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Recently Published Articles
- Washless Method Enables Multilayer Coating of an Aggregation-Prone Nanoparticulate Drug Delivery System with Enhanced Yields, Colloidal Stability, and Scalability
Lamees Nayef, Rafael Castiello and Maryam Tabrizian
Version of Record online: 22 FEB 2017 | DOI: 10.1002/mabi.201600535
Washless method titrations allow coating aggregation-prone liposome core nanoparticle with eight layers of polyelectrolyte with higher yields and reproducibility promising greater success in investigating a broader range of multilayer-coated nanoparticles for applications like drug delivery.
- Imaging Cell–Matrix Interactions in 3D Collagen Hydrogel Culture Systems
Aaron R. Short, Catherine Czeisler, Benjamin Stocker, Sara Cole, José Javier Otero and Jessica O. Winter
Version of Record online: 21 FEB 2017 | DOI: 10.1002/mabi.201600478
Hydrogels provide more accurate representations of cell behaviors in vivo; however, imaging in hydrogels can be challenging. This work develops new methods that enable imaging of cellular interactions with their hydrogel microenvironments in a collagen model.
- A Robust Method to Generate Mechanically Anisotropic Vascular Smooth Muscle Cell Sheets for Vascular Tissue Engineering
Daniel E. Backman, Bauer L. LeSavage, Shivem B. Shah and Joyce Y. Wong
Version of Record online: 16 FEB 2017 | DOI: 10.1002/mabi.201600434
Vascular smooth muscle cell sheets are cultured using a novel, micropatterned, thermoresponsive cell culture platform. The method is optimized to produce vascular smooth muscle cell sheets with cellular and extracellular alignment. Aligned cell sheets exhibit nonlinear, anisotropic mechanical properties that make them an attractive material for building a vascular graft that mimics the structural and mechanical properties of native vascular tissue.
- Synthesis and Characterization of Stimuli-Responsive Star-Like Polypept(o)ides: Introducing Biodegradable PeptoStars
Regina Holm, Benjamin Weber, Philipp Heller, Kristina Klinker, Dana Westmeier, Dominic Docter, Roland H. Stauber and Matthias Barz
Version of Record online: 15 FEB 2017 | DOI: 10.1002/mabi.201600514
The synthesis of three-arm polypeptoid and polypept(o)ide star polymers is reported. Incorporation of disulfide bonds between the core and the individual side chains enables degradation of star polymers in the presence of glutathione. The size of star polymers can be adjusted between 4 and 10 nm, yielding core–shell structures well tolerated by HeLa, HEK 293, and DC 2.4 cells.
- Bioprinting Using Mechanically Robust Core–Shell Cell-Laden Hydrogel Strands
Pritesh Mistry, Ahmed Aied, Morgan Alexander, Kevin Shakesheff, Andrew Bennett and Jing Yang
Version of Record online: 3 FEB 2017 | DOI: 10.1002/mabi.201600472
Combining good biological and mechanical properties in bioprinted constructs is desirable for them to be employed in many tissue engineering and regenerative medicine applications. Bioprinted cell-laden constructs with core–shell strands have been developed. The cell-supporting materials in the core support high cell viability and tissue-like functions while the shell material offers mechanical robustness to the bioprinted constructs.