Macromolecular Bioscience

Cover image for Vol. 15 Issue 9

Editor-in-Chief: Kirsten Severing, Editor: Anne Pfisterer

Online ISSN: 1616-5195

Associated Title(s): Advanced Healthcare Materials, Macromolecular Chemistry and Physics, Macromolecular Materials and Engineering, Macromolecular Rapid Communications

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Recently Published Articles

  1. A Stimulated Mixed Micelle System for In Vitro Study on Chemo-Photodynamic Therapy

    Ching-Yi Chen, Chao-Kai Syu and Hsin Chang Lin

    Article first published online: 8 OCT 2015 | DOI: 10.1002/mabi.201500269

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    A stimulated mixed micelle system with photosensitizer-centered for encapsulation of doxorubicin was developed for chemo-photodynamic therapy. This mixed micelle system shows good stability, controlled release rate and high singlet oxygen generation efficiency. In vitro study demonstrates a higher cytotoxicity under light condition relative to individual single drug loaded micelle, indicating improved therapeutic efficiency due to combination therapy.

  2. PolyDOPA Mussel-Inspired Coating as a Means for Hydroxyapatite Entrapment on Polytetrafluoroethylene Surface for Application in Periodontal Diseases

    Tiziana Nardo, Valeria Chiono, Gianluca Ciardelli and Maryam Tabrizian

    Article first published online: 7 OCT 2015 | DOI: 10.1002/mabi.201500241

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    This work gives a thorough characterization of non-resorbable polytetrafluoroethylene films, coated with hydroxyapatite nanoparticles (HAp) through an adhesive coating of self-polymerized 3,4-dihydroxy-DL-phenylalanine (polyDOPA). This coating technique represents an interesting approach able to improve MC3T3-E1 pre-osteoblastic cells adhesion and proliferation on polyDOPA/HAp-coated substrates.

  3. Non-Fouling Biodegradable Poly(ϵ-caprolactone) Nanofibers for Tissue Engineering

    Nina Yu. Kostina, Ognen Pop-Georgievski, Michael Bachmann, Neda Neykova, Michael Bruns, Jiří Michálek, Martin Bastmeyer and Cesar Rodriguez-Emmenegger

    Article first published online: 7 OCT 2015 | DOI: 10.1002/mabi.201500252

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    Four antifouling polymer brushes are grown from biodegradable poly(ϵ-caprolactone) nanofibers without impairing their unique architecture. The nanofibers are challenged with mouse embryonic fibroblasts. Fibroblasts are repelled from the nanofibers coated with brushes while the cells could rapidly adhere and form cell–matrix adhesions on pristine nanofibers. The nanofibers modified with protein repellent brushes are able to suppress cell adhesion.

  4. A Periosteum-Inspired 3D Hydrogel-Bioceramic Composite for Enhanced Bone Regeneration

    Yong Yao Chun, Jun Kit Wang, Nguan Soon Tan, Peggy Puk Yik Chan, Timothy Thatt Yang Tan and Cleo Choong

    Article first published online: 7 OCT 2015 | DOI: 10.1002/mabi.201500258

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    A hydrogel-bioceramic composite consisting of fish scale-derived CaP incorporated into a Gtn-HPA/CMC-Tyr hydrogel is demonstrated as a potential periosteum-inspired injectable system to enhance bone healing. The incorporation of CaP into the hydrogel significantly improves its mechanical properties, provides a bioactive environment for nucleation and formation of apatite, encourages cell proliferation, and shows a zero order FITC-dextran release profile.

  5. Disruption of Amyloid Prion Protein Aggregates by Cationic Pyridylphenylene Dendrimers

    Svetlana A. Sorokina, Yulia Yu. Stroylova, Zinaida B. Shifrina and Vladimir I. Muronetz

    Article first published online: 7 OCT 2015 | DOI: 10.1002/mabi.201500268

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    Cationic pyridylphenylene dendrimers are able to disrupt amyloid protein aggregates, e.g., prion protein inclusion bodies (PrP IB). The incubation of PrP IB with the dendrimers leads to formation of stable PrP-dendrimer complexes and the amyloid properties of PrP are decreased upon the interaction with the dendrimer.