EMBO Molecular Medicine

Cover image for Vol. 6 Issue 4

Early View (Online Version of Record published before inclusion in an issue)

Edited By: Stefanie Dimmeler (Chief Editor), Roberto Buccione and Céline Carret (EMBO Editors)

Online ISSN: 1757-4684

VIEW

  1. 1 - 12
  1. Research Articles

    1. You have full text access to this OnlineOpen article
      Fibrates ameliorate the course of bacterial sepsis by promoting neutrophil recruitment via CXCR2

      Ivan Tancevski, Manfred Nairz, Kristina Duwensee, Kristina Auer, Andrea Schroll, Christiane Heim, Clemens Feistritzer, Julia Hoefer, Romana R Gerner, Alexander R Moschen, Ingrid Heller, Petra Pallweber, Xiaorong Li, Markus Theurl, Egon Demetz, Anna M Wolf, Dominik Wolf, Philipp Eller, Andreas Ritsch and Guenter Weiss

      Article first published online: 22 APR 2014 | DOI: 10.1002/emmm.201303415

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      In this study, fibrates are shown to protect against bacteria-induced sepsis by promoting neutrophil influx to the primary site of infection, aiding in an efficient elimination of bacteria, and contributing to improved clinical outcomes from sepsis.

    2. You have full text access to this OnlineOpen article
      HES6 drives a critical AR transcriptional programme to induce castration-resistant prostate cancer through activation of an E2F1-mediated cell cycle network

      Antonio Ramos-Montoya, Alastair D Lamb, Roslin Russell, Thomas Carroll, Sarah Jurmeister, Nuria Galeano-Dalmau, Charlie E Massie, Joan Boren, Helene Bon, Vasiliki Theodorou, Maria Vias, Greg L Shaw, Naomi L Sharma, Helen Ross-Adams, Helen E Scott, Sarah L Vowler, William J Howat, Anne Y Warren, Richard F Wooster, Ian G Mills and David E Neal

      Article first published online: 14 APR 2014 | DOI: 10.1002/emmm.201303581

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      HES6 promotes castration resistance, maintains AR chromatin binding at a subset of sites in the absence of hormone stimulation and predicts poor outcome after prostatectomy. Inhibition of HES6-responsive gene PLK1 enhances anti-androgen sensitivity.

    3. You have full text access to this OnlineOpen article
      Maternally inherited genetic variants of CADPS2 are present in Autism Spectrum Disorders and Intellectual Disability patients

      Elena Bonora, Claudio Graziano, Fiorella Minopoli, Elena Bacchelli, Pamela Magini, Chiara Diquigiovanni, Silvia Lomartire, Francesca Bianco, Manuela Vargiolu, Piero Parchi, Elena Marasco, Vilma Mantovani, Luca Rampoldi, Matteo Trudu, Antonia Parmeggiani, Agatino Battaglia, Luigi Mazzone, Giada Tortora, IMGSAC, Elena Maestrini, Marco Seri and Giovanni Romeo

      Article first published online: 14 APR 2014 | DOI: 10.1002/emmm.201303235

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      Monoallelic and tissue-specific expression of novel CADPS2 gene variants was identified in two siblings with borderline cognitive decline and epilepsy, suggesting a role for CADPS2 in intellectual disability and autism spectrum disorders.

    4. You have full text access to this OnlineOpen article
      Monocyte-derived dendritic cells promote T follicular helper cell differentiation

      Svetoslav Chakarov and Nicolas Fazilleau

      Article first published online: 11 APR 2014 | DOI: 10.1002/emmm.201403841

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      Adding CpG-B oligonucleotides to vaccine adjuvants is shown to increase T-cell-dependent B-cell response via IL-6 secretion. Conventional and monocyte-derived dendritic cells activate CD4+ T cells towards the Tfh lineage resulting in a more efficient vaccine.

    5. You have full text access to this OnlineOpen article
      HIF factors cooperate with PML-RARα to promote acute promyelocytic leukemia progression and relapse

      Nadia Coltella, Stefano Percio, Roberta Valsecchi, Roberto Cuttano, Jlenia Guarnerio, Maurilio Ponzoni, Pier Paolo Pandolfi, Giovanni Melillo, Linda Pattini and Rosa Bernardi

      Article first published online: 7 APR 2014 | DOI: 10.1002/emmm.201303065

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      PML-RARα cooperates with HIF-1α to activate a pro-leukemogenic program. Consequently, HIF-1α inhibition curbs leukemia progression and, in synergy with retinoic acid, eliminates leukemia-initiating cells.

    6. You have full text access to this OnlineOpen article
      Effective treatment of mitochondrial myopathy by nicotinamide riboside, a vitamin B3

      Nahid A Khan, Mari Auranen, Ilse Paetau, Eija Pirinen, Liliya Euro, Saara Forsström, Lotta Pasila, Vidya Velagapudi, Christopher J Carroll, Johan Auwerx and Anu Suomalainen

      Article first published online: 7 APR 2014 | DOI: 10.1002/emmm.201403943

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      Nicotinamide riboside (vitamin B3) delays the progression of mitochondrial myopathy by preventing pathology-associated mitochondrial ultrastructure, improving mitochondrial DNA stability and further stimulating mitochondrial unfolded protein response.

    7. You have full text access to this OnlineOpen article
      The unfolded protein response affects readthrough of premature termination codons

      Yifat S Oren, Michelle L McClure, Steven M Rowe, Eric J Sorscher, Assaf C Bester, Miriam Manor, Eitan Kerem, Joseph Rivlin, Fouad Zahdeh, Matthias Mann, Tamar Geiger and Batsheva Kerem

      Article first published online: 4 APR 2014 | DOI: 10.1002/emmm.201303347

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      Activation of the unfolded protein response (UPR) governs the response to readthrough treatment by regulating the levels of transcripts with PTCs. Furthermore, a novel nonsense-mediated mRNA decay (NMD)-UPR feedback loop is described.

    8. You have full text access to this OnlineOpen article
      Local acting Sticky-trap inhibits vascular endothelial growth factor dependent pathological angiogenesis in the eye

      Iacovos P Michael, Peter D Westenskow, Sabiha Hacibekiroglu, Alissa Cohen Greenwald, Brian G Ballios, Toshihide Kurihara, Zhijie Li, Carmen M Warren, Puzheng Zhang, Edith Aguilar, Laura Donaldson, Valentina Marchetti, Takeshi Baba, Samer M Hussein, Hoon-Ki Sung, M Luisa Iruela-Arispe, James M Rini, Derek van der Kooy, Martin Friedlander and Andras Nagy

      Article first published online: 4 APR 2014 | DOI: 10.1002/emmm.201303708

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      A locally delivered, bifunctional recombinant “Sticky-trap” comprising a VEGF-trap and a heparin-binding domain can prevent aberrant ocular angiogenesis without affecting systemic physiological VEGF-processes.

  2. Perspectives

    1. You have full text access to this OnlineOpen article
      Diffusion MRI: what water tells us about the brain

      Denis Le Bihan

      Article first published online: 4 APR 2014 | DOI: 10.1002/emmm.201404055

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      2014 Louis-Jeantet prize awardee Denis Le Bihan gives us his personal account of the development of diffusion MRI imaging, a fundamental method for the early detection of stroke, and how it is now being applied to further our understanding of brain activity.

  3. Research Articles

    1. You have full text access to this OnlineOpen article
      Embelin inhibits endothelial mitochondrial respiration and impairs neoangiogenesis during tumor growth and wound healing

      Oliver Coutelle, Hue-Tran Hornig-Do, Axel Witt, Maria Andree, Lars M Schiffmann, Michael Piekarek, Kerstin Brinkmann, Jens M Seeger, Maxim Liwschitz, Satomi Miwa, Michael Hallek, Martin Krönke, Aleksandra Trifunovic, Sabine A Eming, Rudolf J Wiesner, Ulrich T Hacker and Hamid Kashkar

      Article first published online: 20 MAR 2014 | DOI: 10.1002/emmm.201303016

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      Weak mitochondrial uncouplers prevent neoangiogenesis in vitro and in vivo by depleting cellular energy reserves in proliferating but not normal quiescent endothelial cells.

    2. You have full text access to this OnlineOpen article
      Mild expression differences of MECP2 influencing aggressive social behavior

      Martesa Tantra, Christian Hammer, Anne Kästner, Liane Dahm, Martin Begemann, Chiranjeevi Bodda, Kurt Hammerschmidt, Ina Giegling, Beata Stepniak, Aracely Castillo Venzor, Bettina Konte, Begun Erbaba, Annette Hartmann, Asieh Tarami, Walter Schulz-Schaeffer, Dan Rujescu, Ashraf U Mannan and Hannelore Ehrenreich

      Article first published online: 20 MAR 2014 | DOI: 10.1002/emmm.201303744

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      The transcriptional regulator MECP2 is known to affect neurodevelopment. This study associates aggressive social behavior with MECP2 genotype and expression changes in both male schizophrenic patients and mouse models of different genetic background.

  4. Reviews

    1. You have full text access to this OnlineOpen article
      Mitochondrial response to nutrient availability and its role in metabolic disease

      Arwen W Gao, Carles Cantó and Riekelt H Houtkooper

      Article first published online: 12 MAR 2014 | DOI: 10.1002/emmm.201303782

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      In this review, the authors introduce the concept of understanding and further maintaining metabolic flexibility as a way to limit spreading of metabolic disorders. By modifying function or biogenesis, the mitochondria perfectly illustrate this point as they adapt to different stress situations.

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