PROTEOMICS - Clinical Applications

Cover image for Vol. 11 Issue 7-8

Editor: Lorna Stimson (Editor-in-Chief), Deputy Editor: Lucie Kalvodova

Impact Factor: 3.814

ISI Journal Citation Reports © Ranking: 2016: 19/77 (BIOCHEMICAL RESEARCH METHODS)

Online ISSN: 1862-8354

Associated Title(s): PROTEOMICS

2_02/2008Cover Picture: Proteomics – Clinical Applications 2/2008

Cover Illustration: The application of proteomics to investigate cartilage function and disease. Mouse cartilage structures throughout development and in disease are depicted. The articular surface, meniscal fibrocartilage and underlying bone at 3 weeks are stained with haematoxilin/eosin (upper left panel). The high magnification confocal micrograph is stained to highlight collagen VI, a marker for the pericellular matrix (upper right panel). The neonatal shoulder joint is stained with toluidine blue to illustrate the dense proteoglycan-rich extracellular matrix (lower left panel). Proteoglycan is lost from the articular cartilage in a mouse model of arthritis (central panels). Resolution of cartilage extracts and cellular proteins by 2-D electrophoresis (lower right panel). For further details see Wilson, R., Bateman, J. F., Proteomics Clin. Appl. 2008, 2, 251–263 (in this issue).

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