Macromolecular Bioscience

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Recently Published Articles

  1. New Semi-Biodegradable Materials from Semi-Interpenetrated Networks of Poly(ϵ-caprolactone) and Poly(ethyl acrylate)

    P. Lozano Picazo, M. Pérez Garnes, C. Martínez Ramos, A. Vallés-Lluch and M. Monleón Pradas

    Article first published online: 30 SEP 2014 | DOI: 10.1002/mabi.201400331

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    Semi-degradable materials may have find applications. Poly-(ethyl acrylate) and poly(ϵ-caprolactone) are here combined as semi-IPNs. Materials are obatined which combine their outstanding biological properties and possess mechanical properties tunable in a wide range of moduli. The behavior of fibroblasts and adipose-tissue-derived stem cells on these new materials is studied.

  2. Revisiting Complexation between DNA and Polyethylenimine: Does the Disulfide Linkage Play a Critical Role in Promoting Gene Delivery?

    Yongzheng Ma, Baizhu Chen, Ning He, Gaojian Chen, Lianwei Li and Chi Wu

    Article first published online: 29 SEP 2014 | DOI: 10.1002/mabi.201400253

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    To improve transfection efficiency and lower cytotoxicity, disulfide bonds have been applied in gene vectors. However, the disulfide bonds may not play an important role in promoting gene delivery, but do extend the chain length. A long free PEI chain could efficiently protect DNA from degradation, so that more DNA is transported into the nucleus.

  3. A Cancer-Recognizing Polymeric Photosensitizer Based on the Tumor Extracellular pH Response of Conjugated Polymers for Targeted Cancer Photodynamic Therapy

    Songhee Jeong, Wooram Park, Chung-Sung Lee and Kun Na

    Article first published online: 24 SEP 2014 | DOI: 10.1002/mabi.201400361

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    A cancer-recognizing polymeric photosensitizer (CRPP) for targeted photodynamic cancer therapy is developed through a facile synthetic process. The newly synthesized CRPP is capable of reversing its charge from negative to positive at the tumor extracellular pH (pHe, pH ∼6.5) to facilitate cellular internalization, which can lead to enhanced therapeutic efficacy against tumor cells.

  4. Sulfated Hyaluronan Influences the Formation of Artificial Extracellular Matrices and the Adhesion of Osteogenic Cells

    Alina Miron, Sandra Rother, Linda Huebner, Ute Hempel, Iris Käppler, Stephanie Moeller, Matthias Schnabelrauch, Dieter Scharnweber and Vera Hintze

    Article first published online: 12 SEP 2014 | DOI: 10.1002/mabi.201400292

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    The presence of sulfated glycosaminoglycans (GAG), like sulfated hyaluronan derivatives and chondroitin sulfate, during in vitro-fibrillogenesis of collagen type I alters the structure of the resulting artificial extracellular matrices. Besides, the GAG amount associated to collagen increases in a sulfation-dependent manner. Moreover, GAG sulfation influences the cytoskeletal arrangement of SaOS-2 cells which implies that adhesion-related intracellular signaling is affected.

  5. pH-Responsive Single Walled Carbon Nanotube Dispersion for Target Specific Release of Doxorubicin to Cancer Cells

    Moumita Ghosh, Sayanti Brahmachari and Prasanta Kumar Das

    Article first published online: 11 SEP 2014 | DOI: 10.1002/mabi.201400290

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    pH Responsive cholesterol based dipeptide carboxylates were synthesized as efficient dispersing agents for SWNTs in water. These highly dispersed nanotubes were used for the uploading of anticancer drug doxorubicin. The nanohybrid showed excellent pH responsive drug release at the extracellular tumorogenic environmental pH (6.0–6.5) and selectively kills cancer cells.