EMBO Molecular Medicine

Cover image for Vol. 8 Issue 6

Early View (Online Version of Record published before inclusion in an issue)

Edited By: Stefanie Dimmeler (Chief Editor), Roberto Buccione and Céline Carret (EMBO Editors)

Online ISSN: 1757-4684

VIEW

  1. 1 - 18
  1. Research Articles

    1. You have full text access to this OnlineOpen article
      FADD is a key regulator of lipid metabolism

      Hongqin Zhuang, Xueshi Wang, Daolong Zha, Ziyi Gan, Fangfang Cai, Pan Du, Yunwen Yang, Bingya Yang, Xiangyu Zhang, Chun Yao, Yuqiang Zhou, Chizhou Jiang, Shengwen Guan, Xuerui Zhang, Jing Zhang, Wenhui Jiang, Qingang Hu and Zi-Chun Hua

      Version of Record online: 29 JUN 2016 | DOI: 10.15252/emmm.201505924

      Thumbnail image of graphical abstract

      FADD is a classical adaptor protein in death receptor signaling. For the first time, FADD is shown to have a major role in modulating adipose tissue lipid metabolism by regulating PPAR-α activation.

    2. You have full text access to this OnlineOpen article
      Defective glutamate and K+ clearance by cortical astrocytes in familial hemiplegic migraine type 2

      Clizia Capuani, Marcello Melone, Angelita Tottene, Luca Bragina, Giovanna Crivellaro, Mirko Santello, Giorgio Casari, Fiorenzo Conti and Daniela Pietrobon

      Version of Record online: 27 JUN 2016 | DOI: 10.15252/emmm.201505944

      Thumbnail image of graphical abstract

      FHM2 is a rare monogenic form of migraine with aura caused by loss-of-function mutations in the astrocytic α2 Na,K ATPase. Investigating the mechanisms underlying the facilitation of cortical spreading depression (CSD) in a genetic mouse model of FHM2 uncovers insights into migraine pathophysiology.

  2. Reports

    1. You have full text access to this OnlineOpen article
      Plasmodium falciparum var genes expressed in children with severe malaria encode CIDRα1 domains

      Jakob S Jespersen, Christian W Wang, Sixbert I Mkumbaye, Daniel TR Minja, Bent Petersen, Louise Turner, Jens EV Petersen, John PA Lusingu, Thor G Theander and Thomas Lavstsen

      Version of Record online: 27 JUN 2016 | DOI: 10.15252/emmm.201606188

      Thumbnail image of graphical abstract

      Plasmodium falciparum parasites anchor infected erythrocytes to blood vessel walls using diverse PfEMP1 adhesion proteins. Severe malaria is caused by parasites expressing a particular type of PfEMP1, which if identified could lead to development of a disease reducing adjunctive drug or vaccine intervention.

    2. You have full text access to this OnlineOpen article
      USP9X stabilizes XIAP to regulate mitotic cell death and chemoresistance in aggressive B-cell lymphoma

      Katharina Engel, Martina Rudelius, Jolanta Slawska, Laura Jacobs, Behnaz Ahangarian Abhari, Bettina Altmann, Julia Kurutz, Abirami Rathakrishnan, Vanesa Fernández-Sáiz, Andrä Brunner, Bianca-Sabrina Targosz, Felicia Loewecke, Christian Johannes Gloeckner, Marius Ueffing, Simone Fulda, Michael Pfreundschuh, Lorenz Trümper, Wolfram Klapper, Ulrich Keller, Philipp J Jost, Andreas Rosenwald, Christian Peschel and Florian Bassermann

      Version of Record online: 17 JUN 2016 | DOI: 10.15252/emmm.201506047

      Thumbnail image of graphical abstract

      USP9X deubiquitylates and stabilizes anti-apoptotic protein XIAP and promotes mitotic survival. Overexpression of USP9X/XIAP confers chemotherapy resistance and associates with decreased survival in aggressive B-cell lymphoma patients.

    3. You have full text access to this OnlineOpen article
      Defining the optimal animal model for translational research using gene set enrichment analysis

      Christopher Weidner, Matthias Steinfath, Elisa Opitz, Michael Oelgeschläger and Gilbert Schönfelder

      Version of Record online: 16 JUN 2016 | DOI: 10.15252/emmm.201506025

      Thumbnail image of graphical abstract

      Ongoing debates on the inconsistency between transcriptomic profiles from humans and mice question the relevance of mouse models for translational research. Here, a standardized, unbiased approach is used to identify the optimal animal models.

  3. Research Articles

    1. You have full text access to this OnlineOpen article
      CUEDC2 modulates cardiomyocyte oxidative capacity by regulating GPX1 stability

      Zhao Jian, Bing Liang, Xin Pan, Guang Xu, Sai-Sai Guo, Ting Li, Tao Zhou, Ying-Bin Xiao and Ai-Ling Li

      Version of Record online: 10 JUN 2016 | DOI: 10.15252/emmm.201506010

      Thumbnail image of graphical abstract

      CUEDC2 plays a critical role in oxidative stress-induced cardiac injury. Modulation of CUEDC2 level might be an attractive therapeutic strategy against ischemic heart disease.

    2. You have full text access to this OnlineOpen article
      Identification of a novel PPARβ/δ/miR-21-3p axis in UV-induced skin inflammation

      Gwendoline Degueurce, Ilenia D'Errico, Christine Pich, Mark Ibberson, Frédéric Schütz, Alexandra Montagner, Marie Sgandurra, Lionel Mury, Paris Jafari, Akash Boda, Julien Meunier, Roger Rezzonico, Nicolò Costantino Brembilla, Daniel Hohl, Antonios Kolios, Günther Hofbauer, Ioannis Xenarios and Liliane Michalik

      Version of Record online: 1 JUN 2016 | DOI: 10.15252/emmm.201505384

      Thumbnail image of graphical abstract

      The skin response to UV as well as psoriasis or squamous cell carcinoma are complex pathophysiological situations. The microRNA miR-21-3p is shown to be a novel target of PPARβ/δ and TGFβ that controls inflammation in mouse and human epidermis.

    3. You have full text access to this OnlineOpen article
      A novel thermoregulatory role for PDE10A in mouse and human adipocytes

      Mohammed K Hankir, Mathias Kranz, Thorsten Gnad, Juliane Weiner, Sally Wagner, Winnie Deuther-Conrad, Felix Bronisch, Karen Steinhoff, Julia Luthardt, Nora Klöting, Swen Hesse, John P Seibyl, Osama Sabri, John T Heiker, Matthias Blüher, Alexander Pfeifer, Peter Brust and Wiebke K Fenske

      Version of Record online: 31 MAY 2016 | DOI: 10.15252/emmm.201506085

      Thumbnail image of graphical abstract

      PDE inhibitors hold promise for the treatment of obesity due to their ability to induce a thermogenic program in adipocytes. This study reveals that the PDE10A inhibitor MP-10 has thermoregulatory effects on mouse and human white and brown adipocytes.

    4. You have full text access to this OnlineOpen article
      Follistatin-like 1 promotes cardiac fibroblast activation and protects the heart from rupture

      Sonomi Maruyama, Kazuto Nakamura, Kyriakos N Papanicolaou, Soichi Sano, Ippei Shimizu, Yasuhide Asaumi, Maurice J van den Hoff, Noriyuki Ouchi, Fabio A Recchia and Kenneth Walsh

      Version of Record online: 27 MAY 2016 | DOI: 10.15252/emmm.201506151

      Thumbnail image of graphical abstract

      The secreted glycoprotein Fstl1 is found to be robustly expressed in fibroblasts and myofibroblasts in the infarcted heart. Fstl1 is essential for the acute repair of the infarcted myocardium, and stimulation of early cardiac fibroblast activation is a novel function of Fstl1.

  4. Commentary

    1. You have full text access to this OnlineOpen article
      The decision-making process and criteria in selecting candidate drugs for progeria clinical trials

      Leslie B Gordon, Mark W Kieran, Monica E Kleinman and Tom Misteli

      Version of Record online: 27 MAY 2016 | DOI: 10.15252/emmm.201606280

      Thumbnail image of graphical abstract

      Conducting clinical trials for children with progeria or any rare disease is especially complex. However, given the lack of treatments and the dismal outcomes, any treatment that meets suitable standards to advance to trial should be vigorously pursued.

  5. Research Articles

    1. You have full text access to this OnlineOpen article
      Endoplasmic reticulum stress enhances fibrosis through IRE1α-mediated degradation of miR-150 and XBP-1 splicing

      Femke Heindryckx, François Binet, Markella Ponticos, Krista Rombouts, Joey Lau, Johan Kreuger and Pär Gerwins

      Version of Record online: 25 MAY 2016 | DOI: 10.15252/emmm.201505925

      Thumbnail image of graphical abstract

      Endoplasmic reticulum (ER) stress is a conserved mechanism in the development of fibrosis. Targeting ER stress-induced signaling might be a therapeutic strategy to combat fibrotic diseases.

    2. You have full text access to this OnlineOpen article
      The time-of-day of myocardial infarction onset affects healing through oscillations in cardiac neutrophil recruitment

      Maximilian J Schloss, Michael Horckmans, Katrin Nitz, Johan Duchene, Maik Drechsler, Kiril Bidzhekov, Christoph Scheiermann, Christian Weber, Oliver Soehnlein and Sabine Steffens

      Version of Record online: 25 MAY 2016 | DOI: 10.15252/emmm.201506083

      Thumbnail image of graphical abstract

      Expression levels of chemokine receptor CXCR2 on circulating neutrophils exhibit diurnal oscillations. This causes time-of-day-dependent variations in the number of neutrophils infiltrating the heart after myocardial infarction, with major consequences for infarction healing.

    3. You have full text access to this OnlineOpen article
      TGFβ signaling directs serrated adenomas to the mesenchymal colorectal cancer subtype

      Evelyn Fessler, Jarno Drost, Sander R van Hooff, Janneke F Linnekamp, Xin Wang, Marnix Jansen, Felipe De Sousa E Melo, Pramudita R Prasetyanti, Joep EG IJspeert, Marek Franitza, Peter Nürnberg, Carel JM van Noesel, Evelien Dekker, Louis Vermeulen, Hans Clevers and Jan Paul Medema

      Version of Record online: 24 MAY 2016 | DOI: 10.15252/emmm.201606184

      Thumbnail image of graphical abstract

      Sessile serrated adenomas (SSAs)—precursor lesions of the serrated neoplasia pathway to colorectal cancer (CRC)—are predicted to give rise to either the good- or the poor-prognosis CRC consensus molecular subtype (CMS1 and CMS4, respectively).

    4. You have full text access to this OnlineOpen article
      Inducing mitophagy in diabetic platelets protects against severe oxidative stress

      Seung Hee Lee, Jing Du, Jeremiah Stitham, Gourg Atteya, Suho Lee, Yaozu Xiang, Dandan Wang, Yu Jin, Kristen L Leslie, Geralyn Spollett, Anup Srivastava, Praveen Mannam, Allison Ostriker, Kathleen A Martin, Wai Ho Tang and John Hwa

      Version of Record online: 24 MAY 2016 | DOI: 10.15252/emmm.201506046

      Thumbnail image of graphical abstract

      Under conditions of the severe oxidative stress commonly associated with diabetes mellitus in patients, induction of platelet mitophagy protects the platelet from apoptosis by removing the damaged mitochondria and preserves platelets function.

    5. You have full text access to this OnlineOpen article
      Clusterin knockdown sensitizes prostate cancer cells to taxane by modulating mitosis

      Nader Al Nakouzi, Chris Kedong Wang, Eliana Beraldi, Wolfgang Jager, Susan Ettinger, Ladan Fazli, Lucia Nappi, Jennifer Bishop, Fan Zhang, Anne Chauchereau, Yohann Loriot and Martin Gleave

      Version of Record online: 19 MAY 2016 | DOI: 10.15252/emmm.201506059

      Thumbnail image of graphical abstract

      CLU silencing sensitizes prostate cancer cells to taxane by inducing a constitutive activation of Cdc25C leading to a delay in exit from mitosis. In response, cells up-regulate protective mechanisms through Wee1 kinase.

    6. You have full text access to this OnlineOpen article
      Smooth muscle FGF/TGFβ cross talk regulates atherosclerosis progression

      Pei-Yu Chen, Lingfeng Qin, Guangxin Li, George Tellides and Michael Simons

      Version of Record online: 13 MAY 2016 | DOI: 10.15252/emmm.201506181

      Thumbnail image of graphical abstract

      TGFβ signaling promotes smooth muscle cell (SMC) proliferative-to-contractile phenotype switch. FGF signaling input is the critical regulator of SMC TGFβ signaling: A decline in FGF signaling input leads to increased TGFβ signaling.

  6. Reports

    1. You have full text access to this OnlineOpen article
      Safe engineering of CAR T cells for adoptive cell therapy of cancer using long-term episomal gene transfer

      Chuan Jin, Grammatiki Fotaki, Mohanraj Ramachandran, Berith Nilsson, Magnus Essand and Di Yu

      Version of Record online: 6 MAY 2016 | DOI: 10.15252/emmm.201505869

      Thumbnail image of graphical abstract

      CAR T cells for cancer immunotherapy are commonly engineered ex vivo via a viral vector with integration of the transgene and possible tumorigenic risk. A new vector, NILV-S/MAR, allows long-term episomal engineering of T cells to reduce such risk.

  7. Reviews

    1. You have full text access to this OnlineOpen article
      The impact of genome-wide association studies on the pathophysiology and therapy of cardiovascular disease

      Thorsten Kessler, Baiba Vilne and Heribert Schunkert

      Version of Record online: 4 MAY 2016 | DOI: 10.15252/emmm.201506174

      Thumbnail image of graphical abstract

      A comprehensive, detailed review on where we stand on GWAS and cardiovascular disease and what to expect in the near future.

VIEW

  1. 1 - 18

SEARCH

SEARCH BY CITATION