ChemMedChem

Cover image for Vol. 12 Issue 6

Editorial Board Chairs: Antonello Mai, Rainer Metternich. Assoc. Editors: David Peralta, Scott Williams (Sr)

Impact Factor: 2.98

ISI Journal Citation Reports © Ranking: 2015: 18/59 (Chemistry Medicinal); 77/255 (Pharmacology & Pharmacy)

Online ISSN: 1860-7187

Associated Title(s): Angewandte Chemie International Edition, Chemistry - A European Journal, Chemistry – An Asian Journal, ChemBioChem, Medicinal Research Reviews, Molecular Informatics

Recently Published Issues

See all

Latest News

Browse more news

March 22, 2017

VIP: The Emerging Picture of Sulfoximines in Drug Discovery

VIP: The Emerging Picture of Sulfoximines in Drug DiscoveryJuan Alberto Sirvent, Dr. Ulrich Lücking*

After being neglected for a long time, sulfoximines, the mono-aza analogues of sulfones, have recently gained considerable recognition as a new and versatile structural motif in the life sciences. The synthetic methodology for sulfoximines has progressed significantly over the last decade; however, the general understanding of this functional group regarding its medicinal-chemistry-relevant properties is still limited. Read more...

Your Comment...

[Browse more news]

Recently Published Articles

  1. Benzylphenylpyrrolizinones with anti-amyloid and scavenging effects, potentially useful in Alzheimer's disease treatment.

    Jean-Pierre Gabriel JOURDAN, Marc Since, Laîla El Kihel, Cédric Lecoutey, Sophie Corvaisier, Rémi Legay, Jana Sopkova-de Oliveira Santos, Thierry Cresteil, Aurélie Malzert-Fréon, Christophe Rochais and Patrick Dallemagne

    Accepted manuscript online: 25 MAR 2017 04:05AM EST | DOI: 10.1002/cmdc.201700102

  2. Elongated and shortened peptidomimetic inhibitors of the proprotein convertase furin

    Kornelia Hardes, Teodora Ivanova, Bastian Thaa, Gerald M. McInerney, Tove Irene Klokk, Kirsten Sandvig, Sebastian Künzel, Iris Lindberg and Torsten Steinmetzer

    Accepted manuscript online: 23 MAR 2017 12:05PM EST | DOI: 10.1002/cmdc.201700108

  3. Molecular features of the YAP inhibitor, Verteporfin - synthesis of hexasubstituted dipyrrins as potential inhibitors of YAP/TAZ, the downstream effectors of the Hippo pathway

    FLORIANE GIBAULT, FABRICE BAILLY, matthieu corvaisier, mathilde coevoet, guillemette huet, patricia Melnyk and Philippe Cotelle

    Accepted manuscript online: 23 MAR 2017 11:00AM EST | DOI: 10.1002/cmdc.201700063

  4. An improved model of the Trypanosoma brucei CTP synthetase glutaminase domain:acivicin complex.

    Juliana Oliveira de Souza, Alice Dawson and William Nigel Hunter

    Accepted manuscript online: 23 MAR 2017 08:00AM EST | DOI: 10.1002/cmdc.201700118

  5. N-Guanidino Derivatives of 1,5-Dideoxy-1,5-imino-d-xylitol are Potent, Selective, and Stable Inhibitors of β-Glucocerebrosidase

    Alen Sevšek, Luka Šrot, Jakob Rihter, Maša Čelan, Linda Quarles van Ufford, Dr. Ed E. Moret, Dr. Nathaniel I. Martin and Prof. Dr. Roland J. Pieters

    Version of Record online: 22 MAR 2017 | DOI: 10.1002/cmdc.201700050

    Thumbnail image of graphical abstract

    Sweet GBA inhibitors! A series of 1-N-iminosugars were synthesized to supply the need for glycosidase inhibitors that are both highly potent and selective for β-glycosidases. These iminosugar inhibitors differ from the currently available inhibitors in that they possess a guanidine or urea group at the endocyclic position of the 1,5-dideoxy-1,5-imino-d-xylitol ring. The guanidine series was found to be extremely potent and highly specific against the β-glycosidases, with IC50 values in the nanomolar range.

SEARCH

SEARCH BY CITATION