© WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Editor-in-Chief: Natalia Ortúzar
Impact Factor: 2.968
ISI Journal Citation Reports © Ranking: 2014: 19/59 (Chemistry Medicinal); 83/254 (Pharmacology & Pharmacy)
Online ISSN: 1860-7187
August 28, 2015
VIP: Acyclic Nucleoside Phosphonates as Plasmodium and Human HG(X)PRT Inhibitors
Given the development of resistance to current antimalarial medications, new treatments with novel modes of action are urgently needed to combat this infectious disease. Acyclic nucleoside phosphonates have been shown to be potent inhibitors of Plasmodium hypoxanthine-guanine-(xanthine) phosphoribosyltransferase [HG(X)PRT], a key enzyme of the parasitic purine nucleotide salvage pathway. Read more...
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