Cover image for Vol. 9 Issue 9

Editor-in-Chief: Natalia Ortúzar

Impact Factor: 3.046

ISI Journal Citation Reports © Ranking: 2013: 18/58 (Chemistry Medicinal); 74/254 (Pharmacology & Pharmacy)

Online ISSN: 1860-7187

Associated Title(s): Angewandte Chemie International Edition, Chemistry - A European Journal, Chemistry – An Asian Journal, ChemBioChem, Medicinal Research Reviews, Molecular Informatics

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August 28, 2014

C. A. Olsen interview at ChemistryViews

C. A. Olsen interview at ChemistryViewsChemMedChem author and this year's recipient of the EFMC Prize for a Young Medicinal Chemist in Academia, Professor Christian A. Olsen (University of Copenhagen), recently answered some questions we had about the work behind his paper Effect of Various Zinc Binding Groups on Inhibition of Histone Deacetylases 1–11, which appeared earlier this year in our Special Issue on Epigenetics and Drug Discovery. He also discussed his research projects and goals in general, and what makes his successful research group tick. The full interview can be found at ChemistryViews. Be sure to catch Olsen's Concept article, also in the Epigenetics special issue.

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    Matthew C. O'Reilly, Thomas H. Oguin III, Dr. Sarah A. Scott, Prof. Paul G. Thomas, Dr. Charles W. Locuson, Ryan D. Morrison, Prof. J. Scott Daniels, Prof. H. Alex Brown and Prof. Craig W. Lindsley

    Article first published online: 10 SEP 2014 | DOI: 10.1002/cmdc.201402333

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    PLD2, viral killer! Focused optimization efforts led to the development of ML395, a potent (IC50=360 nM) and >80-fold selective phospholipase D2 (PLD2) inhibitor with improved physiochemical properties, no cytotoxicity, high CNS penetration and a favorable DMPK profile. The PLD2 inhibitors displayed pan-anti-influenza activity across various influenza strains (H1N1, H3N2, H5N1, H7N9).

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    Article first published online: 10 SEP 2014 | DOI: 10.1002/cmdc.201402295

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    A privileged view: The binding between dendrimers and nucleic acids is typically a complex process that involves various types of interactions at different scales. Molecular simulation can support experimental data, providing a privileged point of view on intermolecular interactions and on the aggregation process.