ChemMedChem

Cover image for Vol. 12 Issue 4

Editorial Board Chairs: Antonello Mai, Rainer Metternich. Assoc. Editors: David Peralta, Scott Williams (Sr)

Impact Factor: 2.98

ISI Journal Citation Reports © Ranking: 2015: 18/59 (Chemistry Medicinal); 77/255 (Pharmacology & Pharmacy)

Online ISSN: 1860-7187

Associated Title(s): Angewandte Chemie International Edition, Chemistry - A European Journal, Chemistry – An Asian Journal, ChemBioChem, Medicinal Research Reviews, Molecular Informatics

Recently Published Issues

See all

Latest News

Browse more news

February 06, 2017

VIP: Aqueous Instability of δ-Fluorobutylpiperidines

VIP: Aqueous Instability of δ-FluorobutylpiperidinesRaffael Vorberg, Erick M. Carreira, Klaus Müller*

Partially fluorinated alkyl groups have been explored successfully by medicinal chemists over the past few years as interesting modulators of compound properties. Fluorinated alkyl groups are generally quite robust, but when carrying a single fluorine atom four carbon centers away from an amine nitrogen center, a fluoroalkyl group may become labile under very mild bioassay conditions. This reactivity is extraordinary, as such fluorinated N-alkylamine derivatives are otherwise fully stable in various organic solvents during synthesis, isolation, and purification. Read more...

Your Comment...

[Browse more news]

Recently Published Articles

  1. Enrichment and Viability Inhibition of Circulating Tumor Cells on a Dual Acid-responsive Composite Nanofiber Film

    Wenqian Wang, Yaya Cheng, Yansheng Li, Hao Zhou, Li-Ping Xu, Yongqiang Wen, Liang Zhao and Xueji Zhang

    Accepted manuscript online: 23 FEB 2017 02:20AM EST | DOI: 10.1002/cmdc.201600633

  2. Medicinal Chemistry Profiling of Monocyclic 1,2-Azaborines

    Dr. Peng Zhao, Dr. David O. Nettleton, Dr. Rajeshri G. Karki, Dr. Frédéric J. Zécri and Prof. Dr. Shih-Yuan Liu

    Version of Record online: 21 FEB 2017 | DOI: 10.1002/cmdc.201700047

    Thumbnail image of graphical abstract

    BOR-ing? NO! Monocyclic 1,2-azaborines can serve as a novel pharmacophore with improved in vitro aqueous solubility, improved bioactivity, and better in vivo oral availability than their carbonaceous analogues.

  3. Synthesis and antiproliferative effect of ethyl 4-(4-substitutedpiperidin-1-yl)]benzylpyrrolo[1,2-a]quinoxaline-carboxylate derivatives on human leukemic cells

    Jean Guillon, vanessa desplat, marian vincenzi, romain lucas, stéphane moreau, solène savrimoutou, noel pinaud, david bigat, elodie enriquez, mathieu marchivie, sylvain routier, pascal sonnet, filomena rossi and luisa ronga

    Accepted manuscript online: 20 FEB 2017 11:20AM EST | DOI: 10.1002/cmdc.201700049

  4. Optimization of bicyclic lactam derivatives as NMDA receptor antagonists

    Margarida Espadinha, Jorge Dourado, Rocio Lajarin-Cuesta, Clara Herrera-Arozamena, Lidia Gonçalves, Maria Isabel Rodríguez-Franco, Cristobal de los Rios and Maria M. M. Santos

    Accepted manuscript online: 20 FEB 2017 07:15AM EST | DOI: 10.1002/cmdc.201700037

SEARCH

SEARCH BY CITATION