EMBO Molecular Medicine

• Whole genome sequencing identifies zoonotic transmission of MRSA isolates with the novel mecA homologue mecC
  Ewan M. Harrison, Gavin K. Paterson, Matthew T.G. Holden, Jesper Larsen, Marc Stegger, Anders Rhod Larsen, Andreas Petersen, Robert L. Skov, Judit Marta Christensen, Anne Bak Zeuthen, Ole Heltberg, Simon R. Harris, Ruth N. Zadoks, Julian Parkhill, Sharon J. Peacock, Mark A. Holmes
  EMBO Mol Med, 5(4), 509–515

• Autophagic control of cell ‘stemness’
  Huize Pan, Ning Cai, Mo Li, Guang-Hui Liu, Juan Carlos Izpisua Belmonte
  EMBO Mol Med, 5(3), 327–331

• Telomerase gene therapy in adult and old mice delays aging and increases longevity without increasing cancer
  Bruno Bernardes de Jesus, Elsa Vera, Kerstin Schneeberger, Agueda M. Tejera, Eduard Ayuso, Fatima Bosch, Maria A. Blasco
  EMBO Mol Med, 4(8), 691–704

• Reactive astrocytes promote the metastatic growth of breast cancer stem-like cells by activating Notch signalling in brain
  Fei Xing, Aya Kobayashi, Hiroshi Okuda, Misako Watabe, Sudha K. Pai, Puspa R. Pandey, Shigeru Hirota, Andrew Wilber, Yin-Yuan Mo, Brian E. Moore, Wen Liu, Koji Fukuda, Megumi Iiizumi, Sambad Sharma, Yin Liu, Kerui Wu, Elizabeth Peralta, Kounosuke Watabe
  EMBO Mol Med, 5(3), 384–396

• A novel small molecule RAD51 inactivator overcomes imatinib-resistance in chronic myeloid leukaemia
  Jiewen Zhu, Longen Zhou, Guikai Wu, Heiko Konig, Xiaoqin Lin, Guideng Li, Xiao-Long Qiu, Chi-Fen Chen, Chun-Mei Hu, Erin Goldblatt, Ravi Bhatia, A. Richard Chamberlin, Phang-Lang Chen, Wen-Hwa Lee
  EMBO Mol Med, 5(3), 353–365

• The isolation and characterization of renal cancer initiating cells from human Wilms' tumour xenografts unveils new therapeutic targets
  Naomi Pode-Shakked, Rachel Shukrun, Michal Mark-Danieli, Peter Tsvetkov, Sarit Bahar, Sara Pri-Chen, Ronald S. Goldstein, Eithan Rom-Gross, Yoram Mor, Edward Fridman, Karen Meir, Amos Simon, Marcus Magister, Naftali Kaminski, Victor S. Goldmacher, Orit Harari-Steinberg, Benjamin Dekel
  EMBO Mol Med, 5(1), 18–37

• SIRT1 regulates differentiation of mesenchymal stem cells by deacetylating β-catenin
  Petra Simic, Kayvan Zainabadi, Eric Bell, David B. Sykes, Borja Saez, Sutada Lotinun, Roland Baron, David Scadden, Ernestina Schipani, Leonard Guarente
  EMBO Mol Med, 5(3), 430–440

• SIRT1 and SIRT2: emerging targets in neurodegeneration
  Gizem Donmez, Tiago F. Outeiro
  EMBO Mol Med, 5(3), 344–352

• Disruption of SMIM1 causes the Vel– blood type
  Bryan A. Ballif, Virginie Helias, Thierry Peyrard, Cécile Menanteau, Carole Saison, Nicole Lucien, Sébastien Bourgouin, Maude Le Gall, Jean-Pierre Cartron, Lionel Arnaud
  EMBO Mol Med, Accepted Article Express

• Loss of TIMP3 underlies diabetic nephropathy via FoxO1/STAT1 interplay
  Loredana Fiorentino, Michele Cavalera, Stefano Menini, Valentina Marchetti, Maria Mavilio, Marta Fabrizi, Francesca Conserva, Viviana Casagrande, Rossella Menghini, Paola Pontrelli, Ivan Arisi, Mara D'Onofrio, Davide Lauro, Rama Khokha, Domenico Accili, Giuseppe Pugliese, Loreto Gesualdo, Renato Lauro, Massimo Federici
  EMBO Mol Med, 5(3), 441–455

Most Accessed 1/2012–12/2012

• Telomerase gene therapy in adult and old mice delays aging and increases longevity without increasing cancer
  Bruno Bernardes de Jesus, Elsa Vera, Kerstin Schneeberger, Agueda M. Tejera, Eduard Ayuso, Fatima Bosch, Maria A. Blasco
  EMBO Mol Med, 4(8), 691–704

• MicroRNA dysregulation in cancer: diagnostics, monitoring and therapeutics. A comprehensive review
  Marilena V. Iorio, Carlo M. Croce
  EMBO Mol Med, 4(3), 143–159

• Towards a new tuberculosis drug: pyridomycin – nature's isoniazid
  Ruben C. Hartkoorn, Claudia Sala, João Neres, Florence Pojer, Sophie Magnet, Raju Mukherjee, Swapna Uplekar, Stefanie Boy-Röttger, Karl-Heinz Altmann, Stewart T. Cole
  EMBO Mol Med, 4(10), 1032–1042

• Disease-specific phenotypes in dopamine neurons from human iPS-based models of genetic and sporadic Parkinson's disease
  Adriana Sánchez-Danés, Yvonne Richaud-Patin, Iria Carballo-Carbajal, Senda Jiménez-Delgado, Carles Caig, Sergio Mora, Claudia Di Guglielmo, Mario Ezquerra, Bindiben Patel, Albert Giralt, Josep M. Canals, Maurizio Memo, Jordi Alberch, José López-Barneo, Miquel Vila, Ana Maria Cuervo, Eduard Tolosa, Antonella Consiglio, Angel Raya
  EMBO Mol Med, 4(5), 380–395

• Proteomics for biomedicine: a half-completed journey
  Matthias Mann
  EMBO Mol Med, 4(2), 75–77

• Telomerase gene therapy: a novel approach to combat aging
  Virginia Boccardi, Utz Herbig
  EMBO Mol Med, 4(8), 685–687

• Rapid targeted mutational analysis of human tumours: a clinical platform to guide personalized cancer medicine
  Dora Dias-Santagata, Sara Akhavanfard, Serena S. David, Kathy Vernovsky, Georgiana Kuhlmann, Susan L. Boisvert, Hannah Stubbs, Ultan McDermott, Jeffrey Settleman, Eunice L. Kwak, Jeffrey W. Clark, Steven J. Isakoff, Lecia V. Sequist, Jeffrey A. Engelman, Thomas J. Lynch, Daniel A. Haber, David N. Louis, Leif W. Ellisen, Darrell R. Borger, A. John Iafrate
  EMBO Mol Med, 2(5), 146–158

• Hedgehog-EGFR cooperation response genes determine the oncogenic phenotype of basal cell carcinoma and tumour-initiating pancreatic cancer cells
  Markus Eberl, Stefan Klingler, Doris Mangelberger, Andrea Loipetzberger, Helene Damhofer, Kerstin Zoidl, Harald Schnidar, Hendrik Hache, Hans-Christian Bauer, Flavio Solca, Cornelia Hauser-Kronberger, Alexandre N. Ermilov, Monique E. Verhaegen, Christopher K. Bichakjian, Andrzej A. Dlugosz, Wilfried Nietfeld, Maria Sibilia, Hans Lehrach, Christoph Wierling, Fritz Aberger
  EMBO Mol Med, 4(3), 218–233

• Inflammation and EMT: an alliance towards organ fibrosis and cancer progression
  Jose Miguel López-Novoa, M. Angela Nieto
  EMBO Mol Med, 1(6-7), 303–314

• MicroRNA therapeutics in cardiovascular medicine
  Thomas Thum
  EMBO Mol Med, 4(1), 3–14