ChemMedChem

Cover image for Vol. 10 Issue 5

Editor-in-Chief: Natalia Ortúzar

Impact Factor: 3.046

ISI Journal Citation Reports © Ranking: 2013: 18/58 (Chemistry Medicinal); 75/256 (Pharmacology & Pharmacy)

Online ISSN: 1860-7187

Associated Title(s): Angewandte Chemie International Edition, Chemistry - A European Journal, Chemistry – An Asian Journal, ChemBioChem, Medicinal Research Reviews, Molecular Informatics

Preview

Here's a selection of upcoming papers. Also see the EarlyView page for the latest papers published online.

Structure–Activity Relationship Analysis of the Peptide Deformylase Inhibitor 5-Bromo-1H-indole-3-acetohydroxamic Acid
[Full Paper]

Sylvain Petit, Yann Duroc, Valéry Larue, Carmela Giglione, Carole Léon, Coralie Soulama, Alexis Denis, Frédéric Dardel, Thierry Meinnel, Isabelle Artaud*

Coming soon.

Rational Design of Ruthenium Complexes Containing 2,6-Bis(benzimidazolyl)pyridine Derivatives with Radiosensitization Activity by Enhancing p53 Activation
[Full Paper]

Zhiqin Deng, Lianling Yu, Wenqiang Cao, Wenjie Zheng, Tianfeng Chen*

Published online on April 27, 2015.
DOI: 10.1002/cmdc.201500127

Multitarget-Directed Tricyclic Pyridazinones as G Protein-Coupled Receptor Ligands and Cholinesterase Inhibitors
[Full Paper]

Amedeo Pau*, Marco Catto*, Giovanni Pinna, Simona Frau, Gabriele Murineddu, Battistina Asproni, Maria M. Curzu, Leonardo Pisani, Francesco Leonetti, Maria Isabel Loza, José Brea, Gérard A. Pinna, Angelo Carotti

Published online on April 29, 2015.
DOI: 10.1002/cmdc.201500124

MS565: A SPECT Tracer for Evaluating the Brain Penetration of BAF312 (Siponimod)
[Full Paper]

Emmanuelle Briard*, Bettina Rudolph, Sandrine Desrayaud, Joel A. Krauser, Yves P. Auberson*

Published online on April 29, 2015.
DOI: 10.1002/cmdc.201500115

Multitarget Therapeutic Leads for Alzheimer´s Disease: Quinolizidinyl Derivatives of Bi- and Tricyclic Systems as Dual Inhibitors of Cholinesterases and β-Amyloid (Aβ) Aggregation
[Full Paper]

Michele Tonelli*, Marco Catto*, Bruno Tasso, Federica Novelli, Caterina Canu, Giovanna Iusco, Leonardo Pisani, Angelo De Stradis, Nunzio Denora, Anna Sparatore, Vito Boido, Angelo Carotti, Fabio Sparatore

Published online on April 29, 2015.
DOI: 10.1002/cmdc.201500104

Aryloxyethyl Thiocyanates Are Potent Growth Inhibitors of Trypanosoma cruzi and Toxoplasma gondii
[Full Paper]

María N. Chao, Carolina Exeni Matiuzzi, Melissa Storey, Catherine Li, Sergio H. Szajnman, Roberto Docampo, Silvia N. J. Moreno, Juan B. Rodriguez*

Published online on April 27, 2015.
DOI: 10.1002/cmdc.201500100

Approaching ‘Kit-Type´ Labelling with 68Ga: The DATA Chelators
[Full Paper]

Johanna Seemann*, Bradley P. Waldron, Frank Roesch, David Parker

Coming soon.

Selective Inhibitors of the Protein Tyrosine Phosphatase SHP2 Block Cellular Motility and Growth of Cancer Cells in vitro and in vivo
[Full Paper]

Stefanie Grosskopf[WWW], Chris Eckert, Christoph Arkona, Silke Radetzki, Kerstin Böhm, Udo Heinemann, Gerhard Wolber, Jens-Peter von Kries, Walter Birchmeier, Jörg Rademann*

Published online on April 30, 2015.
DOI: 10.1002/cmdc.201500015

Discovery of 14-3-3 Protein–Protein Interaction Inhibitors that Sensitize Multidrug-Resistant Cancer Cells to Doxorubicin and the Akt Inhibitor GSK690693
[Full Paper]

Mattia Mori, Giulia Vignaroli, Ylenia Cau, Jelena Dinić, Richard Hill, Matteo Rossi, David Colecchia, Milica Pešić, Wolfgang Link, Mario Chiariello, Christian Ottmann, Maurizio Botta*

Coming soon.

Unfolding and Conformational Variations of Thrombin-Binding DNA Aptamers: Synthesis, Circular Dichroism and Molecular Dynamics Simulations
[Full Paper]

Lidan Sun, Hongwei Jin, Xiaoyang Zhao, Zhenming Liu, Yifu Guan, Zhenjun Yang, Liangren Zhang*, Lihe Zhang

Coming soon.

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