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Materials Science Weekly Newsletter
Recently Published Articles
- Biofunctional Materials Based on Amino Cellulose Derivatives – A Nanobiotechnological Concept
Thomas Heinze, Melanie Siebert, Peter Berlin and Andreas Koschella
Article first published online: 30 JUL 2015 | DOI: 10.1002/mabi.201500184
Amino cellulose derivatives simply available by nucleophilic displacement reactions of tosyl cellulose with a broad variety of amines possess an extraordinary ability for self-assembling. Nanocomposites and monolayers may be formed on various substrates. For example, the modified surfaces are efficient carriers for (bio) functional molecules yielding efficient biosensors.
- Anti-Resorptive Functions of Poly(ethylene sodium phosphate) on Human Osteoclasts
Sujit Kootala, Masahiro Tokunaga, Jöns Hilborn and Yasuhiko Iwasaki
Article first published online: 29 JUL 2015 | DOI: 10.1002/mabi.201500166
The effect of poly(ethylene sodium phosphate) (PEP · Na) on human osteoclasts is studied. PEP · Na exhibits excellent biocompatibility with osteoblasts, whereas the polymer effectively reduces the adhesion of osteoclasts adhered on bone slices. This is the first report to describe the possibility of using polyphosphoesters for selective inhibition of osteoclast adhesion and function.
- Anti-Bioadhesive Coating Based on Easy to Make Pseudozwitterionic RAFT Block Copolymers for Blood-Contacting Applications
Sabrina Nehache, Chin-Cheng Yeh, Mona Semsarilar, André Deratani, Yung Chang and Damien Quemener
Article first published online: 29 JUL 2015 | DOI: 10.1002/mabi.201500185
Well-defined pseudozwitterionic diblock copolymers are synthesized using RAFT chemistry. These charged polymers are then used to prepare anti-bioadhesion surfaces that could be used in blood-contact devices. It is demonstrated that such coatings prevent blood protein adsorption to the polymer modified surfaces.
- Bioreducible Poly-l-Lysine–Poly[HPMA] Block Copolymers Obtained by RAFT-Polymerization as Efficient Polyplex-Transfection Reagents
Kristof Tappertzhofen, Simone Beck, Evelyn Montermann, David Huesmann, Matthias Barz, Kaloian Koynov, Matthias Bros and Rudolf Zentel
Article first published online: 29 JUL 2015 | DOI: 10.1002/mabi.201500212
Polylysine-S-S-b-poly[N-(2-hydroxypropyl) methacrylamide] (p[HPMA]) copolymers with a bioreducible disulfide group can be obtained by RAFT polymerization of a macromolecular disulfide chain transfer agent (CTA). Polyplex formation with pDNA leads to increased transfection efficiencies compared to non disulfide containing block copolymers.
- N-(2-Hydroxypropyl)methacrylamide Copolymer–Drug Conjugates for Combination Chemotherapy of Acute Myeloid Leukemia
Rui Zhang, Jiyuan Yang, Yan Zhou, Paul J. Shami and Jindřich Kopeček
Article first published online: 29 JUL 2015 | DOI: 10.1002/mabi.201500193
Four different drugs, including cytarabine, daunorubicin, GDC-0980, and JS-K, are used for two-drug combination treatment against acute myeloid leukemia. Combining cytarabine with GDC-0980 shows the strongest synergistism. N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer-cytarabine/GDC-0980 conjugates are synthesized. They also hve potent cytotoxicity and strong synergstism in combination.