EMBO Molecular Medicine

Cover image for Vol. 8 Issue 2

Early View (Online Version of Record published before inclusion in an issue)

Edited By: Stefanie Dimmeler (Chief Editor), Roberto Buccione and Céline Carret (EMBO Editors)

Online ISSN: 1757-4684

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  1. News & Views

    1. You have full text access to this OnlineOpen article
      Amyloid-β in mitochondrial disease: mutation in a human metallopeptidase links amyloidotic neurodegeneration with mitochondrial processing

      Veronika Boczonadi and Rita Horvath

      Article first published online: 26 JAN 2016 | DOI: 10.15252/emmm.201506050

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      Boczonadi and Horvath comment on the Brunetti et al's paper in this issue describing a mitochondrial metallopeptidase PITRM1 pathogenic mutation in a Norwegian family, underlying a novel mitochondrial neurodegenerative phenotype with Aβ accumulation.

  2. Research Articles

    1. You have full text access to this OnlineOpen article
      mTORC2 sustains thermogenesis via Akt-induced glucose uptake and glycolysis in brown adipose tissue

      Verena Albert, Kristoffer Svensson, Mitsugu Shimobayashi, Marco Colombi, Sergio Muñoz, Veronica Jimenez, Christoph Handschin, Fatima Bosch and Michael N Hall

      Article first published online: 15 JAN 2016 | DOI: 10.15252/emmm.201505610

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      Albert et al show that β-adrenergic stimulation activates mTORC2 in brown adipocytes. Active mTORC2 signaling in BAT is required for cold-induced stimulation of glucose uptake and glycolysis to maintain temperature homeostasis upon cold stress.

    2. You have full text access to this OnlineOpen article
      Defective PITRM1 mitochondrial peptidase is associated with Aβ amyloidotic neurodegeneration

      Dario Brunetti, Janniche Torsvik, Cristina Dallabona, Pedro Teixeira, Pawel Sztromwasser, Erika Fernandez-Vizarra, Raffaele Cerutti, Aurelio Reyes, Carmela Preziuso, Giulia D'Amati, Enrico Baruffini, Paola Goffrini, Carlo Viscomi, Ileana Ferrero, Helge Boman, Wenche Telstad, Stefan Johansson, Elzbieta Glaser, Per M Knappskog, Massimo Zeviani and Laurence A Bindoff

      Article first published online: 23 DEC 2015 | DOI: 10.15252/emmm.201505894

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      A clinically peculiar neurodegenerative disorder in humans was indentified and shown to be caused by a pathogenic homozygous mutation in PITRM1, encoding an oligopeptidase of the mitochondrial inner compartment. The neuropathology of a PITRM1−/+ mouse provides genetic evidence that Aβ is present within mitochondria, and demonstrates a link between impaired PITRM1 activity and Aβ amyloidotic neurodegeneration in mammals.

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