ChemMedChem

Most Accessed in 3/2013

• M. Zouhir Hammamy, Caroline Haase, Maya Hammami, Rolf Hilgenfeld, Torsten Steinmetzer*
  Development and Characterization of New Peptidomimetic Inhibitors of the West Nile Virus NS2B–NS3 Protease [Full Paper]
  ChemMedChem 2013, vol. 8, p. 231
• Lluís Ballell*, Robert H. Bates, Rob J. Young, Daniel Alvarez-Gomez, Emilio Alvarez-Ruiz, Vanessa Barroso, Delia Blanco, Benigno Crespo, Jaime Escribano, Rubén González, Sonia Lozano, Sophie Huss, Angel Santos-Villarejo, José Julio Martín-Plaza, Alfonso Mendoza, María José Rebollo-Lopez, Modesto Remuiñan-Blanco, José Luis Lavandera, Esther Pérez-Herran, Francisco Javier Gamo-Benito, José Francisco García-Bustos, David Barros, Julia P. Castro, Nicholas Cammack
  Fueling Open-Source Drug Discovery: 177 Small-Molecule Leads against Tuberculosis [Full Paper]
  ChemMedChem 2013, vol. 8, p. 313
• Carlo Ballatore*, Donna M. Huryn, Amos B. Smith
  Carboxylic Acid (Bio)Isosteres in Drug Design [Minireview]
  ChemMedChem 2013, vol. 8, p. 385
• Yijing Li, Jingkun Geng, Yang Liu, Shenghui Yu, Guisen Zhao*
  Thiadiazole—a Promising Structure in Medicinal Chemistry [Minireview]
  ChemMedChem 2013, vol. 8, p. 27
• Lars Bärfacker*, Alexander Kuhl, Alexander Hillisch, Rolf Grosser, Santiago Figueroa-Pérez, Heike Heckroth, Adam Nitsche, Jens-Kerim Ergüden, Heike Gielen-Haertwig, Karl-Heinz Schlemmer, Joachim Mittendorf, Holger Paulsen, Johannes Platzek, Peter Kolkhof
  Discovery of BAY 94-8862: A Nonsteroidal Antagonist of the Mineralocorticoid Receptor for the Treatment of Cardiorenal Diseases [Full Paper]
  ChemMedChem 2012, vol. 7, p. 1385
• Fry, David; Huang, Kuo-Sen; Di Lello, Paola; Mohr, Peter; Müller, Klaus; So, Sung-Sau; Harada, Takeo; Stahl, Martin; Vu, Binh; Mauser, Harald
  Design of Libraries Targeting Protein–Protein Interfaces [Communication]
  ChemMedChem, 10.1002/cmdc.201200540
• Stefan Peukert*, Karen Miller-Moslin*
  Small-Molecule Inhibitors of the Hedgehog Signaling Pathway as Cancer Therapeutics [Review]
  ChemMedChem 2010, vol. 5, p. 500
• Michael Harder, Bernd Kuhn*, François Diederich*
  Efficient Stacking on Protein Amide Fragments [Full Paper]
  ChemMedChem 2013, vol. 8, p. 397
• Peter Michael Moyle*, Istvan Toth
  Modern Subunit Vaccines: Development, Components, and Research Opportunities [Review]
  ChemMedChem 2013, vol. 8, p. 360
• Felix Kratz*, Ivonne A. Müller, Claudia Ryppa, André Warnecke
  Prodrug Strategies in Anticancer Chemotherapy [Review]
  ChemMedChem 2008, vol. 3, p. 20
• Andreas F. G. Glawar, Sarah F. Jenkinson, Amber L. Thompson, Shinpei Nakagawa, Atsushi Kato*, Terry D. Butters, George W. J. Fleet*
  3-Hydroxyazetidine Carboxylic Acids: Non-Proteinogenic Amino Acids for Medicinal Chemists [Full Paper]
  ChemMedChem 2013, vol. 8, p. 658
• Ruth Brenk*, Alessandro Schipani, Daniel James, Agata Krasowski, Ian Hugh Gilbert, Julie Frearson, Paul Graham Wyatt
  Lessons Learnt from Assembling Screening Libraries for Drug Discovery for Neglected Diseases [Full Paper]
  ChemMedChem 2008, vol. 3, p. 435
• Vanessa Baeriswyl, Christian Heinis*
  Polycyclic Peptide Therapeutics [Minireview]
  ChemMedChem 2013, vol. 8, p. 377
• Marco F. Schmidt, Oliver Korb, Nigel I. Howard, Marcio V. B. Dias, Tom L. Blundell, Chris Abell*
  Discovery of Schaeffer’s Acid Analogues as Lead Structures of Mycobacterium tuberculosis Type II Dehydroquinase Using a Rational Drug Design Approach [Communication]
  ChemMedChem 2013, vol. 8, p. 54
• Zhengying Pan*, Heleen Scheerens, Shyr-Jiann Li, Brian E. Schultz, Paul A. Sprengeler, L. Chuck Burrill, Rohan V. Mendonca, Michael D. Sweeney, Keana C. K. Scott, Paul G. Grothaus, Douglas A. Jeffery, Jill M. Spoerke, Lee A. Honigberg, Peter R. Young, Stacie A. Dalrymple, James T. Palmer
  Discovery of Selective Irreversible Inhibitors for Bruton’s Tyrosine Kinase [Communication]
  ChemMedChem 2007, vol. 2, p. 58

Most Accessed 4/2012–3/2013

• Barry Marshall*
  Helicobacter Connections [Review]
  ChemMedChem 2006, vol. 1, p. 783
• Stefan Peukert*, Karen Miller-Moslin*
  Small-Molecule Inhibitors of the Hedgehog Signaling Pathway as Cancer Therapeutics [Review]
  ChemMedChem 2010, vol. 5, p. 500
• Felix Kratz*, Ivonne A. Müller, Claudia Ryppa, André Warnecke
  Prodrug Strategies in Anticancer Chemotherapy [Review]
  ChemMedChem 2008, vol. 3, p. 20
• Kejing Zhang, Kwame Sefah, Lili Tang, Zilong Zhao, Guizhi Zhu, Mao Ye, Weijia Sun*, Steve Goodison, Weihong Tan*
  A Novel Aptamer Developed for Breast Cancer Cell Internalization [Full Paper]
  ChemMedChem 2012, vol. 7, p. 79
• Tian-miao Ou, Yu-jing Lu, Jia-heng Tan, Zhi-shu Huang*, Kwok-Yin Wong, Lian-quan Gu*
  G-Quadruplexes: Targets in Anticancer Drug Design [Review]
  ChemMedChem 2008, vol. 3, p. 690
• Zhengying Pan*, Heleen Scheerens, Shyr-Jiann Li, Brian E. Schultz, Paul A. Sprengeler, L. Chuck Burrill, Rohan V. Mendonca, Michael D. Sweeney, Keana C. K. Scott, Paul G. Grothaus, Douglas A. Jeffery, Jill M. Spoerke, Lee A. Honigberg, Peter R. Young, Stacie A. Dalrymple, James T. Palmer
  Discovery of Selective Irreversible Inhibitors for Bruton’s Tyrosine Kinase [Communication]
  ChemMedChem 2007, vol. 2, p. 58
• Steven R. LaPlante*, Paul J. Edwards, Lee D. Fader, Araz Jakalian, Oliver Hucke*
  Revealing Atropisomer Axial Chirality in Drug Discovery [Full Paper]
  ChemMedChem 2011, vol. 6, p. 505
• Jeremy L. Yap, Shilpa Worlikar, Alexander D. MacKerell, Paul Shapiro*, Steven Fletcher*
  Small-Molecule Inhibitors of the ERK Signaling Pathway: Towards Novel Anticancer Therapeutics [Minireview]
  ChemMedChem 2011, vol. 6, p. 38
• Elizabeth I. Parkinson, Paul J. Hergenrother*
  Runaway ROS as a Selective Anticancer Strategy [Highlight]
  ChemMedChem 2011, vol. 6, p. 1957
• Daniel Spinks, Leah S. Torrie, Stephen Thompson, Justin R. Harrison, Julie A. Frearson, Kevin D. Read, Alan H. Fairlamb, Paul G. Wyatt, Ian H. Gilbert*
  Design, Synthesis and Biological Evaluation of Trypanosoma brucei Trypanothione Synthetase Inhibitors [Full Paper]
  ChemMedChem 2012, vol. 7, p. 95
• Lluís Ballell*, Robert H. Bates, Rob J. Young, Daniel Alvarez-Gomez, Emilio Alvarez-Ruiz, Vanessa Barroso, Delia Blanco, Benigno Crespo, Jaime Escribano, Rubén González, Sonia Lozano, Sophie Huss, Angel Santos-Villarejo, José Julio Martín-Plaza, Alfonso Mendoza, María José Rebollo-Lopez, Modesto Remuiñan-Blanco, José Luis Lavandera, Esther Pérez-Herran, Francisco Javier Gamo-Benito, José Francisco García-Bustos, David Barros, Julia P. Castro, Nicholas Cammack
  Fueling Open-Source Drug Discovery: 177 Small-Molecule Leads against Tuberculosis [Full Paper]
  ChemMedChem 2013, vol. 8, p. 313
• Martin Morgenthaler, Eliane Schweizer, Anja Hoffmann-Röder, Fausta Benini, Rainer E. Martin, Georg Jaeschke, Björn Wagner, Holger Fischer, Stefanie Bendels, Daniel Zimmerli, Josef Schneider, François Diederich*, Manfred Kansy*, Klaus Müller*
  Predicting and Tuning Physicochemical Properties in Lead Optimization: Amine Basicities [Review]
  ChemMedChem 2007, vol. 2, p. 1100
• Paul J. Coleman*, John D. Schreier, Christopher D. Cox, Michael J. Breslin, David B. Whitman, Michael J. Bogusky, Georgia B. McGaughey, Rodney A. Bednar, Wei Lemaire, Scott M. Doran, Steven V. Fox, Susan L. Garson, Anthony L. Gotter, C. Meacham Harrell, Duane R. Reiss, Tamara D. Cabalu, Donghui Cui, Thomayant Prueksaritanont, Joanne Stevens, Pamela L. Tannenbaum, Richard G. Ball, Joyce Stellabott, Steven D. Young, George D. Hartman, Christopher J. Winrow, John J. Renger
  Discovery of [(2R,5R)-5-{[(5-Fluoropyridin-2-yl)oxy]methyl}-2-methylpiperidin-1-yl][5-methyl-2-(pyrimidin-2-yl)phenyl]methanone (MK-6096): A Dual Orexin Receptor Antagonist with Potent Sleep-Promoting Properties [Full Paper]
  ChemMedChem 2012, vol. 7, p. 415
• Mia Lace Huang, Sung Bin Y. Shin, Meredith A. Benson, Victor J. Torres, Kent Kirshenbaum*
  A Comparison of Linear and Cyclic Peptoid Oligomers as Potent Antimicrobial Agents [Full Paper]
  ChemMedChem 2012, vol. 7, p. 114
• Astrid Spannhoff, Alexander-Thomas Hauser, Ralf Heinke, Wolfgang Sippl, Manfred Jung*
  The Emerging Therapeutic Potential of Histone Methyltransferase and Demethylase Inhibitors [Review]
  ChemMedChem 2009, vol. 4, p. 1568
• Edgar Jacoby*, Rochdi Bouhelal, Marc Gerspacher, Klaus Seuwen
  The 7 TM G-Protein-Coupled Receptor Target Family [Review]
  ChemMedChem 2006, vol. 1, p. 760
• Maximilian Tischer, Gabriele Pradel, Knut Ohlsen, Ulrike Holzgrabe*
  Quaternary Ammonium Salts and Their Antimicrobial Potential: Targets or Nonspecific Interactions? [Review]
  ChemMedChem 2012, vol. 7, p. 22
• Ruth Brenk*, Alessandro Schipani, Daniel James, Agata Krasowski, Ian Hugh Gilbert, Julie Frearson, Paul Graham Wyatt
  Lessons Learnt from Assembling Screening Libraries for Drug Discovery for Neglected Diseases [Full Paper]
  ChemMedChem 2008, vol. 3, p. 435
• Lars Bärfacker*, Alexander Kuhl, Alexander Hillisch, Rolf Grosser, Santiago Figueroa-Pérez, Heike Heckroth, Adam Nitsche, Jens-Kerim Ergüden, Heike Gielen-Haertwig, Karl-Heinz Schlemmer, Joachim Mittendorf, Holger Paulsen, Johannes Platzek, Peter Kolkhof
  Discovery of BAY 94-8862: A Nonsteroidal Antagonist of the Mineralocorticoid Receptor for the Treatment of Cardiorenal Diseases [Full Paper]
  ChemMedChem 2012, vol. 7, p. 1385
• Navnath Gavande, Nasiara Karim, Graham A. R. Johnston, Jane R. Hanrahan, Mary Chebib*
  Identification of Benzopyran-4-one Derivatives (Isoflavones) as Positive Modulators of GABA_A Receptors [Communication]
  ChemMedChem 2011, vol. 6, p. 1340
• Sören J. Wacker, Wiktor Jurkowski, Katie J. Simmons, Colin W. G. Fishwick, A. Peter Johnson, David Madge, Erik Lindahl, Jean-Francois Rolland*, Bert L. de Groot*
  Identification of Selective Inhibitors of the Potassium Channel Kv1.1–1.2₍₃₎ by High-Throughput Virtual Screening and Automated Patch Clamp [Full Paper]
  ChemMedChem 2012, vol. 7, p. 1775
• Alberto Massarotti*, Antonio Coluccia, Romano Silvestri, Giovanni Sorba, Andrea Brancale
  The Tubulin Colchicine Domain: a Molecular Modeling Perspective [Minireview]
  ChemMedChem 2012, vol. 7, p. 33
• Thomas W. Bell*
  Drugs for Hepatitis C: Unlocking a New Mechanism of Action [Highlight]
  ChemMedChem 2010, vol. 5, p. 1663
• Danqi Chen, Ying Wang, Yuchi Ma, Bing Xiong, Jing Ai, Yi Chen, Meiyu Geng*, Jingkang Shen*
  Discovery of 3H-Imidazo[4,5-b]pyridines as Potent c-Met Kinase Inhibitors: Design, Synthesis, and Biological Evaluation [Full Paper]
  ChemMedChem 2012, vol. 7, p. 1057
• Charlotte C. Williams, San H. Thang, Tina Hantke, Uwe Vogel, Peter H. Seeberger, John Tsanaktsidis*, Bernd Lepenies*
  RAFT-Derived Polymer–Drug Conjugates: Poly(hydroxypropyl methacrylamide) (HPMA)–7-Ethyl-10-hydroxycamptothecin (SN-38) Conjugates [Full Paper]
  ChemMedChem 2012, vol. 7, p. 281