Macromolecular Bioscience

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Recently Published Articles

  1. Structural Mimetic Silk Fiber-Reinforced Composite Scaffolds Using Multi-Angle Fibers

    Gang Li, Jian Liu, Zhaozhu Zheng, Xiaoqin Wang and David L. Kaplan

    Article first published online: 16 APR 2015 | DOI: 10.1002/mabi.201400502

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    In order to develop a successful tissue engineered scaffold for the treatment of meniscus loss, this work starts with understanding and mimicking its complex internal architecture and function, and then develops a structural mimetic scaffolds reinforced with multi-angle silk fibers. The fiber reinforcement technique and mechanisms elucidated in this study can also be expanded to other mechanical strength-demanding tissue regeneration needs.

  2. Enzymatic Polymerization of an Ibuprofen-Containing Monomer and Subsequent Drug Release

    Nicholas D. Stebbins, Weiling Yu and Kathryn E. Uhrich

    Article first published online: 16 APR 2015 | DOI: 10.1002/mabi.201500030

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    Through enzymatic methods, drug-containing monomers were polymerized to afford linear polyesters with pendant bioactive groups. Nuclear magnetic resonance and Fourier transform infrared spectroscopies determined precursor and polymer structures. The polymers exhibited sustained hydrolytic release of ibuprofen, along with other natural and biocompatible compounds over the 30 d study. Released ibuprofen retained its chemical structure following synthesis and hydrolytic degradation.

  3. Poly(α-Peptoid)s Revisited: Synthesis, Properties, and Use as Biomaterial

    Christian Secker, Sarah M. Brosnan, Robert Luxenhofer and Helmut Schlaad

    Article first published online: 7 APR 2015 | DOI: 10.1002/mabi.201500023

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    Polypeptoids, or poly(N-alkyl glycine)s, are undergoing renaissance in interest because of their immense potential as biologically relevant materials. Here, we review the methods of polypeptoid synthesis by ring-opening polymerization of amino acid N-carboxyanhydrides, polypeptoid bulk and solution properties, self-assembly, and use as biomaterial.

  4. Living Composites of Bacteria and Polymers as Biomimetic Films for Metal Sequestration and Bioremediation

    Christian Knierim, Michaela Enzeroth, Patrick Kaiser, Christian Dams, David Nette, Andreas Seubert, Andreas Klingl, Charles L. Greenblatt, Valérie Jérôme, Seema Agarwal, Ruth Freitag and Andreas Greiner

    Article first published online: 7 APR 2015 | DOI: 10.1002/mabi.201400538

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    Water-insoluble core-shell fibers of PVA and PPX containing M. luteus or N. winogradskyi were achieved by utilizing wet spinning in combination with CVD. The leaking of bacteria from the fibers is retarded in aqueous solution. The immobilized bacteria were used for sequestration of gold and degradation of nitrite from aqueous solutions. The biosorption of gold lead to encapsulated gold nanoparticles as analyzed by EDX, ICP-MS, and TEM.

  5. Fabrication and Characterization of Gd-DTPA-Loaded Chitosan–Poly(Acrylic Acid) Nanoparticles for Magnetic Resonance Imaging

    Arsalan Ahmed, Chao Zhang, Jian Guo, Yong Hu and Xiqun Jiang

    Article first published online: 7 APR 2015 | DOI: 10.1002/mabi.201500034

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    Gd-DTPA-loaded chitosan–poly(acrylic acid) NPs were fabricated. These obtained NPs have a spherical shape with a size about 220 nm. They were stable in normal aqueous solution with positive surface charges and showed pH sensitivity in in vitro release and relaxation experiments. In vivo biodistribution and MRI studies have also demonstrated selective localization of contrast agent and enhanced contrast, respectively.