDP/PGlu20, are synthesized. The CDDP-loaded nanoparticles show remarkably longer blood circulation time than free cisplatin. Due to its higher hydrophobic moity content, the CDDP/PGlu10 exhibits enhanced stability and prolonged circulation time as compared to CDDP/PGlu20.

  4. Communication

    1. Zwitterionic Red Fluorescent Polymeric Nanoparticles for Cell Imaging

      Haiyin Li, Xiqi Zhang, Xiaoyong Zhang, Bin Yang, Yang Yang, Zengfang Huang and Yen Wei

      Article first published online: 13 JUN 2014 | DOI: 10.1002/mabi.201400223

      Thumbnail image of graphical abstract

      Cross-linked zwitterionic red fluorescent copolymers are fabricated by incorporating phospholipid monomer and aggregation-induced emission dye-based dimer via reversible addition–fragmentation transfer polymerization. These cross-linked polymers are easy to self-assembly into uniform nanoparticles that show high water dispersibility, intense red fluorescence, and excellent biocompatibility, making them promising for cell imaging applications.

  5. Full Papers

    1. Miktoarm Star Polymer Based Multifunctional Traceable Nanocarriers for Efficient Delivery of Poorly Water Soluble Pharmacological Agents

      Ghareb M. Soliman, Rocio Redon, Anjali Sharma, Diana Mejía, Dusica Maysinger and Ashok Kakkar

      Article first published online: 6 JUN 2014 | DOI: 10.1002/mabi.201400123

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      Miktoarm stars containing a covalently linked dye self-assemble into inherently fluorescent nanocarriers which perform multiple functions including enhanced hydrophobic drug solubilization, sustained release, and tracking their cellular fate.

    2. Nanoparticles of Esterified Polymalic Acid for Controlled Anticancer Drug Release

      Alberto Lanz-Landázuri, José Portilla-Arias, Antxon Martínez de Ilarduya, Montserrat García-Alvarez, Eggehard Holler, Julia Ljubimova and Sebastián Muñoz-Guerra

      Article first published online: 6 JUN 2014 | DOI: 10.1002/mabi.201400124

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      100–300 nm particles of microbial poly(β,L-malic acid), partially esterified with ethanol, degrade in physiological environments to L-malic acid and ethanol. Doxorubicin (DOX) loaded particles steadily release the drug for weeks whereas Temozolomide is fully liberated within hours. These particles are shown to favor internalization of DOX in glioma cells.

    3. Chitosan Microsphere Scaffold Tethered with RGD-Conjugated Poly(methacrylic acid) Brushes as Effective Carriers for the Endothelial Cells

      Zhenyi Yang, Shaojun Yuan, Bin Liang, Yang Liu, Cleo Choong and Simo O. Pehkonen

      Article first published online: 4 JUN 2014 | DOI: 10.1002/mabi.201400136

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      Chitosan (CS) microspheres are functionalized with RGD-poly(methacrylic acid) conjugates by surface-initiated atom transfer polymerization of methacrylate sodium and carbodiimide chemistry of RGD peptide. The favorable cell adhesion and proliferation of human umbilical vein endothelial cells (HUVECs) are observed on the RGD-immobilized microspheres as compared the pristine CS microspheres.

    4. Bioengineered Silk Gene Delivery System for Nuclear Targeting

      Sezin Yigit, Olena Tokareva, Antonio Varone, Irene Georgakoudi and D. L. Kaplan

      Article first published online: 30 MAY 2014 | DOI: 10.1002/mabi.201400113

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      A novel design of recombinant spider silk plasmid for gene delivery and nuclear targeting is established by combining endosomal escape unit and a viral transactivation peptide sequence. Non-viral polyplexes formed by condensing pDNA and the recombinant protein show increased localization around nucleus and high-transfection values as well as excellent biocompatibility.

    5. Charge-Conversional and pH-Sensitive PEGylated Polymeric Micelles as Efficient Nanocarriers for Drug Delivery

      Gong-Yan Liu, Min Li, Cong-Shan Zhu, Qiao Jin, Zong-Cai Zhang and Jian Ji

      Article first published online: 28 MAY 2014 | DOI: 10.1002/mabi.201400162

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      Charge-conversion and pH-sensitive PEGylated polymeric micelles with nano-sizes are prepared as drug carries. Anti-cancer drugs can be loaded into the micelle core formed by hydrophobic amide. At acidic tumor environment, the hydrolysis of amide bonds results in a negative-to-positive charge conversion and disassembly of the micelles, with simultaneously pH-triggered drug release.

    6. Biocatalytic Synthesis of Maltodextrin-Based Acrylates from Starch and α-Cyclodextrin

      Wouter M. J. Kloosterman, Gerda Spoelstra-van Dijk and Katja Loos

      Article first published online: 26 MAY 2014 | DOI: 10.1002/mabi.201400091

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      The cyclodextrin glycosyltransferase from Bacillus macerans is found to catalyze the transglycosidation of 2-(β-glucosyloxy)-ethyl acrylate with starch and α-cylcodextrin to yield novel 2-(β-maltooligooxy)-ethyl-acrylate and methacrylate monomers. The maltooligooxy-acrylate monomers are subsequently polymerized by aqueous free radical polymerization to yield a new kind of comb-shaped glycopolymers.

    7. Functionalized Polyglycerol Amine Nanogels as Nanocarriers for DNA

      Markus Hellmund, Haixia Zhou, Olga Samsonova, Pia Welker, Thomas Kissel and Rainer Haag

      Article first published online: 26 MAY 2014 | DOI: 10.1002/mabi.201400144

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      Polyglycerol amine nanogels are studied as cationic carrier systems for non-viral DNA delivery and show successful cellular uptake. These homogeneous nanogels with a size of ≈ 100 nm and a varying percentage of amine groups demonstrate a different polyplex formation behavior due to polyvalency.

    8. Poly(2-Hydroxyethyl Methacrylate)-b-Poly(L-Lysine) Cationic Hybrid Materials for Non-Viral Gene Delivery in NIH 3T3 Mouse Embryonic Fibroblasts

      Renjith P. Johnson, Saji Uthaman, Johnson V. John, Min Seon Heo, In Kyu Park, Hongsuk Suh and Il Kim

      Article first published online: 23 MAY 2014 | DOI: 10.1002/mabi.201400071

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      This work investigates new biocompatible polycationic hybrid materials, poly[(2-hydroxyethyl methacrylate)-b-(L-lysine)], as the non-viral gene vectors for pDNA delivery into mouse embryonic fibroblast cells. The biocompatible cationic vectors have a great potential as a promising candidate for future gene therapeutic applications.

    9. Injectable In Situ Forming Hybrid Iron Oxide-Hyaluronic Acid Hydrogel for Magnetic Resonance Imaging and Drug Delivery

      Yu Zhang, Yi Sun, Xia Yang, Jöns Hilborn, Arend Heerschap and Dmitri A. Ossipov

      Article first published online: 23 MAY 2014 | DOI: 10.1002/mabi.201400117

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      Iron oxide nanoparticles are encapsulated in the hydrophobic fluorescent core of “click” cross-linkable nanogels of hyaluronic acid. These nanogels are in situ converted into a bulk hydrogel and subsequently liberated through enzymatic degradation of the hydrogel to provide magnetic resonance imaging of the degradation process.

    10. Polylysine Crosslinked AIE Dye Based Fluorescent Organic Nanoparticles for Biological Imaging Applications

      Meiying Liu, Xiqi Zhang, Bin Yang, Liangji Liu, Fengjie Deng, Xiaoyong Zhang and Yen Wei

      Article first published online: 22 MAY 2014 | DOI: 10.1002/mabi.201400140

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      A novel one-pot method for the fabrication of crosslinked RO-OA-Ply FONs, which occurs at room temperature in air without catalyst or initiator, is discussed. These readily assemble into FONs in pure aqueous solution, exhibiting strong red fluorescence, high water dispersibility, uniform morphology, and excellent biocompatibility, making them potentially suitable for various biomedical applications.

    11. Polymersomes from Polypeptide Containing Triblock Co- and Terpolymers for Drug Delivery against Pancreatic Cancer: Asymmetry of the External Hydrophilic Blocks

      Hermis Iatrou, Konstantinos Dimas, Manos Gkikas, Chrisida Tsimblouli and Sosanna Sofianopoulou

      Article first published online: 19 MAY 2014 | DOI: 10.1002/mabi.201400137

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      Model amphiphilic poly(L-lysine hydrochloride)-b-poly(γ-benzyl(d7)-L-glutamate)-b-poly(L-lysine hydrochloride) and poly(ethylene oxide)-b-poly(γ-benzyl-L-glutamate)-b-poly(L-lysine hydrochloride) are synthesized. Both form polymersomes in water and are loaded with doxorubicin or paclitaxel. Due to asymmetry of the hydrophilic blocks, poly(ethylene oxide) is always on the periphery. The loaded polymersomes are tested in vivo and in vitro against human pancreatic cancer cell lines.

    12. Tailor-Made Nanocontainers for Combined Magnetic-Field-Induced Release and MRI

      Markus B. Bannwarth, Sandro Ebert, Maximilian Lauck, Ulrich Ziener, Stephanie Tomcin, Gerhard Jakob, Kerstin Münnemann, Volker Mailänder, Anna Musyanovych and Katharina Landfester

      Article first published online: 9 MAY 2014 | DOI: 10.1002/mabi.201400122

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      All-in-one nanocontainers: Tailor-made nanocapsules with integrated superparamagnetic nanoparticles and equipped with a thermo-labile shell possess dual-functionality. After efficient encapsulation of a model dye, a release of the payload can be externally triggered by application of an alternating magnetic field. Additionally, the nanocontainers with encapsulated magnetic nanoparticles can act as contrast agents for magnetic resonance imaging.

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