Macromolecular Bioscience

Cover image for Vol. 15 Issue 11

Editor-in-Chief: Kirsten Severing, Editor: Anne Pfisterer

Online ISSN: 1616-5195

Associated Title(s): Advanced Healthcare Materials, Macromolecular Chemistry and Physics, Macromolecular Materials and Engineering, Macromolecular Rapid Communications

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Recently Published Articles

  1. Cellularized Cellular Solids via Freeze-Casting

    Sarah Christoph, Julien Kwiatoszynski, Thibaud Coradin and Francisco M. Fernandes

    Article first published online: 4 NOV 2015 | DOI: 10.1002/mabi.201500319

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    The elaboration of metabolically active cell-containing materials is a decisive step toward the successful application of cell based technologies. The present work unveils a new process allowing to simultaneously encapsulate living cells and shaping cell-containing materials into solid-state macroporous foams with precisely controlled morphology using freeze casting.

  2. Patterned Polypeptoid Brushes

    Maximilian Schneider, Zian Tang, Marcus Richter, Claudia Marschelke, Paul Förster, Erik Wegener, Ihsan Amin, Heike Zimmermann, Dieter Scharnweber, Hans-Georg Braun, Robert Luxenhofer and Rainer Jordan

    Article first published online: 2 NOV 2015 | DOI: 10.1002/mabi.201500314

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    The preparation of patterned polypeptoid (POI) brushes on gold and oxide substrates by surface-initiated polymerization of N-substituted glycine N-carboxyanhydrides from patterned self-assembled monolayers is presented. Furthermore, the chemoselective functionalization and anti-biofouling properties of POI brushes are shown.

  3. A Stimulated Mixed Micelle System for In Vitro Study on Chemo-Photodynamic Therapy

    Ching-Yi Chen, Chao-Kai Syu and Hsin Chang Lin

    Article first published online: 8 OCT 2015 | DOI: 10.1002/mabi.201500269

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    A stimulated mixed micelle system with photosensitizer-centered for encapsulation of doxorubicin was developed for chemo-photodynamic therapy. This mixed micelle system shows good stability, controlled release rate and high singlet oxygen generation efficiency. In vitro study demonstrates a higher cytotoxicity under light condition relative to individual single drug loaded micelle, indicating improved therapeutic efficiency due to combination therapy.

  4. PolyDOPA Mussel-Inspired Coating as a Means for Hydroxyapatite Entrapment on Polytetrafluoroethylene Surface for Application in Periodontal Diseases

    Tiziana Nardo, Valeria Chiono, Gianluca Ciardelli and Maryam Tabrizian

    Article first published online: 7 OCT 2015 | DOI: 10.1002/mabi.201500241

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    This work gives a thorough characterization of non-resorbable polytetrafluoroethylene films, coated with hydroxyapatite nanoparticles (HAp) through an adhesive coating of self-polymerized 3,4-dihydroxy-DL-phenylalanine (polyDOPA). This coating technique represents an interesting approach able to improve MC3T3-E1 pre-osteoblastic cells adhesion and proliferation on polyDOPA/HAp-coated substrates.

  5. Non-Fouling Biodegradable Poly(ϵ-caprolactone) Nanofibers for Tissue Engineering

    Nina Yu. Kostina, Ognen Pop-Georgievski, Michael Bachmann, Neda Neykova, Michael Bruns, Jiří Michálek, Martin Bastmeyer and Cesar Rodriguez-Emmenegger

    Article first published online: 7 OCT 2015 | DOI: 10.1002/mabi.201500252

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    Four antifouling polymer brushes are grown from biodegradable poly(ϵ-caprolactone) nanofibers without impairing their unique architecture. The nanofibers are challenged with mouse embryonic fibroblasts. Fibroblasts are repelled from the nanofibers coated with brushes while the cells could rapidly adhere and form cell–matrix adhesions on pristine nanofibers. The nanofibers modified with protein repellent brushes are able to suppress cell adhesion.