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Recently Published Articles
- A Luteolin-Loaded Electrospun Fibrous Implantable Device for Potential Therapy of Gout Attacks
Yi Wang, Chao Luo, Guang Yang, Xiao Wei, Dian Liu and Shaobing Zhou
Version of Record online: 22 JUL 2016 | DOI: 10.1002/mabi.201600123
A biodegradable polymer composite fiber device loading with luteolin is successfully developed via an electrospinning technology. The loaded drug can be controlled release from this device by simply adjusting the blend ratio of polymers, enabling it to potentially treat gout attacks.
- Enzymatic Crosslinking of Polymer Conjugates is Superior over Ionic or UV Crosslinking for the On-Chip Production of Cell-Laden Microgels
Sieger Henke, Jeroen Leijten, Evelien Kemna, Martin Neubauer, Andreas Fery, Albert van den Berg, Aart van Apeldoorn and Marcel Karperien
Version of Record online: 21 JUL 2016 | DOI: 10.1002/mabi.201600174
Cell encapsulating microgels are a promising tool for drug screening and tissue engineering approaches. However, only a limited amount of biomaterials have been reported to be compatible with on-chip microgel formation. Here, on-chip fabrication of dextran-tyramine microgels has been explored and reported that these microgels possess significant advantages over commonly used biomaterials, including improved cell survival, metabolic activity, and microgel stability.
- Synthesis of pH-Cleavable dPG-Amines for Gene Delivery Application
Mathias Dimde, Dirk Steinhilber, Falko Neumann, Yan Li, Florian Paulus, Nan Ma and Rainer Haag
Version of Record online: 19 JUL 2016 | DOI: 10.1002/mabi.201600190
This paper describes the development of two pH-cleavable polyglycerol-amine-based nanocarriers. The benzacetal bond represents the pH-sensitive cleavage site between dendritic polyglycerol (dPG) and glycerol-based 1,2-diamines that can complex genetic material. In vitro experiments demonstrate the ability of the cleavable dPG-amine to transfect HeLa cells with GFP-DNA, which resulted in cell-compatible cleavage products.
- Physico-Chemical Strategies to Enhance Stability and Drug Retention of Polymeric Micelles for Tumor-Targeted Drug Delivery
Yang Shi, Twan Lammers, Gert Storm and Wim E. Hennink
Version of Record online: 14 JUL 2016 | DOI: 10.1002/mabi.201600160
In this review, the most promising physico-chemical approaches to enhance polymeric micelle stability and drug retention are described, and how these strategies contribute to polymeric micelles with promising therapeutic efficacy in animal models, paving the way for clinical translation, is summarized.
- Intracellular Delivery and Triggered Release of DNA Using Biodegradable Poly(2-hydroxypropylene imine)s Containing Cystamine Units
Alma Bockuviene, Kristina Slavuckyte, Ausvydas Vareikis, Sarunas Zigmantas, Lolita Zaliauskiene and Ricardas Makuska
Version of Record online: 14 JUL 2016 | DOI: 10.1002/mabi.201600155
Novel polymers containing different amounts of disulfide linkages. Polymers are able to break down and release DNA following the treatment with reducing agent 1,4-dithiothreitol. Downstream application of poly(2-hydroxypropylene imines) containing segments of cystamine transfected cells for RNA purification shows that RNA yield is not affected even after the double transfection suggesting that these polymers could be great candidates for in vitro and in vivo transfection.