Macromolecular Bioscience

Cover image for Vol. 15 Issue 6

Editor-in-Chief: Kirsten Severing, Editor: Anne Pfisterer

Online ISSN: 1616-5195

Associated Title(s): Advanced Healthcare Materials, Macromolecular Chemistry and Physics, Macromolecular Materials and Engineering, Macromolecular Rapid Communications

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Recently Published Articles

  1. Multi-Layered Scaffolds for Osteochondral Tissue Engineering: In Vitro Response of Co-Cultured Human Mesenchymal Stem Cells

    Sofia Amadori, Paola Torricelli, Silvia Panzavolta, Annapaola Parrilli, Milena Fini and Adriana Bigi

    Article first published online: 30 JUN 2015 | DOI: 10.1002/mabi.201500165

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    Multi-layered, easily synthesized scaffolds made of gelatin and hydroxyapatite are able to promote chondrogenic and osteogenic differentiation of human mesenchymal stem cells.

  2. Advanced Evaluation Strategies for Protein-Imprinted Polymer Nanobeads

    Bettina Pluhar and Boris Mizaikoff

    Article first published online: 26 JUN 2015 | DOI: 10.1002/mabi.201500106

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    An analytical strategy for providing exhaustive information on the selective binding and inhibition properties of nano-MIPs. Inhibited and active pepsin, respectively, along with two other proteins were incubated to equilibrium with pepsin-imprinted nanobeads, separated from the nanobeads by centrifugation, and the remaining supernatant was analyzed via SDS-PAGE.

  3. EGFP-Based Protein Nanoparticles with Cell-Penetrating Peptide for Efficient siRNA Delivery

    Xingang Guan, Xiuli Hu, Fengchao Cui, Yunqi Li, Xiabing Jing and Zhigang Xie

    Article first published online: 24 JUN 2015 | DOI: 10.1002/mabi.201500163

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    Fluorescent protein (EGFP) nanoparticles are developed and used for siRNA delivery. Protein nanoparticle can condense siRNA into stable nanoparticle/siRNA complexes, and transfect cy3-labelled siRNA into tumor cells.

  4. Probing the Mucoadhesive Interactions Between Porcine Gastric Mucin and Some Water-Soluble Polymers

    Yasser A. Albarkah, Rebecca J. Green and Vitaliy V. Khutoryanskiy

    Article first published online: 23 JUN 2015 | DOI: 10.1002/mabi.201500158

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    This study reports the structural features of porcine gastric mucin in aqueous dispersions and its interactions with water-soluble polymers. Sonication of mucin dispersion results in disaggregation of particles. However, the interaction of mucin with poly(carboxylic acids) via hydrogen bonding causes further aggregation of its particles.

  5. Hydrolysis-Sensitive Dithiolethione Prodrug Micelles

    Urara Hasegawa, Naoya Tateishi, Hiroshi Uyama and André J. van der Vlies

    Article first published online: 23 JUN 2015 | DOI: 10.1002/mabi.201500156

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    Hydrolysis-sensitive micellar prodrugs of desmethyl anethole dithiolethione (ADTOH), a chemopreventive agent, are prepared from amphiphilic block copolymers composed of a hydrophilic poly(N-acryloyl morpholine) block and a hydrophobic block linking ADT-OH via an ester bond using glycine and isoleucine linkers. This ADT-ester approach enables to modulate the release rate of ADT-OH and thus might find potential application in cancer therapy and prevention.