ChemMedChem

Cover image for Vol. 12 Issue 15

Editorial Board Chairs: Karl-Heinz Altmann, Antonello Mai, Rainer Metternich. Editor: David Peralta

Impact Factor: 3.225

ISI Journal Citation Reports © Ranking: 2016: 17/60 (Chemistry Medicinal); 73/256 (Pharmacology & Pharmacy)

Online ISSN: 1860-7187

Associated Title(s): Angewandte Chemie International Edition, Chemistry - A European Journal, Chemistry – An Asian Journal, ChemBioChem, Medicinal Research Reviews, Molecular Informatics

January 03, 2013

VIP: Butyltin(IV) Benzoates: Inhibition of Thioredoxin Reductase, Tumor Cell Growth Inhibition, and Interactions with Proteins

VIP: Butyltin(IV) Benzoates: Inhibition of Thioredoxin Reductase, Tumor Cell Growth Inhibition, and Interactions with ProteinsKely Navakoski de Oliveira, Vincent Andermark, Susanne von Grafenstein, Liliane A. Onambele, Gregor Dahl, Riccardo Rubbiani, Gerhard Wolber, Chiara Gabbiani, Luigi Messori, Aram Prokop, Ingo Ott*

Organometallic compounds are widely used in catalytic chemistry, but so far they remain a curiosity concerning their use in drug design. Over the last few years medicinal chemistry research into organometallics has increased significantly, and many reported results indicate a considerable potential for these metal complexes in drug development.

The strong cytotoxic effects of tin organometallics are well known and make them potential anticancer drug candidates. However, knowledge regarding the mode of action of these compounds is limited. A multidisciplinary and international group of research teams coordinated by Ingo Ott at the Technische Universität Braunschweig in Germany has provided evidence that inhibition of thioredoxin reductase is a contributing factor in the biological effects of tin-based complexes. Virtual screening for thioredoxin reductase inhibitors had indicated this mechanism, which was further confirmed by a combination of synthetic, analytical, and biological chemistry experiments. These results contribute to a better understanding of the biochemistry of tin organometallics and provide new options for the rational design of improved derivatives.

Received October 31, 2012; published online December 23, 2012, DOI: 10.1002/cmdc.201200505.

Your Comment...

[Browse more news]

SEARCH

SEARCH BY CITATION