ChemMedChem

Cover image for Vol. 13 Issue 1

Editorial Board Chairs: Karl-Heinz Altmann, Antonello Mai, Rainer Metternich. Editor: David Peralta

Impact Factor: 3.225

ISI Journal Citation Reports © Ranking: 2016: 17/60 (Chemistry Medicinal); 73/257 (Pharmacology & Pharmacy)

Online ISSN: 1860-7187

Associated Title(s): Angewandte Chemie International Edition, Chemistry - A European Journal, Chemistry – An Asian Journal, ChemBioChem, Medicinal Research Reviews, Molecular Informatics

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Increasing Oxygen Delivery

Allosteric Effectors of Human Hemoglobin.
Numerous diseases, such as cardiovascular ailments and cancer, are characterized by a lack of oxygen in specific tissues. Therefore, increasing the supply of oxygen delivered by red blood cells (RBCs) to counteract the effects of hypoxia has much potential therapeutic interest. Nobel laureate Jean-Marie Lehn and colleagues at the Université de Strasbourg (France) have undertaken a series of collaborative research efforts to address this.

Read more.

No.Press ReleaseOriginal Communication

06/2010

Increasing Oxygen Delivery
Allosteric Effectors of Human Hemoglobin
(PDF)

Polyphosphates and Pyrophosphates of Hexopyranoses as Allosteric Effectors of Human Hemoglobin: Synthesis, Molecular Recognition, and Effect on Oxygen Release

Jean-Marie Lehn, Université de Strasbourg (France)


05/2010

Clicking Tc-99m SPECT Probes Together
Molecular Assembly of Multifunctional 99mTc Radiopharmaceuticals Using "Clickable" Amino Acid Derivatives
(PDF)

Molecular Assembly of Multifunctional 99mTc Radiopharmaceuticals Using "Clickable" Amino Acid Derivatives

Thomas Mindt, Universität / Universitätsspital Basel (Switzerland)


04/2010

Putting the Brakes on Drug-Resistant HIV
Probing Multidrug Resistance and Protein–Ligand Interactions with Oxatricyclic Designed Ligands in HIV-1 Protease Inhibitors
(PDF)

Probing Multidrug-Resistance and Protein–Ligand Interactions with Oxatricyclic Designed Ligands in HIV-1 Protease Inhibitors

Arun K. Ghosh, Purdue University, West Lafayette, IN (USA)


03/2010

Activation against Malaria
Facile Oxidation of Leucomethylene Blue and Dihydroflavins by Artemisinins
(PDF)

Facile Oxidation of Leucomethylene Blue and Dihydroflavins by Artemisinins: Relationship with Flavoenzyme Function and Antimalarial Mechanism of Action

Richard K. Haynes, The Hong Kong University of Science and Technology (China)


02/2010

Improving Kinase Inhibitors
Molecular editing of resorcylic acid lactones
(PDF)

Molecular Editing of Kinase-Targeting Resorcylic Acid Lactones (RAL): Fluoroenone RAL

Nicolas Winssinger, Université de Strasbourg (France)


01/2010

Understanding the APJ Receptor Binding Site
Exploring the RPRL Motif of Apelin-13 through Molecular Simulation and Biological Evaluation of Cyclic Peptide Analogues
(PDF)

Exploring the RPRL Motif of Apelin-13 through Molecular Simulation and Biological Evaluation of Cyclic Peptide Analogues

Robert C. Glen, University of Cambridge (UK)


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