Multimodal optical analysis of meningioma and comparison with histopathology
Marc Zanello, Fanny Poulon, Pascale Varlet, Fabrice Chretien, Felipe Andreiuolo, Mélanie Pages, Ali Ibrahim, Johan Pallud, Edouard Dezamis, Georges Abi-Lahoud, François Nataf, Baris Turak, Bertrand Devaux and Darine Abi-Haidar
Version of Record online: 12 FEB 2016 | DOI: 10.1002/jbio.201500251
This study explores one- and two-photon microscopy abilities to help neurosurgeons in refining the margins of resection of meningioma. Two-photon autofluorescence gives images near to the gold standard histopathology and benign meningiomas exhibited less autofluorescence and longer lifetime values than aggressive meningiomas. Two-photon microscopy can give real-time information on the histopathological structure of the tissue (meningioma, infiltrated dura mater, healthy dura mater) encountered during resection.