Copyright © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
February 15, 2011
Stem Cells: Low Thrombogenicity Coatings for Vascular Grafts
Sashka Dimitrievska, Marion Maire, Gerardo A. Diaz-Quijada, Lucie Robitaille, Abdellah Ajji, L'Hocine Yahia, Maria Moreno, Yahye Merhi, and Martin N. Bureau*
Vascular polyethylene terephthalate (PET) grafts have shown good performance in large vessels (> 6mm) applications. However, in small diameter applications, high failure-rates due to thrombosis and compliance mismatch-induced myointimal hyperplasia are encountered. To address the urgent unmet need for small-diameter (2–6mm) vascular grafts, proprietary high-compliance nonwoven PET fiber structures were modified with various polyethylene glycol (PEG) concentrations using poly(vinylamine) (PVA) as a cross-linking agent. These PEG coated nonwoven PET structures have the advantages of (1) being based on a well-known and accepted polymer in the vascular prosthesis field, (2) showing artery-matching compliance, and (3) having a highly biostable and minimally thrombogenic off-the-shelf coating.
Macromol. Biosci., DOI: 10.1002/mabi.201000390