ChemMedChem

Cover image for Vol. 9 Issue 12

Editor-in-Chief: Natalia Ortúzar

Impact Factor: 3.046

ISI Journal Citation Reports © Ranking: 2013: 18/58 (Chemistry Medicinal); 75/256 (Pharmacology & Pharmacy)

Online ISSN: 1860-7187

Associated Title(s): Angewandte Chemie International Edition, Chemistry - A European Journal, Chemistry – An Asian Journal, ChemBioChem, Medicinal Research Reviews, Molecular Informatics

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Here's a selection of upcoming papers. Also see the EarlyView page for the latest papers published online.

“Squalenoylcurcumin” Nanoassemblies as Water-Dispersible Drug Candidates with Antileishmanial Activity
[Full Paper]

Zakaria Cheikh-Ali, Joachim Caron, Sandrine Cojean, Christian Bories, Patrick Couvreur, Philippe M. Loiseau, Didier Desmaële, Erwan Poupon, Pierre Champy*

Published online on December 18, 2014.
DOI: 10.1002/cmdc.201402449

Structure–Activity Relationship Analysis of the Peptide Deformylase Inhibitor 5-Bromo-1H-indole-3-acetohydroxamic Acid
[Full Paper]

Sylvain Petit, Yann Duroc, Valéry Larue, Carmela Giglione, Carole Léon, Coralie Soulama, Alexis Denis, Frédéric Dardel, Thierry Meinnel, Isabelle Artaud*

Coming soon.

Rational Design, Synthesis, and Biological Evaluation of Lactam-Bridged Gramicidin A Analogues: Discovery of a Low-Hemolytic Antibacterial Peptide
[Full Paper]

Ji Mao, Takefumi Kuranaga, Hiroshi Hamamoto, Kazuhisa Sekimizu, Masayuki Inoue*

Published online on December 15, 2014.
DOI: 10.1002/cmdc.201402473

Design, Synthesis, and Biological Evaluation of Unconventional Aminopyrimidine, Aminopurine, and Amino-1,3,5-triazine Methyloxynucleosides
[Full Paper]

Gloria Fernández-Cureses, Sonia de Castro*, María-Luisa Jimeno, Jan Balzarini, María-José Camarasa*

Coming soon.

Discovery of Mono- and Disubstituted 1H-Pyrazolo[3,4]pyrimidines and 9H-Purines as Catalytic Inhibitors of Human DNA Topoisomerase IIα
[Full Paper]

Barbara Pogorelčnik, Matjaž Brvar, Bojana Žegura, Metka Filipič, Tom Solmajer, Andrej Perdih*

Published online on December 17, 2014.
DOI: 10.1002/cmdc.201402459

Optimization of 1,2,5-Thiadiazole Carbamates as Potent and Selective ABHD6 Inhibitors
[Full Paper]

Jayendra Z. Patel*, Tapio J. Nevalainen, Juha R. Savinainen, Yahaya Adams, Tuomo Laitinen, Robert S. Runyon, Miia Vaara, Stephen Ahenkorah, Agnieszka A. Kaczor, Dina Navia-Paldanius, Mikko Gynther, Niina Aaltonen, Amit A. Joharapurkar, Mukul R. Jain, Abigail S. Haka, Frederick R. Maxfield, Jarmo T. Laitinen, Teija Parkkari*

Published online on December 19, 2014.
DOI: 10.1002/cmdc.201402453

“Squalenoylcurcumin” Nanoassemblies as Water-Dispersible Drug Candidates with Antileishmanial Activity
[Full Paper]

Zakaria Cheikh-Ali, Joachim Caron, Sandrine Cojean, Christian Bories, Patrick Couvreur, Philippe M. Loiseau, Didier Desmaële, Erwan Poupon, Pierre Champy*

Published online on December 18, 2014.
DOI: 10.1002/cmdc.201402449

Electrochemical and mARC-Catalyzed Enzymatic Reduction of para-Substituted Benzamidoximes: Consequences for the Prodrug Concept "Amidoximes instead of Amidines"
[Full Paper]

Eva Bauch, Debora Reichmann, Ralf-Rainer Mendel, Florian Bittner, Anne-Marie Manke, Philipp Kurz*, Ulrich Girreser, Antje Havemeyer, Bernd Clement*

Published online on December 15, 2014.
DOI: 10.1002/cmdc.201402437

Investigating the Anti-leishmanial Effects of Linear Peptoids
[Communication]

Gabriela A. Eggimann, Hannah L. Bolt, Paul W. Denny*, Steven L. Cobb*

Published online on December 15, 2014.
DOI: 10.1002/cmdc.201402416

Carborane-Derived Local Anesthetics are Isomer Dependent
[Communication]

George R. Kracke, Monika R. VanGordon, Yulia V. Sevryugina, Peter J. Kueffer, Kuanysh Kabytaev, Satish S. Jalisatgi, M. Frederick Hawthorne*

Coming soon.

Design of gem-Difluoro-bis-Tetrahydrofuran as P2 Ligand for HIV-1 Protease Inhibitors to Improve Brain Penetration: Synthesis, X-ray Studies, and Biological Evaluation
[Full Paper]

Arun K. Ghosh*, Sofiya Yashchuk, Akira Mizuno, Nilanjana Chakraborty, Johnson Agniswamy, Yuan-Fang Wang, Manabu Aoki, Pedro Miguel Salcedo Gomez, Masayuki Amano, Irene T. Weber, Hiroaki Mitsuya

Coming soon.

Discovery of 14-3-3 Protein–Protein Interaction Inhibitors that Sensitize Multidrug-Resistant Cancer Cells to Doxorubicin and the Akt Inhibitor GSK690693
[Full Paper]

Mattia Mori, Giulia Vignaroli, Ylenia Cau, Jelena Dinić, Richard Hill, Matteo Rossi, David Colecchia, Milica Pešić, Wolfgang Link, Mario Chiariello, Christian Ottmann, Maurizio Botta*

Coming soon.

Unfolding and Conformational Variations of Thrombin-Binding DNA Aptamers: Synthesis, Circular Dichroism and Molecular Dynamics Simulations
[Full Paper]

Lidan Sun, Hongwei Jin, Xiaoyang Zhao, Zhenming Liu, Yifu Guan, Zhenjun Yang, Liangren Zhang*, Lihe Zhang

Coming soon.

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