ChemMedChem

Cover image for Vol. 13 Issue 4

Editorial Board Chairs: Karl-Heinz Altmann, Antonello Mai, Rainer Metternich. Editor: David Peralta

Impact Factor: 3.225

ISI Journal Citation Reports © Ranking: 2016: 17/60 (Chemistry Medicinal); 73/257 (Pharmacology & Pharmacy)

Online ISSN: 1860-7187

Associated Title(s): Angewandte Chemie International Edition, Chemistry - A European Journal, Chemistry – An Asian Journal, ChemBioChem, Medicinal Research Reviews, Molecular Informatics

Recently Published Issues

See all

Latest News

Browse more news

February 09, 2018

VIP: Hit Dexter: Predicting Frequent Hitters

VIP: Hit Dexter: Predicting Frequent HittersC. Stork, J. Wagner, N.-O. Friedrich, C. de Bruyn Kops, M. Šícho, J. Kirchmair*

False-positive assay readouts caused by badly behaving compounds pose a major challenge to experimental screening. Few in silico methods exist that allow the prediction of such problematic compounds. Scientists at the Center for Bioinformatics of the University of Hamburg developed a machine-learning approach that allows the identification of compounds likely to trigger positive signals in biochemical assays with high accuracy Read more...

Your Comment...

[Browse more news]

Recently Published Articles

  1. Preparation of Tetradentate Copper Chelators as Potential Anti-Alzheimer Agents

    Weixin Zhang, Daya Huang, Meijie Huang, Ju Huang, Dean Wang, Dr. Xingguo Liu, Dr. Michel Nguyen, Dr. Laure Vendier, Dr. Serge Mazères, Dr. Anne Robert, Prof. Yan Liu and Prof. Bernard Meunier

    Version of Record online: 23 FEB 2018 | DOI: 10.1002/cmdc.201700734

    Thumbnail image of graphical abstract

    Regulating copper homeostasis for AD: New tetradendate ligands (TDMQ) based on 8-aminoquinoline were found to be specific chelators of copper(II) ions and are able to extract Cu2+ from toxic copper-loaded amyloids. These ligands can transfer copper ions to physiological copper acceptors. They should be considered as potential regulators of copper homeostasis for Alzheimer's disease (AD) therapy.

  2. Caveat Usor: Assessing Differences between Major Chemistry Databases

    Dr. Christopher Southan

    Version of Record online: 23 FEB 2018 | DOI: 10.1002/cmdc.201700724

    Thumbnail image of graphical abstract

    The three databases of PubChem, ChemSpider, and UniChem capture the majority of open chemical structure records. Collectively, they constitute a massively enabling resource for cheminformatics, chemical biology, and drug discovery. It is important for users to have at least some appreciation of differential content to enable utility judgments for the tasks at hand. This turns out to be challenging. By comparing the three resources in detail, this review assesses their differences, some of which are not obvious.

  3. Novel peroxides as promising anticancer agents with unexpected depressed antimalarial activity

    Paolo Coghi, Ivan A Yaremenko, Parichat Prommana, Peter S Radulov, Mikhail A Syroeshkin, Yu Jun Wu, Jia Ying Gao, Flora M Gordillo-Martinez, Simon Mok, Vincent K.W. Wong, Chairat Uthaipibull and Alexander O Terent'ev

    Accepted manuscript online: 22 FEB 2018 07:25AM EST | DOI: 10.1002/cmdc.201700804

  4. Synthesis and Characterization of the R27S Genetic Variant of Insulin-like Peptide 5

    Alexander Zaykov, Vasily Gelfanov, Fa Liu, Richard Dennis DiMarchi and Richard Dennis DiMarchi

    Accepted manuscript online: 21 FEB 2018 03:50PM EST | DOI: 10.1002/cmdc.201800057

SEARCH

SEARCH BY CITATION