ChemMedChem

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Editorial Board Chairs: Karl-Heinz Altmann, Antonello Mai, Rainer Metternich. Editor: David Peralta

Impact Factor: 3.225

ISI Journal Citation Reports © Ranking: 2016: 17/60 (Chemistry Medicinal); 73/257 (Pharmacology & Pharmacy)

Online ISSN: 1860-7187

Associated Title(s): Angewandte Chemie International Edition, Chemistry - A European Journal, Chemistry – An Asian Journal, ChemBioChem, Medicinal Research Reviews, Molecular Informatics

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October 04, 2017

Call for Nominations: 2018 IUPAC–Richter Prize

Call for Nominations: 2018 IUPAC–Richter PrizeThe 2018 IUPAC–Richter Prize will be presented at the 36th National Medicinal Chemistry Symposium (ACS-MEDI NMCS: April 29th to May 2nd, 2018 in Nashville, Tennessee, USA) as well as the XXV International Symposium on Medicinal Chemistry (EFMC-ISMC: September 2nd–6th, 2018 in Ljubljana, Slovenia), where the recipient will also give plenary lectures on the subject of his or her research.

The prize, accompanied by US$10,000, is to be awarded to an internationally recognized scientist, preferably a medicinal chemist, whose activities have made an outstanding contribution to the field of medicinal chemistry.

See the IUPAC website for detailed information, along with an electronic nomination form. The submission deadline for awardee nominations is December 15th, 2017. We hope to see you at these conferences next year!

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Recently Published Articles

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    Dr. John C. Widen, Dr. Aaron M. Kempema, Jordan W. Baur, Hannah M. Skopec, Jacob T. Edwards, Tenley J. Brown, Dr. Dennis A. Brown, Dr. Frederick A. Meece and Prof. Daniel A. Harki

    Version of Record online: 19 JAN 2018 | DOI: 10.1002/cmdc.201700752

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    Sesquiterpenes simplified: A library of small molecules containing α-methylene-γ-butyrolactones and/or cyclopentenones representative of the natural product helenalin was synthesized. The kinetics of hetero-Michael addition of thiols to each electrophile was characterized, as well as the abilities of each compound to regulate NF-κB signaling. We find the α-methylene-γ-butyrolactone reacts irreversibly with biological thiols and contributes most to biological activity amongst the two electrophiles.

  2. You have full text access to this OnlineOpen article
    Achieving Biocompatible SABRE: An in vitro Cytotoxicity Study

    Dr. Anand Manoharan, Dr. Peter J. Rayner, Dr. Wissam Iali, Dr. Michael J. Burns, Prof. V. Hugh Perry and Prof. Simon B. Duckett

    Version of Record online: 18 JAN 2018 | DOI: 10.1002/cmdc.201700725

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    Catalyst removal options: It is possible to head toward the destination, in vivo imaging under SABRE with biocompatibility, via two routes. One requires quenching of catalyst and separation via an ion-exchange column. The second route, biphasic catalysis, employs the aqueous phase, and no catalyst is carried forward. Upon exiting, a biocompatible medium is achieved.

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    Dr. Manuela Basso, Dr. Huan Huan Chen, Dr. Debasmita Tripathy, Dr. Mariarosaria Conte, Dr. Kim Y. P. Apperley, Dr. Angela De Simone, Prof. Dr. Jeffrey W. Keillor, Prof. Dr. Rajiv Ratan, Dr. Angela Nebbioso, Dr. Federica Sarno, Prof. Dr. Lucia Altucci and Dr. Andrea Milelli

    Version of Record online: 18 JAN 2018 | DOI: 10.1002/cmdc.201700601

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    Many hands make light work: We discovered that concomitant inhibition of histone deacetylase (HDAC) and transglutaminase 2 (TG2) synergistically protects cortical neurons from toxic stimuli induced by glutamate. Based on this finding, we have developed a new class of multiple ligands that are able to modulate both targets. Compound 3 inhibits both targets in vitro and in cells, and is effective in halting oxidative stress-mediated neuronal death.

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    Accepted manuscript online: 16 JAN 2018 09:51AM EST | DOI: 10.1002/cmdc.201800019

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