ChemMedChem

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Here's a selection of upcoming papers. Also see the EarlyView page for the latest papers published online.

Structure–Activity Relationship Analysis of the Peptide Deformylase Inhibitor 5-Bromo-1H-indole-3-acetohydroxamic Acid
[Full Paper]

Sylvain Petit, Yann Duroc, Valéry Larue, Carmela Giglione, Carole Léon, Coralie Soulama, Alexis Denis, Frédéric Dardel, Thierry Meinnel, Isabelle Artaud*

Coming soon.

Conjugates of Cisplatin and Cyclooxygenase Inhibitors as Potent Antitumor Agents Overcoming Cisplatin Resistance
[Communication]

Wilma Neumann, Brenda C. Crews, Lawrence J. Marnett, Evamarie Hey-Hawkins*

Coming soon.

Caulerpenyne and Related Bis-enol Esters Are Novel-Type Inhibitors of Human 5-Lipoxygenase
[Communication]

Phillipp Richter, Gregor Schubert, Anja Maria Schaible, Levent Cavas, Oliver Werz*, Georg Pohnert*

Published online on April 11, 2014.
DOI: 10.1002/cmdc.201402065

High-Throughput Screening of Metal-N-Heterocyclic Carbene Complexes against Biofilm Formation by Pathogenic Bacteria
[Communication]

Thierry Bernardi*, Stéphanie Badel, Pascal Mayer, Jérome Groelly, Pierre de Frémont, Béatrice Jacques, Pierre Braunstein, Marie-Laure Teyssot, Christelle Gaulier, Federico Cisnetti, Arnaud Gautier*, Sylvain Roland*

Published online on April 11, 2014.
DOI: 10.1002/cmdc.201402012

Photodelivery of CO by Designed PhotoCORMs: Correlation between Absorption in the Visible Region and Metal–CO Bond Labilization in Carbonyl Complexes
[Full Paper]

Indranil Chakraborty, Samantha J. Carrington, Pradip K. Mascharak*

Coming soon.

Photoinduced Intercalation and Coordination of a Dirhodium Complex to DNA: Dual DNA Binding
[Full Paper]

Alycia M. Palmer, Scott J. Burya, Judith C. Gallucci, Claudia Turro*

Coming soon.

Inhibition of Cathepsin Activity in a Cell-Based Assay by a Light-Activated Ruthenium Compound
[Full Paper]

Tomasz Respondek, Rajgopal Sharma, Mackenzie K. Herroon, Robert N. Garner, Jessica D. Knoll, Eric Cueny, Claudia Turro, Izabela Podgorski, Jeremy J. Kodanko*

Published online on April 11, 2014.
DOI: 10.1002/cmdc.201400081

The Integrin Ligand c(RGDf(NMe)Nal) Reduces Neointimal Hyperplasia in a Polymer-Free Drug-Eluting Stent System
[Full Paper]

Florian Rechenmacher, Kristin Steigerwald, Burkhardt Laufer, Stefanie Neubauer, Tobias G. Kapp, Liang Li, Carlos Mas-Moruno, Michael Joner, Horst Kessler*

Published online on April 11, 2014.
DOI: 10.1002/cmdc.201400078

Insight into the Recognition, Binding, and Reactivity of Catalytic Metallodrugs Targeting Stem Loop IIb of Hepatitis C IRES RNA
[Full Paper]

Seth S. Bradford, Martin James Ross, Insiya Fidai, J. A. Cowan*

Coming soon.

Synthesis and Biological Evaluation of Imidazo[2,1-b][1,3,4]thiadiazole-Linked Oxindoles as Potent Tubulin Polymerization Inhibitors
[Full Paper]

Ahmed Kamal*, M. P. Narasimha Rao, Pompi Das, P. Swapna, Sowjanya Polepalli, Vijaykumar D. Nimbarte, Kishore Mullagiri, Jeshma Kovvuri, Nishant Jain

Published online on April 8, 2014.
DOI: 10.1002/cmdc.201400069

Getting to the Source: Selective Drug Targeting of Cancer Stem Cells
[Minireview]

Fatima Ismail, David A. Winkler*

Coming soon.

Location and Conformation of Amyloid β(25–35) Peptide and its Sequence-Shuffled Peptides within Membranes: Implications for Aggregation and Toxicity in PC12 Cells
[Full Paper]

Hui-Hsu Gavin Tsai*, Jian-Bin Lee, Yuan-Ci Shih, Lei Wan, Fa-Kuen Shieh, Chin-Yu Chen

Published online on April 11, 2014.
DOI: 10.1002/cmdc.201400062

trans,cis,cis-Bis(benzoato)dichlorido(cyclohexane-1R,2R-diamine)platinum(IV): a Prodrug Candidate for the Treatment of Oxaliplatin-Refractory Colorectal Cancer
[Full Paper]

Valentina Gandin, Cristina Marzano, Giorgio Pelosi, Mauro Ravera, Elisabetta Gabano, Domenico Osella*

Published online on April 8, 2014.
DOI: 10.1002/cmdc.201400061

Investigation of a Vitamin B12 Conjugate as a PET Imaging Probe
[Full Paper]

Oluwatayo F. Ikotun, Bernadette V. Marquez, Christopher H. Fazen, Anna R. Kahkoska, Robert P. Doyle*, Suzanne E. Lapi*

Coming soon.

The Discovery of Potent Nonstructural Protein 5A (NS5A) Inhibitors with a Unique Resistance Profile—Part 2
[Communication]

Florian Wakenhut, Thien Duc Tran, Chris Pickford, Stephen Shaw, Mike Westby, Caroline Smith-Burchnell, Lesa Watson, Michael Paradowski, Jared Milbank, David Stonehouse, Kathy Cheung, Robert Wybrow, Felice Daverio, Samuel Crook, Keith Statham, David Leese, Darren Stead, Fiona Adam, Duncan Hay, Lee R. Roberts, Jean-Yves Chiva, Carly Nichols, David C. Blakemore, Gilles H. Goetz, Ye Che, Iain Gardner, Satish Dayal, Andrew Pike, Rob Webster, David C. Pryde*

Published online on April 11, 2014.
DOI: 10.1002/cmdc.201400046

The Discovery of Potent Nonstructural Protein 5A (NS5A) Inhibitors with a Unique Resistance Profile—Part 1
[Communication]

Thien Duc Tran, Florian Wakenhut, Chris Pickford, Stephen Shaw, Mike Westby, Caroline Smith-Burchnell, Lesa Watson, Michael Paradowski, Jared Milbank, Rebecca A. Brimage, Rebecca Halstead, Rebecca Glen, Craig P. Wilson, Fiona Adam, Duncan Hay, Jean-Yves Chiva, Carly Nichols, David C. Blakemore, Iain Gardner, Satish Dayal, Andrew Pike, Rob Webster, David C. Pryde*

Published online on April 11, 2014.
DOI: 10.1002/cmdc.201400045

Discovery of 14-3-3 Protein–Protein Interaction Inhibitors that Sensitize Multidrug-Resistant Cancer Cells to Doxorubicin and the Akt Inhibitor GSK690693
[Full Paper]

Mattia Mori, Giulia Vignaroli, Ylenia Cau, Jelena Dinić, Richard Hill, Matteo Rossi, David Colecchia, Milica Pešić, Wolfgang Link, Mario Chiariello, Christian Ottmann, Maurizio Botta*

Coming soon.

Chiral Resolution and Pharmacological Characterization of the Enantiomers of the Hsp90 Inhibitor 2-Amino-7-[4-fluoro-2-(3-pyridyl)phenyl]-4-methyl-7,8-dihydro-6H-quinazolin-5-one Oxime
[Full Paper]

Raffaella Amici*, Chiara Bigogno, Roberto Boggio, Andrea Colombo, Stephen M. Courtney, Roberto Dal Zuffo, Giulio Dondio, Fulvia Fusar, Stefania Gagliardi, Saverio Minucci, Marco Molteni, Christian A. G. N. Montalbetti, Annalisa Mortoni, Mario Varasi, Stefania Vultaggio, Ciro Mercurio

Coming soon.

Nonlinear Dimensionality Reduction for Visualizing Toxicity Data: Distance-Based Versus Topology-Based Approaches
[Full Paper]

Natalia V. Kireeva*, Svetlana I. Ovchinnikova, Igor V. Tetko, Abdullah M. Asiri, Konstantin V. Balakin , Aslan Yu. Tsivadze

Published online on April 11, 2014.
DOI: 10.1002/cmdc.201400027

Total Synthesis of Anticoagulant Pentasaccharide Fondaparinux
[Full Paper]

Tiehai Li, Hui Ye, Xuefeng Cao, Jiajia Wang, Yonghui Liu, Lifei Zhou, Qiang Liu, Wenjun Wang, Jie Shen*, Wei Zhao*, Peng Wang*

Published online on April 11, 2014.
DOI: 10.1002/cmdc.201400019

Design, Synthesis, and Activity Evaluation of GK/PPARγ Dual-Target-Directed Ligands as Hypoglycemic Agents
[Communication]

Jianxun Lu, Lei Lei, Yi Huan, Yongqiang Li, Lijing Zhang, Zhufang Shen, Wenxiang Hu, Zhiqiang Feng*

Published online on April 15, 2014.
DOI: 10.1002/cmdc.201400009

G-Quadruplex Structures and Their Interaction Diversity with Ligands
[Minireview]

Sulin Zhang, Yanling Wu*, Wen Zhang*

Published online on April 11, 2014.
DOI: 10.1002/cmdc.201300566

Unfolding and Conformational Variations of Thrombin-Binding DNA Aptamers: Synthesis, Circular Dichroism and Molecular Dynamics Simulations
[Full Paper]

Lidan Sun, Hongwei Jin, Xiaoyang Zhao, Zhenming Liu, Yifu Guan, Zhenjun Yang, Liangren Zhang*, Lihe Zhang

Coming soon.

Insight into the Functional and Structural Properties of 3-Arylcoumarin as an Interesting Scaffold in Monoamine Oxidase B Inhibition
[Full Paper]

Maria João Matos*, Santiago Vilar, Verónica García-Morales, Nicholas P. Tatonetti, Eugenio Uriarte, Lourdes Santana, Dolores Viña

Published online on April 17, 2014.
DOI: 10.1002/cmdc.201300533

Fluorine-Containing 6,7-Dialkoxybiaryl-Based Inhibitors for Phosphodiesterase 10 A: Synthesis and in vitro Evaluation of Inhibitory Potency, Selectivity, and Metabolism
[Full Paper]

Gregor Schwan, Ghadir Barbar Asskar, Norbert Höfgen, Lenka Kubicova, Uta Funke, Ute Egerland, Michael Zahn, Karen Nieber, Matthias Scheunemann, Norbert Sträter, Peter Brust, Detlef Briel*

Published online on April 11, 2014.
DOI: 10.1002/cmdc.201300522

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