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Editorial Board Chairs: Antonello Mai, Rainer Metternich. Assoc. Editors: David Peralta, Scott Williams (Sr)
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ISI Journal Citation Reports © Ranking: 2014: 19/59 (Chemistry Medicinal); 83/255 (Pharmacology & Pharmacy)
Online ISSN: 1860-7187
March 27, 2012
Focusing on Neglected Diseases
The Medicinal Chemistry division of the American Chemical Society (ACS) kicked off the 243rd National Meeting & Exposition on Sunday with an exceptional symposium entitled Challenges in Phenotypic Whole-Cell High-Throughput Screening and Medicinal Chemistry Optimization of Hits: Strategies to Discover Novel Antiparasitic and Antimycobacterial Agents (organizers: K. Chibale, J. Butera). The focus of the symposium on diseases such as malaria and human African trypanosomiasis (HAT) indicates the increasing focus of the drug discovery community toward these neglected diseases and the associated unmet medical needs.
The first speaker was Professor Ian Gilbert from the Drug Discovery Unit (DDU) at the University of Dundee (UK). He delivered an interesting talk about the identification of N-myristoyltransferase (NMT) as a novel target in Trypanosoma brucei, the parasite that causes HAT, and his research group's efforts to identify inhibitors of this enzyme. Prof. Gilbert, who was recently profiled in ChemMedChem, and his collaborators are prominent authors in the journal; see below for a list of recent publications from the DDU.
For further reading, check out last year's Special Issue on Rare and Neglected Diseases.