SPR-based plastic optical fibre biosensor for the detection of C-reactive protein in serum
Ayda Aray, Francesco Chiavaioli, Mojtaba Arjmand, Cosimo Trono, Sara Tombelli, Ambra Giannetti, Nunzio Cennamo, Mahmood Soltanolkotabi, Luigi Zeni and Francesco Baldini
Version of Record online: 18 APR 2016 | DOI: 10.1002/jbio.201500315
A surface plasmon resonance-based biosensor implemented on a plastic optical fibre for the selective detection of C-reactive protein in a real and complex matrix (i.e. serum) is presented. With detection limit of 9 µg L–1 (below that requested in clinical applications), the proposed biosensing platform, integrated into a home-made thermo-stabilized flow cell, could underpin the need for high sensitive, real-time, label-free, portable and low cost platforms for future lab-on-a-chip applications.