Macromolecular Bioscience

Cover image for Vol. 16 Issue 7

Editor-in-Chief: Kirsten Severing, Editor: Anne Pfisterer

Online ISSN: 1616-5195

Associated Title(s): Advanced Healthcare Materials, Macromolecular Chemistry and Physics, Macromolecular Materials and Engineering, Macromolecular Rapid Communications

News

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May 25, 2016

TREND: Configuring Anion-Exchange Membranes for High Conductivity and Alkaline Stability by Using Cationic Polymers with Tailored Side Chains

TREND: Configuring Anion-Exchange Membranes for High Conductivity and Alkaline Stability by Using Cationic Polymers with Tailored Side Chains

Patric Jannasch,* Eva Annika Weiber

Polymeric anion-exchange membranes are crucial components in alkaline membrane fuel cells and other electrochemical energy systems. Recent results show that both OH conductivity and alkaline stability of these materials are significantly enhanced by introducing flexible and hydrolytically stable alkyl side chains in the macromolecular design. Here, the latest trends in this research area are briefly reviewed.

Macromol. Chem. Phys., DOI: 10.1002/macp.201500481

More information on the invited Talent, Trend, and Highlight articles in Macromolecular Chemistry and Physics can be found here.

May 25, 2016

TALENT: Molecular Polymer Brushes in Nanomedicine

TALENT: Molecular Polymer Brushes in Nanomedicine

Markus Müllner

Molecular polymer brushes present an emerging class of polymer nanostructures with the potential to address persevering problems in nanomedicine. Recent improvements in the synthesis of these polymeric architectures allowed the tailoring of sophisticated nanomaterials for applications in drug and gene delivery, as well as the design of new imaging probes and prototype nanomaterials

Macromol. Chem. Phys., DOI: 10.1002/macp.201600086

More information on the invited Talent, Trend, and Highlight articles in Macromolecular Chemistry and Physics can be found here.

May 25, 2016

TALENT: Use of Shewanella oneidensis for Energy Conversion in Microbial Fuel Cells

TALENT: Use of Shewanella oneidensis for Energy Conversion in Microbial Fuel Cells

A. Belen Jorge,* Rachael Hazael

Exoelectrogens are able to transfer electrons outside the cell to oxidize chemicals anareoebically through extracellular electron transfer mechanisms. This allows them to function in microbial fuel cells. However, there are still limitations and open questions about electron transfer mechanisms and biofilm-electrode interactions before this technology can be fully implemented in the real world.

Macromol. Chem. Phys., DOI: 10.1002/macp.201500477

More information on the invited Talent, Trend, and Highlight articles in Macromolecular Chemistry and Physics can be found here.

May 03, 2016

TREND: Engineering of Tough Double Network Hydrogels

TREND: Engineering of Tough Double Network Hydrogels

Qiang Chen, Hong Chen, Lin Zhu, Jie Zheng*

Double network hydrogels (DN gels), consisting of two asymmetric, interpene­trating polymer networks, are considered as the toughest hydrogels. This Trend article summarizes the latest important findings of DN gels, covering new gel structures, functionalities, applications, and future perspectives.

Macromol. Chem. Phys., DOI: 10.1002/macp.201600038

More information on the invited Talent, Trend, and Highlight articles in Macromolecular Chemistry and Physics can be found here.

April 28, 2016

TALENT: Polymeric Nanohybrids as a New Class of Therapeutic Biotransporters

TALENT: Polymeric Nanohybrids as a New Class of Therapeutic Biotransporters

Jonathan Whitlow, Settimio Pacelli, Arghya Paul*

Polymeric nanohybrids offer a useful platform to deliver drugs and genes in a selective and efficient manner. A variety of nanomaterials can be combined together with biomolecules in order to generate the next generation of biotransporters. This Talent article highlights the diverse innovative solutions in this direction with particular emphasis on the development of new biotransporters for drugs and gene delivery.

Macromol. Chem. Phys., DOI: 10.1002/macp.201500464

More information on the invited Talent, Trend, and Highlight articles in Macromolecular Chemistry and Physics can be found here.

April 05, 2016

TREND: Electrochemically Generated Thin Films of Microporous Polymer Networks: Synthesis, Properties, and Applications

TREND: Electrochemically Generated Thin Films of Microporous Polymer Networks: Synthesis, Properties, and Applications

TREND: Electrochemically Generated Thin Films of Microporous Polymer Networks: Synthesis, Properties, and Applications

Alex Palma-Cando, Ullrich Scherf*

Assembling electroactive tetrapods into microporousthin films. Microporous polymer films produced by electrochemical oxidative polymerization of multifunctional, rigid monomers can be applied in fields that have been until now not accessible for the corresponding chemically synthesized bulk materials, e.g., organic electronic devices. High intrinsic surface area combined with a smooth surface represents a unique synergy, best-suited for applications where high quality films are required.

Macromol. Chem. Phys., DOI: 10.1002/macp.201500484

More information on the invited Talent, Trend, and Highlight articles in Macromolecular Chemistry and Physics can be found here.

March 01, 2016

TREND: Configuring Anion-Exchange Membranes for High Conductivity and Alkaline Stability by Using Cationic Polymers with Tailored Side Chains

TREND: Configuring Anion-Exchange Membranes for High Conductivity and Alkaline Stability by Using Cationic Polymers with Tailored Side Chains

Patric Jannasch,* Eva Annika Weiber

Polymeric anion-exchange membranes are crucial components in alkaline membrane fuel cells and other electrochemical energy systems. Recent results show that both OH conductivity and alkaline stability of these materials are significantly enhanced by introducing flexible and hydrolytically stable alkyl side chains in the macromolecular design. Here, the latest trends in this research area are briefly reviewed.

Macromol. Chem. Phys., DOI: 10.1002/macp.201500481

More information on the invited Talent, Trend, and Highlight articles in Macromolecular Chemistry and Physics can be found here.

July 30, 2013

Stem Cells: Advanced Polymers for Stem Cell Research - From Laboratory to Clinic

Stem Cells: Advanced Polymers for Stem Cell Research - From Laboratory to Clinic

Suwan N. Jayasinghe

Guest-editor Suwan N. Jayasinghe introduces the third and last part of the series: Advanced Polymers for Stem Cell Biology and Medicine. In this final part it is further demonstrated how the exploration of biopolymers can lead to a wide range of applications from stem cell culturing to their exploration as vehicles for cells and/or genes. Again, this series demonstrates how progress in this highly interesting field can only be reached by the bridging of several disciplines of research and development.

Macromol. Biosci., DOI: 10.1002/mabi.201300064

July 29, 2013

Stem Cells: In Vitro Neo-Cartilage Formation

Stem Cells: In Vitro Neo-Cartilage Formation

Sumrita Bhat, Lars Lidgren and Ashok Kumar*

Limited blood supply and the avascular nature of articular cartilage restrict its self-repair capacity, frequently leading to osteoarthritis. Researchers from India and Sweden focus on scaffolds for tissue repair from natural polymers, for example gelatin, chitosan, and agarose in the form of composites. A novel way of fabrication, known as cryogelation, is presented, in which matrices are synthesized at sub-zero temperature. Cell seeded scaffolds incubated under appropriate conditions result in the accumulation of matrix components on the surface of the gel in the form of neo-cartilage. Neo-cartilage exhibits similarity to native cartilage with respect to its physical, mechanical and biochemical properties. Based on these similarities it can provide a new approach for the treatment of localized joint injuries.

Macromol. Biosci., DOI: 10.1002/mabi.201200484

July 28, 2013

Stem Cells: The Fate of Tissue Development

Stem Cells: The Fate of Tissue Development

Anuj Tripathi, Tanushree Vishnoi, Deepti Singh, and Ashok Kumar*

Cell to matrix interactions affect in vitro cell adherence and proliferation and further decide the fate of tissue development for biomedical applications. This study demonstrates the role of crosslinking in altering the surface properties of 3D porous cryogel matrices. Glutaraldehyde and 1-ethyl-3(3-dimethylaminopropyl)-carbodiimide crosslinkers are used separately for the crosslinking of alginate and gelatin, respectively. The difference in crosslinking affects the physiochemical properties of these matrices leading to variable cell behavior as demonstrated using four different cell types. The present study demonstrates the successful use of controlled crosslinking in directing the cell growth for tissue engineering.

Macromol. Biosci., DOI: 10.1002/mabi.201200398

July 27, 2013

Stem Cells: Phenotype-Independent Effects of Retroviral Transduction in Human Dental Pulp Stem Cells

Stem Cells: Phenotype-Independent Effects of Retroviral Transduction in Human Dental Pulp Stem Cells

Obi Egbuniwe,* Andrew D. Grant, Tara Renton, and Lucy Di Silvio*

There has been considerable progress in the development of biopolymers that could impact directly on in vivo stem cell fate. Present-day biopolymers are being designed to mirror the well-described relationship existing between stem cells and the extracellular matrix. Researchers from London highlight the importance of the maintenance of cell viability and the development of human tissue-sourced stem cell lines. A better understanding of in vitro responses of these specialized cells to changes in their tightly regulated microenvironments will allow the utilization of their full therapeutic potential in biomimetic constructs

Macromol. Biosci., DOI: 10.1002/mabi.201300020

August 15, 2012

Stem Cells: Maintaining Stem Cells with Hydrogels

Stem Cells: Maintaining Stem Cells with Hydrogels

Yongxing Liu, Lyndon F. Charles, Thomas I. Zarembinski, Kalle I. Johnson, Sarah K. Atzet, Robin L. Wesselschmidt, Mark E. Wight, Liisa T. Kuhn*

Traditionally the maintenance and the propagation of stem cells require feeder cells like mitotically inactivated mouse embryonic fibroblasts or human fibroblasts. The use of these cells comes with some drawbacks like problems in large-scale culture, limited genetic manipulations of the human pluripotent stem cells, and xeno-contamination, particularly when mouse feeder cells are used. Widely used feeder-free systems like MatrigelTM are problematic as they might still carry xenogeneic pathogens and vary from lot to lot. Liisa Kuhn (University of Connecticut Health Center) and coworkers now showed that a fully defined gelatin-modified hyaluronan hydrogel (HyStem-CTM) is able to maintain mouse embryonic stem cells and human induced pluripotent stem cells (hiPSCs) in culture while retaining their growth and pluripotent characteristics. Modified HA hydrogels like the one shown here provide a safer direction towards completely animal-free conditions for clinical application, handling, and understanding of hPSCs.

Macromol. Biosci., DOI: 10.1002/mabi.201200043

May 25, 2016
TREND: Configuring Anion-Exchange Membranes for High Conductivity and Alkaline Stability by Using Cationic Polymers with Tailored Side Chains

May 25, 2016
TALENT: Molecular Polymer Brushes in Nanomedicine

May 25, 2016
TALENT: Use of Shewanella oneidensis for Energy Conversion in Microbial Fuel Cells

May 03, 2016
TREND: Engineering of Tough Double Network Hydrogels

April 28, 2016
TALENT: Polymeric Nanohybrids as a New Class of Therapeutic Biotransporters

April 05, 2016
TREND: Electrochemically Generated Thin Films of Microporous Polymer Networks: Synthesis, Properties, and Applications

March 01, 2016
TREND: Configuring Anion-Exchange Membranes for High Conductivity and Alkaline Stability by Using Cationic Polymers with Tailored Side Chains

July 30, 2013
Stem Cells: Advanced Polymers for Stem Cell Research - From Laboratory to Clinic

July 29, 2013
Stem Cells: In Vitro Neo-Cartilage Formation

July 28, 2013
Stem Cells: The Fate of Tissue Development

July 27, 2013
Stem Cells: Phenotype-Independent Effects of Retroviral Transduction in Human Dental Pulp Stem Cells

August 15, 2012
Stem Cells: Maintaining Stem Cells with Hydrogels

August 15, 2012
Stem Cells: Hydrogel/Mineral Composites for Bone Tissue Repair

August 15, 2012
Stem Cells: Artificial Organs

August 07, 2012
Stem Cells: Hydrogels from Natural Polysaccharides as 3D Cell Delivery System

August 07, 2012
Stem Cells: Electrospun PLA Fibers for Controlled TCP Release

August 02, 2012
Stem Cells: Fiber Thickness to Direct Stem Cell Differentiation

August 02, 2012
Stem Cells: PLLA/MWCNT Composites as Conductive Biomaterials

June 01, 2012
Stem Cells: Understanding Embryo Formation

May 31, 2012
Stem Cells: Multifunctionalized Nanoparticle Systems for Treatment of Central Nervous System Diseases

March 23, 2012
Stem Cells: Gelatin-Based Hydrogels as Potential Implantable Carriers for Stem Cells

March 22, 2012
Stem Cells: Polymeric Systems for Tissue Engineering and Biomedical Applications

January 31, 2012
Stem Cells: Polymer-based Scaffold Designs For In Situ Vascular Tissue Engineering: Controlling Recruitment and Differentiation Behavior of Endothelial Colony Forming Cells

December 20, 2011
Stem Cells: Mechanical Properties and Topographical Features in Concert - Influence on Cell Migration

December 19, 2011
Stem Cells: A Dextran-Based Polymer as Cell-Detaching Substrate

October 24, 2011
Stem Cells: Tissue-Specific Stem Cell Differentiation in an in vitro Airway Model

October 23, 2011
Stem Cells: Pullulan Hydrogels for Skin Regeneration

October 22, 2011
Stem Cells: Advanced Polymers for Stem Cell Research - The Series Continues

June 21, 2011
Stem Cells: A Library of Polyureas for Ligament Tissue Engineering

April 05, 2011
Stem Cells: A Tool for Studying Stem Cells during Wound-Healing Processes

April 05, 2011
Stem Cells: Polymeric Scaffold for Adipose Stem Cells in Bone Tissue Engineering

March 16, 2011
Stem Cells: ECM Functionalized Microcavities to Control Hematopoietic Stem and Progenitor Cell Fate

March 16, 2011
Stem Cells: Injectable Scaffold for Cardiac Tissue Engineering

February 17, 2011
Stem Cells: Moving Gradient Generation to the Third Dimension

February 15, 2011
Stem Cells: Low Thrombogenicity Coatings for Vascular Grafts

January 14, 2011
Stem Cells: Biodegradable Elastomers for Tissue Engineering and Cell–Biomaterial Interactions

December 16, 2010
Stem Cells: Agarose-Alginate Cryogel for Bioengineering Applications

December 16, 2010
Stem Cells: How to Sterilize PET Fibers for Vascular Grafts

November 09, 2010
Stem Cells: Advanced Polymers for Stem Cell Biology and Medicine

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