ChemMedChem

Cover image for Vol. 13 Issue 4

Editorial Board Chairs: Karl-Heinz Altmann, Antonello Mai, Rainer Metternich. Editor: David Peralta

Impact Factor: 3.225

ISI Journal Citation Reports © Ranking: 2016: 17/60 (Chemistry Medicinal); 73/257 (Pharmacology & Pharmacy)

Online ISSN: 1860-7187

Associated Title(s): Angewandte Chemie International Edition, Chemistry - A European Journal, Chemistry – An Asian Journal, ChemBioChem, Medicinal Research Reviews, Molecular Informatics

March 22, 2010

VIP: Azides Derived from Colchicine and Their Use in Library Synthesis: a Practical Entry to New Bioactive Derivatives of an Old Natural Drug

VIP: Azides Derived from Colchicine and Their Use in Library Synthesis: a Practical Entry to New Bioactive Derivatives of an Old Natural Drug

Norman Nicolaus, Janet Zapke, Philipp Riesterer, Jörg-Martin Neudörfl, Aram Prokop, Hartmut Oschkinat, and Hans-Günther Schmalz*

The natural product colchicine is an established antimitotic drug that targets microtubule formation by selective tubulin binding. In this paper Schmalz and colleagues report their efficient semisynthetic access to a library of novel colchicinoids, along with some initial screening results. K. Barry Sharpless commented on the work as being "one of the best quick-connect triazole SARs I've seen yet." Indeed, the compounds identified are promising candidates for the development of new antiproliferative drugs.

Received February 15, 2010; published online March 12, 2010, DOI: 10.1002/cmdc.201000063.

Your Comment...

[Browse more news]

SEARCH

SEARCH BY CITATION