Macromolecular Bioscience

Cover image for Vol. 17 Issue 5

Editor-in-Chief: Kirsten Severing, Editor: Anne Pfisterer

Online ISSN: 1616-5195

Associated Title(s): Advanced Healthcare Materials, Macromolecular Chemistry and Physics, Macromolecular Materials and Engineering, Macromolecular Rapid Communications

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Best of Macros 2017 is now online. Click here to read about the selected articles and their authors.

Recently Published Articles

  1. Biomimetic Macroporous PCL Scaffolds for Ex Vivo Expansion of Cord Blood-Derived CD34+ Cells with Feeder Cells Support

    Xiuwei Pan, Qiong Sun, Yuanhao Zhang, Haibo Cai, Yun Gao, Yongjia Shen and Weian Zhang

    Version of Record online: 24 MAY 2017 | DOI: 10.1002/mabi.201700054

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    Biomimetic macroporous poly(ε-caprolactone) (PCL) scaffolds and feeder cells (human amniotic membrane-derived stromal cells) are utilized in hematopoietic cultures to mimic the physical and biological parameters of hematopoietic stem cell niche. Four culture conditions are designed to evaluate the influence of PCL scaffolds, feeder cells, and contact manner on ex vivo expansion of HSPCs.

  2. Development of Enzyme Loaded Polyion Complex Vesicle (PICsome): Thermal Stability of Enzyme in PICsome Compartment and Effect of Coencapsulation of Dextran on Enzyme Activity

    Hengmin Tang, Yuki Sakamura, Takeshi Mori, Yoshiki Katayama and Akihiro Kishimura

    Version of Record online: 19 MAY 2017 | DOI: 10.1002/mabi.201600542

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    Enzyme encapsulation without deactivation and long-term enzyme storage are still problematic. This study reports on the confinement effects on enzyme activity for the development of a high-performance enzymatic nanoreactor. This approach enhances the enzyme stability at 37 °C. Coloading of dextran helps to maintain the enzyme activity at −20 °C.

  3. Fluorinated PEG-Polypeptide Polyplex Micelles Have Good Serum-Resistance and Low Cytotoxicity for Gene Delivery

    Ting Wu, Longhai Wang, Shenggang Ding and Yezi You

    Version of Record online: 19 MAY 2017 | DOI: 10.1002/mabi.201700114

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    Nonviral gene vectors used in gene delivery must have a high stability to tolerate harsh conditions in physiological fluids. Here a novel PEGylation polypeptide conjugated with fluorocarbon chains is synthesized which has good serum-resistance and low cytotoxicity for gene delivery. The results suggest that the fluorinated polypeptides are promising for safe and efficient gene delivery.

  4. Developing Polyamine-Based Peptide Amphiphiles with Tunable Morphology and Physicochemical Properties

    Mehdi Bin Samad, Yashpal Singh Chhonker, Jacob I. Contreras, Alec McCarthy, Megan M. McClanahan, Daryl J. Murry and Martin Conda-Sheridan

    Version of Record online: 16 MAY 2017 | DOI: 10.1002/mabi.201700096

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    Peptide amphiphiles (PAs) are self-assembling molecules that form diverse nanostructures. PAs are an attractive for drug delivery, imaging, and tissue regeneration. This study describes the synthesis of polyamine-based PAs. These new molecules can assemble into various morphologies with diverse self-assembly kinetics and properties such as stiffness, metabolism, and stability. Polyamine-based PAs are novel materials with potential biomedical applications.

  5. Combined Delivery of a Lipopolysaccharide-Binding Peptide and the Heme Oxygenase-1 Gene Using Deoxycholic Acid-Conjugated Polyethylenimine for the Treatment of Acute Lung Injury

    Ji Yeon Kim, Chunxian Piao, Gyeungyun Kim, Seonyeong Lee, Min Sang Lee, Ji Hoon Jeong and Minhyung Lee

    Version of Record online: 16 MAY 2017 | DOI: 10.1002/mabi.201600490

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    Ternary complexes for combined delivery of the heme oxygenase-1 (HO-1) gene and lipopolysaccharide-binding peptide (LBP) are developed. Deoxycholic acid-conjugated polyethylenimine (DA-PEI) is used to make the ternary complexes. The HO-1 gene and LBP peptide of the ternary complexes have synergistic effects in the acute lung injury (ALI) model, reducing inflammatory reaction. Thus, the pHO-1/PEI-DA/LBP ternary complex may be useful for the treatment of ALI.