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Online ISSN: 1860-7187
October 08, 2007
Nobel Prize in Physiology or Medicine 2007 to Capecchi, Evans, and Smithies
The Nobel Assembly at Karolinska Institutet has awarded the Nobel Prize in Physiology or Medicine for 2007 jointly to Mario R. Capecchi (b. 1937, HHMI and Univ. of Utah, Salt Lake City, USA), Martin J. Evans (b. 1941, Cardiff Univ., UK) and Oliver Smithies (b. 1925, Univ. of North Carolina at Chapel Hill, USA) for their discoveries of principles for introducing specific gene modifications in mice by the use of embryonic stem cells. These discoveries led to the creation of an immensely powerful technology referred to as gene targeting in mice. Gene targeting is often used to inactivate single genes. Such gene "knockout" experiments have elucidated the roles of numerous genes in embryonic development, adult physiology, aging, and disease. With gene targeting it is now possible to produce almost any type of DNA modification in the mouse genome.