Macromolecular Bioscience

Cover image for Vol. 14 Issue 4

Early View (Online Version of Record published before inclusion in an issue)

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  1. 1 - 41
  1. Full Papers

    1. Magnetic Nanoclusters Engineered by Polymer-Controlled Self-Assembly for the Accurate Diagnosis of Atherosclerotic Plaques via Magnetic Resonance Imaging

      Myeong-Hoon Kim, Bongjune Kim, Eun-Kyung Lim, Yuna Choi, Jihye Choi, Eunjung Kim, Eunji Jang, Hyo Seon Park, Jin-Suck Suh, Yong-Min Huh and Seungjoo Haam

      Article first published online: 17 APR 2014 | DOI: 10.1002/mabi.201400029

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      Oleyl dextran (ODex) coated magnetic nanocluster (ODMC) is developed and engineered by polymer-controlled self-assembly to be used as efficient MR imaging nanoprobe of atherosclerosis. T2 relaxivity of ODMCs is highly enhanced by controlling the condition of ODex including the degree of substitution of the oleyl group and the concentration used for the synthesis of ODMCs.

    2. Electrospun Nanofiber Scaffolds and Plasma Polymerization: A Promising Combination Towards Complete, Stable Endothelial Lining for Vascular Grafts

      Houman Savoji, Afra Hadjizadeh, Marion Maire, Abdellah Ajji, Michael R. Wertheimer and Sophie Lerouge

      Article first published online: 17 APR 2014 | DOI: 10.1002/mabi.201300545

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      Electrospinning and plasma polymerization are combined to provide vascular graft scaffolds. These bear similarity to the extracellular matrix beneath the luminal endothelium, are mechanically compliant and biocompatible, and facilitate formation of a cofluent monolayer of endothelial cells on the lumen, one that is stable under static and shear-induced flow conditions.

    3. Sequential pH-Dependent Adsorption of Ionic Amphiphilic Diblock Copolymer Micelles and Choline Oxidase Onto Conductive Substrates: Toward the Design of Biosensors

      Larisa V. Sigolaeva, Ulrike Günther, Dmitry V. Pergushov, Snezhana Yu. Gladyr, Ilya N. Kurochkin and Felix H. Schacher

      Article first published online: 17 APR 2014 | DOI: 10.1002/mabi.201300580

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      Block copolymer/enzyme biosensors are prepared via electrostatically driven co-assembly. Amphiphilic diblock copolymer micelles of poly(n-butylmethacrylate)-block-poly(N,N-dimethylaminoethyl methacrylate) and choline oxidase are used as building blocks to fabricate bilayer films on conductive substrates (modified graphite or gold) at different pH-values. The resulting hybrid thin-films represent highly active and stable biosensors for choline.

    4. Thiolated Eudragit-based Nanoparticles for Oral Insulin Delivery: Preparation, Characterization, and Evaluation Using Intestinal Epithelial Cells In Vitro

      Yan Zhang, Xuli Du, Yu Zhang, Guofei Li, Cuifang Cai, Jinghua Xu and Xing Tang

      Article first published online: 16 APR 2014 | DOI: 10.1002/mabi.201300515

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      Novel nanoparticles composed of Eudragit L100-cysteine (Eul-cys) and reduced glutathione (GSH) are prepared as potential nanocarriers for the oral delivery of insulin. The permeation enhancement of GSH is evaluated by Caco-2 and Caco-2/HT29-MTX co-cultured cells in vitro, which is compared to sodium caprate (SC). The results indicate that the mucus layer may be a barrier for transportation of thiolated nanoparticles, and the paracellular route may represent the main mechanism by which nanoparticles facilitate insulin permeation.

    5. pH-Sensitive Chitosan-based Hydrogel Nanoparticles through Miniemulsion Polymerization Mediated by Peroxide Containing Macromonomer

      Nadiya Solomko, Olga Budishevska, Stanislav Voronov, Katharina Landfester and Anna Musyanovych

      Article first published online: 8 APR 2014 | DOI: 10.1002/mabi.201300512

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      The synthesis of cross-linked pH-sensitive hydrogel nanoparticles (HNp) based on free-radical graft copolymerization between peroxide-modified chitosan and 1-vinyl-2-pyrrolidone is reported. The formation of HNp with a size average 155–190 nm is achieved in the aqueous nanodroplets of inverse miniemulsion. Parameters such as cross-linking density, pH, and nature of ionic “payload” molecules greatly affect the swelling behavior and release profile from HNp.

    6. Multiresponsive Hyaluronan-p(NiPAAm) “Click”-Linked Hydrogels

      Sharad K. Pasale, Barbara Cerroni, Shivkumar V. Ghugare and Gaio Paradossi

      Article first published online: 6 APR 2014 | DOI: 10.1002/mabi.201400021

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      Telechelic pNiPAAm chains, with controlled molecular weight, bearing alkyne functionalities at both chain ends, obtained by a novel modification of RAFT polymerization, and grafted hyaluronan backbones with side-chains ending with azido groups are crosslinked according to “click chemistry” protocols as monolithic hydrogels. The constructs display combined or separated responsivities to temperature, pH and ionic strength and are biodegradable. Proliferation is enhanced in the case of tumor cells.

    7. Synthesis and Characterization of Homopolymers Bearing Acid-Cleavable Cationic Side-Chains for pH-Modulated Release of DNA

      Zhangyan Xu, Junping Lai, Rupei Tang, Weihang Ji, Rui Wang, Jun Wang and Chun Wang

      Article first published online: 4 APR 2014 | DOI: 10.1002/mabi.201400004

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      A new mechanism of pH-modulated release of DNA from polymeric carrier (PMAOE) through a combination of cationic side-chain cleavage with increased polymer hydrophilicity and neutralization of residual cationic charges is demonstrated. These structurally simple side-chain degradable PMAOE homopolymers may have great potential as gene delivery vectors capable of releasing DNA in response to external or intracellular pH environment.

  2. Communication

    1. Glycopolymer Functionalization of Engineered Spider Silk Protein-based Materials for Improved Cell Adhesion

      John G. Hardy, André Pfaff, Aldo Leal-Egaña, Axel H. E. Müller and Thomas R. Scheibel

      Article first published online: 2 APR 2014 | DOI: 10.1002/mabi.201400020

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      Recombinantly produced spider silk protein-based materials are promising for use as tissue scaffolds. Herein, the preparation of films functionalized with extracellular matrix protein-binding glycopolymers, and their potential as biocompatible coatings, are reported.

    2. Fluorescent Amphiphilic PEG-Peptide-PEG Triblock Conjugate Micelles for Cell Imaging

      Tapas K. Paira, Anupam Saha, Sanjib Banerjee, Tamalika Das, Pradip Das, Nikhil R. Jana and Tarun K. Mandal

      Article first published online: 31 MAR 2014 | DOI: 10.1002/mabi.201400083

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      A blue fluorescent amphiphilic poly(ethylene glycol)-peptide-fluorophore-peptide-poly(ethylene glycol) triblock conjugate is synthesized by “grafting to” technique based on Schiff base coupling chemistry, which undergo self-assembly in water to from micelles. The highly stable and low toxic conjugate micelles are used for fluorescent imaging of HeLa cells.

  3. Full Papers

    1. Enzymatic Control of Chitosan Gelation for Delivery of Periodontal Ligament Cells

      Xiang-Zhen Yan, Arnold W. G. Nijhuis, Jeroen J. J. P. van den Beucken, Sanne K. Both, John A. Jansen, Sander C. G. Leeuwenburgh and Fang Yang

      Article first published online: 31 MAR 2014 | DOI: 10.1002/mabi.201400040

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      Physically crosslinked chitosan hydrogels for biomedical purpose can be easily fabricated via enzymatic control. The gelation time, strength, and degradation rate of chitosan hydrogels can be fine-tuned through variation of the concentrations of urea and urease. Periodontal ligament cells remain viable and maintain their capacities upon encapsulation within these hydrogels for up to 30 days.

  4. Review Articles

    1. Electrospun Nanofibers as Dressings for Chronic Wound Care: Advances, Challenges, and Future Prospects

      Martina Abrigo, Sally L. McArthur and Peter Kingshott

      Article first published online: 28 MAR 2014 | DOI: 10.1002/mabi.201300561

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      Chronic non-healing wounds show delayed and incomplete healing exposing patients to a high risk of infection. Electrospinning is one potential way to fabricate innovative wound dressings. Strategic material selection that includes drugs, surface modification, and sensors are currently being explored to address specific wound challenges.

  5. Feature Articles

    1. Bioreducible Polycations in Nucleic Acid Delivery: Past, Present, and Future Trends

      David Oupický and Jing Li

      Article first published online: 28 MAR 2014 | DOI: 10.1002/mabi.201400061

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      This Feature Article provides an overview of the current status of research into the chemistry of bioreducible polycations and their use in nucleic acid delivery.

  6. Communication

    1. Microsphere-Based Intracellular Sensing of Caspase-3/7 in Apoptotic Living Cells

      Juan Manuel Cárdenas-Maestre, Ana M. Pérez-López, Mark Bradley and Rosario M. Sánchez-Martín

      Article first published online: 25 MAR 2014 | DOI: 10.1002/mabi.201300525

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      Monitoring enzymatic activity inside living cells. A novel probe for the detection of a particular enzymatic activity intracellularly in living cells are successfully developed. In particular, the applicability of these microspheres for sensing caspase-3/7 enzymatic activity in living cells by flow cytometry is reported.

  7. Feature Articles

    1. New Perspectives of HPMA-based Copolymers Derived by Post-Polymerization Modification

      Lutz Nuhn, Matthias Barz and Rudolf Zentel

      Article first published online: 19 MAR 2014 | DOI: 10.1002/mabi.201400028

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      Poly[N-(2-hydroxypropyl)methacrylamide] (HPMA) copolymers prepared by post-polymerization modification. This Feature Article highlights multifunctional HPMA-based copolymers prepared by post-polymerization modification of well-defined precursor polymers and their first applications in drug delivery, diagnostic imaging, and tumor immunotherapy.

  8. Full Papers

    1. Electrospun Micelles/Drug-Loaded Nanofibers for Time-Programmed Multi-Agent Release

      Guang Yang, Jie Wang, Long Li, Shan Ding and Shaobing Zhou

      Article first published online: 13 MAR 2014 | DOI: 10.1002/mabi.201300575

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      A nanoscale multi-drug delivery system, whose release behavior shows a time-programmed release and can be temporally and spatially controlled for each cargo, is fabricated based on polymer micelle-enriched electrospun nanofibers. The combination of multiple agents possesses great potential in improving the efficiency of cancer chemotherapy compared with only one therapeutic agent.

    2. Peptide-Directed Self-Assembly of Functionalized Polymeric Nanoparticles Part I: Design and Self-Assembly of Peptide–Copolymer Conjugates into Nanoparticle Fibers and 3D Scaffoldsa

      Xiaochu Ding, Jagadeesh Janjanam, Ashutosh Tiwari, Martin Thompson and Patricia A. Heiden

      Article first published online: 7 MAR 2014 | DOI: 10.1002/mabi.201300569

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      A fundamentally new approach to fabricate an ionic complementary peptide-directed self-assembly of polymeric nanoparticles into continuous nanoparticle fibers and 3D scaffolds is presented. This scaffolding system possesses the advantages of individually controlling the release of each drug-loaded nanoparticle with the potential to serve as a scaffolding.

    3. Enzymatic Mineralization of Silk Scaffolds

      Sangram K. Samal, Mamoni Dash, Heidi A. Declercq, Tom Gheysens, Jolien Dendooven, Pascal Van Der Voort, Ria Cornelissen, Peter Dubruel and David L. Kaplan

      Article first published online: 7 MAR 2014 | DOI: 10.1002/mabi.201300513

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      Alkaline phosphatase-mediated formation of apatitic minerals on porous silk protein (SFP) scaffolds. The mineral structures differ as a function of ALP concentration. The mineralized SFP scaffolds are effective in improving cellular adhesion, proliferation, and colonization by osteogenic cells.

    4. You have full text access to this OnlineOpen article
      Silk-Pectin Hydrogel with Superior Mechanical Properties, Biodegradability, and Biocompatibility

      Keiji Numata, Shoya Yamazaki, Takuya Katashima, Jo-Ann Chuah, Naofumi Naga and Takamasa Sakai

      Article first published online: 7 MAR 2014 | DOI: 10.1002/mabi.201300482

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      The silk-pectin hydrogel reported here is composed of a heterogeneous network, which is different from fiber-reinforced, interpenetrated networks and double-network hydrogels. The silk-pectin hydrogel is also high-strength hydrogel (elastic modulus of 4.7 ± 0.9 MPa, elastic stress limit of 3.9 ± 0.1 MPa, and elastic strain limit of 48.4 ± 0.5%) with regard to biocompatibility and biodegradability.

    5. Cell Behavior on Surface Modified Polydimethylsiloxane (PDMS)

      Morgan M. Stanton, Johanna M. Rankenberg, Byung-Wook Park, W. Grant McGimpsey, Christopher Malcuit and Christopher R. Lambert

      Article first published online: 6 MAR 2014 | DOI: 10.1002/mabi.201300504

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      A biochemical micro-pattern is successfully combined with a micro-rough polymer surface as a scaffold to mimic in vivo environments for tissue engineering. Cells cultured on the modified polymer exhibit alignment and significantly altered gene expression. This novel substrate has useful applications for complex tissue design and biomimetic scaffolds.

    6. Poly(hydroxybutyrate-co-hydroxyvalerate) Bilayer Skin Tissue Engineering Constructs with Improved Epidermal Rearrangement

      Alessandra Zonari, Mariana T. Cerqueira, Silviene Novikoff, Alfredo M. Goes, Alexandra P. Marques, Vitor M. Correlo and Rui L. Reis

      Article first published online: 4 MAR 2014 | DOI: 10.1002/mabi.201400005

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      Taking in consideration skin two main strata, epidermis and dermis, a bilayer structure based on poly(hydroxybutyrate-co-hydroxyvalerate) is developed, combining a 2D thin nanoporous upper layer and a 3D scaffold. The bilayer system favors human fibroblasts and keratinocytes performance under defined co-culture conditions and leads to the particular rearrangement of human keratinocytes in a multilayer structure.

  9. Special Article Series–Full Papers

    1. Effect of Cell Density on Mesenchymal Stem Cells Aggregation in RGD-Alginate 3D Matrices under Osteoinductive Conditions

      F. Raquel Maia, Ana H. Lourenço, Pedro L. Granja, Raquel M. Gonçalves and Cristina C. Barrias

      Article first published online: 28 FEB 2014 | DOI: 10.1002/mabi.201300567

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      The importance of optimizing initial cell densities in 3D-cultures, a critical and frequently overlooked parameter that differentially affects distinct cellular activities, is highlighted. In MSCs cultures within RGD-alginate hydrogels, one of the most commonly used cell-entrapment matrices, high cell densities promote cell-cell contacts with formation of multicellular aggregates stabilized by endogenous ECM, and also stimulate osteogenesis.

  10. Full Papers

    1. Dexamethasone-Loaded Reconstitutable Charged Polymeric (PLGA)n-b-bPEI Micelles for Enhanced Nuclear Delivery of Gene Therapeutics

      Deepa Mishra, Han Chang Kang, Hana Cho and You Han Bae

      Article first published online: 18 FEB 2014 | DOI: 10.1002/mabi.201300432

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      Using cationic micelles, layer-by-layer micelle-based polymeric gene and drug nanocarriers are constructed. Dexamethasone and plasmid DNA are co-loaded into single nanocarriers via hydrophobic interaction and electrostatic attraction, respectively. Dexamethasone induces enhanced nuclear uptake of plasmid DNA, leading to 3- to 13-fold higher gene transfection efficiency compared to dexamethasone-free counterparts.

    2. Enzymatically Cross-Linked Gelatin/Chitosan Hydrogels: Tuning Gel Properties and Cellular Response

      Marcelo A. da Silva, Franziska Bode, Alex F. Drake, Silvia Goldoni, Molly M. Stevens and Cécile A. Dreiss

      Article first published online: 18 FEB 2014 | DOI: 10.1002/mabi.201300472

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      The natural gelation of gelatin is exploited to direct the enzymatic cross-linking of mixed chitosan/gelatin hydrogels. Using a hybrid gelation process improves the elastic modulus of the chemical network in the blends and cell proliferation. These gels, made from a mixture of widely available biopolymers obtained from waste products, combined to an enzymatic process, provide a facile and cheap approach towards functional materials.

    3. Stimuli-Responsive Capsules Prepared from Regenerated Silk Fibroin Microspheres

      Cheng Cheng, Ian Teasdale and Oliver Brüggemann

      Article first published online: 14 FEB 2014 | DOI: 10.1002/mabi.201300497

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      Stimuli-responsive microcapsules are synthesized via the self-assembly of silk fibroin microspheres with polycaprolactone in a colliodosome preparation procedure. The microsphere building blocks with controlled diameter are first prepared from the naturally occurring biopolymer, silk fibroin, and then act as stabilizers for oil-in-water (O/W) emulsion and form the capsules. The post-loaded capsules are observed as pH-responsive.

    4. Cell Adhesion Behavior in 3D Hydrogel Scaffolds Functionalized with D- or L-Aminoacids

      Kathrin Benson, Hans-Joachim Galla and Nermin Seda Kehr

      Article first published online: 10 FEB 2014 | DOI: 10.1002/mabi.201300485

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      3D alginate scaffolds are functionalized with the D- or L-penicillamine (PEN). Cells recognize and differentiate between the 3D scaffold surfaces functionalized with D-PEN or L-PEN. The affinity of C-6-glioma and endothelial cells is higher to D-PEN functionalized alginate scaffold than to L-PEN alginate scaffold.

  11. Communication

    1. Polyvalent Display of Monosaccharides on Ferritin Protein Cage Nanoparticles for the Recognition and Binding of Cell-Surface Lectins

      Young Ji Kang, Hyun Ji Yang, Sangbin Jeon, Young-Sun Kang, Yoonkyung Do, Sung You Hong and Sebyung Kang

      Article first published online: 10 FEB 2014 | DOI: 10.1002/mabi.201300528

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      Carbohydrate-lectin interactions are important in many biological events. Endogenous cell-surface lectins are attractive markers for the recognition and targeting. Ferritin protein cage nanoparticles are used as delivery nanoplatforms for polyvalently displaying monosaccharides on the surface to recognize and bind to specific cell-surface lectins.

    2. Gene Regulation by Intracellular Delivery and Photodegradation of Nanoparticles Containing Small Interfering RNA

      Shuhei Murayama, Petra Kos, Kanjiro Miyata, Kazunori Kataoka, Ernst Wagner and Masaru Kato

      Article first published online: 7 FEB 2014 | DOI: 10.1002/mabi.201300393

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      Photodegradable nanoparticle is proposed as the siRNA carrier to regulate genes in cells. Without UV, the siRNA shows no gene-silencing effects, after UV irradiation, siRNA is released leading to sequence-specific silencing of the mRNA. This indicates that siRNA-containing nanoparticles can be useful for spatiotemporal regulation of gene expression in cells.

  12. Full Papers

    1. Shell-Crosslinked Hyaluronic Acid Nanogels for Live Monitoring of Hyaluronidase Activity In Vivo

      Jihyun Kim, Youhoon Chong and Hyejung Mok

      Article first published online: 6 FEB 2014 | DOI: 10.1002/mabi.201300511

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      In this study, indocyanine green-embeded and shell-crosslinked hyaluronic acid (HA) nanogels (sc-nanogels) are fabricated. Characteristics and fluorescence signals of sc-nanogels are examined for selective imaging of hyaluronidases (HAdases) with appreciable signal-to-noise (S/N) ratios in vitro and in vivo.

    2. Easy Daylight Fabricated Hydrogel Array for Colorimetric DNA Analysis

      Antje Beyer, Sibyll Pollok, Albrecht Berg, Karina Weber and Jürgen Popp

      Article first published online: 3 FEB 2014 | DOI: 10.1002/mabi.201300487

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      A 3D in gel hybridization detection by naked eye, concomitant with a fast and simple one-pot polymerization technique at daylight, is presented. The array of surface bound hydrogel-pads (60 μm) reduces the needed amount of DNA and washing solutions. Enzymatically generated silver nanoparticles allow the detection of DNA hybridization without additional equipment.

    3. Xyloglucan-block-Poly(ϵ-Caprolactone) Copolymer Nanoparticles Coated with Chitosan as Biocompatible Mucoadhesive Drug Delivery System

      Letícia Mazzarino, Issei Otsuka, Sami Halila, Lorena dos Santos Bubniak, Suelen Mazzucco, Maria C. Santos-Silva, Elenara Lemos-Senna and Redouane Borsali

      Article first published online: 28 JAN 2014 | DOI: 10.1002/mabi.201300465

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      Monodisperse self-assembled nanoparticles are prepared from the new diblock copolymer XGO-b-PCL. The ability of nanoparticles to load hydrophobic drugs is demonstrated using curcumin. Mucoadhesive properties are achieved by coating the nanoparticles with chitosan, as evidenced by surface plasmon resonance measurements. In vitro studies indicate that curcumin-loaded nanoparticles show higher cytotoxic effects on B16F10 melanoma cells than L929 fibroblast cells.

    4. Hydrophilic Block Azidation of PCL-b-PEO Block Copolymers from Epichlorohydrin

      Junjie Liu and Zhihua Gan

      Article first published online: 28 JAN 2014 | DOI: 10.1002/mabi.201300488

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      Amphiphilic diblock copolymers PCL-b-PEO with well-controlled azido groups as pendant groups along the PEO block are synthesized from epichlorohydrin. The shell crosslinking of micelles from those block copolymers with dialkynyl-PEO via click chemistry not only stabilizes the micelles, but also improves the drug loading capacity and drug release rate.

    5. Additive Benefits of Chondroitin Sulfate and Oriented Tethered Epidermal Growth Factor for Vascular Smooth Muscle Cell Survival

      Pauline Lequoy, Benoît Liberelle, Gregory De Crescenzo and Sophie Lerouge

      Article first published online: 28 JAN 2014 | DOI: 10.1002/mabi.201300443

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      An anti-apoptotic coating created by oriented immobilization of EGF via coiled–coil peptides is shown to display higher protein surface densities and bioactivity compared to random grafting. In addition, the huge benefit of chondroitin sulfate as a sublayer for growth factor immobilization is highlighted by comparison with another low-fouling surface.

    6. Poly(ethylene glycol) Hydrogels with Adaptable Mechanical and Degradation Properties for Use in Biomedical Applications

      Matthew Parlato, Sarah Reichert, Neal Barney and William L. Murphy

      Article first published online: 25 JAN 2014 | DOI: 10.1002/mabi.201300418

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      Requirements of hydrogels for drug delivery, wound dressings, and surgical implantation can be extensive. A PEG-based hydrogel whose mechanical properties and degradation rate can be systematically adjusted to meet these criteria is described. These hydrogels are capable of a broad range of degradation and mechanical properties. Their performance in physical manipulations, indicative of manipulations that they may undergo during typical biomedical use, is also assessed.

    7. Dual Delivery of Vascular Endothelial Growth Factor and Hepatocyte Growth Factor Coacervate Displays Strong Angiogenic Effects

      Hassan K. Awada, Noah R. Johnson and Yadong Wang

      Article first published online: 23 JAN 2014 | DOI: 10.1002/mabi.201300486

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      The polyvalent coacervate serves as an exciting new controlled delivery system for heparin-binding growth factors. The coacervate strongly induces endothelial cell proliferation and tube formation through the simultaneous dual delivery of VEGF and HGF. By controlling the release of an optimal combination of growth factors, this delivery platform may lead to advancements in the area of therapeutic angiogenesis.

    8. Shape-Memory Effect by Specific Biodegradable Polymer Blending for Biomedical Applications

      Kook Jin Cha, Eugene Lih, Jiyeon Choi, Yoon Ki Joung, Dong Jun Ahn and Dong Keun Han

      Article first published online: 21 JAN 2014 | DOI: 10.1002/mabi.201300481

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      PLCL50/PLGA50 blend polymer has the structure with semi-crystalline and amorphous domain. It displays that the degree of shape recovery is 100% at 37 °C and the shape recovery proceeds within only 15 s.

    9. The Effect of Polyglycerol Sulfate Branching On Inflammatory Processes

      Florian Paulus, Ronny Schulze, Dirk Steinhilber, Maximilian Zieringer, Ingo Steinke, Pia Welker, Kai Licha, Stefanie Wedepohl, Jens Dernedde and Rainer Haag

      Article first published online: 21 JAN 2014 | DOI: 10.1002/mabi.201300420

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      Scaffold branching in polyglycerol sulfates determine the multivalent display of surface exposed functionalities and, together with polymer flexibility and particle size, can interfere with complex biological systems. For individual biological targets, it is possible to identify an optimal degree of branching, which is usually located at 60 and/or 100% branching.

    10. In Situ Generation of Cell-Laden Porous MMP-Sensitive PEGDA Hydrogels by Gelatin Leaching

      Sonja Sokic, Megan Christenson, Jeffery Larson and Georgia Papavasiliou

      Article first published online: 20 JAN 2014 | DOI: 10.1002/mabi.201300406

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      Fabrication approaches used to generate degradable porous scaffolds that allow encapsulation of cells in situ are beneficial for engineering tissues. Free-radical polymerization combined with gelatin leaching results in the formation of protease-sensitive porous PEG hydrogels that support cell encapsulation and enhanced proliferation.

    11. Improving Stability and Biocompatibility of Alginate/Chitosan Microcapsule by Fabricating Bi-Functional Membrane

      Guoshuang Zheng, Xiudong Liu, Xiuli Wang, Li Chen, Hongguo Xie, Feng Wang, Huizhen Zheng, Weiting Yu and Xiaojun Ma

      Article first published online: 17 JAN 2014 | DOI: 10.1002/mabi.201300474

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      A novel microcapsule with bi-functional membrane for cell implantation is developed by sequentially complexing two kinds of chitosan on alginate bead. The introduction of chitosan with lower deacetylation degree results in notably decreased surface roughness and increased mechanical strength of membrane, which contributes to the improvement of in vitro and in vivo stability and biocompatibility of the microcapsules.

    12. Effects of Physical and Chemical Treatments on the Molecular Weight and Degradation of Alginate–Hydroxyapatite Composites

      Daniel Alves Cardoso, Ann-Sissel Ulset, Johan Bender, John A. Jansen, Bjørn E. Christensen and Sander C. G. Leeuwenburgh

      Article first published online: 17 JAN 2014 | DOI: 10.1002/mabi.201300415

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      Alginate gels are interesting for applications in the biomedical field in view of their efficient ionic crosslinking mechanism, but the human body lacks enzymes that can degrade the polymer. Alginate treated by irradiation, autoclaving, or partial oxidation can lead to a more refined control of polymer properties and obtention of more degradable injectable alginate/CaP gels for bone regeneration.

    13. Shear Reversible Cell/Microsphere Aggregate as an Injectable for Tissue Regeneration

      Eunkyeong Woo, Honghyun Park and Kuen Yong Lee

      Article first published online: 16 JAN 2014 | DOI: 10.1002/mabi.201300365

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      Cell/microsphere aggregate is useful to deliver chondrocytes into an animal model using a syringe, and effectively regenerates cartilage tissues in vivo.

    14. Recombinant Human Elastin-like Magnetic Microparticles for Drug Delivery and Targeting

      Gianni Ciofani, Giada Graziana Genchi, Pablo Guardia, Barbara Mazzolai, Virgilio Mattoli and Antonella Bandiera

      Article first published online: 9 DEC 2013 | DOI: 10.1002/mabi.201300361

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      Human elastin-like polypeptide microparticles are prepared through a water-in-oil emulsion followed by enzymatic crosslinking. Magnetic properties are given to this system by addition of superparamagnetic iron oxide nanoparticles. Obtained microparticles are characterized in terms of morphology, structure, magnetic properties, drug release, and magnetic drivability.

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