EMBO Molecular Medicine

Cover image for Vol. 8 Issue 5

Early View (Online Version of Record published before inclusion in an issue)

Edited By: Stefanie Dimmeler (Chief Editor), Roberto Buccione and Céline Carret (EMBO Editors)

Online ISSN: 1757-4684

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  1. 1 - 10
  1. Reviews

    1. You have full text access to this OnlineOpen article
      The impact of genome-wide association studies on the pathophysiology and therapy of cardiovascular disease

      Thorsten Kessler, Baiba Vilne and Heribert Schunkert

      Article first published online: 4 MAY 2016 | DOI: 10.15252/emmm.201506174

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      A comprehensive, detailed review on where we stand on GWAS and cardiovascular disease and what to expect in the near future.

  2. Reports

    1. You have full text access to this OnlineOpen article
      Interferon-beta signaling in retinal mononuclear phagocytes attenuates pathological neovascularization

      Anika Lückoff, Albert Caramoy, Rebecca Scholz, Marco Prinz, Ulrich Kalinke and Thomas Langmann

      Article first published online: 3 MAY 2016 | DOI: 10.15252/emmm.201505994

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      Innate immune activation is a hallmark of age-related macular degeneration (AMD). Here, interferon-beta signaling was identified as an intrinsic regulator of retinal mononuclear phagocytes and therefore as potential therapeutic target for AMD.

  3. Research Articles

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      Fasting-induced liver GADD45β restrains hepatic fatty acid uptake and improves metabolic health

      Jessica Fuhrmeister, Annika Zota, Tjeerd P Sijmonsma, Oksana Seibert, Şahika Cıngır, Kathrin Schmidt, Nicola Vallon, Roldan M de Guia, Katharina Niopek, Mauricio Berriel Diaz, Adriano Maida, Matthias Blüher, Jürgen G Okun, Stephan Herzig and Adam J Rose

      Article first published online: 3 MAY 2016 | DOI: 10.15252/emmm.201505801

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      Fasting is shown to induce liver GADD45β, which functions as an adapter protein to retain FABP1 in the cytoplasm and restrain fatty acid uptake. The blunting of GADD45β induction occurring in obesity/aging may explain the altered lipid metabolism.

    2. You have full text access to this OnlineOpen article
      Chronic miR-29 antagonism promotes favorable plaque remodeling in atherosclerotic mice

      Victoria Ulrich, Noemi Rotllan, Elisa Araldi, Amelia Luciano, Philipp Skroblin, Mélanie Abonnenc, Paola Perrotta, Xiaoke Yin, Ashley Bauer, Kristen L Leslie, Pei Zhang, Binod Aryal, Rusty L Montgomery, Thomas Thum, Kathleen Martin, Yajaira Suarez, Manuel Mayr, Carlos Fernandez-Hernando and William C Sessa

      Article first published online: 2 MAY 2016 | DOI: 10.15252/emmm.201506031

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      Antagonizing miR-29 decreases atherosclerotic lesion size and improves indices of plaque stability. LNA-miR-29 treatment increases ECM components in the plaque compared to adjacent non-plaque vessel, and treated VSMC secretome analysis indicates that ECM proteins are highly regulated by miR-29.

    3. You have full text access to this OnlineOpen article
      A brain microvasculature endothelial cell-specific viral vector with the potential to treat neurovascular and neurological diseases

      Jakob Körbelin, Godwin Dogbevia, Stefan Michelfelder, Dirk A Ridder, Agnes Hunger, Jan Wenzel, Henning Seismann, Melanie Lampe, Jacqueline Bannach, Manolis Pasparakis, Jürgen A Kleinschmidt, Markus Schwaninger and Martin Trepel

      Article first published online: 22 APR 2016 | DOI: 10.15252/emmm.201506078

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      A capsid AAV2 mutant, AAV-BR1, with tropism for the neurovascular endothelium, generated by selecting an AAV2 display peptide library in vivo, holds promise as a gene therapy vector for neurovascular and potentially other central nervous system diseases.

  4. Commentary

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      Ethical and legal issues in mitochondrial transfer

      Ainsley J Newson, Stephen Wilkinson and Anthony Wrigley

      Article first published online: 21 APR 2016 | DOI: 10.15252/emmm.201606281

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      A timely commentary on the ethical and legal issues in mitochondrial transfer/replacement techniques in the aftermath of the recent UK and US regulations.

  5. Opinion

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      Is the global health community prepared for future pandemics? A need for solidarity, resources and strong governance

      Tikki Pang

      Article first published online: 21 APR 2016 | DOI: 10.15252/emmm.201606337

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      In the wake of recent outbreaks of Zika, Ebola and the MERS-CoV viruses, many are asking: how prepared is the global public health community to deal with future emerging pandemics? Collective action at national, regional and global levels is the best way forward.

  6. Reports

    1. You have full text access to this OnlineOpen article
      Inhibition of DPP4 activity in humans establishes its in vivo role in CXCL10 post-translational modification: prospective placebo-controlled clinical studies

      Jérémie Decalf, Kristin V Tarbell, Armanda Casrouge, Jeffrey D Price, Grace Linder, Estelle Mottez, Philippe Sultanik, Vincent Mallet, Stanislas Pol, Darragh Duffy and Matthew L Albert

      Article first published online: 14 APR 2016 | DOI: 10.15252/emmm.201506145

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      The N-terminal truncation of CXCL10 by DPP4 results in the generation of an antagonist form of the chemokine that limits T-cell and NK cell migration. This study shows for the first time that in vivo DPP4 inhibition in humans can preserve the bioactive form of CXCL10.

  7. Research Articles

    1. You have full text access to this OnlineOpen article
      IGSF10 mutations dysregulate gonadotropin-releasing hormone neuronal migration resulting in delayed puberty

      Sasha R Howard, Leonardo Guasti, Gerard Ruiz-Babot, Alessandra Mancini, Alessia David, Helen L Storr, Lousie A Metherell, Michael JE Sternberg, Claudia P Cabrera, Helen R Warren, Michael R Barnes, Richard Quinton, Nicolas de Roux, Jacques Young, Anne Guiochon-Mantel, Karoliina Wehkalampi, Valentina André, Yoav Gothilf, Anna Cariboni and Leo Dunkel

      Article first published online: 13 APR 2016 | DOI: 10.15252/emmm.201606250

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      Self-limited delayed puberty (DP) has strong familial inheritance, but the underlying genetic determinants are unknown. IGSF10 deficiency is found to affect embryonic GnRH neuronal migration and results in DP in humans.

  8. Reviews

    1. You have full text access to this OnlineOpen article
      The amyloid hypothesis of Alzheimer's disease at 25 years

      Dennis J Selkoe and John Hardy

      Article first published online: 29 MAR 2016 | DOI: 10.15252/emmm.201606210

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      This review by Selkoe and Hardy provides a comprehensive and commanding analysis on the causative role of Abeta and the amyloid cascade hypothesis in the pathology of Alzheimer's disease.

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