Molecular profiling of sepsis in mice using Fourier Transform Infrared Microspectroscopy
Rekha Gautam, Mukta Deobagkar-Lele, Shamik Majumdar, Bhagawat Chandrasekar, Emmanuel Victor, Syed Moiz Ahmed, Nitin Wadhwa, Taru Verma, Srividya Kumar, Nagalingam Ravi Sundaresan, Siva Umapathy and Dipankar Nandi
Article first published online: 23 MAR 2015 | DOI: 10.1002/jbio.201400089
Sepsis is the systemic inflammatory response syndrome that may occur during infections. This disorder is the leading cause of deaths in intensive care units and a major health care problem. In this study, mice models to study the progression of sepsis are used involving injection with live Salmonella Typhimurium or lipopolysacharride. The utility of using a combination of immune assays and spectroscopy in following the progression of sepsis is discussed.