Macromolecular Bioscience

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Recently Published Articles

  1. Injectable Hybrid Hydrogels of Hyaluronic Acid Crosslinked by Well-Defined Synthetic Polycations: Preparation and Characterization In Vitro and In Vivo

    Daisy Cross, Xiaoze Jiang, Weihang Ji, Wenqing Han and Chun Wang

    Article first published online: 28 JAN 2015 | DOI: 10.1002/mabi.201400491

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    Hyaluronic acid and well-defined synthetic cationic copolymers form hybrid hydrogels through electrostatic interactions. These materials may have potential medical applications such as injectable carriers for cells.

  2. New Ionic bis-MPA and PAMAM Dendrimers: A Study of Their Biocompatibility and DNA-Complexation

    Julie Movellan, Rebeca González-Pastor, Pilar Martín-Duque, Teresa Sierra, Jesús M. de la Fuente and José Luis Serrano

    Article first published online: 28 JAN 2015 | DOI: 10.1002/mabi.201400422

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    Ionic dendrimers are described that consist on quaternary salts of amino-terminated PAMAM and bis-MPA derivatives and biocompatible chains derived from 2-[2-(2-methoxyethoxy) ethoxy]acetic acid. Whereas the PAMAM compounds remain cytotoxic, the I-bis-MPA compound exhibits high loading capacity for pDNA and very low toxicity.

  3. Novel Linear Polymers Able to Inhibit Bacterial Quorum Sensing

    Eliana Cavaleiro PhD, Ana Sofia Duarte PhD, Ana Cristina Esteves PhD, António Correia PhD, Michael J. WhitcombePhD, Elena V. Piletska PhD, Sergey A. Piletsky PhD and Iva Chianella PhD

    Article first published online: 28 JAN 2015 | DOI: 10.1002/mabi.201400447

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    The conventional treatment of bacterial infections is based on the administration of antibiotics, which promotes bacterial resistance. We present the development of linear polymers able to disrupt quorum sensing as shown by the reduction of bacterial bioluminescence and biofilm formation. The polymers could be used to control bacterial virulence without promoting resistance, thus constituting a safe alternative to the use of antibiotics.

  4. Polymer Brushes Interfacing Blood as a Route Toward High Performance Blood Contacting Devices

    František Surman, Tomáš Riedel, Michael Bruns, Nina Yu. Kostina, Zdeňka Sedláková and Cesar Rodriguez-Emmenegger

    Article first published online: 21 JAN 2015 | DOI: 10.1002/mabi.201400470

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    Hydrophilic polymer brushes based on HPMA prepared by surface initiated ATRP provide an excellent surface modification to prevent the adhesion of blood components as well as the fouling from whole blood. This surface modification opens new opportunities to improve the performance of blood contacting devices.

  5. Reduction-Sensitive Amphiphilic Triblock Copolymers Self-Assemble Into Stimuli-Responsive Micelles for Drug Delivery

    Smahan Toughraï, Violeta Malinova, Raffaello Masciadri, Sindhu Menon, Pascal Tanner, Cornelia Palivan, Nico Bruns and Wolfgang Meier

    Article first published online: 13 JAN 2015 | DOI: 10.1002/mabi.201400400

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    Polymeric micelles obtained from the self-assembly of redox-sensitive amphiphilic triblock copolymers with a cleavable disulfide bond in the center of the hydrophobic block were investigated as potential drug delivery systems. The degradation products of the micelles are amphiphilic diblock copolymers and should therefore allow for facile clearing from biological systems.