Macromolecular Bioscience

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Recently Published Articles

  1. Novel Poly(Ethylene Oxide)-b-Poly(Propylene Oxide) Copolymer-Glucose Conjugate by the Microwave-Assisted Ring Opening of a Sugar Lactone

    Romina J. Glisoni and Alejandro Sosnik

    Article first published online: 27 AUG 2014 | DOI: 10.1002/mabi.201400235

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    The surface modification of Pluronic®F127 polymeric micelles with glucose residues by means of a fast and efficient ring opening reaction of gluconolactone leads to their recognition by a soluble vegetal lectin, Concanavalin A, and their subsequent agglutination.

  2. Stabilization of Gelatin Nanoparticles Without Crosslinking

    Saeed Ahmad Khan and Marc Schneider

    Article first published online: 26 AUG 2014 | DOI: 10.1002/mabi.201400214

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    Crosslinking free preparation of gelatin nanoparticles is described, offering a flexible drug carrier system for hydrophilic materials. The structural integrity of gelatin nanoparticles is kept intact by coating them with Eudragit® E 100 forming hybrid nanospheres. For preparation, a hybrid technique of nanoprecipitation-emulsion solvent evaporation is employed.

  3. Synthesis of Homopolypeptides by Aminolysis Mediated by Proteases Encapsulated in Silica Nanospheres

    Peter J. Baker, Siddharth V. Patwardhan and Keiji Numata

    Article first published online: 25 AUG 2014 | DOI: 10.1002/mabi.201400295

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    The encapsulation of three different proteases (bromelain, papain, and trypsin) in bioinspired silica enhances their thermal stability for both hydrolysis and aminolysis reactions. The enhanced thermal activity resulted in increased production of poly-L-leucine, poly-L-alanine, and poly-L-valine by protease-mediated aminolysis at 50 °C.

  4. Boronic Acid Shell-Crosslinked Dextran-b-PLA Micelles for Acid-Responsive Drug Delivery

    Ziwei Zhao, Xuemei Yao, Zhe Zhang, Li Chen, Chaoliang He and Xuesi Chen

    Article first published online: 21 AUG 2014 | DOI: 10.1002/mabi.201400251

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    3-carboxy-5-nitrophenylboronic acid (CNPBA) shell-crosslinked micelles based on amphiphilic dextran-block-polylactide (Dex-b-PLA) are prepared and used for efficient intracellular drug delivery. The pH-responsive biodegradable CNPBA-Dex-b-PLA can efficiently load and deliver DOX into tumor cells and enhance the inhibition of cellular proliferation in vitro, providing a favorable platform as a drug delivery system for cancer therapy.

  5. Functional Brush-Decorated Poly(globalide) Films by ARGET-ATRP for Bioconjugation

    Zeliha Ates, Fabrice Audouin, Amy Harrington, Brendan O'Connor and Andreas Heise

    Article first published online: 21 AUG 2014 | DOI: 10.1002/mabi.201400282

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    Poly(acrylic) acid brushes were grafted from polyester films obtained from the unsaturated macrolactone globalide by ARGET ATRP of tert.-butyl acrylate. After mild in situ deprotection high-density acrylic acid functional films were obtained while avoiding polyester hydrolysis. The conjugation with green fluorescent protein (GFP) and an enzyme was successfully carried out retaining the enzymatic activity.