EMBO Molecular Medicine

Cover image for Vol. 6 Issue 10

Early View (Online Version of Record published before inclusion in an issue)

Edited By: Stefanie Dimmeler (Chief Editor), Roberto Buccione and Céline Carret (EMBO Editors)

Online ISSN: 1757-4684

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  1. Research Articles

    1. You have full text access to this OnlineOpen article
      R-flurbiprofen attenuates experimental autoimmune encephalomyelitis in mice

      Katja Schmitz, Natasja de Bruin, Philipp Bishay, Julia Männich, Annett Häussler, Christine Altmann, Nerea Ferreirós, Jörn Lötsch, Alfred Ultsch, Michael J Parnham, Gerd Geisslinger and Irmgard Tegeder

      Article first published online: 30 SEP 2014 | DOI: 10.15252/emmm.201404168

      Thumbnail image of graphical abstract

      R-flurbiprofen treatment of experimental autoimmune encephalomyelitis in mouse models of multiple sclerosis prevented and attenuated relapsing-remitting and primary progressive EAE, suggesting that R-flurbiprofen could restore motor functions and alleviate MS-associated chronic pain in humans.

    2. You have full text access to this OnlineOpen article
      N-WASP is required for Amphiphysin-2/BIN1-dependent nuclear positioning and triad organization in skeletal muscle and is involved in the pathophysiology of centronuclear myopathy

      Sestina Falcone, William Roman, Karim Hnia, Vincent Gache, Nathalie Didier, Jeanne Lainé, Frederic Auradé, Isabelle Marty, Ichizo Nishino, Nicolas Charlet-Berguerand, Norma Beatriz Romero, Giovanna Marazzi, David Sassoon, Jocelyn Laporte and Edgar R Gomes

      Article first published online: 29 SEP 2014 | DOI: 10.15252/emmm.201404436

      Thumbnail image of graphical abstract

      Amphiphysin-2/BIN1 is known to associate with centronuclear myopathy (CNM) and myotonic dystrophy. N-WASP is found downstream of Amphiphysin-2/BIN1 and aberrantly distributed in skeletal muscle of patients. Activation of N-WASP could provide a therapeutic option for CNM.

    3. You have full text access to this OnlineOpen article
      ZIPCO, a putative metal ion transporter, is crucial for Plasmodium liver-stage development

      Tejram Sahu, Bertrand Boisson, Céline Lacroix, Emmanuel Bischoff, Quentin Richier, Pauline Formaglio, Sabine Thiberge, Irina Dobrescu, Robert Ménard and Patricia Baldacci

      Article first published online: 25 SEP 2014 | DOI: 10.15252/emmm.201403868

      Thumbnail image of graphical abstract

      ZIPCO is a novel Plasmodium berghei ZIP family protein, which might be involved in the transport of iron and possibly zinc. Parasites lacking ZIPCO present a normal blood phase but display a major developmental block in the host liver, which can be rescued by iron and zinc supplementation.

    4. You have full text access to this OnlineOpen article
      Tumor cell-specific inhibition of MYC function using small molecule inhibitors of the HUWE1 ubiquitin ligase

      Stefanie Peter, Jennyfer Bultinck, Kevin Myant, Laura A Jaenicke, Susanne Walz, Judith Müller, Michael Gmachl, Matthias Treu, Guido Boehmelt, Carsten P Ade, Werner Schmitz, Armin Wiegering, Christoph Otto, Nikita Popov, Owen Sansom, Norbert Kraut and Martin Eilers

      Article first published online: 24 SEP 2014 | DOI: 10.15252/emmm.201403927

      Thumbnail image of graphical abstract

      New highly specific inhibitors of HUWE1 have been identified that can inhibit MYC function in a tumour cell-specific manner, by preventing the HUWE1-mediated block of a repressive complex of MYC with MIZ1 on MYC-activated target genes.

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