EMBO Molecular Medicine

Cover image for Vol. 8 Issue 5

Early View (Online Version of Record published before inclusion in an issue)

Edited By: Stefanie Dimmeler (Chief Editor), Roberto Buccione and Céline Carret (EMBO Editors)

Online ISSN: 1757-4684

VIEW

  1. 1 - 20
  1. Research Articles

    1. You have full text access to this OnlineOpen article
      Follistatin-like 1 promotes cardiac fibroblast activation and protects the heart from rupture

      Sonomi Maruyama, Kazuto Nakamura, Kyriakos N Papanicolaou, Soichi Sano, Ippei Shimizu, Yasuhide Asaumi, Maurice J van den Hoff, Noriyuki Ouchi, Fabio A Recchia and Kenneth Walsh

      Version of Record online: 27 MAY 2016 | DOI: 10.15252/emmm.201506151

      Thumbnail image of graphical abstract

      The secreted glycoprotein Fstl1 is found to be robustly expressed in fibroblasts and myofibroblasts in the infarcted heart. Fstl1 is essential for the acute repair of the infarcted myocardium, and stimulation of early cardiac fibroblast activation is a novel function of Fstl1.

  2. Commentary

    1. You have full text access to this OnlineOpen article
      The decision-making process and criteria in selecting candidate drugs for progeria clinical trials

      Leslie B Gordon, Mark W Kieran, Monica E Kleinman and Tom Misteli

      Version of Record online: 27 MAY 2016 | DOI: 10.15252/emmm.201606280

      Thumbnail image of graphical abstract

      Conducting clinical trials for children with progeria or any rare disease is especially complex. However, given the lack of treatments and the dismal outcomes, any treatment that meets suitable standards to advance to trial should be vigorously pursued.

  3. Research Articles

    1. You have full text access to this OnlineOpen article
      Endoplasmic reticulum stress enhances fibrosis through IRE1α-mediated degradation of miR-150 and XBP-1 splicing

      Femke Heindryckx, François Binet, Markella Ponticos, Krista Rombouts, Joey Lau, Johan Kreuger and Pär Gerwins

      Version of Record online: 25 MAY 2016 | DOI: 10.15252/emmm.201505925

      Thumbnail image of graphical abstract

      Endoplasmic reticulum (ER) stress is a conserved mechanism in the development of fibrosis. Targeting ER stress-induced signaling might be a therapeutic strategy to combat fibrotic diseases.

    2. You have full text access to this OnlineOpen article
      The time-of-day of myocardial infarction onset affects healing through oscillations in cardiac neutrophil recruitment

      Maximilian J Schloss, Michael Horckmans, Katrin Nitz, Johan Duchene, Maik Drechsler, Kiril Bidzhekov, Christoph Scheiermann, Christian Weber, Oliver Soehnlein and Sabine Steffens

      Version of Record online: 25 MAY 2016 | DOI: 10.15252/emmm.201506083

      Thumbnail image of graphical abstract

      Expression levels of chemokine receptor CXCR2 on circulating neutrophils exhibit diurnal oscillations. This causes time-of-day-dependent variations in the number of neutrophils infiltrating the heart after myocardial infarction, with major consequences for infarction healing.

    3. You have full text access to this OnlineOpen article
      TGFβ signaling directs serrated adenomas to the mesenchymal colorectal cancer subtype

      Evelyn Fessler, Jarno Drost, Sander R van Hooff, Janneke F Linnekamp, Xin Wang, Marnix Jansen, Felipe De Sousa E Melo, Pramudita R Prasetyanti, Joep EG IJspeert, Marek Franitza, Peter Nürnberg, Carel JM van Noesel, Evelien Dekker, Louis Vermeulen, Hans Clevers and Jan Paul Medema

      Version of Record online: 24 MAY 2016 | DOI: 10.15252/emmm.201606184

      Thumbnail image of graphical abstract

      Sessile serrated adenomas (SSAs)—precursor lesions of the serrated neoplasia pathway to colorectal cancer (CRC)—are predicted to give rise to either the good- or the poor-prognosis CRC consensus molecular subtype (CMS1 and CMS4, respectively).

    4. You have full text access to this OnlineOpen article
      Inducing mitophagy in diabetic platelets protects against severe oxidative stress

      Seung Hee Lee, Jing Du, Jeremiah Stitham, Gourg Atteya, Suho Lee, Yaozu Xiang, Dandan Wang, Yu Jin, Kristen L Leslie, Geralyn Spollett, Anup Srivastava, Praveen Mannam, Allison Ostriker, Kathleen A Martin, Wai Ho Tang and John Hwa

      Version of Record online: 24 MAY 2016 | DOI: 10.15252/emmm.201506046

      Thumbnail image of graphical abstract

      Under conditions of the severe oxidative stress commonly associated with diabetes mellitus in patients, induction of platelet mitophagy protects the platelet from apoptosis by removing the damaged mitochondria and preserves platelets function.

    5. You have full text access to this OnlineOpen article
      Clusterin knockdown sensitizes prostate cancer cells to taxane by modulating mitosis

      Nader Al Nakouzi, Chris Kedong Wang, Eliana Beraldi, Wolfgang Jager, Susan Ettinger, Ladan Fazli, Lucia Nappi, Jennifer Bishop, Fan Zhang, Anne Chauchereau, Yohann Loriot and Martin Gleave

      Version of Record online: 19 MAY 2016 | DOI: 10.15252/emmm.201506059

      Thumbnail image of graphical abstract

      CLU silencing sensitizes prostate cancer cells to taxane by inducing a constitutive activation of Cdc25C leading to a delay in exit from mitosis. In response, cells up-regulate protective mechanisms through Wee1 kinase.

    6. You have full text access to this OnlineOpen article
      Smooth muscle FGF/TGFβ cross talk regulates atherosclerosis progression

      Pei-Yu Chen, Lingfeng Qin, Guangxin Li, George Tellides and Michael Simons

      Version of Record online: 13 MAY 2016 | DOI: 10.15252/emmm.201506181

      Thumbnail image of graphical abstract

      TGFβ signaling promotes smooth muscle cell (SMC) proliferative-to-contractile phenotype switch. FGF signaling input is the critical regulator of SMC TGFβ signaling: A decline in FGF signaling input leads to increased TGFβ signaling.

  4. News & Views

    1. You have full text access to this OnlineOpen article
      Brain endothelial cell-targeted gene therapy of neurovascular disorders

      Serena Marchiò, Richard L Sidman, Wadih Arap and Renata Pasqualini

      Version of Record online: 10 MAY 2016 | DOI: 10.15252/emmm.201606407

      Thumbnail image of graphical abstract

      Commentary on the paper by Körbelin et al in this issue of EMBO Molecular Medicine, describing an engineered adeno-associated virus (AAV) with exceptional tropism for the brain that restores a normal phenotype in a mouse incontinentia pigmenti model.

  5. Reports

    1. You have full text access to this OnlineOpen article
      Safe engineering of CAR T cells for adoptive cell therapy of cancer using long-term episomal gene transfer

      Chuan Jin, Grammatiki Fotaki, Mohanraj Ramachandran, Berith Nilsson, Magnus Essand and Di Yu

      Version of Record online: 6 MAY 2016 | DOI: 10.15252/emmm.201505869

      Thumbnail image of graphical abstract

      CAR T cells for cancer immunotherapy are commonly engineered ex vivo via a viral vector with integration of the transgene and possible tumorigenic risk. A new vector, NILV-S/MAR, allows long-term episomal engineering of T cells to reduce such risk.

  6. Reviews

    1. You have full text access to this OnlineOpen article
      The impact of genome-wide association studies on the pathophysiology and therapy of cardiovascular disease

      Thorsten Kessler, Baiba Vilne and Heribert Schunkert

      Version of Record online: 4 MAY 2016 | DOI: 10.15252/emmm.201506174

      Thumbnail image of graphical abstract

      A comprehensive, detailed review on where we stand on GWAS and cardiovascular disease and what to expect in the near future.

  7. Reports

    1. You have full text access to this OnlineOpen article
      Interferon-beta signaling in retinal mononuclear phagocytes attenuates pathological neovascularization

      Anika Lückoff, Albert Caramoy, Rebecca Scholz, Marco Prinz, Ulrich Kalinke and Thomas Langmann

      Version of Record online: 3 MAY 2016 | DOI: 10.15252/emmm.201505994

      Thumbnail image of graphical abstract

      Innate immune activation is a hallmark of age-related macular degeneration (AMD). Here, interferon-beta signaling was identified as an intrinsic regulator of retinal mononuclear phagocytes and therefore as potential therapeutic target for AMD.

  8. Research Articles

    1. You have full text access to this OnlineOpen article
      Fasting-induced liver GADD45β restrains hepatic fatty acid uptake and improves metabolic health

      Jessica Fuhrmeister, Annika Zota, Tjeerd P Sijmonsma, Oksana Seibert, Şahika Cıngır, Kathrin Schmidt, Nicola Vallon, Roldan M de Guia, Katharina Niopek, Mauricio Berriel Diaz, Adriano Maida, Matthias Blüher, Jürgen G Okun, Stephan Herzig and Adam J Rose

      Version of Record online: 3 MAY 2016 | DOI: 10.15252/emmm.201505801

      Thumbnail image of graphical abstract

      Fasting is shown to induce liver GADD45β, which functions as an adapter protein to retain FABP1 in the cytoplasm and restrain fatty acid uptake. The blunting of GADD45β induction occurring in obesity/aging may explain the altered lipid metabolism.

    2. You have full text access to this OnlineOpen article
      Chronic miR-29 antagonism promotes favorable plaque remodeling in atherosclerotic mice

      Victoria Ulrich, Noemi Rotllan, Elisa Araldi, Amelia Luciano, Philipp Skroblin, Mélanie Abonnenc, Paola Perrotta, Xiaoke Yin, Ashley Bauer, Kristen L Leslie, Pei Zhang, Binod Aryal, Rusty L Montgomery, Thomas Thum, Kathleen Martin, Yajaira Suarez, Manuel Mayr, Carlos Fernandez-Hernando and William C Sessa

      Version of Record online: 2 MAY 2016 | DOI: 10.15252/emmm.201506031

      Thumbnail image of graphical abstract

      Antagonizing miR-29 decreases atherosclerotic lesion size and improves indices of plaque stability. LNA-miR-29 treatment increases ECM components in the plaque compared to adjacent non-plaque vessel, and treated VSMC secretome analysis indicates that ECM proteins are highly regulated by miR-29.

    3. You have full text access to this OnlineOpen article
      A brain microvasculature endothelial cell-specific viral vector with the potential to treat neurovascular and neurological diseases

      Jakob Körbelin, Godwin Dogbevia, Stefan Michelfelder, Dirk A Ridder, Agnes Hunger, Jan Wenzel, Henning Seismann, Melanie Lampe, Jacqueline Bannach, Manolis Pasparakis, Jürgen A Kleinschmidt, Markus Schwaninger and Martin Trepel

      Version of Record online: 22 APR 2016 | DOI: 10.15252/emmm.201506078

      Thumbnail image of graphical abstract

      A capsid AAV2 mutant, AAV-BR1, with tropism for the neurovascular endothelium, generated by selecting an AAV2 display peptide library in vivo, holds promise as a gene therapy vector for neurovascular and potentially other central nervous system diseases.

  9. Commentary

    1. You have full text access to this OnlineOpen article
      Ethical and legal issues in mitochondrial transfer

      Ainsley J Newson, Stephen Wilkinson and Anthony Wrigley

      Version of Record online: 21 APR 2016 | DOI: 10.15252/emmm.201606281

      Thumbnail image of graphical abstract

      A timely commentary on the ethical and legal issues in mitochondrial transfer/replacement techniques in the aftermath of the recent UK and US regulations.

  10. Opinion

    1. You have full text access to this OnlineOpen article
      Is the global health community prepared for future pandemics? A need for solidarity, resources and strong governance

      Tikki Pang

      Version of Record online: 21 APR 2016 | DOI: 10.15252/emmm.201606337

      Thumbnail image of graphical abstract

      In the wake of recent outbreaks of Zika, Ebola and the MERS-CoV viruses, many are asking: how prepared is the global public health community to deal with future emerging pandemics? Collective action at national, regional and global levels is the best way forward.

  11. Reports

    1. You have full text access to this OnlineOpen article
      Inhibition of DPP4 activity in humans establishes its in vivo role in CXCL10 post-translational modification: prospective placebo-controlled clinical studies

      Jérémie Decalf, Kristin V Tarbell, Armanda Casrouge, Jeffrey D Price, Grace Linder, Estelle Mottez, Philippe Sultanik, Vincent Mallet, Stanislas Pol, Darragh Duffy and Matthew L Albert

      Version of Record online: 14 APR 2016 | DOI: 10.15252/emmm.201506145

      Thumbnail image of graphical abstract

      The N-terminal truncation of CXCL10 by DPP4 results in the generation of an antagonist form of the chemokine that limits T-cell and NK cell migration. This study shows for the first time that in vivo DPP4 inhibition in humans can preserve the bioactive form of CXCL10.

  12. Research Articles

    1. You have full text access to this OnlineOpen article
      IGSF10 mutations dysregulate gonadotropin-releasing hormone neuronal migration resulting in delayed puberty

      Sasha R Howard, Leonardo Guasti, Gerard Ruiz-Babot, Alessandra Mancini, Alessia David, Helen L Storr, Lousie A Metherell, Michael JE Sternberg, Claudia P Cabrera, Helen R Warren, Michael R Barnes, Richard Quinton, Nicolas de Roux, Jacques Young, Anne Guiochon-Mantel, Karoliina Wehkalampi, Valentina André, Yoav Gothilf, Anna Cariboni and Leo Dunkel

      Version of Record online: 13 APR 2016 | DOI: 10.15252/emmm.201606250

      Thumbnail image of graphical abstract

      Self-limited delayed puberty (DP) has strong familial inheritance, but the underlying genetic determinants are unknown. IGSF10 deficiency is found to affect embryonic GnRH neuronal migration and results in DP in humans.

  13. Reviews

    1. You have full text access to this OnlineOpen article
      The amyloid hypothesis of Alzheimer's disease at 25 years

      Dennis J Selkoe and John Hardy

      Version of Record online: 29 MAR 2016 | DOI: 10.15252/emmm.201606210

      Thumbnail image of graphical abstract

      This review by Selkoe and Hardy provides a comprehensive and commanding analysis on the causative role of Abeta and the amyloid cascade hypothesis in the pathology of Alzheimer's disease.

VIEW

  1. 1 - 20

SEARCH

SEARCH BY CITATION