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Materials Science Weekly Newsletter
Recently Published Articles
- Multi-Layered Scaffolds for Osteochondral Tissue Engineering: In Vitro Response of Co-Cultured Human Mesenchymal Stem Cells
Sofia Amadori, Paola Torricelli, Silvia Panzavolta, Annapaola Parrilli, Milena Fini and Adriana Bigi
Article first published online: 30 JUN 2015 | DOI: 10.1002/mabi.201500165
Multi-layered, easily synthesized scaffolds made of gelatin and hydroxyapatite are able to promote chondrogenic and osteogenic differentiation of human mesenchymal stem cells.
- Advanced Evaluation Strategies for Protein-Imprinted Polymer Nanobeads
Bettina Pluhar and Boris Mizaikoff
Article first published online: 26 JUN 2015 | DOI: 10.1002/mabi.201500106
An analytical strategy for providing exhaustive information on the selective binding and inhibition properties of nano-MIPs. Inhibited and active pepsin, respectively, along with two other proteins were incubated to equilibrium with pepsin-imprinted nanobeads, separated from the nanobeads by centrifugation, and the remaining supernatant was analyzed via SDS-PAGE.
- EGFP-Based Protein Nanoparticles with Cell-Penetrating Peptide for Efficient siRNA Delivery
Xingang Guan, Xiuli Hu, Fengchao Cui, Yunqi Li, Xiabing Jing and Zhigang Xie
Article first published online: 24 JUN 2015 | DOI: 10.1002/mabi.201500163
Fluorescent protein (EGFP) nanoparticles are developed and used for siRNA delivery. Protein nanoparticle can condense siRNA into stable nanoparticle/siRNA complexes, and transfect cy3-labelled siRNA into tumor cells.
- Probing the Mucoadhesive Interactions Between Porcine Gastric Mucin and Some Water-Soluble Polymers
Yasser A. Albarkah, Rebecca J. Green and Vitaliy V. Khutoryanskiy
Article first published online: 23 JUN 2015 | DOI: 10.1002/mabi.201500158
This study reports the structural features of porcine gastric mucin in aqueous dispersions and its interactions with water-soluble polymers. Sonication of mucin dispersion results in disaggregation of particles. However, the interaction of mucin with poly(carboxylic acids) via hydrogen bonding causes further aggregation of its particles.
- Hydrolysis-Sensitive Dithiolethione Prodrug Micelles
Urara Hasegawa, Naoya Tateishi, Hiroshi Uyama and André J. van der Vlies
Article first published online: 23 JUN 2015 | DOI: 10.1002/mabi.201500156
Hydrolysis-sensitive micellar prodrugs of desmethyl anethole dithiolethione (ADTOH), a chemopreventive agent, are prepared from amphiphilic block copolymers composed of a hydrophilic poly(N-acryloyl morpholine) block and a hydrophobic block linking ADT-OH via an ester bond using glycine and isoleucine linkers. This ADT-ester approach enables to modulate the release rate of ADT-OH and thus might find potential application in cancer therapy and prevention.