EMBO Molecular Medicine

Cover image for Vol. 7 Issue 1

Early View (Online Version of Record published before inclusion in an issue)

Edited By: Stefanie Dimmeler (Chief Editor), Roberto Buccione and Céline Carret (EMBO Editors)

Online ISSN: 1757-4684

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  1. 1 - 8
  1. Research Articles

    1. You have full text access to this OnlineOpen article
      Alzheimer-associated Aβ oligomers impact the central nervous system to induce peripheral metabolic deregulation

      Julia R Clarke, Natalia M Lyra e Silva, Claudia P Figueiredo, Rudimar L Frozza, Jose H Ledo, Danielle Beckman, Carlos K Katashima, Daniela Razolli, Bruno M Carvalho, Renata Frazão, Marina A Silveira, Felipe C Ribeiro, Theresa R Bomfim, Fernanda S Neves, William L Klein, Rodrigo Medeiros, Frank M LaFerla, Jose B Carvalheira, Mario J Saad, Douglas P Munoz, Licio A Velloso, Sergio T Ferreira and Fernanda G De Felice

      Article first published online: 23 JAN 2015 | DOI: 10.15252/emmm.201404183

      Thumbnail image of graphical abstract

      Centrally administered Aβ oligomers can trigger insulin resistance by engaging ER stress and inflammatory signals in the central nervous system. This study provides important insights into the link between Alzheimer's disease and diabetes by pointing to a common etiology.

  2. Perspectives

    1. You have full text access to this OnlineOpen article
      FAT FLUX: enzymes, regulators, and pathophysiology of intracellular lipolysis

      Rudolf Zechner

      Article first published online: 21 JAN 2015 | DOI: 10.15252/emmm.201404846

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      The 2015 Louis–Jeantet Prize for Medicine winner Rudolf Zechner offers his personal account of the history and current state of the art of research in the pathophysiology of intracellular lipolysis and its implications for disease.

  3. Research Articles

    1. You have full text access to this OnlineOpen article
      Apolipoprotein E promotes subretinal mononuclear phagocyte survival and chronic inflammation in age-related macular degeneration

      Olivier Levy, Bertrand Calippe, Sophie Lavalette, Shulong J Hu, William Raoul, Elisa Dominguez, Michael Housset, Michel Paques, José-Alain Sahel, Alexis-Pierre Bemelmans, Christophe Combadiere, Xavier Guillonneau and Florian Sennlaub

      Article first published online: 20 JAN 2015 | DOI: 10.15252/emmm.201404524

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      In age-related macular degeneration, subretinal mononuclear phagocytes (MP) express high APOE levels, which prolongs their survival and accumulation by inducing IL-6, which in turn promotes chronic subretinal inflammation.

    2. You have full text access to this OnlineOpen article
      An aberrant sugar modification of BACE1 blocks its lysosomal targeting in Alzheimer's disease

      Yasuhiko Kizuka, Shinobu Kitazume, Reiko Fujinawa, Takashi Saito, Nobuhisa Iwata, Takaomi C Saido, Miyako Nakano, Yoshiki Yamaguchi, Yasuhiro Hashimoto, Matthias Staufenbiel, Hiroyuki Hatsuta, Shigeo Murayama, Hiroshi Manya, Tamao Endo and Naoyuki Taniguchi

      Article first published online: 15 JAN 2015 | DOI: 10.15252/emmm.201404438

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      Bisecting GlcNAc modification of BACE1 by GnT-III is a novel regulator of BACE1 stability. Loss of GnT-III curbs BACE1-mediated Aβ plaque generation. Hence, the bisecting GlcNAc biosynthesis pathway is a promising new target for AD therapy.

    3. You have full text access to this OnlineOpen article
      Impairment of chaperone-mediated autophagy leads to selective lysosomal degradation defects in the lysosomal storage disease cystinosis

      Gennaro Napolitano, Jennifer L Johnson, Jing He, Celine J Rocca, Jlenia Monfregola, Kersi Pestonjamasp, Stephanie Cherqui and Sergio D Catz

      Article first published online: 13 JAN 2015 | DOI: 10.15252/emmm.201404223

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      Impaired chaperone-mediated autophagy (CMA) due to aberrant CMA receptor LAMP2A expression and localization is shown to be an important pathogenic factor in cystinosis, a lysosomal storage disorder due to defects in the cystine transporter cystinosin.

    4. You have full text access to this OnlineOpen article
      Functional drug screening reveals anticonvulsants as enhancers of mTOR-independent autophagic killing of Mycobacterium tuberculosis through inositol depletion

      Mark Schiebler, Karen Brown, Krisztina Hegyi, Sandra M Newton, Maurizio Renna, Lucy Hepburn, Catherine Klapholz, Sarah Coulter, Andres Obregón-Henao, Marcela Henao Tamayo, Randall Basaraba, Beate Kampmann, Katherine M Henry, Joseph Burgon, Stephen A Renshaw, Angeleen Fleming, Robert R Kay, Karen E Anderson, Phillip T Hawkins, Diane J Ordway, David C Rubinsztein and Rodrigo Andres Floto

      Article first published online: 22 DEC 2014 | DOI: 10.15252/emmm.201404137

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      Carbamazepine reveals a novel mechanism of mTOR-independent control of autophagy that may be manipulated pharmacologically and provides proof of principle that therapeutic autophagy stimulation can be an effective strategy to treat multidrug-resistant tuberculosis.

  4. Closeup

    1. You have full text access to this OnlineOpen article
      New TB treatments hiding in plain sight

      Andrew J Olive and Christopher M Sassetti

      Article first published online: 22 DEC 2014 | DOI: 10.15252/emmm.201404815

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      AJ Olive and CM Sassetti discuss autophagy and metabolism pathways as key to modulate host immune response to mycobacteria infection by using FDA-approved anticonvulsant drugs and highlight unexpected low degrees of separation in these pathways.

  5. Research Articles

    1. You have full text access to this OnlineOpen article
      Modulation of TNF-α mRNA stability by human antigen R and miR181s in sepsis-induced immunoparalysis

      Cao Dan, Bian Jinjun, Hua Zi-Chun, Ma Lin, Chen Wei, Zhang Xu, Zhou Ri, Cheng Shun, Sun Wen-Zhu, Jiao Qing-Cai and Yin Wu

      Article first published online: 22 DEC 2014 | DOI: 10.15252/emmm.201404797

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      Ouabain, a Na+,K+-ATPase ligand, is shown as the first small molecule able to reverse sepsis-induced immunoparalysis in rodents and in clinical samples through a novel mechanism resulting in TH1 cytokines post-transcriptional reprogramming in monocytes.

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