EMBO Molecular Medicine

Cover image for Vol. 9 Issue 1

Early View (Online Version of Record published before inclusion in an issue)

Edited By: Stefanie Dimmeler (Chief Editor), Roberto Buccione and Céline Carret (EMBO Editors)

Online ISSN: 1757-4684

VIEW

  1. 1 - 15
  1. Louis-Jeantet Prize Winner: Commentary

    1. You have full text access to this OnlineOpen article
      Sensing infection and tissue damage

      Caetano Reis e Sousa

      Version of Record online: 24 JAN 2017 | DOI: 10.15252/emmm.201607227

      Thumbnail image of graphical abstract

      Louis-Jeantet Prize for Medicine 2017 winner Caetano Reis e Sousa provides an engaging account of his contribution to our understanding of the mechanisms by which the immune system senses pathogen invasion and tissue damage.

    2. You have full text access to this OnlineOpen article
      Organization and function of neuronal circuits controlling movement

      Silvia Arber

      Version of Record online: 24 JAN 2017 | DOI: 10.15252/emmm.201607226

      Thumbnail image of graphical abstract

      The 2017 Louis-Jeantet Prize for Medicine winner Silvia Arber describes her laboratory's contributions to our understanding of the neuronal circuits underlying the control of movement in mammals.

  2. Reports

    1. You have full text access to this OnlineOpen article
      Loss of AXIN1 drives acquired resistance to WNT pathway blockade in colorectal cancer cells carrying RSPO3 fusions

      Gabriele Picco, Consalvo Petti, Alessia Centonze, Erica Torchiaro, Giovanni Crisafulli, Luca Novara, Andrea Acquaviva, Alberto Bardelli and Enzo Medico

      Version of Record online: 18 JAN 2017 | DOI: 10.15252/emmm.201606773

      Thumbnail image of graphical abstract

      In colorectal cancer (CRC), translocations of the RSPO3 gene, leading to its expression as a fusion transcript, pinpoint a therapeutically actionable mechanism of Wnt pathway activation.

  3. Research Articles

    1. You have full text access to this OnlineOpen article
      Sequence variation in PPP1R13L results in a novel form of cardio-cutaneous syndrome

      Tzipora C Falik-Zaccai, Yiftah Barsheshet, Hanna Mandel, Meital Segev, Avraham Lorber, Shachaf Gelberg, Limor Kalfon, Shani Ben Haroush, Adel Shalata, Liat Gelernter-Yaniv, Sarah Chaim, Dorith Raviv Shay, Morad Khayat, Michal Werbner, Inbar Levi, Yishay Shoval, Galit Tal, Stavit Shalev, Eli Reuveni, Emily Avitan-Hersh, Eugene Vlodavsky, Liat Appl-Sarid, Dorit Goldsher, Reuven Bergman, Zvi Segal, Ora Bitterman-Deutsch and Orly Avni

      Version of Record online: 9 JAN 2017 | DOI: 10.15252/emmm.201606523

      Thumbnail image of graphical abstract

      A new cardio-cutaneous syndrome associated with fatal dilated cardiomyopathy is discovered in children with sequence variations in PPP1R13L, which encodes for iASPP.

    2. You have full text access to this OnlineOpen article
      The transcription factor GATA4 promotes myocardial regeneration in neonatal mice

      Mona Malek Mohammadi, Badder Kattih, Andrea Grund, Natali Froese, Mortimer Korf-Klingebiel, Anna Gigina, Ulrike Schrameck, Carsten Rudat, Qiangrong Liang, Andreas Kispert, Kai C Wollert, Johann Bauersachs and Joerg Heineke

      Version of Record online: 4 JAN 2017 | DOI: 10.15252/emmm.201606602

      Thumbnail image of graphical abstract

      Why heart regeneration in mice is no longer possible after the age of 7 days remains unknown. Here, the robust downregulation of cardiac GATA4 levels occurring around the same time is shown to be at least in part responsible for this phenomenon.

    3. You have full text access to this OnlineOpen article
      ROCK signaling promotes collagen remodeling to facilitate invasive pancreatic ductal adenocarcinoma tumor cell growth

      Nicola Rath, Jennifer P Morton, Linda Julian, Lena Helbig, Shereen Kadir, Ewan J McGhee, Kurt I Anderson, Gabriela Kalna, Margaret Mullin, Andreia V Pinho, Ilse Rooman, Michael S Samuel and Michael F Olson

      Version of Record online: 28 DEC 2016 | DOI: 10.15252/emmm.201606743

      Thumbnail image of graphical abstract

      ROCK signaling contributes to the progression of pancreatic ductal adenocarcinoma (PDAC): Increased production and release of collagenases induce remodeling of the extracellular matrix to facilitate invasive tumor cell growth.

  4. Reviews

    1. You have full text access to this OnlineOpen article
      Genetically engineered mouse models in oncology research and cancer medicine

      Kelly Kersten, Karin E de Visser, Martine H van Miltenburg and Jos Jonkers

      Version of Record online: 27 DEC 2016 | DOI: 10.15252/emmm.201606857

      Thumbnail image of graphical abstract

      Tumors arising in advanced genetically engineered mouse models (GEMMs) mimic their human counterparts including heterogeneity and spontaneous metastases. This review provides a sweeping overview of the field and a discussion of their bright future.

  5. Opinion

    1. You have full text access to this OnlineOpen article
      How to tackle antimalarial resistance?

      Didier Leroy

      Version of Record online: 27 DEC 2016 | DOI: 10.15252/emmm.201607295

      Thumbnail image of graphical abstract

      In the context of drug resistance, malaria is no exception. Even the latest artemisinins have started to lose their full efficacy in patients. Didier Leroy tells us about the strategies adopted by Medicines for Malaria Venture to reduce this terrible culprit.

  6. Research Articles

    1. You have full text access to this OnlineOpen article
      Reprogramming-derived gene cocktail increases cardiomyocyte proliferation for heart regeneration

      Yuan-Yuan Cheng, Yu-Ting Yan, David J Lundy, Annie HA Lo, Yu-Ping Wang, Shu-Chian Ruan, Po-Ju Lin and Patrick CH Hsieh

      Version of Record online: 23 DEC 2016 | DOI: 10.15252/emmm.201606558

      Thumbnail image of graphical abstract

      The proliferation rate of remnant cardiomyocytes (CMs) is too low for cardiac regeneration after injury. Here, a gene cocktail is defined to induce CMs to efficiently proliferate, while improving cardiac function after myocardial infarction in mice.

    2. You have full text access to this OnlineOpen article
      HUWE1 is a critical colonic tumour suppressor gene that prevents MYC signalling, DNA damage accumulation and tumour initiation

      Kevin B Myant, Patrizia Cammareri, Michael C Hodder, Jimi Wills, Alex Von Kriegsheim, Balázs Győrffy, Mamun Rashid, Simona Polo, Elena Maspero, Lynsey Vaughan, Basanta Gurung, Evan Barry, Angeliki Malliri, Fernando Camargo, David J Adams, Antonio Iavarone, Anna Lasorella and Owen J Sansom

      Version of Record online: 22 DEC 2016 | DOI: 10.15252/emmm.201606684

      Thumbnail image of graphical abstract

      The E3 ubiquitin ligase HUWE1 is found to be a critical intestinal tumour suppressor gene whose loss of function leads to accelerated tumour initiation via elevated levels of MYC, DNA damage and MCL1.

  7. Reports

    1. You have full text access to this OnlineOpen article
      Polysialic acid blocks mononuclear phagocyte reactivity, inhibits complement activation, and protects from vascular damage in the retina

      Marcus Karlstetter, Jens Kopatz, Alexander Aslanidis, Anahita Shahraz, Albert Caramoy, Bettina Linnartz-Gerlach, Yuchen Lin, Anika Lückoff, Sascha Fauser, Katharina Düker, Janine Claude, Yiner Wang, Johannes Ackermann, Tobias Schmidt, Veit Hornung, Christine Skerka, Thomas Langmann and Harald Neumann

      Version of Record online: 22 DEC 2016 | DOI: 10.15252/emmm.201606627

      Thumbnail image of graphical abstract

      Low molecular weight polysialic acid (polySia avDP20) ameliorates laser-induced inflammation and choroidal neovascularization in a humanized mouse model of AMD-like laser-induced retinal injury.

  8. Research Articles

    1. You have full text access to this OnlineOpen article
      The RAS-related GTPase RHOB confers resistance to EGFR-tyrosine kinase inhibitors in non-small-cell lung cancer via an AKT-dependent mechanism

      Olivier Calvayrac, Julien Mazières, Sarah Figarol, Claire Marty-Detraves, Isabelle Raymond-Letron, Emilie Bousquet, Magali Farella, Estelle Clermont-Taranchon, Julie Milia, Isabelle Rouquette, Nicolas Guibert, Amélie Lusque, Jacques Cadranel, Nathalie Mathiot, Ariel Savina, Anne Pradines and Gilles Favre

      Version of Record online: 22 DEC 2016 | DOI: 10.15252/emmm.201606646

      Thumbnail image of graphical abstract

      High RHOB levels in EGFR-mutated lung tumors predict resistance to EGFR-tyrosine kinase inhibitor (TKI) therapy. Combination therapy with an AKT inhibitor might restore drug sensitivity in RHOB-positive patients.

    2. You have full text access to this OnlineOpen article
      VEGF blockade enhances the antitumor effect of BRAFV600E inhibition

      Valentina Comunanza, Davide Corà, Francesca Orso, Francesca Maria Consonni, Emanuele Middonti, Federica Di Nicolantonio, Anton Buzdin, Antonio Sica, Enzo Medico, Dario Sangiolo, Daniela Taverna and Federico Bussolino

      Version of Record online: 14 DEC 2016 | DOI: 10.15252/emmm.201505774

      Thumbnail image of graphical abstract

      A combination of bevacizumab and vemurafenib analog PLX4720, which targets BRAF(V600E), sustains the decrease of tumor hypoxia, accumulation of antitumor macrophages, and reduction in cancer-associated fibroblasts, delaying the onset of PLX4720 resistance.

  9. News & Views

    1. You have full text access to this OnlineOpen article
      Immune checkpoint blockade can synergize with radiation therapy, even in tumors resistant to checkpoint monotherapy

      Jan Dörrie

      Version of Record online: 13 DEC 2016 | DOI: 10.15252/emmm.201607219

      Thumbnail image of graphical abstract

      Jan Dörrie comments on an EMBO Molecular Medicine report by Azad, Fokas, and collaborators showing in a mouse model that pancreatic ductal adenocarcinoma becomes responsive to immune checkpoint blocking therapy if administered with radiation therapy.

  10. Research Articles

    1. You have full text access to this OnlineOpen article
      PD-L1 blockade enhances response of pancreatic ductal adenocarcinoma to radiotherapy

      Abul Azad, Su Yin Lim, Zenobia D'Costa, Keaton Jones, Angela Diana, Owen J Sansom, Philipp Kruger, Stanley Liu, W Gillies McKenna, Omer Dushek, Ruth J Muschel and Emmanouil Fokas

      Version of Record online: 8 DEC 2016 | DOI: 10.15252/emmm.201606674

      Thumbnail image of graphical abstract

      Local recurrence is a major cause of morbidity and mortality in pancreatic ductal adenocarcinoma (PDAC). Here, radiotherapy (RT) and gemcitabine chemotherapy are shown to have substantial immunomodulatory effects, including upregulation of PD-L1.

VIEW

  1. 1 - 15

SEARCH

SEARCH BY CITATION