Copyright © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Editor-in-Chief: Natalia Ortúzar
Impact Factor: 3.046
ISI Journal Citation Reports © Ranking: 2013: 18/58 (Chemistry Medicinal); 75/256 (Pharmacology & Pharmacy)
Online ISSN: 1860-7187
October 22, 2009
VIP: Interaction of Artemisinins with Oxyhemoglobin Hb–FeII, Hb–FeII, CarboxyHb–FeII, Heme–FeII, and Carboxyheme FeII: Significance for Mode of Action and Implications for Therapy of Cerebral Malaria
Paolo Coghi, Nicoletta Basilico, Donatella Taramelli, Wing-Chi Chan, Richard K. Haynes*, Diego Monti*
Members of the artemisinin class of antimalarial drugs are commonly thought to exert their effects from activation by hemoglobin–FeII or heme–FeII species. From a series of carefully executed experiments, Haynes, Monti, and colleagues report strong evidence against this mechanism of drug activation. These findings not only shed new light on the antiplasmodial activity of artemisinins, but will very likely facilitate the design and optimization of future antimalarial drugs.
Received August 19, 2009; published online October 20, 2009, DOI: 10.1002/cmdc.200900342.