Chronic miR-29 antagonism promotes favorable plaque remodeling in atherosclerotic mice
Victoria Ulrich, Noemi Rotllan, Elisa Araldi, Amelia Luciano, Philipp Skroblin, Mélanie Abonnenc, Paola Perrotta, Xiaoke Yin, Ashley Bauer, Kristen L Leslie, Pei Zhang, Binod Aryal, Rusty L Montgomery, Thomas Thum, Kathleen Martin, Yajaira Suarez, Manuel Mayr, Carlos Fernandez-Hernando and William C Sessa
Version of Record online: 2 MAY 2016 | DOI: 10.15252/emmm.201506031
Antagonizing miR-29 decreases atherosclerotic lesion size and improves indices of plaque stability. LNA-miR-29 treatment increases ECM components in the plaque compared to adjacent non-plaque vessel, and treated VSMC secretome analysis indicates that ECM proteins are highly regulated by miR-29.