Tuning the Surface of Nanoparticles: Impact of Poly(2-ethyl-2-oxazoline) on Protein Adsorption in Serum and Cellular Uptake
Olga Koshkina, Dana Westmeier, Thomas Lang, Christoph Bantz, Angelina Hahlbrock, Christian Würth, Ute Resch-Genger, Ulrike Braun, Raphael Thiermann, Christoph Weise, Murat Eravci, Benjamin Mohr, Helmut Schlaad, Roland H. Stauber, Dominic Docter, Annabelle Bertin and Michael Maskos
Version of Record online: 9 JUN 2016 | DOI: 10.1002/mabi.201600074
While biomedical applications of nanoparticles are steadily increasing, undesirable adsorption of biomolecules in biological fluids represents one major challenge. Here, biocompatible poly(2-ethyl-2-oxazoline) (PEtOx) for the stealth modification of nanoparticles is probed. Comparing protein adsorption and cellular uptake of PEtOxylated nanoparticles to other modifications, it is demonstrated that PEtOx is at least as effective as the gold standard poly(ethylene glycol).