Chemistry – An Asian Journal

Cover image for Vol. 11 Issue 10

Editor: Theresa Kueckmann, Deputy Editor: Heiko Kuhn; Chairman of the Editorial Board: Ryoji Noyori

Impact Factor: 4.587

ISI Journal Citation Reports © Ranking: 2014: 26/157 (Chemistry Multidisciplinary)

Online ISSN: 1861-471X

Associated Title(s): Angewandte Chemie International Edition, Asian Journal of Organic Chemistry, Chemistry - A European Journal, ChemNanoMat, Chinese Journal of Chemistry, Journal of the Chinese Chemical Society, The Chemical Record

7_10/2012Cover Picture: Chiral-Substrate-Assisted Stereoselective Epoxidation Catalyzed by H2O2-Dependent Cytochrome P450SPα (Chem. Asian J. 10/2012)

Chiral substrate analogues assist in the enantioselective epoxidation of styrene catalyzed by H2O2-dependent cytochrome P450SPα. In their Full Paper on page 2286 ff., Yoshihito Watanabe et al. report that the stereoselectivity of styrene oxide is largely affected by the chirality of the substrate analogues and that (R)-ibuprofen greatly enhances the formation of (S)-styrene oxide, thus showing that ibuprofen works as a chiral inducer. This unique strategy using the chiral substrate analogues allows for the alteration of the enantioselectivity of enzymes without any mutagenesis and thus contributes to the development of novel asymmetric biocatalysts.

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