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Recently Published Articles
- Comparative Endocytosis Mechanisms and Anticancer Effect of HPMA Copolymer- and PAMAM Dendrimer-MTCP Conjugates for Photodynamic Therapy
Raziye Mohammadpour, Shahrokh Safarian, Brandon Buckway and Hamidreza Ghandehari
Version of Record online: 25 OCT 2016 | DOI: 10.1002/mabi.201600333
The association of photosensitizers with polymeric carriers can improve solubility, influence the route and the rate of cellular internalization, and drastically enhance the uptake of the photosensitizer. Random coil HPMA copolymer-MTCP has more chance for physical association with cell membrane than spherical hyperbranched PAMAM-MTCP. Negatively charged MTCP might be taken up via lipid raft domain on the cell membrane surface.
- Understanding Polymer-Cell Attachment
Andrea Venturato, Gillian MacFarlane, Jin Geng and Mark Bradley
Version of Record online: 25 OCT 2016 | DOI: 10.1002/mabi.201600253
Well-defined random and block copolymers from single-electron transfer living radical polymerization are examined for their performance in the attachment and growth of HeLa and HEK cells. Cellular attachment can be controlled by the adjustment of the polymer structure, with correlations observed between cell attachment and monomer composition and distinguished polymer chain length.
- A Modified Polysaccharide-Based Hydrogel for Enhanced Osteogenic Maturation and Mineralization Independent of Differentiation Factors
Sridhar Sanyasi, Satish Kumar, Arijit Ghosh, Rakesh Kumar Majhi, Navneet Kaur, Priyanka Choudhury, Udai P. Singh, Chandan Goswami and Luna Goswami
Version of Record online: 21 OCT 2016 | DOI: 10.1002/mabi.201600268
A hydrogel prepared by grafting of tamarind kernel polysaccharide with acrylic acid supports growth of both osteogenic and associated nonosteogenic cell types. It has the unique capability of promoting adhesion, proliferation, differentiation, and mineralization of bone cells without the addition of exogenous differentiation factors. This hydrogel can be used as a potential low-cost scaffold for efficient bone tissue engineering.
- Thin Poly(Di(Ethylene Glycol)Methyl Ether Methacrylate) Homopolymer Brushes Allow Controlled Adsorption and Desorption of PaTu 8988t Cells
Yvonne Voß, Ekram Wassel, Siyu Jiang, Qimeng Song, Sergey I. Druzhinin and Holger Schönherr
Version of Record online: 20 OCT 2016 | DOI: 10.1002/mabi.201600337
Thin poly(di(ethylene glycol)methyl ether methacrylate) (PDEGMA) brushes exhibit interesting thermoresponsive behavior that can be tuned by variations of brush thickness and grafting density. This detailed investigation of (i) the temperature dependence of the adsorption of fibronectin and proteins from cell culture media and (ii) the thermally triggered release of PaTu 8988t cells underpins the potential of PDEGMA as thermoresponsive cell release coating.
- Crosslinked Platform Coatings Incorporating Bioactive Signals for the Control of Biointerfacial Interactions
Berkay Ozcelik, Renxun Chen, Veronica Glattauer, Naresh Kumar, MarkD.P. Willcox and Helmut Thissen
Version of Record online: 20 OCT 2016 | DOI: 10.1002/mabi.201600315
Poly(ethylene glycol)-based crosslinked platform coatings described in this study allow for the facile covalent incorporation of bioactive cell adhesive and antimicrobial peptides. The coatings provide low-biofouling properties while maintaining the function of the incorporated peptides. Cell attachment studies confirm the activity of the cRGDfK peptide while incorporation of the antimicrobial peptide melimine further reduces bacterial colonization on surfaces.