ChemMedChem

Cover image for Vol. 11 Issue 22

Editorial Board Chairs: Antonello Mai, Rainer Metternich. Assoc. Editors: David Peralta, Scott Williams (Sr)

Impact Factor: 2.98

ISI Journal Citation Reports © Ranking: 2015: 18/59 (Chemistry Medicinal); 77/255 (Pharmacology & Pharmacy)

Online ISSN: 1860-7187

Associated Title(s): Angewandte Chemie International Edition, Chemistry - A European Journal, Chemistry – An Asian Journal, ChemBioChem, Medicinal Research Reviews, Molecular Informatics

June 17, 2010

VIP: Proteins as Possible Targets for Cytotoxic trans-Platinum(II) Complexes with Aliphatic Amine Ligands: Further Exceptions to the DNA Paradigm

VIP: Proteins as Possible Targets for Cytotoxic trans-Platinum(II) Complexes with Aliphatic Amine Ligands: Further Exceptions to the DNA Paradigm

Leticia Cubo, Michael Groessl, Paul J. Dyson, Adoración G. Quiroga,* Carmen Navarro-Ranninger, and Angela Casini*

Efforts to improve the activity of platinum-based anticancer drugs have long been focused on cis geometric compounds; trans-configured species are thus considered "rule-breakers", and have thus been widely left alone. In their Full Paper, Quiroga, Casini, and colleagues show that certain trans-PtII species warrant attention, particularly for cases in which preferential drug binding to peptide targets over oligonucleotides is desired.

Received March 12, 2010; published online June 16, 2010, DOI: 10.1002/cmdc.201000104.

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