Copyright © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
July 18, 2014
VIP: Importance of the 6'-Hydroxy Group and Its Configuration for Apramycin Activity
Appi Reddy Mandhapati, Dimitri Shcherbakov, Stefan Duscha, Andrea Vasella,* Erik C. Böttger,* David Crich*
The relative lack of success of combinatorial drug discovery platforms in the search for novel antibacterial drugs warrants a renewed focus on the optimization of established drug classes such as the aminoglycoside antibiotics. Most aminoglycosides in current use suffer from toxicity problems, the most serious of which is drug-induced ototoxicity.
Researchers in this collaboration focus on apramycin, an aminoglycoside antibiotic currently only used in veterinary medicine, that has previously been demonstrated to be substantially ototoxicity-free and efficacious in the treatment of methicillin-resistant Staphylococcus aureus in animal models. Read more...
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