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Recently Published Articles
- Cellularized Cellular Solids via Freeze-Casting
Sarah Christoph, Julien Kwiatoszynski, Thibaud Coradin and Francisco M. Fernandes
Article first published online: 4 NOV 2015 | DOI: 10.1002/mabi.201500319
The elaboration of metabolically active cell-containing materials is a decisive step toward the successful application of cell based technologies. The present work unveils a new process allowing to simultaneously encapsulate living cells and shaping cell-containing materials into solid-state macroporous foams with precisely controlled morphology using freeze casting.
- Patterned Polypeptoid Brushes
Maximilian Schneider, Zian Tang, Marcus Richter, Claudia Marschelke, Paul Förster, Erik Wegener, Ihsan Amin, Heike Zimmermann, Dieter Scharnweber, Hans-Georg Braun, Robert Luxenhofer and Rainer Jordan
Article first published online: 2 NOV 2015 | DOI: 10.1002/mabi.201500314
The preparation of patterned polypeptoid (POI) brushes on gold and oxide substrates by surface-initiated polymerization of N-substituted glycine N-carboxyanhydrides from patterned self-assembled monolayers is presented. Furthermore, the chemoselective functionalization and anti-biofouling properties of POI brushes are shown.
- A Stimulated Mixed Micelle System for In Vitro Study on Chemo-Photodynamic Therapy
Ching-Yi Chen, Chao-Kai Syu and Hsin Chang Lin
Article first published online: 8 OCT 2015 | DOI: 10.1002/mabi.201500269
A stimulated mixed micelle system with photosensitizer-centered for encapsulation of doxorubicin was developed for chemo-photodynamic therapy. This mixed micelle system shows good stability, controlled release rate and high singlet oxygen generation efficiency. In vitro study demonstrates a higher cytotoxicity under light condition relative to individual single drug loaded micelle, indicating improved therapeutic efficiency due to combination therapy.
- PolyDOPA Mussel-Inspired Coating as a Means for Hydroxyapatite Entrapment on Polytetrafluoroethylene Surface for Application in Periodontal Diseases
Tiziana Nardo, Valeria Chiono, Gianluca Ciardelli and Maryam Tabrizian
Article first published online: 7 OCT 2015 | DOI: 10.1002/mabi.201500241
This work gives a thorough characterization of non-resorbable polytetrafluoroethylene films, coated with hydroxyapatite nanoparticles (HAp) through an adhesive coating of self-polymerized 3,4-dihydroxy-DL-phenylalanine (polyDOPA). This coating technique represents an interesting approach able to improve MC3T3-E1 pre-osteoblastic cells adhesion and proliferation on polyDOPA/HAp-coated substrates.
- Non-Fouling Biodegradable Poly(ϵ-caprolactone) Nanofibers for Tissue Engineering
Nina Yu. Kostina, Ognen Pop-Georgievski, Michael Bachmann, Neda Neykova, Michael Bruns, Jiří Michálek, Martin Bastmeyer and Cesar Rodriguez-Emmenegger
Article first published online: 7 OCT 2015 | DOI: 10.1002/mabi.201500252
Four antifouling polymer brushes are grown from biodegradable poly(ϵ-caprolactone) nanofibers without impairing their unique architecture. The nanofibers are challenged with mouse embryonic fibroblasts. Fibroblasts are repelled from the nanofibers coated with brushes while the cells could rapidly adhere and form cell–matrix adhesions on pristine nanofibers. The nanofibers modified with protein repellent brushes are able to suppress cell adhesion.