Copyright © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Materials Science Weekly Newsletter
Recently Published Articles
- Structural Mimetic Silk Fiber-Reinforced Composite Scaffolds Using Multi-Angle Fibers
Gang Li, Jian Liu, Zhaozhu Zheng, Xiaoqin Wang and David L. Kaplan
Article first published online: 16 APR 2015 | DOI: 10.1002/mabi.201400502
In order to develop a successful tissue engineered scaffold for the treatment of meniscus loss, this work starts with understanding and mimicking its complex internal architecture and function, and then develops a structural mimetic scaffolds reinforced with multi-angle silk fibers. The fiber reinforcement technique and mechanisms elucidated in this study can also be expanded to other mechanical strength-demanding tissue regeneration needs.
- Enzymatic Polymerization of an Ibuprofen-Containing Monomer and Subsequent Drug Release
Nicholas D. Stebbins, Weiling Yu and Kathryn E. Uhrich
Article first published online: 16 APR 2015 | DOI: 10.1002/mabi.201500030
Through enzymatic methods, drug-containing monomers were polymerized to afford linear polyesters with pendant bioactive groups. Nuclear magnetic resonance and Fourier transform infrared spectroscopies determined precursor and polymer structures. The polymers exhibited sustained hydrolytic release of ibuprofen, along with other natural and biocompatible compounds over the 30 d study. Released ibuprofen retained its chemical structure following synthesis and hydrolytic degradation.
- Poly(α-Peptoid)s Revisited: Synthesis, Properties, and Use as Biomaterial
Christian Secker, Sarah M. Brosnan, Robert Luxenhofer and Helmut Schlaad
Article first published online: 7 APR 2015 | DOI: 10.1002/mabi.201500023
Polypeptoids, or poly(N-alkyl glycine)s, are undergoing renaissance in interest because of their immense potential as biologically relevant materials. Here, we review the methods of polypeptoid synthesis by ring-opening polymerization of amino acid N-carboxyanhydrides, polypeptoid bulk and solution properties, self-assembly, and use as biomaterial.
- Living Composites of Bacteria and Polymers as Biomimetic Films for Metal Sequestration and Bioremediation
Christian Knierim, Michaela Enzeroth, Patrick Kaiser, Christian Dams, David Nette, Andreas Seubert, Andreas Klingl, Charles L. Greenblatt, Valérie Jérôme, Seema Agarwal, Ruth Freitag and Andreas Greiner
Article first published online: 7 APR 2015 | DOI: 10.1002/mabi.201400538
Water-insoluble core-shell fibers of PVA and PPX containing M. luteus or N. winogradskyi were achieved by utilizing wet spinning in combination with CVD. The leaking of bacteria from the fibers is retarded in aqueous solution. The immobilized bacteria were used for sequestration of gold and degradation of nitrite from aqueous solutions. The biosorption of gold lead to encapsulated gold nanoparticles as analyzed by EDX, ICP-MS, and TEM.
- Fabrication and Characterization of Gd-DTPA-Loaded Chitosan–Poly(Acrylic Acid) Nanoparticles for Magnetic Resonance Imaging
Arsalan Ahmed, Chao Zhang, Jian Guo, Yong Hu and Xiqun Jiang
Article first published online: 7 APR 2015 | DOI: 10.1002/mabi.201500034
Gd-DTPA-loaded chitosan–poly(acrylic acid) NPs were fabricated. These obtained NPs have a spherical shape with a size about 220 nm. They were stable in normal aqueous solution with positive surface charges and showed pH sensitivity in in vitro release and relaxation experiments. In vivo biodistribution and MRI studies have also demonstrated selective localization of contrast agent and enhanced contrast, respectively.