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Recently Published Articles
- Novel On-Demand Bioadhesion to Soft Tissue in Wet Environments
Vishal Mogal, Vladislav Papper, Alok Chaurasia, Gao Feng, Robert Marks and Terry Steele
Article first published online: 2 DEC 2013 | DOI: 10.1002/mabi.201300380
A novel diazirine-based bioadhesive that can be applied across various clinically important surfaces is developed. After plasma post-irradiation on PLGA films, on-demand and tuneable bioadhesion is demonstrated on ex vivo swine aorta soft tissues. The non-optimized bioadhesive strength is stronger than many hydrogel bioadhesives while having superior material properties. The poly-diazirine surface grafted thin films could allow expansion onto previously developed technologies for minimally invasive surgeries.
- Blocked Bacteria Escape by ATRP Grafting of a PMMA Shell on PVA Microparticles
Christian Knierim, Charles L. Greenblatt, Seema Agarwal and Andreas Greiner
Article first published online: 29 NOV 2013 | DOI: 10.1002/mabi.201300398
The escape of immobilized bacteria from hydrogel microparticles is prevented by water stable core–shell composites. Therefore, a surface initiated ATRP of MMA at room temperature is employed to obtain a hydrophobic PMMA shell. However, the viability of the immobilized bacteria is demonstrated afterwards. The core–shell architecture is examined by the copolymerization of FMA and MMA and by TEM.
- One-Pot Synthesis of Glycopolymer-Porphyrin Conjugate as Photosensitizer for Targeted Cancer Imaging and Photodynamic Therapy
Jiawei Lu, Weidong Zhang, Lin Yuan, Wenjuan Ma, Xiao Li, Wei Lu, Yun Zhao and Gaojian Chen
Article first published online: 27 NOV 2013 | DOI: 10.1002/mabi.201300451
Novel glycopolymer-porphyrin conjugates are prepared via a one-pot reaction catalyzed by sodium mercury amalgam for multi-reactions. High efficiency of singlet oxygen yield of the novel glycopolymer-porphyrin conjugate is obtained, preliminary in vitro results show its potential application in photodynamic therapy and cancer imaging.
- Effect of Polymer Porosity on Aqueous Self-Healing Encapsulation of Proteins in PLGA Microspheres
Samuel E. Reinhold and Steven P. Schwendeman
Article first published online: 27 NOV 2013 | DOI: 10.1002/mabi.201300323
Development of advanced functional biomaterials termed “self-healing biomaterials” have created a paradigm shift by which large molecules are encapsulated in biodegradable polymers by healing the polymer above the polymer glass transition temperature (Tg) in water or air, without organic solvent. The means of controlling the percolating pore network for protein entry and encapsulation, and the resulting dosage form performance are described.
- Acidity-Promoted Cellular Uptake and Drug Release Mediated by Amine-Functionalized Block Polycarbonates Prepared via One-Shot Ring-Opening Copolymerization
Hua-Fen Wang, Hui-Zhen Jia, Yan-Feng Chu, Jun Feng, Xian-Zheng Zhang and Ren-Xi Zhuo
Article first published online: 25 NOV 2013 | DOI: 10.1002/mabi.201300414
Controllable ring-opening block copolymerization of amino-functionalized PADMC-b-PTeMC block copolycarbonates in the “one-shot feeding” pathway and the fabrication of their core–shell nanomicelles are reported. The pH-dependent deprotonation-to-protonation transition of PADMC shell allows a selective control over both the cellular uptake and the drug release pattern, in response to acidic microenvironments such as tumor sites.