Macromolecular Bioscience

Cover image for Vol. 14 Issue 7

Early View (Online Version of Record published before inclusion in an issue)


  1. 1 - 38
  1. Full Papers

    1. Hybrid Polyglycerols with Long Blood Circulation: Synthesis, Biocompatibility, and Biodistribution

      Muhammad Imran ul-haq, Benjamin F. L. Lai and Jayachandran N. Kizhakkedathu

      Article first published online: 11 JUL 2014 | DOI: 10.1002/mabi.201400152

      Thumbnail image of graphical abstract

      Hybrid polyglycerols (inline image ≈ 100 kDa) with different compositions (15–80 mol% linear polyglycerol) with excellent blood and cell compatibility are synthesized. The polymers show long blood circulation with minimal organ accumulation in mice and are attractive for the development of multifunctional drug delivery systems.

    2. Cell–Microsphere Constructs Formed with Human Adipose-Derived Stem Cells and Gelatin Microspheres Promotes Stemness, Differentiation, and Controlled Pro-Angiogenic Potential

      Anjaneyulu Kodali, Thiam Chye Lim, David Tai Leong and Yen Wah Tong

      Article first published online: 1 JUL 2014 | DOI: 10.1002/mabi.201400094

      Thumbnail image of graphical abstract

      Three-dimensional cell–microsphere constructs formed with gelatin microspheres are found to be suitable platforms for the growth and differentiation of adipose-derived stem cells (ADSCs). These constructs also tend to preserve the stemness properties of the ADSCs along with enhancing their pro-angiogenic properties.

    3. Toward Anticancer Immunotherapeutics: Well-Defined Polymer–Antibody Conjugates for Selective Dendritic Cell Targeting

      Kristof Tappertzhofen, Monika Bednarczyk, Kaloian Koynov, Matthias Bros, Stephan Grabbe and Rudolf Zentel

      Article first published online: 30 JUN 2014 | DOI: 10.1002/mabi.201400190

      Thumbnail image of graphical abstract

      The synthesis of multifunctionalizable semitelechelic maleimide-modifided HPMA based polymers of narrow dispersity that can be conjugated to anti-DEC-205 antibodies affording “star-like” topologies is described. Primary in vitro studies show their high potential to target dendritic cells (DCs). This opens the opportunity to present tumor antigens to DCs and thus to induce antitumor immune responses.

    4. Enzymatic Synthesis of Dendritic Amphoteric α-Glucans by Thermostable Phosphorylase Catalysis

      Yusei Takata, Riko Shimohigoshi, Kazuya Yamamoto and Jun-Ichi Kadokawa

      Article first published online: 30 JUN 2014 | DOI: 10.1002/mabi.201400204

      Thumbnail image of graphical abstract

      Enzymatic synthesis of dendritic amphoteric α-glucans having both glucuronic acid and glucosamine residues at the non-reducing ends is performed by phosphorylase catalysis, which shows inherent isoelectric points and assembling/disassembling behaviors in water in accordance of the pH values.

    5. Synthesis of Functionalized Poly(ester carbonate) with Laminin-Derived Peptide for Promoting Neurite Outgrowth of PC12 cells

      Dongming Xing, Lie Ma and Changyou Gao

      Article first published online: 25 JUN 2014 | DOI: 10.1002/mabi.201400186

      Thumbnail image of graphical abstract

      Laminin-derived peptide functionalized poly(ester carbonate) (PEC) is synthesized to promote neurite outgrowth of PC12 cells. The maleimide-functionalized PECs are clicked with various thiol-containing molecules. The CQAASIKVAV-grafted PEC could support cell proliferation and neurite outgrowth. Therefore, the maleimide-functionalized PECs can serve as a versatile platform for diverse functionalization and have comprehensive potential in biomedical applications.

    6. Thermoresponsive Double Network Micropillared Hydrogels for Controlled Cell Release

      Ruochong Fei, Huijie Hou, Dany Munoz-Pinto, Arum Han, Mariah S. Hahn and Melissa A. Grunlan

      Article first published online: 23 JUN 2014 | DOI: 10.1002/mabi.201400172

      Thumbnail image of graphical abstract

      Thermoresponsive poly(N-isopropylacrylamide) (PNIPAAm) hydrogels may achieve “self-cleaning” via thermal cycling to cause cellular detachment. In this work, a double network (DN) design and micropatterning approaches are utilized for enhancing deswelling-driven cell release. DN hydrogels exhibit enhanced thermosensitivity and cell release efficiency versus the conventional single network (SN) hydrogel, particularly for the micropillar arrays.

    7. Hydrophobic Polyalanine Modified Hyperbranched Polyethylenimine as High Efficient pDNA and siRNA Carrier

      Zhaopei Guo, Huayu Tian, Lin Lin, Jie Chen, Chaoliang He, Zhaohui Tang and Xuesi Chen

      Article first published online: 20 JUN 2014 | DOI: 10.1002/mabi.201400044

      Thumbnail image of graphical abstract

      Successful gene therapy for cancer and various human genetic diseases treatment relies on high efficient gene carriers. But for most carriers, either DNA or RNA can be effectively delivered. Here, amphiphilic copolymers polyethylenimine-polyalanine, with good biocompatibility, are prepared for high efficient transfection both in DNA and RNA.

    8. Star-Shape Redox-Responsive PEG-Sheddable Copolymer of Disulfide-Linked Polyethylene Glycol-Lysine-di-Tocopherol Succinate for Tumor-Triggering Intracellular Doxorubicin Rapid Release: Head-to-Head Comparison

      Xiaoyu Ai, Jin Sun, Lu Zhong, Chunnuan Wu, Handong Niu, Tao Xu, He Lian, Xiaopeng Han, Guolian Ren, Wenya Ding, Jia Wang, Xiaohui Pu and Zhonggui He

      Article first published online: 20 JUN 2014 | DOI: 10.1002/mabi.201400149

      Thumbnail image of graphical abstract

      Self-assembled redox-responsive nanomicelles are endocytosed into tumor cells. Then, disulfide bonds in micelles are cleaved and poly(ethylene glycol) (PEG) hydration shell is shed, induced by the high glutathione concentration. The nanomicelles are disassembled and the loaded doxorubicin (DOX) is released into the plasma and translocates into the nucleus to exert its anticancer effect.

    9. Protease-Sensitive PEG Hydrogels Regulate Vascularization In Vitro and In Vivo

      Marina Vigen, Jacob Ceccarelli and Andrew J. Putnam

      Article first published online: 18 JUN 2014 | DOI: 10.1002/mabi.201400161

      Thumbnail image of graphical abstract

      Co-encapsulation of endothelial cells and supportive fibroblasts within proteolyzable poly(ethylene glycol) (PEG)-based hydrogels led to vascular morphogenesis in vitro that was robust to changes in crosslinking peptide identity, but was significantly attenuated by gel crosslinking and MMP inhibition. In vivo, perfused vasculature formed from transplanted cells in all gel types, and vascularization was not attenuated in more crosslinked gels.

    10. Introducing PeptoPlexes: Polylysine-block-Polysarcosine Based Polyplexes for Transfection of HEK 293T Cells

      Philipp Heller, Alexander Birke, David Huesmann, Benjamin Weber, Karl Fischer, Angelika Reske-Kunz, Matthias Bros and Matthias Barz

      Article first published online: 18 JUN 2014 | DOI: 10.1002/mabi.201400167

      Thumbnail image of graphical abstract

      The synthesis, characterization, and application of polypeptide-polypeptoid block copolymers and polyplexes thereof based on the body's own amino acids sarcosine and lysine are presented. The pathway to PLys-block-PSar and the use of the synthesized block ionomers for the formation of polyplexes (PeptoPlexes) and for first transfection studies in HEK 293T cells are described.

    11. Cisplatin Loaded Methoxy Poly (ethylene glycol)-block-Poly (L-glutamic acid-co-L-Phenylalanine) Nanoparticles against Human Breast Cancer Cell

      Zaheer Ahmad, Zhaohui Tang, Afzal Shah, Shixian Lv, Dawei Zhang, Ying Zhang and Xuesi Chen

      Article first published online: 16 JUN 2014 | DOI: 10.1002/mabi.201400109

      Thumbnail image of graphical abstract

      Novel cisplatin loaded nanoparticles of poly (amino acids) block copolymers with two different formulations, CDDP/PGlu10 and CDDP/PGlu20, are synthesized. The CDDP-loaded nanoparticles show remarkably longer blood circulation time than free cisplatin. Due to its higher hydrophobic moity content, the CDDP/PGlu10 exhibits enhanced stability and prolonged circulation time as compared to CDDP/PGlu20.

  2. Communication

    1. Zwitterionic Red Fluorescent Polymeric Nanoparticles for Cell Imaging

      Haiyin Li, Xiqi Zhang, Xiaoyong Zhang, Bin Yang, Yang Yang, Zengfang Huang and Yen Wei

      Article first published online: 13 JUN 2014 | DOI: 10.1002/mabi.201400223

      Thumbnail image of graphical abstract

      Cross-linked zwitterionic red fluorescent copolymers are fabricated by incorporating phospholipid monomer and aggregation-induced emission dye-based dimer via reversible addition–fragmentation transfer polymerization. These cross-linked polymers are easy to self-assembly into uniform nanoparticles that show high water dispersibility, intense red fluorescence, and excellent biocompatibility, making them promising for cell imaging applications.

  3. Full Papers

    1. Miktoarm Star Polymer Based Multifunctional Traceable Nanocarriers for Efficient Delivery of Poorly Water Soluble Pharmacological Agents

      Ghareb M. Soliman, Rocio Redon, Anjali Sharma, Diana Mejía, Dusica Maysinger and Ashok Kakkar

      Article first published online: 6 JUN 2014 | DOI: 10.1002/mabi.201400123

      Thumbnail image of graphical abstract

      Miktoarm stars containing a covalently linked dye self-assemble into inherently fluorescent nanocarriers which perform multiple functions including enhanced hydrophobic drug solubilization, sustained release, and tracking their cellular fate.

    2. Nanoparticles of Esterified Polymalic Acid for Controlled Anticancer Drug Release

      Alberto Lanz-Landázuri, José Portilla-Arias, Antxon Martínez de Ilarduya, Montserrat García-Alvarez, Eggehard Holler, Julia Ljubimova and Sebastián Muñoz-Guerra

      Article first published online: 6 JUN 2014 | DOI: 10.1002/mabi.201400124

      Thumbnail image of graphical abstract

      100–300 nm particles of microbial poly(β,L-malic acid), partially esterified with ethanol, degrade in physiological environments to L-malic acid and ethanol. Doxorubicin (DOX) loaded particles steadily release the drug for weeks whereas Temozolomide is fully liberated within hours. These particles are shown to favor internalization of DOX in glioma cells.

    3. Chitosan Microsphere Scaffold Tethered with RGD-Conjugated Poly(methacrylic acid) Brushes as Effective Carriers for the Endothelial Cells

      Zhenyi Yang, Shaojun Yuan, Bin Liang, Yang Liu, Cleo Choong and Simo O. Pehkonen

      Article first published online: 4 JUN 2014 | DOI: 10.1002/mabi.201400136

      Thumbnail image of graphical abstract

      Chitosan (CS) microspheres are functionalized with RGD-poly(methacrylic acid) conjugates by surface-initiated atom transfer polymerization of methacrylate sodium and carbodiimide chemistry of RGD peptide. The favorable cell adhesion and proliferation of human umbilical vein endothelial cells (HUVECs) are observed on the RGD-immobilized microspheres as compared the pristine CS microspheres.

    4. Bioengineered Silk Gene Delivery System for Nuclear Targeting

      Sezin Yigit, Olena Tokareva, Antonio Varone, Irene Georgakoudi and D. L. Kaplan

      Article first published online: 30 MAY 2014 | DOI: 10.1002/mabi.201400113

      Thumbnail image of graphical abstract

      A novel design of recombinant spider silk plasmid for gene delivery and nuclear targeting is established by combining endosomal escape unit and a viral transactivation peptide sequence. Non-viral polyplexes formed by condensing pDNA and the recombinant protein show increased localization around nucleus and high-transfection values as well as excellent biocompatibility.

    5. Charge-Conversional and pH-Sensitive PEGylated Polymeric Micelles as Efficient Nanocarriers for Drug Delivery

      Gong-Yan Liu, Min Li, Cong-Shan Zhu, Qiao Jin, Zong-Cai Zhang and Jian Ji

      Article first published online: 28 MAY 2014 | DOI: 10.1002/mabi.201400162

      Thumbnail image of graphical abstract

      Charge-conversion and pH-sensitive PEGylated polymeric micelles with nano-sizes are prepared as drug carries. Anti-cancer drugs can be loaded into the micelle core formed by hydrophobic amide. At acidic tumor environment, the hydrolysis of amide bonds results in a negative-to-positive charge conversion and disassembly of the micelles, with simultaneously pH-triggered drug release.

    6. Biocatalytic Synthesis of Maltodextrin-Based Acrylates from Starch and α-Cyclodextrin

      Wouter M. J. Kloosterman, Gerda Spoelstra-van Dijk and Katja Loos

      Article first published online: 26 MAY 2014 | DOI: 10.1002/mabi.201400091

      Thumbnail image of graphical abstract

      The cyclodextrin glycosyltransferase from Bacillus macerans is found to catalyze the transglycosidation of 2-(β-glucosyloxy)-ethyl acrylate with starch and α-cylcodextrin to yield novel 2-(β-maltooligooxy)-ethyl-acrylate and methacrylate monomers. The maltooligooxy-acrylate monomers are subsequently polymerized by aqueous free radical polymerization to yield a new kind of comb-shaped glycopolymers.

    7. Functionalized Polyglycerol Amine Nanogels as Nanocarriers for DNA

      Markus Hellmund, Haixia Zhou, Olga Samsonova, Pia Welker, Thomas Kissel and Rainer Haag

      Article first published online: 26 MAY 2014 | DOI: 10.1002/mabi.201400144

      Thumbnail image of graphical abstract

      Polyglycerol amine nanogels are studied as cationic carrier systems for non-viral DNA delivery and show successful cellular uptake. These homogeneous nanogels with a size of ≈ 100 nm and a varying percentage of amine groups demonstrate a different polyplex formation behavior due to polyvalency.

    8. Poly(2-Hydroxyethyl Methacrylate)-b-Poly(L-Lysine) Cationic Hybrid Materials for Non-Viral Gene Delivery in NIH 3T3 Mouse Embryonic Fibroblasts

      Renjith P. Johnson, Saji Uthaman, Johnson V. John, Min Seon Heo, In Kyu Park, Hongsuk Suh and Il Kim

      Article first published online: 23 MAY 2014 | DOI: 10.1002/mabi.201400071

      Thumbnail image of graphical abstract

      This work investigates new biocompatible polycationic hybrid materials, poly[(2-hydroxyethyl methacrylate)-b-(L-lysine)], as the non-viral gene vectors for pDNA delivery into mouse embryonic fibroblast cells. The biocompatible cationic vectors have a great potential as a promising candidate for future gene therapeutic applications.

    9. Injectable In Situ Forming Hybrid Iron Oxide-Hyaluronic Acid Hydrogel for Magnetic Resonance Imaging and Drug Delivery

      Yu Zhang, Yi Sun, Xia Yang, Jöns Hilborn, Arend Heerschap and Dmitri A. Ossipov

      Article first published online: 23 MAY 2014 | DOI: 10.1002/mabi.201400117

      Thumbnail image of graphical abstract

      Iron oxide nanoparticles are encapsulated in the hydrophobic fluorescent core of “click” cross-linkable nanogels of hyaluronic acid. These nanogels are in situ converted into a bulk hydrogel and subsequently liberated through enzymatic degradation of the hydrogel to provide magnetic resonance imaging of the degradation process.

    10. Polylysine Crosslinked AIE Dye Based Fluorescent Organic Nanoparticles for Biological Imaging Applications

      Meiying Liu, Xiqi Zhang, Bin Yang, Liangji Liu, Fengjie Deng, Xiaoyong Zhang and Yen Wei

      Article first published online: 22 MAY 2014 | DOI: 10.1002/mabi.201400140

      Thumbnail image of graphical abstract

      A novel one-pot method for the fabrication of crosslinked RO-OA-Ply FONs, which occurs at room temperature in air without catalyst or initiator, is discussed. These readily assemble into FONs in pure aqueous solution, exhibiting strong red fluorescence, high water dispersibility, uniform morphology, and excellent biocompatibility, making them potentially suitable for various biomedical applications.

    11. Polymersomes from Polypeptide Containing Triblock Co- and Terpolymers for Drug Delivery against Pancreatic Cancer: Asymmetry of the External Hydrophilic Blocks

      Hermis Iatrou, Konstantinos Dimas, Manos Gkikas, Chrisida Tsimblouli and Sosanna Sofianopoulou

      Article first published online: 19 MAY 2014 | DOI: 10.1002/mabi.201400137

      Thumbnail image of graphical abstract

      Model amphiphilic poly(L-lysine hydrochloride)-b-poly(γ-benzyl(d7)-L-glutamate)-b-poly(L-lysine hydrochloride) and poly(ethylene oxide)-b-poly(γ-benzyl-L-glutamate)-b-poly(L-lysine hydrochloride) are synthesized. Both form polymersomes in water and are loaded with doxorubicin or paclitaxel. Due to asymmetry of the hydrophilic blocks, poly(ethylene oxide) is always on the periphery. The loaded polymersomes are tested in vivo and in vitro against human pancreatic cancer cell lines.

    12. Mussel-Inspired Cell-Adhesion Peptide Modification for Enhanced Endothelialization of Decellularized Blood Vessels

      Jung Seung Lee, Kihong Lee, Sung-Hwan Moon, Hyung-Min Chung, Jun Hyup Lee, Soong Ho Um, Dong-Ik Kim and Seung-Woo Cho

      Article first published online: 16 MAY 2014 | DOI: 10.1002/mabi.201400052

      Thumbnail image of graphical abstract

      Mussel-inspired catechol functionalization by polydopamine coating leads to efficient immobilization of cell adhesion peptides on decellularized blood vessel matrices. Peptide modification promotes adhesion, metabolic activity, and endothelial differentiation of human endothelial progenitor cells, which ultimately facilitates endothelialization of the decellularized matrices.

    13. Tailor-Made Nanocontainers for Combined Magnetic-Field-Induced Release and MRI

      Markus B. Bannwarth, Sandro Ebert, Maximilian Lauck, Ulrich Ziener, Stephanie Tomcin, Gerhard Jakob, Kerstin Münnemann, Volker Mailänder, Anna Musyanovych and Katharina Landfester

      Article first published online: 9 MAY 2014 | DOI: 10.1002/mabi.201400122

      Thumbnail image of graphical abstract

      All-in-one nanocontainers: Tailor-made nanocapsules with integrated superparamagnetic nanoparticles and equipped with a thermo-labile shell possess dual-functionality. After efficient encapsulation of a model dye, a release of the payload can be externally triggered by application of an alternating magnetic field. Additionally, the nanocontainers with encapsulated magnetic nanoparticles can act as contrast agents for magnetic resonance imaging.

    14. Synergistic Effect of Dual-Functionalized Fibrous Scaffold with BCP and RGD Containing Peptide for Improved Osteogenic Differentiation

      Young Min Shin, Sun-Young Jo, Jong-Seok Park, Hui-Jeong Gwon, Sung In Jeong and Youn-Mook Lim

      Article first published online: 7 MAY 2014 | DOI: 10.1002/mabi.201400023

      Thumbnail image of graphical abstract

      Appropriate bone regeneration is systemically regulated by bioceramics and biomolecules in the extracellular matrix. Multi-functional scaffolds are required for facilitating the bone regeneration. Herein, dual-functional fibrous scaffolds with biphasic calcium phosphate (BCP) and Arg–Gly–Asp (RGD) peptide are introduced for bone tissue engineering and the effect to hMSC behavior control is investigated.

    15. Antimicrobial Polyurethane Thermosets Based on Undecylenic Acid: Synthesis and Evaluation

      Cristina Lluch, Braulio Esteve-Zarzoso, Albert Bordons, Gerard Lligadas, Juan C. Ronda, Marina Galià and Virginia Cádiz

      Article first published online: 6 MAY 2014 | DOI: 10.1002/mabi.201400017

      Thumbnail image of graphical abstract

      Plant-derived polyurethanes with enhanced surface hydrophilicity coupled with antimicrobial property are prepared from methyl ester-containing polyurethane networks via aminolysis and subsequently iodine complexation.

    16. Synthesis, Cellular Uptake, and Biodistribution of Whey-Rich Nanoparticles

      Xu Zhen, Xin Wang, Chenchen Yang, Qin Liu, Wei Wu, Baorui Liu and Xiqun Jiang

      Article first published online: 2 MAY 2014 | DOI: 10.1002/mabi.201400018

      Thumbnail image of graphical abstract

      The cellular uptakes and penetration of DOX-loaded whey-PAA nanoparticles are observed in monolayer cells and 3D cellular model. The distribution of DOX-loaded whey-PAA nanoparticles in tumor-bearing mice is examined. The nanoparticles can penetrate 3D cellular model more deeply and well accumulated in the tumor site.

    17. Human Epidermal Keratinocyte Cell Response on Integrin-Specific Artificial Extracellular Matrix Proteins

      Monica Suryana Tjin, Alvin Wen Choong Chua, Dong Rui Ma, Seng Teik Lee and Eileen Fong

      Article first published online: 2 MAY 2014 | DOI: 10.1002/mabi.201400015

      Thumbnail image of graphical abstract

      Artificial extracellular matrix (aECM) proteins bearing integrin-specific cell binding domains are designed to enhance cell adhesion and growth of keratinocytes while maintaining their stem cell characteristics. The attachment of keratinocytes on aECM proteins is shown to be a specific interaction between integrins and the cell binding domains present within each construct. It is demonstrated that aECM proteins have potential for use as artificial skin substrates.

    18. Efficient Gene Carriers Composed of 2-Hydroxypropyl-β-Cyclodextrin, Ethanolamine-Functionalized Poly(glycidyl methacrylate), and Poly((2-dimethyl amino)ethyl methacrylate) by Combination of ATRP and Click Chemistry

      Yun Zhu, Xuefeng Zheng, Bingran Yu, Wantai Yang, Nana Zhao and Fujian Xu

      Article first published online: 2 MAY 2014 | DOI: 10.1002/mabi.201400062

      Thumbnail image of graphical abstract

      An efficient copolymer gene vector composed of 2-hydroxypropyl-β-cyclodextrin, ethanolamine-functionalized poly(glycidyl methacrylate), and poly((2-dimethyl amino)ethyl methacrylate) is proposed via ATRP and click chemistry.

    19. Chitosan-coated Gold Nanorods for Cancer Therapy Combining Chemical and Photothermal Effects

      Ruiping Duan, Zhimin Zhou, Guanghao Su, Lingrong Liu, Man Guan, Bo Du and Qiqing Zhang

      Article first published online: 2 MAY 2014 | DOI: 10.1002/mabi.201300563

      Thumbnail image of graphical abstract

      A novel type of nanocarrier is prepared from chitosan derivatives and gold nanorods. The nanocarriers exhibit high stability and may be useful for cancer therapy combining chemical and photothermal effects.

    20. Multifunctional Poly(Vinyl Amine)s Bearing Azetidinium Groups: One Pot Preparation in Water and Antimicrobial Properties

      Subrata Chattopadhyay, Elisabeth Therese Heine, Helmut Keul and Martin Möller

      Article first published online: 29 APR 2014 | DOI: 10.1002/mabi.201300576

      Thumbnail image of graphical abstract

      Post polymerization modification of poly(vinyl amine) in aqueous solution with hydrophobic and cationic reactive building blocks results in multifunctional antimicrobial polymers. These polymers with alkyl chains and azetidinium groups differentiate between microorganisms and mammalian cells.

    21. Redox-Responsive Nanoparticles with Aggregation-Induced Emission (AIE) Characteristic for Fluorescence Imaging

      Weiren Cheng, Guan Wang, Xiaoyong Pan, Yong Zhang, Ben Zhong Tang and Ye Liu

      Article first published online: 28 APR 2014 | DOI: 10.1002/mabi.201400076

      Thumbnail image of graphical abstract

      The nanoparticles with PEG shells and low cytotoxcity are fluorescent in intracellular compartments but non-fluorescent in extracellular matrix, therefore, to provide fluorescence imaging with a high contrast. Furthermore, the fluorescent intensity increases with the concentration of thiol, making it promising for differentiation of redox environment using fluorescence imaging.

    22. Overcoming Cancer Multidrug Resistance by Codelivery of Doxorubicin and Verapamil with Hydrogel Nanoparticles

      Ming Qin, Yong-Eun Koo Lee, Aniruddha Ray and Raoul Kopelman

      Article first published online: 28 APR 2014 | DOI: 10.1002/mabi.201400035

      Thumbnail image of graphical abstract

      A new kind of hydrogel nanoparticles is developed as a delivery vehicle for codelivery of doxorubicin, an anti-cancer drug (affects DNA), and verapamil, a chemosensitizer (blocks efflux pump), to tumor cells, aiming at overcoming multidrug resistance.

    23. Regulating Schwann Cells Growth by Chitosan Micropatterning for Peripheral Nerve Regeneration In Vitro

      Guicai Li, Xueying Zhao, Luzhong Zhang, Caiping Wang, Yunwei Shi and Yumin Yang

      Article first published online: 23 APR 2014 | DOI: 10.1002/mabi.201400098

      Thumbnail image of graphical abstract

      Most Schwann Cells (SCs) grow along well with the chitosan micropatterning on 30/30 µm sample, while some cells grow across the micropatterning on the 20/20 µm sample. And the neurite of the SCs on the 30/30 µm sample present better ductility along the stripe structure than the 20/20 µm sample after culturing for 1 d.

    24. Polymeric Nanocarriers for siRNA Delivery to Murine Macrophages

      Diane C. Forbes and Nicholas A. Peppas

      Article first published online: 22 APR 2014 | DOI: 10.1002/mabi.201400027

      Thumbnail image of graphical abstract

      This work investigates the interactions of a polycationic nanocarrier with siRNA and with RAW264.7 cells in order to better understand the capabilities and limitations of the carrier. The cross-linked, DEAEMA-based nanoparticles are synthesized using ARGET ATRP in a single-step reaction. The carriers efficiently bind siRNA and are internalized by cells for siRNA delivery.

    25. Electrospun Nanofiber Scaffolds and Plasma Polymerization: A Promising Combination Towards Complete, Stable Endothelial Lining for Vascular Grafts

      Houman Savoji, Afra Hadjizadeh, Marion Maire, Abdellah Ajji, Michael R. Wertheimer and Sophie Lerouge

      Article first published online: 17 APR 2014 | DOI: 10.1002/mabi.201300545

      Thumbnail image of graphical abstract

      Electrospinning and plasma polymerization are combined to provide vascular graft scaffolds. These bear similarity to the extracellular matrix beneath the luminal endothelium, are mechanically compliant and biocompatible, and facilitate formation of a cofluent monolayer of endothelial cells on the lumen, one that is stable under static and shear-induced flow conditions.

    26. pH-Sensitive Chitosan-based Hydrogel Nanoparticles through Miniemulsion Polymerization Mediated by Peroxide Containing Macromonomer

      Nadiya Solomko, Olga Budishevska, Stanislav Voronov, Katharina Landfester and Anna Musyanovych

      Article first published online: 8 APR 2014 | DOI: 10.1002/mabi.201300512

      Thumbnail image of graphical abstract

      The synthesis of cross-linked pH-sensitive hydrogel nanoparticles (HNp) based on free-radical graft copolymerization between peroxide-modified chitosan and 1-vinyl-2-pyrrolidone is reported. The formation of HNp with a size average 155–190 nm is achieved in the aqueous nanodroplets of inverse miniemulsion. Parameters such as cross-linking density, pH, and nature of ionic “payload” molecules greatly affect the swelling behavior and release profile from HNp.


  1. 1 - 38