Macromolecular Bioscience

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November 11, 2014

TREND: Benzothiadiazole-Containing Conjugated Polyelectrolytes for Biological Sensing and Imaging

TREND: Benzothiadiazole-Containing Conjugated Polyelectrolytes for Biological Sensing and Imaging

Ruoyu Zhan*, Bin Liu*

This article summarizes the recent advances of benzothiadiazole (BT)-containing conjugated polyelectrolytes (CPEs) for biological sensing and imaging. After a brief introduction of the molecular design principles, the application of linear BT-containing CPEs as multicolor or light-up probes for visual sensing of biomolecules is reviewed. Then, linear, grafted, and hyperbranched BT-containing CPEs that can self-assemble into nanoparticles or have intrinsic 3D structures for in vitro and in vivo imaging are summarized. The future outlook of BT-containing CPEs for biomedical applications is also discussed at the end.

Macromol. Chem. Phys., DOI: 10.1002/macp.201400408

More information on the invited Talent, Trend, and Highlight articles in Macromolecular Chemistry and Physics can be found here.

November 05, 2014

Functional Polymers: Improvement in Power Conversion Efficiency and Performance of P3HT/PCBM Solar Cells Using Dithiafulvalene-Based π-Conjugated Oligomers

Functional Polymers: Improvement in Power Conversion Efficiency and Performance of P3HT/PCBM Solar Cells Using Dithiafulvalene-Based π-Conjugated Oligomers

Po-Chih Yang,* Hua-Wen Wen, Cheng-Chieh Huang, Zheng-Huie Yang, Hung-Lun Liao

Three dithiafulvalene (DTF)-based oligomers as a dopant for poly(3-hexylthiophene) P3HT/[6,6]-phenyl-C61butyric acid methyl ester (PCBM) solar cells are developed by incorporating a π-conjugated DTF unit that serves as an electron-rich donor in the main chain. Using poly[2-(9H-fluoren-9-ylidene)-4,5-bis(hexylthio)-1,3-dithiole-ran-(2,1,3-benzothiadiazole)] (PTBT) as a dopant in bulk-heterojunction (BHJ) solar cells improves the charge-carrier mobilities, the open-circuit voltage, and the stability of the devices.

Macromol. Chem. Phys., DOI: 10.1002/macp.201400307

Other contributions to the special series on functional polymers can be found here.

November 05, 2014

TREND: The Interaction Between Amphiphilic Polymer Materials and Guest Molecules: Selective Adsorption and Its Related Applications

TREND: The Interaction Between Amphiphilic Polymer Materials and Guest Molecules: Selective Adsorption and Its Related Applications

Bing Yu, Xuesong Jiang,* Jie Yin

Amphiphilic polymer materials possess selective adsorption to guest molecules, such as dyes, drugs, proteins, and other biomolecules, which is beneficial for their application in the separation, temporally controlled release, and patterning of guest molecules

Macromol. Chem. Phys., DOI: 10.1002/macp.201400389

More information on the invited Talent, Trend, and Highlight articles in Macromolecular Chemistry and Physics can be found here.

November 05, 2014

TALENT: Toughening Polylactide with Phase-Separating Complex Copolymer Architectures

TALENT: Toughening Polylactide with Phase-Separating Complex Copolymer Architectures

William M. Gramlich

Block and graft copolymers of polylactide (PLA) and a rubbery polymer can create nanometer-scale phase separation that leads to tough plastics, but past work has relied on a non-sustainable rubbery material. Through novel chemistry and copolymerizations, graft copolymers of sustainable polyisoprene and PLA can create a fully sustainable nanometer-scale phase-separated plastic.

Macromol. Chem. Phys., DOI: 10.1002/macp.201400350

More information on the invited Talent, Trend, and Highlight articles in Macromolecular Chemistry and Physics can be found here.

November 05, 2014

TALENT: Effect and Evolution of Nanostructural Complexity in Sensitive Polymer Gels

TALENT: Effect and Evolution of Nanostructural Complexity in Sensitive Polymer Gels

Sebastian Seiffert

Sensitive and supramolecular polymer gels can be selectively swollen and deswollen or gelled and degelled in response to external stimulation; to truly benefit from this ability, the impact of nanometer-scale structural heterogeneity in the constituent polymer networks must be understood and accounted for in materials design.

Macromol. Chem. Phys., DOI: 10.1002/macp.201400410

More information on the invited Talent, Trend, and Highlight articles in Macromolecular Chemistry and Physics can be found here.

August 26, 2014

POLYOLEFINS: Thermal Behavior of Polyethylene Reactor Alloys Polymerized by Ziegler-Natta/Late Transition Metal Hybrid Catalyst

POLYOLEFINS: Thermal Behavior of Polyethylene Reactor Alloys Polymerized by Ziegler-Natta/Late Transition Metal Hybrid Catalyst

Saeid Ahmadjo, Samaneh Dehghani, Gholam Hossein Zohuri, Gholam Reza Nejabat, Hamed Jafarian, Mostafa Ahmadi and Seyed Mohammad Mahdi Mortazavi*

Ziegler-Natta (ZN) and late transition metal (LTM) hybrid catalysts were synthesized and utilized in preparation of polyethylene (PE) reactor alloys. By changing reaction parameters, versatile thermal behavior from LTM-PE to ZN-PE could be obtained. The proposed method seems to be a promising approach for synthesis of tailor-made polyethylene in a single reactor.

Macromol. React. Eng. DOI: 10.1002/mren.201400024

Other contributions to the article series on "Polyolefins - Catalyst and Process Innovations" can be found here.

July 30, 2013

Stem Cells: Advanced Polymers for Stem Cell Research - From Laboratory to Clinic

Stem Cells: Advanced Polymers for Stem Cell Research - From Laboratory to Clinic

Suwan N. Jayasinghe

Guest-editor Suwan N. Jayasinghe introduces the third and last part of the series: Advanced Polymers for Stem Cell Biology and Medicine. In this final part it is further demonstrated how the exploration of biopolymers can lead to a wide range of applications from stem cell culturing to their exploration as vehicles for cells and/or genes. Again, this series demonstrates how progress in this highly interesting field can only be reached by the bridging of several disciplines of research and development.

Macromol. Biosci., DOI: 10.1002/mabi.201300064

July 29, 2013

Stem Cells: In Vitro Neo-Cartilage Formation

Stem Cells: In Vitro Neo-Cartilage Formation

Sumrita Bhat, Lars Lidgren and Ashok Kumar*

Limited blood supply and the avascular nature of articular cartilage restrict its self-repair capacity, frequently leading to osteoarthritis. Researchers from India and Sweden focus on scaffolds for tissue repair from natural polymers, for example gelatin, chitosan, and agarose in the form of composites. A novel way of fabrication, known as cryogelation, is presented, in which matrices are synthesized at sub-zero temperature. Cell seeded scaffolds incubated under appropriate conditions result in the accumulation of matrix components on the surface of the gel in the form of neo-cartilage. Neo-cartilage exhibits similarity to native cartilage with respect to its physical, mechanical and biochemical properties. Based on these similarities it can provide a new approach for the treatment of localized joint injuries.

Macromol. Biosci., DOI: 10.1002/mabi.201200484

July 28, 2013

Stem Cells: The Fate of Tissue Development

Stem Cells: The Fate of Tissue Development

Anuj Tripathi, Tanushree Vishnoi, Deepti Singh, and Ashok Kumar*

Cell to matrix interactions affect in vitro cell adherence and proliferation and further decide the fate of tissue development for biomedical applications. This study demonstrates the role of crosslinking in altering the surface properties of 3D porous cryogel matrices. Glutaraldehyde and 1-ethyl-3(3-dimethylaminopropyl)-carbodiimide crosslinkers are used separately for the crosslinking of alginate and gelatin, respectively. The difference in crosslinking affects the physiochemical properties of these matrices leading to variable cell behavior as demonstrated using four different cell types. The present study demonstrates the successful use of controlled crosslinking in directing the cell growth for tissue engineering.

Macromol. Biosci., DOI: 10.1002/mabi.201200398

July 27, 2013

Stem Cells: Phenotype-Independent Effects of Retroviral Transduction in Human Dental Pulp Stem Cells

Stem Cells: Phenotype-Independent Effects of Retroviral Transduction in Human Dental Pulp Stem Cells

Obi Egbuniwe,* Andrew D. Grant, Tara Renton, and Lucy Di Silvio*

There has been considerable progress in the development of biopolymers that could impact directly on in vivo stem cell fate. Present-day biopolymers are being designed to mirror the well-described relationship existing between stem cells and the extracellular matrix. Researchers from London highlight the importance of the maintenance of cell viability and the development of human tissue-sourced stem cell lines. A better understanding of in vitro responses of these specialized cells to changes in their tightly regulated microenvironments will allow the utilization of their full therapeutic potential in biomimetic constructs

Macromol. Biosci., DOI: 10.1002/mabi.201300020

August 15, 2012

Stem Cells: Maintaining Stem Cells with Hydrogels

Stem Cells: Maintaining Stem Cells with Hydrogels

Yongxing Liu, Lyndon F. Charles, Thomas I. Zarembinski, Kalle I. Johnson, Sarah K. Atzet, Robin L. Wesselschmidt, Mark E. Wight, Liisa T. Kuhn*

Traditionally the maintenance and the propagation of stem cells require feeder cells like mitotically inactivated mouse embryonic fibroblasts or human fibroblasts. The use of these cells comes with some drawbacks like problems in large-scale culture, limited genetic manipulations of the human pluripotent stem cells, and xeno-contamination, particularly when mouse feeder cells are used. Widely used feeder-free systems like MatrigelTM are problematic as they might still carry xenogeneic pathogens and vary from lot to lot. Liisa Kuhn (University of Connecticut Health Center) and coworkers now showed that a fully defined gelatin-modified hyaluronan hydrogel (HyStem-CTM) is able to maintain mouse embryonic stem cells and human induced pluripotent stem cells (hiPSCs) in culture while retaining their growth and pluripotent characteristics. Modified HA hydrogels like the one shown here provide a safer direction towards completely animal-free conditions for clinical application, handling, and understanding of hPSCs.

Macromol. Biosci., DOI: 10.1002/mabi.201200043

August 15, 2012

Stem Cells: Hydrogel/Mineral Composites for Bone Tissue Repair

Stem Cells: Hydrogel/Mineral Composites for Bone Tissue Repair

Ameya Phadke, Yu-Ru V. Shih, Shyni Varghese*

Bone consists of an inorganic apatite-like mineral phase as well as an organic protein phase composed primarily of type-I collagen, proteoglycans, and noncollagenous proteins. To mimic this structure, researchers in the USA and Taiwan have synthesized a hydrogel/mineral composite through templated mineralization of polyanionic hydrogels. These materials were found to promote osteogenic differentiation of human mesenchymal stem cells even in the absence of osteogenesis-inducing medium supplements. The potential of these materials to provide an instructive environment for osteogenic differentiation of stem cells is shown here. This study thus demonstrates the development of an osteoinductive synthetic material containing bone-like calcium phosphate mineral as a promising candidate for bone tissue repair.

Macromol. Biosci., DOI: 10.1002/mabi.201100289

November 11, 2014
TREND: Benzothiadiazole-Containing Conjugated Polyelectrolytes for Biological Sensing and Imaging

November 05, 2014
Functional Polymers: Improvement in Power Conversion Efficiency and Performance of P3HT/PCBM Solar Cells Using Dithiafulvalene-Based π-Conjugated Oligomers

November 05, 2014
TREND: The Interaction Between Amphiphilic Polymer Materials and Guest Molecules: Selective Adsorption and Its Related Applications

November 05, 2014
TALENT: Toughening Polylactide with Phase-Separating Complex Copolymer Architectures

November 05, 2014
TALENT: Effect and Evolution of Nanostructural Complexity in Sensitive Polymer Gels

August 26, 2014
POLYOLEFINS: Thermal Behavior of Polyethylene Reactor Alloys Polymerized by Ziegler-Natta/Late Transition Metal Hybrid Catalyst

July 30, 2013
Stem Cells: Advanced Polymers for Stem Cell Research - From Laboratory to Clinic

July 29, 2013
Stem Cells: In Vitro Neo-Cartilage Formation

July 28, 2013
Stem Cells: The Fate of Tissue Development

July 27, 2013
Stem Cells: Phenotype-Independent Effects of Retroviral Transduction in Human Dental Pulp Stem Cells

August 15, 2012
Stem Cells: Maintaining Stem Cells with Hydrogels

August 15, 2012
Stem Cells: Hydrogel/Mineral Composites for Bone Tissue Repair

August 15, 2012
Stem Cells: Artificial Organs

August 07, 2012
Stem Cells: Hydrogels from Natural Polysaccharides as 3D Cell Delivery System

August 07, 2012
Stem Cells: Electrospun PLA Fibers for Controlled TCP Release

August 02, 2012
Stem Cells: Fiber Thickness to Direct Stem Cell Differentiation

August 02, 2012
Stem Cells: PLLA/MWCNT Composites as Conductive Biomaterials

June 01, 2012
Stem Cells: Understanding Embryo Formation

May 31, 2012
Stem Cells: Multifunctionalized Nanoparticle Systems for Treatment of Central Nervous System Diseases

March 23, 2012
Stem Cells: Gelatin-Based Hydrogels as Potential Implantable Carriers for Stem Cells

March 22, 2012
Stem Cells: Polymeric Systems for Tissue Engineering and Biomedical Applications

January 31, 2012
Stem Cells: Polymer-based Scaffold Designs For In Situ Vascular Tissue Engineering: Controlling Recruitment and Differentiation Behavior of Endothelial Colony Forming Cells

December 20, 2011
Stem Cells: Mechanical Properties and Topographical Features in Concert - Influence on Cell Migration

December 19, 2011
Stem Cells: A Dextran-Based Polymer as Cell-Detaching Substrate

October 24, 2011
Stem Cells: Tissue-Specific Stem Cell Differentiation in an in vitro Airway Model

October 23, 2011
Stem Cells: Pullulan Hydrogels for Skin Regeneration

October 22, 2011
Stem Cells: Advanced Polymers for Stem Cell Research - The Series Continues

June 21, 2011
Stem Cells: A Library of Polyureas for Ligament Tissue Engineering

April 05, 2011
Stem Cells: A Tool for Studying Stem Cells during Wound-Healing Processes

April 05, 2011
Stem Cells: Polymeric Scaffold for Adipose Stem Cells in Bone Tissue Engineering

March 16, 2011
Stem Cells: ECM Functionalized Microcavities to Control Hematopoietic Stem and Progenitor Cell Fate

March 16, 2011
Stem Cells: Injectable Scaffold for Cardiac Tissue Engineering

February 17, 2011
Stem Cells: Moving Gradient Generation to the Third Dimension

February 15, 2011
Stem Cells: Low Thrombogenicity Coatings for Vascular Grafts

January 14, 2011
Stem Cells: Biodegradable Elastomers for Tissue Engineering and Cell–Biomaterial Interactions

December 16, 2010
Stem Cells: Agarose-Alginate Cryogel for Bioengineering Applications

December 16, 2010
Stem Cells: How to Sterilize PET Fibers for Vascular Grafts

November 09, 2010
Stem Cells: Advanced Polymers for Stem Cell Biology and Medicine

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