Macromolecular Bioscience

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Recently Published Articles

  1. Polymeric Nanocarriers for siRNA Delivery to Murine Macrophages

    Diane C. Forbes and Nicholas A. Peppas

    Article first published online: 22 APR 2014 | DOI: 10.1002/mabi.201400027

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    This work investigates the interactions of a polycationic nanocarrier with siRNA and with RAW264.7 cells in order to better understand the capabilities and limitations of the carrier. The cross-linked, DEAEMA-based nanoparticles are synthesized using ARGET ATRP in a single-step reaction. The carriers efficiently bind siRNA and are internalized by cells for siRNA delivery.

  2. Magnetic Nanoclusters Engineered by Polymer-Controlled Self-Assembly for the Accurate Diagnosis of Atherosclerotic Plaques via Magnetic Resonance Imaging

    Myeong-Hoon Kim, Bongjune Kim, Eun-Kyung Lim, Yuna Choi, Jihye Choi, Eunjung Kim, Eunji Jang, Hyo Seon Park, Jin-Suck Suh, Yong-Min Huh and Seungjoo Haam

    Article first published online: 17 APR 2014 | DOI: 10.1002/mabi.201400029

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    Oleyl dextran (ODex) coated magnetic nanocluster (ODMC) is developed and engineered by polymer-controlled self-assembly to be used as efficient MR imaging nanoprobe of atherosclerosis. T2 relaxivity of ODMCs is highly enhanced by controlling the condition of ODex including the degree of substitution of the oleyl group and the concentration used for the synthesis of ODMCs.

  3. Electrospun Nanofiber Scaffolds and Plasma Polymerization: A Promising Combination Towards Complete, Stable Endothelial Lining for Vascular Grafts

    Houman Savoji, Afra Hadjizadeh, Marion Maire, Abdellah Ajji, Michael R. Wertheimer and Sophie Lerouge

    Article first published online: 17 APR 2014 | DOI: 10.1002/mabi.201300545

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    Electrospinning and plasma polymerization are combined to provide vascular graft scaffolds. These bear similarity to the extracellular matrix beneath the luminal endothelium, are mechanically compliant and biocompatible, and facilitate formation of a cofluent monolayer of endothelial cells on the lumen, one that is stable under static and shear-induced flow conditions.

  4. Sequential pH-Dependent Adsorption of Ionic Amphiphilic Diblock Copolymer Micelles and Choline Oxidase Onto Conductive Substrates: Toward the Design of Biosensors

    Larisa V. Sigolaeva, Ulrike Günther, Dmitry V. Pergushov, Snezhana Yu. Gladyr, Ilya N. Kurochkin and Felix H. Schacher

    Article first published online: 17 APR 2014 | DOI: 10.1002/mabi.201300580

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    Block copolymer/enzyme biosensors are prepared via electrostatically driven co-assembly. Amphiphilic diblock copolymer micelles of poly(n-butylmethacrylate)-block-poly(N,N-dimethylaminoethyl methacrylate) and choline oxidase are used as building blocks to fabricate bilayer films on conductive substrates (modified graphite or gold) at different pH-values. The resulting hybrid thin-films represent highly active and stable biosensors for choline.

  5. Thiolated Eudragit-based Nanoparticles for Oral Insulin Delivery: Preparation, Characterization, and Evaluation Using Intestinal Epithelial Cells In Vitro

    Yan Zhang, Xuli Du, Yu Zhang, Guofei Li, Cuifang Cai, Jinghua Xu and Xing Tang

    Article first published online: 16 APR 2014 | DOI: 10.1002/mabi.201300515

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    Novel nanoparticles composed of Eudragit L100-cysteine (Eul-cys) and reduced glutathione (GSH) are prepared as potential nanocarriers for the oral delivery of insulin. The permeation enhancement of GSH is evaluated by Caco-2 and Caco-2/HT29-MTX co-cultured cells in vitro, which is compared to sodium caprate (SC). The results indicate that the mucus layer may be a barrier for transportation of thiolated nanoparticles, and the paracellular route may represent the main mechanism by which nanoparticles facilitate insulin permeation.