Biotechnology Journal

Cover image for Vol. 12 Issue 8

Edited By: Alois Jungbauer and Sang Yup Lee

Impact Factor: 3.649

ISI Journal Citation Reports © Ranking: 2016: 23/77 (BIOCHEMICAL RESEARCH METHODS); 39/158 (Biotechnology & Applied Microbiology)

Online ISSN: 1860-7314

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Congratulations to the winning cover of BTJ's 2016 cover contest!

Biotechnology Journal 2016 cover contest winner: October cover

The October issue cover was provided by the authors of the article Chlorella species as hosts for genetic engineering and expression of heterologous proteins: Progress, challenge and perspective, Bo Yang, Jin Liu, Yue Jiang and Feng Chen. The winner of the book voucher was informed via email. Many thanks to the more than 1000 participants who were voting for these covers!


CRISPR autumn collection

Recently Published Articles

  1. Human Pulmonary 3D Models For Translational Research

    Katja Zscheppang, Johanna Berg, Sarah Hedtrich, Leonie Verheyen, Darcy E. Wagner, Norbert Suttorp, Stefan Hippenstiel and Andreas C. Hocke

    Version of Record online: 20 SEP 2017 | DOI: 10.1002/biot.201700341

    Thumbnail image of graphical abstract

    Illustration of the different requirements and achievements (first and second level) for different types of 3D human pulmonary models (third level), which then can be applied in different methodological modalities and read-out systems (fourth level) to give insight in toxicological, functional, or disease related aspects (fifth level).

  2. A Cost-Effective Culture System for the In Vitro Assembly, Maturation, and Stimulation of Advanced Multilayered Multiculture Tubular Tissue Models

    Caroline Loy, Daniele Pezzoli, Gabriele Candiani and Diego Mantovani

    Version of Record online: 20 SEP 2017 | DOI: 10.1002/biot.201700359

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    Tubular tissues of the human body are usually composed by multiple cell types arranged in concentric layers. Their (re)generation in laboratory is a challenging area of research for the development of engineered tissue substitutes and in vitro models to test drugs, medical devices, and to study biological processes. Herein, a system for the fabrication of tubular tri-layered structures is designed and validated for the production of advanced artery models. Tri-layered tissues incorporating the three cell types of blood vessels could be prepared in 2 days and then cultured in static and dynamic conditions allowing to easily investigate their structural and mechanical properties.

  3. Recombinant Domain V of Human Perlecan Is a Bioactive Vascular Proteoglycan

    Jelena Rnjak-Kovacina, Fengying Tang, Xiaoting Lin, John M. Whitelock and Megan S. Lord

    Version of Record online: 19 SEP 2017 | DOI: 10.1002/biot.201700196

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    The C-terminal domain V of the extracellular matrix proteoglycan perlecan plays unique and often divergent roles in a number of biological processes. In this study, the authors recombinantly expressed and characterized the C-terminal region of perlecan, which includes domain V. This recombinantly expressed proteoglycan (rDV) supported endothelial cell interactions to the same extent as full-length perlecan and has potential therapeutic applications in blood contacting medical devices.

  4. In Situ Bone Tissue Engineering with an Endogenous Stem Cell Mobilizer and Osteoinductive Nanofibrous Polymeric Scaffolds

    Jong Seung Lee, Yoonhee Jin, Hyun-Ji Park, Kisuk Yang, Min Suk Lee, Hee Seok Yang and Seung-Woo Cho

    Accepted manuscript online: 19 SEP 2017 05:20AM EST | DOI: 10.1002/biot.201700062

  5. Biomaterial substrate-mediated multicellular spheroid formation and their applications in tissue engineering

    Ting-Chen Tseng, Chui-Wei Wong, Fu-Yu Hsieh and Shan-hui Hsu

    Accepted manuscript online: 19 SEP 2017 05:20AM EST | DOI: 10.1002/biot.201700064