Macromolecular Bioscience

Cover image for Vol. 17 Issue 2

Early View (Online Version of Record published before inclusion in an issue)

Editor-in-Chief: Kirsten Severing, Editor: Anne Pfisterer

Online ISSN: 1616-5195

Associated Title(s): Advanced Healthcare Materials, Macromolecular Chemistry and Physics, Macromolecular Materials and Engineering, Macromolecular Rapid Communications

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  1. Full Papers

    1. Enhanced Antimetastatic Activity of the Ruthenium Anticancer Drug RAPTA-C Delivered in Fructose-Coated Micelles

      Mingxia Lu, Fan Chen, Janina-Miriam Noy, Hongxu Lu and Martina H. Stenzel

      Version of Record online: 24 FEB 2017 | DOI: 10.1002/mabi.201600513

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      Coating micelles with fructose can enhance the antimetastatic effect of ruthenium drugs. The sugar-based nanocarrier, compared to a micelle based on a nonfunctional nanocarrier, shows higher uptake by breast cancer cells and better penetration in MCF-7 tumor spheroids.

    2. Regulation of Scaffold Cell Adhesion Using Artificial Membrane Binding Proteins

      Madeline Burke, James P. K. Armstrong, Andrew Goodwin, Robert C. Deller, Benjamin M. Carter, Robert L. Harniman, Aasiya Ginwalla, Valeska P. Ting, Sean A. Davis and Adam W. Perriman

      Version of Record online: 24 FEB 2017 | DOI: 10.1002/mabi.201600523

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      A novel strategy is developed where chemical, biochemical, and morphological properties of biomaterials scaffolds are varied by the covalent coupling of cationized and surfactant-conjugated proteins. These artificial membrane binding proteins not only increase cellular adhesion via electrostatic and hydrophobic mechanisms, but can also be used as oxygen reservoirs to prevent slowdown of proliferation in hypoxic conditions.

    3. Washless Method Enables Multilayer Coating of an Aggregation-Prone Nanoparticulate Drug Delivery System with Enhanced Yields, Colloidal Stability, and Scalability

      Lamees Nayef, Rafael Castiello and Maryam Tabrizian

      Version of Record online: 22 FEB 2017 | DOI: 10.1002/mabi.201600535

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      Washless method titrations allow coating aggregation-prone liposome core nanoparticle with eight layers of polyelectrolyte with higher yields and reproducibility promising greater success in investigating a broader range of multilayer-coated nanoparticles for applications like drug delivery.

    4. Imaging Cell–Matrix Interactions in 3D Collagen Hydrogel Culture Systems

      Aaron R. Short, Catherine Czeisler, Benjamin Stocker, Sara Cole, José Javier Otero and Jessica O. Winter

      Version of Record online: 21 FEB 2017 | DOI: 10.1002/mabi.201600478

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      Hydrogels provide more accurate representations of cell behaviors in vivo; however, imaging in hydrogels can be challenging. This work develops new methods that enable imaging of cellular interactions with their hydrogel microenvironments in a collagen model.

    5. A Robust Method to Generate Mechanically Anisotropic Vascular Smooth Muscle Cell Sheets for Vascular Tissue Engineering

      Daniel E. Backman, Bauer L. LeSavage, Shivem B. Shah and Joyce Y. Wong

      Version of Record online: 16 FEB 2017 | DOI: 10.1002/mabi.201600434

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      Vascular smooth muscle cell sheets are cultured using a novel, micropatterned, thermoresponsive cell culture platform. The method is optimized to produce vascular smooth muscle cell sheets with cellular and extracellular alignment. Aligned cell sheets exhibit nonlinear, anisotropic mechanical properties that make them an attractive material for building a vascular graft that mimics the structural and mechanical properties of native vascular tissue.

    6. Synthesis and Characterization of Stimuli-Responsive Star-Like Polypept(o)ides: Introducing Biodegradable PeptoStars

      Regina Holm, Benjamin Weber, Philipp Heller, Kristina Klinker, Dana Westmeier, Dominic Docter, Roland H. Stauber and Matthias Barz

      Version of Record online: 15 FEB 2017 | DOI: 10.1002/mabi.201600514

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      The synthesis of three-arm polypeptoid and polypept(o)ide star polymers is reported. Incorporation of disulfide bonds between the core and the individual side chains enables degradation of star polymers in the presence of glutathione. The size of star polymers can be adjusted between 4 and 10 nm, yielding core–shell structures well tolerated by HeLa, HEK 293, and DC 2.4 cells.

  2. Communications

    1. Bioprinting Using Mechanically Robust Core–Shell Cell-Laden Hydrogel Strands

      Pritesh Mistry, Ahmed Aied, Morgan Alexander, Kevin Shakesheff, Andrew Bennett and Jing Yang

      Version of Record online: 3 FEB 2017 | DOI: 10.1002/mabi.201600472

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      Combining good biological and mechanical properties in bioprinted constructs is desirable for them to be employed in many tissue engineering and regenerative medicine applications. Bioprinted cell-laden constructs with core–shell strands have been developed. The cell-supporting materials in the core support high cell viability and tissue-like functions while the shell material offers mechanical robustness to the bioprinted constructs.

  3. Full Papers

    1. Polymeric Delivery of siRNA against Integrin-β1 (CD29) to Reduce Attachment and Migration of Breast Cancer Cells

      Daniel Nisakar Meenakshi Sundaram, Cezary Kucharski, Manoj B. Parmar, Remant Bahadur KC and Hasan Uludağ

      Version of Record online: 3 FEB 2017 | DOI: 10.1002/mabi.201600430

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      Cancer cell migration is inhibited by targeting cell-surface integrins with lipopolymer/siRNA complexes.

    2. Reverse Thermal Gel for In Utero Coverage of Spina Bifida Defects: An Innovative Bioengineering Alternative to Open Fetal Repair

      Ahmed I. Marwan, Sarah M. Williams, James R. Bardill, Jane Gralla, Noraishah M. Abdul-Aziz and Daewon Park

      Version of Record online: 30 JAN 2017 | DOI: 10.1002/mabi.201600473

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      Neural tube defects (NTDs) cause progressive damage to the central nervous system during development. Covering NTDs in fetuses has demonstrated improved outcomes but the associated invasiveness causes significant risks to mother and fetus. Our solution is to cover NTDs with an injectable biomaterial at earlier stages of pregnancy without invasive surgical intervention, potentially providing fewer risks to mother and fetus.

    3. Design of a Bioabsorbable Multilayered Patch for Esophagus Tissue Engineering

      Rossella Dorati, Antonella De Trizio, Stefania Marconi, Anna Ferrara, Ferdinando Auricchio, Ida Genta, Tiziana Modena, Marco Benazzo, Alberto Benazzo, Gino Volpato and Bice Conti

      Version of Record online: 27 JAN 2017 | DOI: 10.1002/mabi.201600426

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      Multilayered biodegradable polymerpatches combining synthetic polylactide-co-polycaprolacton and natural (chitosan) biopolymers are successfully developed by the temperature-induced precipitation method. Polymer blending designs tailoring patch properties and esophageal tissue characteristics.

    4. Co-Delivery of Docetaxel and p44/42 MAPK siRNA Using PSMA Antibody-Conjugated BSA-PEI Layer-by-Layer Nanoparticles for Prostate Cancer Target Therapy

      See-Tong Pang, Feng-Wei Lin, Cheng-Keng Chuang and Hung-Wei Yang

      Version of Record online: 27 JAN 2017 | DOI: 10.1002/mabi.201600421

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      Prostate-specific membrane antigen antibody-conjugated bovine serum albumin-polyethylenimine layer-by-layer nanoparticle (PSMAab-conjugated BSA-PEILBL) is designed as a versatile and promising carrier for specific and efficient delivery of chemotherapeutics and small interfering RNA (siRNA) to tumor tissues. Successful delivery of docetaxel and p44/42 mitogen-activated protein kinase siRNA by PSMAab-conjugated BSA-PEILBL elicits an enhancement of tumor inhibition without exhibiting other side effect.

    5. Starch Derived Nanosized Graphene Oxide Functionalized Bioactive Porous Starch Scaffolds

      Duo Wu, Eva Bäckström and Minna Hakkarainen

      Version of Record online: 25 JAN 2017 | DOI: 10.1002/mabi.201600397

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      A production route to porous and bioactive fully starch-derived scaffold is demonstrated. Starch-derived bioactive nanosized graphene oxide is covalently attached to starch chains. The functionalized starch is biocompatible and efficiently induces biomineralization in vitro showing promise for bone/cartilage tissue engineering.

    6. A Copolymer Scaffold Functionalized with Nanodiamond Particles Enhances Osteogenic Metabolic Activity and Bone Regeneration

      Mohammed A. Yassin, Kamal Mustafa, Zhe Xing, Yang Sun, Kristine Eldevik Fasmer, Thilo Waag, Anke Krueger, Doris Steinmüller-Nethl, Anna Finne-Wistrand and Knut N. Leknes

      Version of Record online: 24 JAN 2017 | DOI: 10.1002/mabi.201600427

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      Bone marrow stromal cells (BMSCs) are isolated and expanded in vitro for days. The expanded cells are seeded into the copolymer scaffolds functionalized with nanodiamond particles (nDPs). The constructs are used to treat calvarial bone defects and followed-up for 12 weeks.

    7. Optimization of Injectable Thermosensitive Scaffolds with Enhanced Mechanical Properties for Cell Therapy

      Caroline Ceccaldi, Elias Assaad, Eve Hui, Medeine Buccionyte, Atma Adoungotchodo and Sophie Lerouge

      Version of Record online: 24 JAN 2017 | DOI: 10.1002/mabi.201600435

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      Obtaining injectable hydrogels which combine high mechanical properties, tunable gelation rate and compatibility with cell encapsulation, is still a challenge. The chitosan-based thermosensitive hydrogels presented here overcome these limitations without chemical modification or a crosslinking agent. The present data strongly support the gels as excellent candidates for injectable scaffolds in cell therapy and tissue engineering.

    8. Bacterial Nanocellulose Magnetically Functionalized for Neuro-Endovascular Treatment

      Mónica Echeverry-Rendon, Lisa M. Reece, Fernando Pastrana, Sandra L. Arias, Akshath R. Shetty, Juan Jose Pavón and Jean Paul Allain

      Version of Record online: 24 JAN 2017 | DOI: 10.1002/mabi.201600382

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      Bacterial nanocellulose is synthesized and impregnated in situ with iron oxide nanoparticles to yield a magnetic bacterial nanocellulose. The goal is to (1) render an asymmetric region of the stent surface magnetic; (2) induce cell migration and proliferation; (3) locally introduce NiTi neuro-endovascular stents within arterial vessels in the brain for applications in damaged blood vessel reconstruction.

    9. Polyelectrolyte Oil-Core Nanocarriers for Localized and Sustained Delivery of Daunorubicin to Colon Carcinoma MC38 Cells: The Case of Polysaccharide Multilayer Film in Relation to PEG-ylated Shell

      Urszula Bazylińska, Jadwiga Pietkiewicz, Joanna Rossowska, Grzegorz Chodaczek, Andrzej Gamian and Kazimiera A. Wilk

      Version of Record online: 17 JAN 2017 | DOI: 10.1002/mabi.201600356

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      Polysaccharide-based and PEG-ylated polyelectrolytes (PEs) are both utilized for layering of oil-core multilayer nanocapsules and sustained delivery of daunorubicin to colon carcinoma MC38 cells. This study demonstrates that surface charge and outer PE layer type determine nanocarrier features that control their biological activity: protein adsorption, cytotoxicity, cellular internalization and morphological response, induction of apoptosis, and hemolytic activity.

    10. Tough, Semisynthetic Hydrogels for Adipose Derived Stem Cell Delivery for Chondral Defect Repair

      Fraz Anjum, Andrew Carroll, Stuart A. Young, Lauren E. Flynn and Brian G. Amsden

      Version of Record online: 13 JAN 2017 | DOI: 10.1002/mabi.201600373

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      A mechanically robust, in situ forming hydrogel capable of delivering stem cells with high viability via minimally invasive injection is described. This is achieved by combining the mechanical properties of a water-soluble synthetic triblock macromer with a water-soluble, cell instructive extracellular matrix polymer derived macromer, and utilizing a thermal free radical initiator system.

    11. Long-Term Stable Poly(acrylamide) Brush Modified Transparent Microwells for Cell Attachment Studies in 3D

      Inga Lilge, Siyu Jiang and Holger Schönherr

      Version of Record online: 3 JAN 2017 | DOI: 10.1002/mabi.201600451

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      Fabrication of 3D cell microenvironments modified with long-term stable passivating poly(acryl amide) brushes on the topside plateaus revealing cell adhesive areas inside the wells. The microwells are used to study the behavior of fibroblast and pancreatic tumor cells, which attach to the bottom and the sidewalls of the microwells and remain viable for more than 1 week.

    12. Development of a Novel Immobilization Method by Using Microgels to Keep Enzyme in Hydrated Microenvironment in Porous Hydrophobic Membranes

      Giuseppe Vitola, Dominic Büning, Jens Schumacher, Rosalinda Mazzei, Lidietta Giorno and Mathias Ulbricht

      Version of Record online: 27 DEC 2016 | DOI: 10.1002/mabi.201600381

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      Polyacrylamide-based microgel particles, synthesized by inverse miniemulsion polymerization and post-functionalized by Hofmann reaction to contain amino groups, are used to immobilize lipase on the surface of activated porous polyvinylidene fluoride membranes, leading to higher specific enzyme activity compared to direct immobilization at preserved membrane hydrophobicity.

  4. Reviews

    1. AIE Polymers: Synthesis, Properties, and Biological Applications

      Ruoyu Zhan, Yutong Pan, Purnima Naresh Manghnani and Bin Liu

      Version of Record online: 20 DEC 2016 | DOI: 10.1002/mabi.201600433

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      Aggregation induced emission (AIE) polymers are a series of polymers that display enhanced emission upon transforming from isolated molecular state to aggregated state. In this review, the recent progress of AIE polymers is summarized from the perspectives of their synthesis, properties, and biological applications.

  5. Full Papers

    1. PPI-G4 Glycodendrimers Upregulate TRAIL-Induced Apoptosis in Chronic Lymphocytic Leukemia Cells

      Ida Franiak-Pietryga, Kinga Ostrowska, Henryk Maciejewski, Dietmar Appelhans, Małgorzata Misiewicz, Barbara Ziemba, Michał Bednarek, Maria Bryszewska and Maciej Borowiec

      Version of Record online: 20 DEC 2016 | DOI: 10.1002/mabi.201600169

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      The study shows the proapoptotic effects of poly(propylene imine) (PPI) dendrimers with maltotriose (PPI-G4-OS/DS-Mal-III) on the tumor necrosis factor-related apoptosis-inducing ligand in chronic lymphocytic leukemia cells. The development of a molecular profiling is a key issue for the design of personalized approaches to cancer therapy.

    2. The Key Role of Sulfation and Branching on Fucoidan Antitumor Activity

      Catarina Oliveira, Andreia S. Ferreira, Ramon Novoa-Carballal, Cláudia Nunes, Iva Pashkuleva, Nuno M. Neves, Manuel A. Coimbra, Rui L. Reis, Albino Martins and Tiago H. Silva

      Version of Record online: 20 DEC 2016 | DOI: 10.1002/mabi.201600340

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      An effective cancer therapeutic strategy relies on the ability to eliminate tumors without damaging surrounding healthy tissues. Due to inconsistent results regarding fucoidan bioactivity, there is the need to characterize which feature(s) is (are) playing the major role. Herein, sulfation and branching seem to be the properties influencing fucoidan antitumor activity.

    3. pH-Modulating Poly(ethylene glycol)/Alginate Hydrogel Dressings for the Treatment of Chronic Wounds

      Julia Koehler, Leonie Wallmeyer, Sarah Hedtrich, Achim M. Goepferich and Ferdinand P. Brandl

      Version of Record online: 20 DEC 2016 | DOI: 10.1002/mabi.201600369

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      The rational design of pH-modulating hydrogel wound dressings with regard to the required material properties, including fluid handling capacity, mechanical strength, and base neutralizing capacity, is reported. Thereby induced enhanced keratinocyte ingrowth in wounded human skin constructs, suffering from an alkalosis, confirms pH-modulation to be a promising tool promoting normal wound healing in chronic wounds.

    4. Fluorescent Labeling and Biodistribution of Latex Nanoparticles Formed by Surfactant-Free RAFT Emulsion Polymerization

      Cheuk Ka Poon, Owen Tang, Xin-Ming Chen, Byung Kim, Matthias Hartlieb, Carol A. Pollock, Brian S. Hawkett and Sébastien Perrier

      Version of Record online: 14 DEC 2016 | DOI: 10.1002/mabi.201600366

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      Particle preparation is performed using surfactant-free reversible addition-fragmentation chain transfer emulsion polymerisation. Labeling is achieved covalently by amidation with rhodamine B amine enabling particle tracing of sterically stabilized latex particles. The biodistribution is investigated in vitro and in vivo.

    5. Reversible Bioconjugation: Biodegradable Poly(phosphate)-Protein Conjugates

      Tobias Steinbach, Greta Becker, Alina Spiegel, Tamiris Figueiredo, Daniela Russo and Frederik R. Wurm

      Version of Record online: 12 DEC 2016 | DOI: 10.1002/mabi.201600377

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      A biodegradable alternative to PEGylation: Protein-reactive poly(ethyl ethylene phosphate)s are prepared by anionic ring-opening polymerization and coupled to proteins. These poly(phosphate)-protein conjugates show similar activity to PEGylated analogs and degrade enzymatically.

  6. Communications

    1. Inkjetting Plus Peroxidase-Mediated Hydrogelation Produces Cell-Laden, Cell-Sized Particles with Suitable Characters for Individual Applications

      Shinji Sakai, Yusuke Yamamoto, Gantumur Enkhtuul, Kohei Ueda, Kenichi Arai, Masahito Taya and Makoto Nakamura

      Version of Record online: 8 DEC 2016 | DOI: 10.1002/mabi.201600416

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      Cell-laden, cell-sized microparticles (20–60 µm) are prepared by dropping an aqueous solution containing cells, horseradish peroxidase, and a polymer with phenolic hydroxyl moieties from a piezoelectric inkjetting system into an aqueous solution of hydrogen peroxide without causing serious damage to the cells.

  7. Full Papers

    1. Self-Assembled Supramolecular Nanogels as a Safe and Effective Drug Delivery Vector for Cancer Therapy

      Chih-Chia Cheng, Mei-Chih Liang, Zhi-Sheng Liao, Jyun-Jie Huang and Duu-Jong Lee

      Version of Record online: 5 DEC 2016 | DOI: 10.1002/mabi.201600370

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      A novel low-molecular-weight supramolecular nanogel may effectively improve the efficacy of chemotherapy while significantly reducing the side effects of anticancer drugs toward healthy tissues, and represents a highly promising potential drug carrier for cancer therapy.

    2. Evaluation of the Biocompatibility of Polypyrrole Implanted Subdurally in GAERS

      Sebastien H. Bauquier, Karen J. McLean, Jonathan L. Jiang, Ray C. Boston, Alan Lai, Zhilian Yue, Simon E. Moulton, Amy J. Halliday, Gordon Wallace and Mark J. Cook

      Version of Record online: 5 DEC 2016 | DOI: 10.1002/mabi.201600334

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      Alternative therapies aiming at improving the availability of anti-epileptic drugs (AEDs) such as the intracranial implantation of polymer-based drug delivery systems have shown some promising results. This blinded controlled prospective randomized study investigates the biocompatibility of polypyrrole (PPy) polymer that will be used for intracranial triggered release AED delivery. The authors conclude the PPy used offer good histocompatibility with cortical cells.

  8. Communications

    1. Visible Laser-Induced In Situ Cell Detachment from Gold Nanoparticle-Embedded Collagen Gel

      Chie Kojima, Yusuke Nakajima, Naoya Oeda, Takeshi Kawano and Yusuke Taki

      Version of Record online: 2 DEC 2016 | DOI: 10.1002/mabi.201600341

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      Cell sorting is important for cell biology and regenerative medicine. In this study, a visible light-responsive cell scaffold is produced using gold nanoparticles and collagen gel. Various kinds of cells are cultured on the visible light-responsive cell scaffold, and the target cells are selectively detached by photoirradiation without any cytotoxicity. This is a new image-guided cell sorting system.

    2. Thermohydrogel Containing Melanin for Photothermal Cancer Therapy

      Miri Kim, Hyun Soo Kim, Min Ah Kim, Hyanghwa Ryu, Hwan-Jeong Jeong and Chang-Moon Lee

      Version of Record online: 1 DEC 2016 | DOI: 10.1002/mabi.201600371

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      Poloxamer solution containing melanin (Pol–Mel) shows sol–gel transition at body temperature after heat generation induced by near infrared 808 nm laser irradiation. Following intratumoral injection of Pol–Mel and the laser irradiation, the growth of the CT26 tumors is suppressed completely without recurrence. From these results, Pol–Mel is a potentially attractive photothermal therapeutic agent for cancer therapy.

  9. Full Papers

    1. Carboplatin-Complexed and cRGD-Conjugated Unimolecular Nanoparticles for Targeted Ovarian Cancer Therapy

      Yuyuan Wang, Liwei Wang, Guojun Chen and Shaoqin Gong

      Version of Record online: 1 DEC 2016 | DOI: 10.1002/mabi.201600292

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      A multifunctional unimolecular nanoparticle formed by a multi-arm star copolymer PAMAM-PAsp-PEG-Cy5/cRGD is engineered as a stable carboplatin nanocarrier for targeted ovarian cancer therapy.

    2. 3D Printed Polycaprolactone Carbon Nanotube Composite Scaffolds for Cardiac Tissue Engineering

      Chee Meng Benjamin Ho, Abhinay Mishra, Pearlyn Teo Pei Lin, Sum Huan Ng, Wai Yee Yeong, Young-Jin Kim and Yong-Jin Yoon

      Version of Record online: 28 NOV 2016 | DOI: 10.1002/mabi.201600250

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      Well defined scaffolds of polycaprolactone (PCL) and its multi-walled carbon nanotube (CNT) composites are fabricated by 3D printer. PCL-CNT composite scaffolds are characterized for its thermal, mechanical and biological properties. Printed PCL and its CNT composites are able to show cell proliferation and have the potential to be used in cardiac tissue engineering.

    3. Fumarate Copolymer–Chitosan Cross-Linked Scaffold Directed to Osteochondrogenic Tissue Engineering

      María Laura Lastra, María Silvina Molinuevo, Ana María Cortizo and María Susana Cortizo

      Version of Record online: 28 NOV 2016 | DOI: 10.1002/mabi.201600219

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      A borax cross-linked scaffold based on fumarate-vinyl acetate copolymer and chitosan directed to osteochondrondral tissue engineering is developed. Taking advantage of its hydrogel behavior, osteoblastic and chondroblastic cells can grow and maturate in the scaffold producing specific extracellular matrix and molecular markers of phenotype with the additional advantages of degradation time adequate to support tissue regeneration and with low cytotoxicity.

    4. Aliphatic Polyethers with Sulfate, Carboxylate, and Hydroxyl Side Groups—Do They Show Anticoagulant Properties?

      Jagadeesh Malineni, Smriti Singh, Sabine Tillmann, Helmut Keul and Martin Möller

      Version of Record online: 28 NOV 2016 | DOI: 10.1002/mabi.201600274

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      A new protocol is reported for the synthesis of heparin-mimetic linear polyglycidol copolymers. Under ruthenium-catalyzed selective dehydrogenation in basic aqueous media, primary hydroxyl groups are selectively converted to carboxylic acid groups. Treatment with SO3/Et3N complex further converts the remaining hydroxyl groups to sulfate groups. Assays probing the anticoagulant activity confirm the activity of the heparin–mimetic copolymer.

    5. Cytochrome P450 Bioconjugate as a Nanovehicle for Improved Chemotherapy Treatment

      Katrin Quester, Karla Juarez-Moreno, Isamel Secundino, Yvonne Roseinstein, Karla P. Alejo, Alejandro Huerta-Saquero and Rafael Vazquez-Duhalt

      Version of Record online: 28 NOV 2016 | DOI: 10.1002/mabi.201600374

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      Cytochrome P450 (CYP) bioconjugate acts as nanovehicle for the enzyme direct delivery to the tumor tissue in order to improve the local drug activation. Breast cancer cells, treated with CYP-polyethylene glycol (PEG) bioconjugate functionalized folic acid, show increased intracellular enzyme activity and significantly reduce the dose of tamoxifen needed to kill the tumor cells. The CYP-PEG bioconjugate shows no immunogenic activity.

    6. Injectable Polysaccharide Hydrogels as Biocompatible Platforms for Localized and Sustained Delivery of Antibiotics for Preventing Local Infections

      Ziyi Li, Chaoliang He, Baoming Yuan, Xiaoming Dong and Xuesi Chen

      Version of Record online: 28 NOV 2016 | DOI: 10.1002/mabi.201600347

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      The polysaccharide hydrogels as biocompatible delivery systems of antibiotics are presented for preventing local infections. The hydrogels display good biocompatibility both in vitro and in vivo. Moreover, the ceftriaxone-sodium-loaded polysaccharide hydrogels indicate remarkable antibacterial properties in vitro. Furthermore, the results of both animal models confirm that the antibiotic-loaded polysaccharide hydrogels display markedly anti-infective efficacies in vivo.

    7. In Vitro Drug and Gene Delivery Using Random Cationic Copolymers Forming Stable and pH-Sensitive Polymersomes

      Partha Laskar, Joykrishna Dey, Payel Banik, Mahitosh Mandal and Sudip Kumar Ghosh

      Version of Record online: 23 NOV 2016 | DOI: 10.1002/mabi.201600324

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      Spontaneous stable polymersomes formation at pH 7 is reported from a series of highly biocompatible cationic hydrophilic random copolymers, where PEG forms the bilayer. Not only polymersomes can release encapsulated guest at acidic pH, but also the polymers can be used as nonviral vector for DNA transfection. So the polymers can be considered as promising codelivery system for anticancer therapy.

    8. Osmogen-Mediated One-Step Technique of Fabricating Hollow Microparticles for Encapsulation and Delivery of Bioactive Molecules

      Sharad Kharel, Wei Li Lee, Xuan Yi Lee and Say Chye Joachim Loo

      Version of Record online: 16 NOV 2016 | DOI: 10.1002/mabi.201600328

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      A simple, yet ingenious, technique to produce protein-encapsulated, hollow microparticles through a single step process is reported. By simply introducing an osmogen into the emulsion system, hollow microparticles can be fabricated. This novel technique also allows for the tuning of shell thickness, to achieve varying release profiles. In addition, the released protein is shown to maintain its bioactivity.

    9. Enhanced Sealing by Hydrophobic Modification of Alaska Pollock-Derived Gelatin-Based Surgical Sealants for the Treatment of Pulmonary Air Leaks

      Ryo Mizuta and Tetsushi Taguchi

      Version of Record online: 15 NOV 2016 | DOI: 10.1002/mabi.201600349

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      In this study, surgical sealants have been designed with hydrophobically modified Alaska pollock-derived gelatin (hm-ApGltn), and the sealing effect of this novel surgical sealant for lung tissue has been clarified. The maximum burst strength of the hm-ApGltn-based sealant is 1.6-fold higher than the Org-ApGltn-based sealant, and 2.1-fold higher than the commercial fibrin sealant. The new sealant has the potential to be applied clinically for thoracic surgery.

  10. Communications

    1. Identification of a Glypican-3-Binding Peptide for In Vivo Non-Invasive Human Hepatocellular Carcinoma Detection

      Zainen Qin, Jingjing Wang, Ye Wang, Guohao Wang, Xiangyu Wang, Zhiyang Zhou, Gang Liu, Shi Gao and Lei Zhu

      Version of Record online: 15 NOV 2016 | DOI: 10.1002/mabi.201600335

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      Glypican-3 (GPC3) is a protein abnormally expressed in hepatocellular carcinoma (HCC). Exploring a novel molecule that specifically recognizes GPC3 will facilitate early detection of HCC and guide the treatment strategy. A peptide binding to GPC3 is obtained by phage display technology and shows significant accumulation in HCC rather than normal liver as confirmed by in vivo fluorescent imaging.

    2. Multivalent Aptamer–RNA Conjugates for Simple and Efficient Delivery of Doxorubicin/siRNA into Multidrug-Resistant Cells

      Hyosook Jeong, Soo Hyeon Lee, Yeonju Hwang, Hyundong Yoo, Heesun Jung, Sun Hwa Kim and Hyejung Mok

      Version of Record online: 10 NOV 2016 | DOI: 10.1002/mabi.201600343

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      Doxorubicin-incorporated multivalent aptamer–siRNA conjugates containing multiple mucin-1 aptamers and BCL2-specific siRNAs are prepared for combination oncotherapy with chemotherapeutics and nucleic acid drugs. Doxorubicin-incorporated multivalent aptamer–siRNA conjugates deliver efficiently both doxorubicin and siRNA, resulting to overcome multidrug resistance in cancer cells and exert promising anticancer effects.

  11. Full Papers

    1. Thermo-Responsive Complexes of c-Myc Antisense Oligonucleotide with Block Copolymer of Poly(OEGMA) and Quaternized Poly(4-Vinylpyridine)

      Murat Topuzogullari, Yeliz Basaran Elalmis and Sevil Dincer Isoglu

      Version of Record online: 3 NOV 2016 | DOI: 10.1002/mabi.201600263

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      Lower critical solution temperature (LCST) of thermo-responsive polyelectrolyte complexes of c-Myc antisense oligonucleotide with block copolymer of poly(oligoethyleneglycol methyl ether methacrylate) and quaternized poly(4-vinylpyridine) decreases significantly with ratio of components. Dilution of solution significantly affects both LCST and size of complexes. The study briefly shows the importance of detailed characterization of temperature responsive polyelectrolyte complexes for biological applications.

    2. Electrospun Lipid Binding Proteins Composite Nanofibers with Antibacterial Properties

      Simona Tomaselli, Diego Omar Sanchez Ramirez, Riccardo Andrea Carletto, Alessio Varesano, Claudia Vineis, Serena Zanzoni, Henriette Molinari and Laura Ragona

      Version of Record online: 2 NOV 2016 | DOI: 10.1002/mabi.201600300

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      Smart and tunable devices with different biomedical applications can be obtained exploiting the encapsulation capabilities of lipid binding proteins. Nanofibers with excellent antibacterial properties can be obtained by electrospinning an insoluble bactericidal molecule, hosted in a protein shell, and dissolved in a keratin/poly(ethylene oxide) matrix.

    3. Self-Assembled Peptide-Based Hydrogels as Scaffolds for Proliferation and Multi-Differentiation of Mesenchymal Stem Cells

      Yung-Li Wang, Shih-Pei Lin, Srinivasa Rao Nelli, Fu-Kai Zhan, Hsun Cheng, Tsung-Sheng Lai, Mei-Yu Yeh, Hsin-Chieh Lin and Shih-Chieh Hung

      Version of Record online: 28 OCT 2016 | DOI: 10.1002/mabi.201600192

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      Self-assembled peptide-based hydrogels as scaffolds for mesenchymal stem cells (MSCs) proliferation and multi-differention are studied. Self-assembled peptide-based hydrogels prepared from a 1:1 mixture of Fmoc-FF/Fmoc-RGD have no toxic effects and show promise for MSC proliferation and differentiation into osteoblasts, adipocytes, and chondrocytes. The results shown here are helpful in developing new strategies for MSC-based tissue engineering.

    4. Multifunctional Surface Modification: Facile and Flexible Reactivity toward a Precisely Controlled Biointerface

      Ruei-Hung Yuan, Chih-Yu Wu, Hsing-Ying Tung, Hung-Pin Hsieh, Yi-Jye Li, Yu-Chih Chiang and Hsien-Yeh Chen

      Version of Record online: 27 OCT 2016 | DOI: 10.1002/mabi.201600322

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      A multicomponent polymer is synthesized by chemical vapor deposition copolymerization to enable surface modification of a biointerface or nanoscale interface with multifunctional accessibility in N-hydroxysuccinimide ester-amine conjugation and photoinitiated benzophenone crosslinking reactions.

    5. Probing Endosomal Escape Using pHlexi Nanoparticles

      Nachnicha Kongkatigumjorn, Christina Cortez-Jugo, Ewa Czuba, Adelene S. M. Wong, Rebecca Y. Hodgetts, Angus P. R. Johnston and Georgina K. Such

      Version of Record online: 27 OCT 2016 | DOI: 10.1002/mabi.201600248

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      Nanoparticle cellular behavior, including endosomal escape and association is found to depend on molecular weight of the polymeric building blocks. This study is conducted using pH-responsive nanoparticles assembled using a simple and modular nanoprecipitation technique based on PDEAEMA and PEG-b-PDEAEMA. It is found that endosomal escape increases with increasing molecular weight of PDEAEMA while cell association decreases.

    6. Comparative Endocytosis Mechanisms and Anticancer Effect of HPMA Copolymer- and PAMAM Dendrimer-MTCP Conjugates for Photodynamic Therapy

      Raziye Mohammadpour, Shahrokh Safarian, Brandon Buckway and Hamidreza Ghandehari

      Version of Record online: 25 OCT 2016 | DOI: 10.1002/mabi.201600333

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      The association of photosensitizers with polymeric carriers can improve solubility, influence the route and the rate of cellular internalization, and drastically enhance the uptake of the photosensitizer. Random coil HPMA copolymer-MTCP has more chance for physical association with cell membrane than spherical hyperbranched PAMAM-MTCP. Negatively charged MTCP might be taken up via lipid raft domain on the cell membrane surface.

    7. A Modified Polysaccharide-Based Hydrogel for Enhanced Osteogenic Maturation and Mineralization Independent of Differentiation Factors

      Sridhar Sanyasi, Satish Kumar, Arijit Ghosh, Rakesh Kumar Majhi, Navneet Kaur, Priyanka Choudhury, Udai P. Singh, Chandan Goswami and Luna Goswami

      Version of Record online: 21 OCT 2016 | DOI: 10.1002/mabi.201600268

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      A hydrogel prepared by grafting of tamarind kernel polysaccharide with acrylic acid supports growth of both osteogenic and associated nonosteogenic cell types. It has the unique capability of promoting adhesion, proliferation, differentiation, and mineralization of bone cells without the addition of exogenous differentiation factors. This hydrogel can be used as a potential low-cost scaffold for efficient bone tissue engineering.

    8. Thin Poly(Di(Ethylene Glycol)Methyl Ether Methacrylate) Homopolymer Brushes Allow Controlled Adsorption and Desorption of PaTu 8988t Cells

      Yvonne Voß, Ekram Wassel, Siyu Jiang, Qimeng Song, Sergey I. Druzhinin and Holger Schönherr

      Version of Record online: 20 OCT 2016 | DOI: 10.1002/mabi.201600337

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      Thin poly(di(ethylene glycol)methyl ether methacrylate) (PDEGMA) brushes exhibit interesting thermoresponsive behavior that can be tuned by variations of brush thickness and grafting density. This detailed investigation of (i) the temperature dependence of the adsorption of fibronectin and proteins from cell culture media and (ii) the thermally triggered release of PaTu 8988t cells underpins the potential of PDEGMA as thermoresponsive cell release coating.

    9. Crosslinked Platform Coatings Incorporating Bioactive Signals for the Control of Biointerfacial Interactions

      Berkay Ozcelik, Renxun Chen, Veronica Glattauer, Naresh Kumar, MarkD.P. Willcox and Helmut Thissen

      Version of Record online: 20 OCT 2016 | DOI: 10.1002/mabi.201600315

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      Poly(ethylene glycol)-based crosslinked platform coatings described in this study allow for the facile covalent incorporation of bioactive cell adhesive and antimicrobial peptides. The coatings provide low-biofouling properties while maintaining the function of the incorporated peptides. Cell attachment studies confirm the activity of the cRGDfK peptide while incorporation of the antimicrobial peptide melimine further reduces bacterial colonization on surfaces.

    10. Triple Redox Responsive Poly(Ethylene Glycol)-Polycaprolactone Polymeric Nanocarriers for Fine-Controlled Drug Release

      Caiyan Zhao, Leihou Shao, Jianqing Lu, Chenying Zhao, Yujie Wei, Junxing Liu, Mingjun Li and Yan Wu

      Version of Record online: 20 OCT 2016 | DOI: 10.1002/mabi.201600295

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      A polymeric nanoparticle with triple-disulfide bonds at the connection of the polymer blocks (tri-PESC NPs) is prepared. Excitingly, the tri-PESC NPs show high sensitivity to intracellular glutathione level of tumor while have good stability under the low glutathione concentrations similar to physiological conditions, realizing the precise-controlled drug release and safe and highly effective drug delivery.

    11. Use of 5-Fluorouracil Loaded Micelles and Cisplatin in Thermosensitive Chitosan Hydrogel as an Efficient Therapy against Colorectal Peritoneal Carcinomatosis

      Qin Yun, Si Song Wang, Shan Xu, Jin Ping Yang, Juan Fan, Ling Lin Yang, Yue Chen, Shao Zhi Fu and Jing Bo Wu

      Version of Record online: 20 OCT 2016 | DOI: 10.1002/mabi.201600262

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      A novel hydrogel drug system based on thermosensitive chitosan (CS) hydrogel is prepared for simultaneous delivery of 5-fluorouracil micelles and cisplatin. The CS hydrogel drug can inhibit tumor growth and metastasis, and prolongs survival time, thus improving the chemotherapeutic effect. The CS hydrogel drug has also a certain inhibitory effect on colorectal cancer metastasis to the liver and lung.

  12. Communications

    1. Simple and Rapid Bioink Jet Printing for Multiscale Cell Adhesion Islands

      Laura Mecozzi, Oriella Gennari, Romina Rega, Luigi Battista, Pietro Ferraro and Simonetta Grilli

      Version of Record online: 19 OCT 2016 | DOI: 10.1002/mabi.201600307

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      It is reported a simple and rapid method for multiscale patterning of bioinks to achieve live cells clusters down to single cell. The p-jet process uses a pyroelectric effect for printing multiscale bioink islands by an easy to accomplish procedure that is contact free but also free from external electrodes and micromachined nozzles. This technique offers a significant help to biologists to produce micropatterned substrates for high-throughput cell adhesion studies.

  13. Full Papers

    1. A Trifunctional, Modular Biomaterial Coating: Nonadhesive to Bacteria, Chlorhexidine-Releasing and Tissue-Integrating

      Jelmer Sjollema, Heidrun Keul, Henny van der Mei, René Dijkstra, Minie Rustema-Abbing, Joop de Vries, Ton Loontjens, Ton Dirks and Henk Busscher

      Version of Record online: 19 OCT 2016 | DOI: 10.1002/mabi.201600336

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      A modular biomaterial coating-concept is presented in which nonadhesiveness to proteins and bacteria is accomplished by a first module that is applied on top of an antimicrobial, chlorhexidine releasing based-module. The third module enhances tissue integration and is obtained by the incorporation of peptides within the nonadhesive module. Noteworthy, these three modules function completely independent of each other.

    2. Generation of Large-Scale DNA Hydrogels with Excellent Blood and Cell Compatibility

      Heidi Stoll, Heidrun Steinle, Katharina Stang, Silju Kunnakattu, Lutz Scheideler, Bernd Neumann, Julia Kurz, Ilka Degenkolbe, Nadja Perle, Christian Schlensak, Hans Peter Wendel and Meltem Avci-Adali

      Version of Record online: 19 OCT 2016 | DOI: 10.1002/mabi.201600252

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      A DNA hydrogel is enzymatically produced via rolling circle amplification (RCA) and multiprimed chain amplification (MCA) in cm scale as a potential material for tissue engineering. The extensive analyses of this DNA hydrogel demonstrate the excellent cyto- and hemocompatibility, which encourages its prospective application as a scaffold for regenerative medicine.

    3. Acid-Cleavable Unimolecular Micelles from Amphiphilic Star Copolymers for Triggered Release of Anticancer Drugs

      Shan Zhang, Jianbin Xu, Heng Chen, Zhangfa Song, Yalan Wu, Xingyi Dai and Jie Kong

      Version of Record online: 19 OCT 2016 | DOI: 10.1002/mabi.201600258

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      The acid-cleavable unimolecular micelles from amphiphilic star copolymers have been presented for triggered release of anticancer drugs.

    4. Peptide Modified Electrospun Glycopolymer Fibers

      Andrea Fiorani, Filbert Totsingan, Antonio Pollicino, Yifeng Peng, Maria Letizia Focarete, Richard A. Gross and Mariastella Scandola

      Version of Record online: 18 OCT 2016 | DOI: 10.1002/mabi.201600327

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      This paper describes the fabrication, solid-state characterization of polyLSL[6′Ac,6′′Ac] electrospun fibers, and a versatile method by which peptides are conjugated to polyLSL[6′Ac,6″Ac] non-woven mats. X-ray photoelectron spectroscopy analysis reveals that about 50 mol% of polyLSL[6′Ac,6″Ac] repeat units at fiber surfaces are decorated with peptide moieties, out of which about 1/3 of the peptide units are physically adsorbed to polyLSL[6′Ac,6″Ac].

    5. The Synergistic Effect of Cationic Moieties and GRGDSF-Peptides in Hydrogels on Neural Stem Cell Behavior

      Muhammad Sallouh, Marvin Jarocki, Omar Sallouh, Patrick Degen, Andreas Faissner and Ralf Weberskirch

      Version of Record online: 17 OCT 2016 | DOI: 10.1002/mabi.201600178

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      The synergistic effect of cationic groups and arginine-glycine-aspartic acid peptides on neural stem cell (NSC) adhesion in 2D cell experiments is shown. The process is initiated by long-range electrostatic interaction of the pericellular matrix of the NSCs and the cationic gel surface followed by short-range peptide-integrin interaction.

  14. Communications

    1. Gold Nanocarriers for Macrophage-Targeted Therapy of Human Immunodeficiency Virus

      Hinojal Zazo, Clara I. Colino, Klaudia T. Warzecha, Mareike Hoss, Uwe Gbureck, Christian Trautwein, Frank Tacke, José M. Lanao and Matthias Bartneck

      Version of Record online: 17 OCT 2016 | DOI: 10.1002/mabi.201600359

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      Macrophages are long-term deposits for human immunodeficiency virus (HIV). The authors demonstrate that macrophages can be targeted efficiently by using gold nanoparticles as carriers for stavudine, a frequently used antiretroviral drug. In addition to incrementing phagocytic uptake, the carriers induce proinflammatory activation of macrophages, which makes the carriers promising for novel therapies of HIV.

  15. Full Papers

    1. Microparticle-Mediated Delivery of BMP4 for Generation of Meiosis-Competent Germ Cells from Embryonic Stem Cells

      Fereshteh Esfandiari, Mohammad Kazemi Ashtiani, Mehdi Sharifi-Tabar, Maryam Saber, Hamed Daemi, Mohammad Hossein Ghanian, Abdolhossein Shahverdi and Hossein Baharvand

      Version of Record online: 17 OCT 2016 | DOI: 10.1002/mabi.201600284

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      Microparticles (MPs) from alginate sulfate loaded with bone morphogenetic protein 4 (BMP4) have been developed. BMP4 release from alginate sulfate MPs is significantly retarded by the sulfated groups compared to neat alginate. MP-mediated delivery of BMP4 during embryonic stem cells differentiation into germ cells (GCs) establishes meiosis-competent GCs which can serve as an attractive GC source for reproductive medicine.

    2. Gelatin Porous Scaffolds as Delivery Systems of Calcium Alendronate

      Silvia Panzavolta, Paola Torricelli, Sonia Casolari, Annapaola Parrilli, Sofia Amadori, Milena Fini and Adriana Bigi

      Version of Record online: 17 OCT 2016 | DOI: 10.1002/mabi.201600272

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      Calcium alendronate containing porous scaffolds sustain osteoblast (OB) proliferation and activity, whereas they inhibit osteoclast (OC) viability and differentiation.

  16. Communications

    1. Efficient Release of Affinity-Captured Cells Using a Coiled-Coil-Based Molecular Trigger

      Mengen Zhang and Wei Shen

      Version of Record online: 14 OCT 2016 | DOI: 10.1002/mabi.201600330

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      A coiled-coil-based molecular trigger and a molecularly engineered capture substrate allow affinity-captured cells to be released efficiently and gently in the absence of enzymes, excessive shear stress, and other harsh chemical and physical conditions. The released cells have neither external molecules attached nor endogenous cell–surface molecules cleaved, which is critical for the viability, phenotype, and function of sensitive cells.

  17. Full Papers

    1. Achieving High Drug Loading and Sustained Release of Hydrophobic Drugs in Hydrogels through In Situ Crystallization

      Tianyuan Ci, Yuning Shen, Shuquan Cui, Ruili Liu, Lin Yu and Jiandong Ding

      Version of Record online: 14 OCT 2016 | DOI: 10.1002/mabi.201600299

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      High drug loading and sustained release of hydrophobic drugs in a hydrogel are achieved via postgelling in situ crystallization. Taking advantage of the solubility difference of some hydrophobic drugs in different media, a large amount of drugs is dispersed in hydrogels in the form of microcrystals, after subcutaneously injecting the mixture of a block copolymer solution and a supersaturated drug solution into the body.

    2. A Two-Step Method for Transferring Single-Walled Carbon Nanotubes onto a Hydrogel Substrate

      Mozhdeh Imaninezhad, Irma Kuljanishvili and Silviya Petrova Zustiak

      Version of Record online: 4 OCT 2016 | DOI: 10.1002/mabi.201600261

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      A novel two-step method is developed to transfer high quality dense single-walled carbon nanotubes onto hydrogels with a high transfer efficiency. The resultant carbon nanotube-hydrogel composites are able to support cell adhesion, spreading and high cell viability. Such nanocomposite materials will be useful in various biomedical applications.

    3. Bioconjugation and Applications of Amino Functional Fluorescence Polymers

      Caner Geyik, Emine Guler, Zinar Pinar Gumus, Firat Baris Barlas, Huseyin Akbulut, Dilek Odaci Demirkol, Suna Timur and Yusuf Yagci

      Version of Record online: 30 SEP 2016 | DOI: 10.1002/mabi.201600232

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      Biofunctional polymers for diagnosis and therapy yield additional tools for various diseases. Three newly synthesized fluorescent polymers, poly(p-phenylene-co-thiophene), poly(p-phenylene), and polythiophene (PPT-NH2, PPP-NH2, and PT-NH2, respectively) can be used for selective imaging after bioconjugation with HER2 antibody. These polymers enhance radiosensitivity of A549 cells. Additionally, PT-NH2, which was used as a drug carrier, can bind and release methotrexate responsive to pH changes.

    4. Nano-Bio Engineered Carbon Dot-Peptide Functionalized Water Dispersible Hyperbranched Polyurethane for Bone Tissue Regeneration

      Satyabrat Gogoi, Somnath Maji, Debasish Mishra, K. Sanjana P. Devi, Tapas Kumar Maiti and Niranjan Karak

      Version of Record online: 29 SEP 2016 | DOI: 10.1002/mabi.201600271

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      Water dispersible hyperbranched polyurethane is conjugated with bio-nano-hybrid of carbon dot and RGD sequenced peptides to obtain a target specific multifunctional system with excellent in vitro and in vivo osteogenic activity.

  18. Reviews

    1. Structure–Function Correlations of Poly(Amido Amine)s for Gene Delivery

      Yanping Sun, Lei Xian, Jiankun Yu, Tianzhi Yang, Jinmin Zhang, Zhen Yang, Jingzheng Jiang, Cuifang Cai, Xiaoyun Zhao, Li Yang and Pingtian Ding

      Version of Record online: 29 SEP 2016 | DOI: 10.1002/mabi.201600297

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      The poly(amido amine)s (PAAs) are used as a unique research platform to elucidate the complicated structure–function relationship. It is shown that guanidinium group, carboxyl group, disulfide bond, alkyl chains, branching, acetyl groups, benzoyl groups, and quaternary nicotinamide moieties can influence PAAs's gene delivery properties, such as DNA condensation capacity, cellular membrane binding capacity, buffer capacity (endosomal escape), polyplex unpacking, nuclear targeting, and cytotoxicity.

  19. Full Papers

    1. Iron Binding and Iron Removal Efficiency of Desferrioxamine Based Polymeric Iron Chelators: Influence of Molecular Size and Chelator Density

      Jasmine L. Hamilton, Muhammad Imran ul-haq, A. Louise Creagh, Charles A. Haynes and Jayachandran N. Kizhakkedathu

      Version of Record online: 28 SEP 2016 | DOI: 10.1002/mabi.201600244

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      Hyperbranched polyglycerol based polymeric iron chelators for iron chelation therapy is reported. The molecular properties of polymeric scaffold and chelator density are shown to be important determinants that contribute to the iron binding and iron removal efficiency. Such properties also influence the ability of conjugates to protect iron mediated oxidation.

    2. Synthesis of Polylactide-Based Core–Shell Interface Cross-Linked Micelles for Anticancer Drug Delivery

      Chih-Kuang Chen, Wei-Jen Lin, Yu Hsia and Leu-Wei Lo

      Version of Record online: 28 SEP 2016 | DOI: 10.1002/mabi.201600191

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      Core–shell interface cross-linked micelles (ICMs) that possess enhanced in vivo stability, biodegradability, and negligible cytotoxicity are created via newly synthesized poly(ethylene glycol)-b-allyl functional polylatide-b-polylactides. Without burst release problems, Dox-loaded ICMs are capable of exhibiting a slow and sustained Dox release feature at pH = 7.4. ICMs are successful in delivering Dox into human uterine sarcoma (MES-SA) cells, followed by the inhibition of MES-SA proliferation.

    3. Mechanically Robust and Transparent N-Halamine Grafted PVA-co-PE Films with Renewable Antimicrobial Activity

      Yang Si, Andrea Cossu, Nitin Nitin, Yue Ma, Cunyi Zhao, Bor-sen Chiou, Trung Cao, Dong Wang and Gang Sun

      Version of Record online: 28 SEP 2016 | DOI: 10.1002/mabi.201600304

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      A mechanically robust and transparent N-halamine grafted PVA-co-PE film with high effective and renewable antimicrobial activity is fabricated by combining melt radical graft polymerization and reactive extrusion technique. The as-prepared film can effectively offer 3–5 logs CFU reduction against typical pathogenic bacterium Escherichia coli in a short contact time of 1 h, even at high organism conditions.

    4. Promoting Cardiomyogenesis of hBMSC with a Forming Self-Assembly hBMSC Microtissues/HA-GRGD/SF-PCL Cardiac Patch Is Mediated by the Synergistic Functions of HA-GRGD

      Tze-Wen Chung, Hsin-Yu Lo, Tzung-Han Chou, Jan-Hou Chen and Shoei-Shen Wang

      Version of Record online: 28 SEP 2016 | DOI: 10.1002/mabi.201600173

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      Hyaluronic acid/GRGD decorated silk cardiac patches mediate human bone marrow–derived mesenchymal stem cell from 2D monolayer migrating to 3D microtissues at cardiomyogenic differentiation.

    5. Phenylboronic Acid-Cross-Linked Nanoparticles with Improved Stability as Dual Acid-Responsive Drug Carriers

      Chunran Wang, Jinze Wang, Xiaofei Chen, Xu Zheng, Zhigang Xie, Li Chen and Xuesi Chen

      Version of Record online: 22 SEP 2016 | DOI: 10.1002/mabi.201600227

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      A kind of dual acid-sensitive nano­particles based on mPEG-imine-b-cyclodextrin was constructed by a facile phenylboronic acid-crosslinked way. The nanoparticles not only possess excellent biocompati­bility but also can efficiently load and deliver anticancer drug into tumor cells to enhance the inhibition of cellular proliferation, outlining a favorable platform as drug carriers.

    6. Valve Tissue Engineering with Living Absorbable Threads

      Albert Ryszard Liberski, Christophe Michel Raynaud, Nadia Ayad, Dorota Wojciechowska and Abbirami Sathappan

      Version of Record online: 12 SEP 2016 | DOI: 10.1002/mabi.201600196

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      The research here is based on the bio-polymer filaments from poly(caprolactone). The filaments are seeded with human mesenchymal cells to obtain “living” heart valve like leaflets. In the paper, the benefits of combining nano- and microfibers are also underlined. The science rarely explores areas where the enthusiasm is as important as the experience. This area is the fiber-based tissue engineering.

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