Cover image for Vol. 9 Issue 8

Editor-in-Chief: Natalia Ortúzar

Impact Factor: 3.046

ISI Journal Citation Reports © Ranking: 2013: 18/58 (Chemistry Medicinal); 74/254 (Pharmacology & Pharmacy)

Online ISSN: 1860-7187

Associated Title(s): Angewandte Chemie International Edition, Chemistry - A European Journal, Chemistry – An Asian Journal, ChemBioChem, Medicinal Research Reviews, Molecular Informatics

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July 29, 2014

New Two-Year Impact Factor:

New Two-Year Impact Factor:The Journal Citation Report numbers are out, and they reflect ChemMedChem's solid performance! With a new two-year impact factor of 3.046, the journal is showing its prominent position in the medicinal chemistry community. Thanks to our Editorial and International Advisory Board members, numerous peer reviewers, as well as authors for helping make this journal the success it is.

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Recently Published Articles

  1. Double GC:GC Mismatch in dsDNA Enhances Local Dynamics Retaining the DNA Footprint: A High-Resolution NMR Study

    Anirban Ghosh, Rajiv Kumar Kar, Dr. Janarthanan Krishnamoorthy, Dr. Subhrangsu Chatterjee and Dr. Anirban Bhunia

    Article first published online: 30 JUL 2014 | DOI: 10.1002/cmdc.201402238

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    An imperfect match! A GC:GC double mismatch DNA structure (red) docked with DNA ligase IV (PDB code: 3W5O) generates the same docked conformation compared to its perfectly matched dsDNA control structure (blue).

  2. Are 1,4- and 1,5-Disubstituted 1,2,3-Triazoles Good Pharmacophoric Groups?

    Dr. Alberto Massarotti, Dr. Silvio Aprile, Dr. Valentina Mercalli, Dr. Erika Del Grosso, Prof. Giorgio Grosa, Prof. Giovanni Sorba and Prof. Gian Cesare Tron

    Article first published online: 30 JUL 2014 | DOI: 10.1002/cmdc.201402233

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    The time is ripe to demonstrate the real ability of 1,2,3-triazoles to play a pivotal role in drug–receptor interactions. We analyzed the X-ray crystal structures of 1,2,3-triazole-containing protein complexes to understand their pharmacophoric role. Furthermore, the metabolic stability, the ability to inhibit cytochromes, and the aqueous solubility contribution of the 1,2,3-triazole nucleus were analyzed.

  3. Activity of Core-Modified 10–23 DNAzymes against HCV

    Dr. Laura Robaldo, Dr. Alfredo Berzal-Herranz, Dr. Javier M. Montserrat and Dr. Adolfo M. Iribarren

    Article first published online: 30 JUL 2014 | DOI: 10.1002/cmdc.201402222

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    Targeting the untranslated: A set of 10–23 DNAzymes modified at the catalytic core against the 5′-IRES region of HCV were synthesized. A fivefold increase in intracellular stability was achieved with the modified DNAzymes at 48 h, with an inhibition of up to 65 % HCV IRES observed in Huh-7 human cells. These findings are important to the development of drugs that inhibit HCV replication.

  4. Dangling Ends Perturb the Stability of RNA Duplexes Responsive to Surrounding Conditions

    Dr. Hisae Tateishi-Karimata, Dr. Smritimoy Pramanik, Prof. Shu-ichi Nakano, Prof. Daisuke Miyoshi and Prof. Naoki Sugimoto

    Article first published online: 28 JUL 2014 | DOI: 10.1002/cmdc.201402167

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    Let′s talk about stability: In the presence of various cosolutes, RNA duplexes with dangling ends are significantly destabilized depending on the hydration type of the dangling ends, although the RNA duplexes are stabilized in the absence of cosolutes. It has been postulated that dangling ends stabilize helices; however, our results suggest that the stabilization is responsive to the surrounding conditions.

  5. Singly Modified Amikacin and Tobramycin Derivatives Show Increased rRNA A-Site Binding and Higher Potency against Resistant Bacteria

    Dr. Richard J. Fair, Dr. Lisa S. McCoy, Dr. Mary E. Hensler, Bernice Aguilar, Prof. Dr. Victor Nizet and Prof. Dr. Yitzhak Tor

    Article first published online: 23 JUL 2014 | DOI: 10.1002/cmdc.201402175

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    Irresistible! Amikacin and tobramycin are two clinically useful RNA-targeting aminoglycosides. Modified versions of these compounds showed equal to or better potency against certain resistant bacterial strains, while their eukaryotic cytotoxicity remained identical to that of the parent antibiotics.