ChemMedChem

Cover image for Vol. 12 Issue 12

Editorial Board Chairs: Antonello Mai, Rainer Metternich. Assoc. Editors: David Peralta, Scott Williams (Sr)

Impact Factor: 3.225

ISI Journal Citation Reports © Ranking: 2016: 17/60 (Chemistry Medicinal); 73/256 (Pharmacology & Pharmacy)

Online ISSN: 1860-7187

Associated Title(s): Angewandte Chemie International Edition, Chemistry - A European Journal, Chemistry – An Asian Journal, ChemBioChem, Medicinal Research Reviews, Molecular Informatics

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June 12, 2017

VIP: Redox-Active Ruthenium(II) Polypyridyl Complexes

N. Alatrash, E. S. Narh, A. Yadav, M.-J. Kim, T. Janaratne, J. Gabriel, F. M. MacDonnell

Various ruthenium polypyridyl complexes (RPCs) have been explored as potential drugs or therapeutics for nearly a half a century now. Relatively few animal studies have been conducted with RPCs, and most of these reveal RPCs to be potent inhibitors of acetylcholine esterase (AChE) which leads to acute neurotoxicity in vivo at modest doses, severely limiting therapeutic potential. Read more...

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