ChemMedChem

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Here's a selection of upcoming papers. Also see the EarlyView page for the latest papers published online.

Structure–Activity Relationship Analysis of the Peptide Deformylase Inhibitor 5-Bromo-1H-indole-3-acetohydroxamic Acid
[Full Paper]

Sylvain Petit, Yann Duroc, Valéry Larue, Carmela Giglione, Carole Léon, Coralie Soulama, Alexis Denis, Frédéric Dardel, Thierry Meinnel, Isabelle Artaud*

Coming soon.

Diaryl-Substituted Azolylthioacetamides: Inhibitor Discovery of New Delhi Metallo-β-Lactamase-1 (NDM-1)
[Communication]

Yi-Lin Zhang, Ke-Wu Yang*, Ya-Jun Zhou, Alecander E. LaCuran, Peter Oelschlaeger, Michael W. Crowder

Published online on July 22, 2014.
DOI: 10.1002/cmdc.201402249

Double GC:GC Mismatch in dsDNA Enhances Local Dynamics Retaining the DNA Footprint: A High-Resolution NMR Study
[Communication]

Anirban Ghosh, Rajiv Kumar Kar, Janarthanan Krishnamoorthy, Subhrangsu Chatterjee*, Anirban Bhunia*

Coming soon.

Are 1,4- and 1,5-Disubstituted 1,2,3-Triazoles Good Pharmacophoric Groups?
[Full Paper]

Alberto Massarotti*, Silvio Aprile*, Valentina Mercalli, Erika Del Grosso, Giorgio Grosa, Giovanni Sorba, Gian Cesare Tron

Coming soon.

Amphiphilic Bicyclic Peptides as Cellular Delivery Agents
[Communication]

Donghoon Oh, Shaban Anwar Darwish, Amir Nasrolahi Shirazi, Rakesh Kumar Tiwari, Keykavous Parang*

Published online on July 22, 2014.
DOI: 10.1002/cmdc.201402230

Activity of Core-Modified 10–23 DNAzymes against HCV
[Full Paper]

Laura Robaldo, Alfredo Berzal-Herranz*, Javier M. Montserrat, Adolfo M. Iribarren*

Coming soon.

Indolicidin Targets Duplex DNA: Structural and Mechanistic Insight through a Combination of Spectroscopy and Microscopy
[Communication]

Anirban Ghosh, Rajiv Kumar Kar, Jagannath Jana, Abhijit Saha, Batakrishna Jana, Janarthanan Krishnamoorthy, Dinesh Kumar, Surajit Ghosh*, Subhrangsu Chatterjee*, Anirban Bhunia*

Published online on July 17, 2014.
DOI: 10.1002/cmdc.201402215

Conjugation to Albumin-Binding Molecule Tags as a Strategy to Improve Both Efficacy and Pharmacokinetic Properties of the Complement Inhibitor Compstatin
[Communication]

Yijun Huang, Edimara S. Reis, Patrick J. Knerr, Wilfred A. van der Donk, Daniel Ricklin, John D. Lambris*

Published online on July 23, 2014.
DOI: 10.1002/cmdc.201402212

Insight into the Interactions between Novel Coumarin Derivatives and Human A3 Adenosine Receptors
[Full Paper]

Maria João Matos*, Santiago Vilar, Sonja Kachler, André Fonseca, Lourdes Santana, Eugenio Uriarte, Fernanda Borges, Nicholas P. Tatonetti, Karl-Norbert Klotz

Published online on July 18, 2014.
DOI: 10.1002/cmdc.201402205

N-Acyl Derivatives of 4-Phenoxyaniline as Neuroprotective Agents
[Full Paper]

Marlene T. Barho, Sina Oppermann, Florian C. Schrader, Inga Degenhardt, Katharina Elsässer, Christof Wegscheid-Gerlach, Carsten Culmsee, Martin Schlitzer*

Published online on July 17, 2014.
DOI: 10.1002/cmdc.201402195

Discovery of Methyl 4′-Methyl-5-(7-nitrobenzo[c][1,2,5]oxadiazol-4-yl)-[1,1′-biphenyl]-3-carboxylate, an Improved Small-Molecule Inhibitor of c-Myc–Max Dimerization
[Full Paper]

Jay Chauhan, Huabo Wang, Jeremy L. Yap, Philip E. Sabato, Angela Hu, Edward V. Prochownik, Steven Fletcher*

Coming soon.

Bis-Pyrene-Modified Unlocked Nucleic Acids: Synthesis, Hybridization Studies, and Fluorescent Properties
[Full Paper]

Pavla Perlíková, Maria Ejlersen, Niels Langkjær, Jesper Wengel*

Published online on July 18, 2014.
DOI: 10.1002/cmdc.201402185

Singly Modified Amikacin and Tobramycin Derivatives Show Increased rRNA A-Site Binding and Higher Potency against Resistant Bacteria
[Full Paper]

Richard J. Fair, Lisa S. McCoy, Mary E. Hensler, Bernice Aguilar, Victor Nizet*, Yitzhak Tor*

Published online on July 23, 2014.
DOI: 10.1002/cmdc.201402175

Preparation and Properties of Clickable Amino Analogues of the Duocarmycins: Factors That Affect the Efficiency of Their Fluorescent Labelling of DNA
[Full Paper]

Moana Tercel*, Sarah P. McManaway, H. D. Sarath Liyanage, Frederik B. Pruijn

Published online on July 17, 2014.
DOI: 10.1002/cmdc.201402169

Dangling Ends Perturb the Stability of RNA Duplexes Responsive to Surrounding Conditions
[Full Paper]

Hisae Tateishi-Karimata[WWW], Smritimoy Pramanik, Shu-ichi Nakano, Daisuke Miyoshi, Naoki Sugimoto*

Coming soon.

Structural and Biochemical Studies of Actin in Complex with Synthetic Macrolide Tail Analogues
[Full Paper]

Jose H. Pereira, Chutima Petchprayoon, Alexander C. Hoepker, Nigel Moriarty, Sarah J. Fink, Giuseppe Cecere, Ian Paterson, Paul D. Adams, Gerard Marriott*

Published online on July 22, 2014.
DOI: 10.1002/cmdc.201402150

Importance of the 6′-Hydroxy Group and Its Configuration for Apramycin Activity
[Full Paper]

Appi Reddy Mandhapati, Dimitri Shcherbakov, Stefan Duscha, Andrea Vasella*, Erik C. Böttger*, David Crich*

Published online on July 17, 2014.
DOI: 10.1002/cmdc.201402146

DNA Nanostructure-Based Imaging Probes and Drug Carriers
[Minireview]

Pengfei Zhan, Qiao Jiang, Zhen-gang Wang, Na Li, Haiyin Yu*, Baoquan Ding*

Published online on July 17, 2014.
DOI: 10.1002/cmdc.201402137

Exploring Directional Invasion of Serum Nuclease into siRNA Duplexes by Asymmetrical Terminal Modifications
[Full Paper]

Ye Huang, Yuan Ma, Yujia Guo, Lang Zou, Hongwei Jin, Lijun Zhong, Yun Wu, Lihe Zhang, Zhenjun Yang*

Published online on July 17, 2014.
DOI: 10.1002/cmdc.201402115

Discovery of 14-3-3 Protein–Protein Interaction Inhibitors that Sensitize Multidrug-Resistant Cancer Cells to Doxorubicin and the Akt Inhibitor GSK690693
[Full Paper]

Mattia Mori, Giulia Vignaroli, Ylenia Cau, Jelena Dinić, Richard Hill, Matteo Rossi, David Colecchia, Milica Pešić, Wolfgang Link, Mario Chiariello, Christian Ottmann, Maurizio Botta*

Coming soon.

Unfolding and Conformational Variations of Thrombin-Binding DNA Aptamers: Synthesis, Circular Dichroism and Molecular Dynamics Simulations
[Full Paper]

Lidan Sun, Hongwei Jin, Xiaoyang Zhao, Zhenming Liu, Yifu Guan, Zhenjun Yang, Liangren Zhang*, Lihe Zhang

Coming soon.

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