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Online ISSN: 1860-7187
August 03, 2010
VIP: High-Resolution Crystal Structure of a Lasso Peptide
Herbert Nar,* Angela Schmid, Carsten Puder, and Olivier Potterat
Lariat protoknot (lasso) peptides, in which the C-terminal tail is threaded through an N-terminal macrolactam ring on the same molecule, are gathering increased attention for their potential use in a variety of bioactive contexts. Nar and colleagues determined the first high-resolution crystal structure of a such a lasso peptide, BI-32169, providing unprecedented detail into the structure of this class of important natural products.
With the first crystal structure of a lasso peptide, it is now possible to analyze the fine structure of the lasso fold at atomic resolution and to discuss structural details in terms of the known biochemical properties of BI-32169 as a representative of this family of peptides. Comparing the NMR with the crystal structure, it is obvious that despite overall similarities (lasso fold, location of ring penetrating residues) there are striking differences in the peptide structure, not only in the side chain conformations, but also in backbone structure.
Received June 23, 2010; published online July 27, 2010, DOI: 10.1002/cmdc.201000264.