Macromolecular Bioscience

Cover image for Vol. 15 Issue 5

Editor-in-Chief: Kirsten Severing, Editor: Anne Pfisterer

Online ISSN: 1616-5195

Associated Title(s): Advanced Healthcare Materials, Macromolecular Chemistry and Physics, Macromolecular Materials and Engineering, Macromolecular Rapid Communications

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Recently Published Articles

  1. Tumor-Targeting Co-Delivery of Drug and Gene from Temperature-Triggered Micelles

    Seog-Jin Seo, Seon-Young Lee, Seong-Jun Choi and Hae-Won Kim

    Article first published online: 19 MAY 2015 | DOI: 10.1002/mabi.201500137

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    Our multifunctional nanocarrier system designed for tumor-targeting co-delivery shows controlled release behaviors of hydrophobic molecules at tumors by a temperature trigger and receptor-mediated gene delivery. The unique property of this system is demonstrated by a series of logical characterization measurements, which suggests that this system has a potential for the hyperthermia treatment.

  2. Trivalent Cation Induced Bundle Formation of Filamentous fd Phages

    Nuriye Korkmaz Zirpel and Eun Jin Park

    Article first published online: 18 MAY 2015 | DOI: 10.1002/mabi.201500046

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    Aggregated bacteriophage bundles are obtained upon treatment of filamentous fd phages with trivalent counterions of varying ionic radii. Condensation of phages results in formation of either networking layer-like structures or denser intertwined agglomerated phage constructs. Self-assembly of molecular sub-units into functional assemblies in vivo and in vitro can be understood by studying polyelectrolyte properties of biomolecules like phages.

  3. Polyphosphate: A Morphogenetically Active Implant Material Serving as Metabolic Fuel for Bone Regeneration

    Werner E. G. Müller, Emad Tolba, Heinz C. Schröder and Xiaohong Wang

    Article first published online: 15 MAY 2015 | DOI: 10.1002/mabi.201500100

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    Polyphosphate (polyP) is a natural inorganic polymer that is synthesized in cells in close vicinity of bone tissue. This polymer is biocompatible and bioresorbable. The characteristic features of polyP are the physiological origin and the huge conserved reservoir of metabolic energy. Since Ca-polyP is built of phosphate and Ca2+, it can be fabricated to bone scaffolds.

  4. Synergistically Improved Anti-tumor Efficacy by Co-delivery Doxorubicin and Curcumin Polymeric Micelles

    Jinling Wang, Wenzhuan Ma and Pengfei Tu

    Article first published online: 15 MAY 2015 | DOI: 10.1002/mabi.201500043

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    Co-encapsulated DOX and Cur micelles are designed to simultaneously deliver chemotherapeutic drug and multi-drug resistance (MDR) modulator to tumor sites. Co-delivery micelles exhibited excellent cytotoxicity, cellular uptake and cellular apoptosis in MCF7/Adr cells, and effective tumor inhibitory effects in 4T1-bearing mice. Therefore, co-encapsulated DOX and Cur micelles could be a promising vehicle for overcoming MDR and improving antitumor efficacy.

  5. Nanoparticle Formulation of AEA and BAEA Cellulose Carbamates Increases Biocompatibility and Antimicrobial Activity

    Cornelia Wiegand, Melanie Nikolajski, Uta-Christina Hipler and Thomas Heinze

    Article first published online: 15 MAY 2015 | DOI: 10.1002/mabi.201500031

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    Antimicrobially active polymers gain increasing interest in health care. AEA and BAEA cellulose carbamates exhibit a significant antimicrobial activity with moderate cell compatibility. Biocompatibility is enhanced by nanoparticle formulation. AEA cellulose carbamate NPs demonstrate a ratio of LC50/IC50 that is four to six times higher than that of BAEA cellulose carbamate NPs.