Macromolecular Bioscience

Cover image for Vol. 16 Issue 7

Editor-in-Chief: Kirsten Severing, Editor: Anne Pfisterer

Online ISSN: 1616-5195

Associated Title(s): Advanced Healthcare Materials, Macromolecular Chemistry and Physics, Macromolecular Materials and Engineering, Macromolecular Rapid Communications

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Recently Published Articles

  1. A Luteolin-Loaded Electrospun Fibrous Implantable Device for Potential Therapy of Gout Attacks

    Yi Wang, Chao Luo, Guang Yang, Xiao Wei, Dian Liu and Shaobing Zhou

    Version of Record online: 22 JUL 2016 | DOI: 10.1002/mabi.201600123

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    A biodegradable polymer composite fiber device loading with luteolin is successfully developed via an electrospinning technology. The loaded drug can be controlled release from this device by simply adjusting the blend ratio of polymers, enabling it to potentially treat gout attacks.

  2. Enzymatic Crosslinking of Polymer Conjugates is Superior over Ionic or UV Crosslinking for the On-Chip Production of Cell-Laden Microgels

    Sieger Henke, Jeroen Leijten, Evelien Kemna, Martin Neubauer, Andreas Fery, Albert van den Berg, Aart van Apeldoorn and Marcel Karperien

    Version of Record online: 21 JUL 2016 | DOI: 10.1002/mabi.201600174

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    Cell encapsulating microgels are a promising tool for drug screening and tissue engineering approaches. However, only a limited amount of biomaterials have been reported to be compatible with on-chip microgel formation. Here, on-chip fabrication of dextran-tyramine microgels has been explored and reported that these microgels possess significant advantages over commonly used biomaterials, including improved cell survival, metabolic activity, and microgel stability.

  3. Synthesis of pH-Cleavable dPG-Amines for Gene Delivery Application

    Mathias Dimde, Dirk Steinhilber, Falko Neumann, Yan Li, Florian Paulus, Nan Ma and Rainer Haag

    Version of Record online: 19 JUL 2016 | DOI: 10.1002/mabi.201600190

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    This paper describes the development of two pH-cleavable polyglycerol-amine-based nanocarriers. The benzacetal bond represents the pH-sensitive cleavage site between dendritic polyglycerol (dPG) and glycerol-based 1,2-diamines that can complex genetic material. In vitro experiments demonstrate the ability of the cleavable dPG-amine to transfect HeLa cells with GFP-DNA, which resulted in cell-compatible cleavage products.

  4. Physico-Chemical Strategies to Enhance Stability and Drug Retention of Polymeric Micelles for Tumor-Targeted Drug Delivery

    Yang Shi, Twan Lammers, Gert Storm and Wim E. Hennink

    Version of Record online: 14 JUL 2016 | DOI: 10.1002/mabi.201600160

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    In this review, the most promising physico-chemical approaches to enhance polymeric micelle stability and drug retention are described, and how these strategies contribute to polymeric micelles with promising therapeutic efficacy in animal models, paving the way for clinical translation, is summarized.

  5. Intracellular Delivery and Triggered Release of DNA Using Biodegradable Poly(2-hydroxypropylene imine)s Containing Cystamine Units

    Alma Bockuviene, Kristina Slavuckyte, Ausvydas Vareikis, Sarunas Zigmantas, Lolita Zaliauskiene and Ricardas Makuska

    Version of Record online: 14 JUL 2016 | DOI: 10.1002/mabi.201600155

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    Novel polymers containing different amounts of disulfide linkages. Polymers are able to break down and release DNA following the treatment with reducing agent 1,4-dithiothreitol. Downstream application of poly(2-hydroxypropylene imines) containing segments of cystamine transfected cells for RNA purification shows that RNA yield is not affected even after the double transfection suggesting that these polymers could be great candidates for in vitro and in vivo transfection.