Cover image for Vol. 11 Issue 3

Editor-in-Chief: Natalia Ortúzar

Impact Factor: 2.968

ISI Journal Citation Reports © Ranking: 2014: 19/59 (Chemistry Medicinal); 83/255 (Pharmacology & Pharmacy)

Online ISSN: 1860-7187

Associated Title(s): Angewandte Chemie International Edition, Chemistry - A European Journal, Chemistry – An Asian Journal, ChemBioChem, Medicinal Research Reviews, Molecular Informatics


Here's a selection of upcoming papers. Also see the EarlyView page for the latest papers published online.

Antivirulence Isoquinolone Mannosides: Optimization of the Biaryl Aglycone for FimH Lectin Binding Affinity and Efficacy in the Treatment of Chronic UTI

Cassie Jarvis, Zhenfu Han, Vasilios Kalas, Roger Klein, Jerome S. Pinkner, Bradley Ford, Jana Binkley, Corinne K. Cusumano, Zachary Cusumano, Laurel Mydock-McGrane, Scott J. Hultgren*, James W. Janetka*

Published online on February 5, 2016.
DOI: 10.1002/cmdc.201600006

Fragment Screening of Soluble Epoxide Hydrolase for Lead Generation—Structure-Based Hit Evaluation and Chemistry Exploration
[Full Paper]

Yafeng Xue*, Thomas Olsson, Carina A Johansson, Linda Öster, Hans-Georg Beisel, Mattias Rohman, David Karis, Stefan Bäckström

Published online on February 4, 2016.
DOI: 10.1002/cmdc.201500575

Substrate Activity Screening (SAS) and Related Approaches in Medicinal Chemistry

Rafaela Gladysz, Anne-Marie Lambeir, Jurgen Joossens, Koen Augustyns, Pieter Van der Veken*

Published online on February 4, 2016.
DOI: 10.1002/cmdc.201500569

Cancer Immunotherapy: Selected Targets and Small-Molecule Modulators

Hilmar Weinmann*

Published online on February 2, 2016.
DOI: 10.1002/cmdc.201500566

A Potent and Selective P-gp Modulator for Altering Multidrug Resistance Due to Pump Overexpression

Stefano Guglielmo*, Marialessandra Contino, Loretta Lazzarato, Maria Grazia Perrone, Marco Blangetti, Roberta Fruttero, Nicola Antonio Colabufo*

Published online on February 2, 2016.
DOI: 10.1002/cmdc.201500538

Current Experimental Methods for Characterizing Protein–Protein Interactions

Mi Zhou, Qing Li, Renxiao Wang*

Coming soon.

Serpin A1 C-Terminal Peptides as Collagen Turnover Modulators
[Full Paper]

Simona Pascarella, Caterina Tiberi, Giuseppina Sabatino, Francesca Nuti, Anna Maria Papini, Lisa Giovannelli*, Paolo Rovero*

Coming soon.

Structural Re-engineering of the α-Helix Mimetic JY-1-106 into Small Molecules: Disruption of the Mcl-1–Bak-BH3 Protein–Protein Interaction with 2,6-Di-Substituted Nicotinates

Brandon Drennen, Jacob A. Scheenstra, Jeremy L. Yap, Lijia Chen, Maryanna E. Lanning, Braden M. Roth, Paul T. Wilder, Steven Fletcher*

Published online on February 4, 2016.
DOI: 10.1002/cmdc.201500461