Biocompatible Size-Defined Dendrimer–Albumin Binding Protein Hybrid Materials as a Versatile Platform for Biomedical Applications
Jan Maly, Ondrej Stanek, Jan Frolik, Marek Maly, Franka Ennen, Dietmar Appelhans, Alena Semeradtova, Dominika Wrobel, Marcel Stofik, Tereza Knapova, Milan Kuchar, Lucie Cervenkova Stastna, Jan Cermak, Peter Sebo and Petr Maly
Article first published online: 8 JAN 2016 | DOI: 10.1002/mabi.201500332
Biotinylated dendrimer is used for a controlled fabrication of biocompatible biohybrid structures to undergo conjugation with a highly HSA-affine tetrameric streptavidin-binding domain protein scaffold. The biohybrid structures are suitable as a potential ligand-tailored drug delivery system, where the dendrimer can render a specifically high affinity to various biological ligands and biomolecules based on the binding property of the mutated binding domain proteins.