Macromolecular Bioscience

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Recently Published Articles

  1. Degradable Glycine-Based Photo-Polymerizable Polyphosphazenes for Use as Scaffolds for Tissue Regeneration

    Sandra Rothemund, Tamara B. Aigner, Aitziber Iturmendi, Maria Rigau, Branislav Husár, Florian Hildner, Eleni Oberbauer, Martina Prambauer, Gbenga Olawale, Reinhard Forstner, Robert Liska, Klaus R. Schröder, Oliver Brüggemann and Ian Teasdale

    Article first published online: 30 OCT 2014 | DOI: 10.1002/mabi.201400390

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    Hydrolytically degradable, porous matrices are prepared via a mild and simple photopolymerization of functionalized poly(organo)phosphazenes. The modular system allows for facile surface functionalization and property tuning. The novel materials are biocompatible and have tunable degradation rates to non-toxic small molecules and thus are promising for use as synthetic scaffolds for tissue regeneration.

  2. Substrate-induced PC12 Cell Differentiation Without Filopodial, Lamellipodial Activity or NGF Stimulationa

    Guillaume Lamour, Sylvie Souès and Ahmed Hamraoui

    Article first published online: 28 OCT 2014 | DOI: 10.1002/mabi.201400323

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    PC12 cells are driven to extend neurites through cell-substrate interactions only, that is, without nerve growth factor (NGF) stimulation. Actin polymerization is destabilized by treating the cells with cytochalasin. As a result the cells are deprived of both filopodia and lamellipodia. However, they extend neurites continuously. This shows that neither filopodia nor lamellipodia are required to trigger substrate-induced neuronal differentiation of PC12 cells.

  3. Poly(anhydride-ester) and Poly(N-vinyl-2-pyrrolidone) Blends: Salicylic Acid-Releasing Blends with Hydrogel-Like Properties that Reduce Inflammation

    Michelle A. Ouimet, Renata Fogaça, Sabrina S. Snyder, Sameer Sathaye, Luiz H. Catalani, Darrin J. Pochan and Kathryn E. Uhrich

    Article first published online: 21 OCT 2014 | DOI: 10.1002/mabi.201400238

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    Hydrogels-like polymer blends that combine the biocompatibility and hydrophilicity of PVP with controlled release of salicylic acid to reduce inflammation are presented. These copolymer blends substantially reduce the inflammatory cytokine, TNF-α, in vitro and indicate no cytotoxic or anti-proliferative effects. Based upon the unique combination, these blended polymer films show great potential for wound healing.

  4. Multi-Technique Characterization of Poly-L-lysine Dendrigrafts–Cu(II) Complexes for Biocatalysis

    Jean-Christophe Rossi, Barbara Maret, Kevin Vidot, Jean-Patrick Francoia, Michela Cangiotti, Susanna Lucchi, Concetta Coppola and Maria Francesca Ottaviani

    Article first published online: 20 OCT 2014 | DOI: 10.1002/mabi.201400341

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    Significant structural features of poly-L-lysine dendrigrafts (DGLs) – Cu(II) complexes are characterized to implement the use of these complexes as biocatalysts. The agreement and complementarity among EPR, potentiometric titration, UV-Vis and CD measurements provide an exhaustive view of the Cu(II)-DGL complexation behavior as a function of DGL generation, relative concentrations, and pH.

  5. Thermoresponsive Nanodevices in Biomedical Applications

    Julián Bergueiro and Marcelo Calderón

    Article first published online: 16 OCT 2014 | DOI: 10.1002/mabi.201400362

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    Thermoresponsive nanodevices are one of the most promising systems in nanomedicine. Due to new building blocks, a number of promising smart systems have been rapidly developed in response to the needs of nanomedicine. This article reviews the innovations in this field from the last four years.

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